editorial board

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An International Review Journal BIOTECHNOLOGY ADVANCES Research Reviews and Patent Abstracts Editors M. Moo-Young (Executive), Institute ,for Biotechnology Research, University ()1 Waterloo, Waterloo, Ontario, Canada N2L 3GI J. D. Bu'Lock, Dept. ()J Chemistry, University of Manchester MI3 9PL, UK C. L. Cooney, Dept. of Chemical Engineering, MIT, Cambridge, MA 02139, USA B. R. Glick, Dept. ()f Biology, University oJ" Waterloo, Ontario, Canada N2L 3GI R. F. Gomez, Genentech lnc., 460 Point San Bruno Blvd, S. San Francisco, CA 94080, USA Managing Editor Jill Price, Pergamon Press, Oxford, UK Editorial Advisory Board D. E. Brown, Manchester, UK E. J. DaSilva, Paris, France A. L. Demain, Cambridge, MA. USA E. L. Gaden, Charlottesville, VA, USA D. Gelfand, Emerw, ille, CA, USA G. Goma, Toulouse, France H. G. Schlegel, GOttingen, FRG H. Taguchi, Osaka, Japan Subscription Rates 1986 (inclusive of postage and insurance) Annual subscription, US$110.00. Two-year subscription, US$209.00. Published as 2 issues per volume Single back volumes and parts are available. Subscription enquiries from customers in North America should be sent to Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523, USA, and for the remainder of the world to Pergamon Press Ltd., Headington ltill Hall, Oxford OX3 0BW, England. Microform Subscriptions and Back Issues Back issues of all previously published volumes are available in the regular edition and on microfilm and microfiche. Current subscriptions are available on microfiche simultaneously with the paper edition and on microfilm on completion of the annual index at the end of the subscription year. Copyright @ 1985 Pergamon Press l.muted [t is a condition of publicalion that manuscripts submitted to this journal have nol been published and v, ilL not bc simultaneously submdted ~r published elsewhere. By submitting a manuscript, the authors agree that the copyright for their article is transferred to the publisher if and when the article is accepted for publication. However. assignment of copyright is riot required from authors who work lor organisations which do not permit such assignment. The copyright covers the excLusive rights to reproduce and distribute the article, including reprints, photographic reproductions. microform or any other reproductions of similar nature and Iranslations. No part of this publication may be reproduced, stored in a relrieva[ system or transmitted in any form or by any means, electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or J.)therwisc. without permission in writing from the copyright holder. Photocopying information for users in the USA The hem-Fee Code for this publication indicates the authorization to photocopy items for internal or personal use is granted by lhc copyright holder for libraries and other users registered with the Copyright Clearance ('enter (CCC) Transactional Reporting Service provided the stated fee for copying beyond that permitted by Section 107 or 1((8 of the United States Copyright Law is paid The appropriate remittance of $1) 511 per page should bc li:,rwarded directly to the Copyright Clearance Center Inc.. 21 Congress Street. Salem. MA (II971L The copyright c, wner's cc,nsem does not extend to copying fi)r general distribution, for promotion, for creating new works, or for resale Specific written permission must bc obtained foam the publisher for such copying. In case of doubt please contact your nearest Pergamon office The Item-Fee ~ode f~)r this publication is 11734-975(I/85 $0.11~1 + 511 Publishing/Adver tising Offices Pergamon Press Ltd,, Headington Hill Hall, Oxford OX3 0BW, England Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, New York 10523, USA.

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Page 1: Editorial Board

A n In te rna t iona l Review Journa l

BIOTECHNOLOGY ADVANCES

Resea rch Reviews and Patent Abs t r ac t s

Editors M. Moo-Young (Executive), Institute ,for Biotechnology Research, University ()1 Waterloo, Waterloo, Ontario, Canada N2L 3GI

J. D. Bu'Lock, Dept. ()J Chemistry, University of Manchester MI3 9PL, UK

C. L. Cooney, Dept. of Chemical Engineering, MIT, Cambridge, MA 02139, USA

B. R. Glick, Dept. ()f Biology, University oJ" Waterloo, Ontario, Canada N2L 3GI

R. F. Gomez, Genentech lnc., 460 Point San Bruno Blvd, S. San Francisco, CA 94080, USA

Managing Editor Jill Price, Pergamon Press, Oxford, UK

Editorial Advisory Board D. E. Brown, Manchester, UK E. J. DaSilva, Paris, France A. L. Demain, Cambridge, MA. USA E. L. Gaden, Charlottesville, VA, USA

D. Gelfand, Emerw, ille, CA, USA G. Goma, Toulouse, France H. G. Schlegel, GOttingen, FRG H. Taguchi, Osaka, Japan

Subscription Rates 1986 (inclusive of postage and insurance) Annual subscription, US$110.00. Two-year subscription, US$209.00. Published as 2 issues per volume

Single back volumes and parts are available. Subscription enquiries from customers in North America should be sent to Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523, USA, and for the remainder of the world to Pergamon Press Ltd., Headington ltill Hall, Oxford OX3 0BW, England.

Microform Subscriptions and Back Issues Back issues of all previously published volumes are available in the regular edition and on microfilm and microfiche. Current subscriptions are available on microfiche simultaneously with the paper edition and on microfilm on completion of the annual index at the end of the subscription year.

Copyright @ 1985 Pergamon Press l .muted

[t is a condition of publicalion that manuscripts submitted to this journal have nol been published and v, ilL not bc simultaneously submdted ~r published elsewhere. By submit t ing a manuscript , the authors agree that the copyright for their article is transferred to the publisher if and when the article is accepted for publication. However . assignment of copyright is riot required from authors who work lor organisations which do not permit such assignment. The copyright covers the excLusive rights to reproduce and distribute the article, including reprints, photographic reproductions. microform or any other reproduct ions of similar nature and Iranslations. No part of this publication may be reproduced, stored in a relrieva[ system or transmitted in any form or by any means, electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or J.)therwisc. without permission in writing from the copyright holder.

Photocopying information for users in the USA

The hem-Fee Code for this publication indicates the authorization to photocopy items for internal or personal use is granted by lhc copyright holder for libraries and other users registered with the Copyright Clearance ( ' en ter (CCC) Transactional Repor t ing Service provided the stated fee for copying beyond that permit ted by Section 107 or 1((8 of the United States Copyright Law is p a i d The appropriate remittance of $1) 511 per page should bc li:,rwarded directly to the Copyright Clearance Center Inc.. 21 Congress Street. Salem. MA (II971L The copyright c, wner 's cc, nsem does not extend to copying fi)r general distribution, for promotion, for creating new works, or for resa le Specific written permission must bc obtained foam the publisher for such copying. In case of doubt please contact your nearest Pergamon office The Item-Fee ~ode f~)r this publication i s 11734-975(I/85 $0.11~1 + 511

Publishing/Adver tising Offices Pergamon Press Ltd,, Headington Hill Hall, Oxford OX3 0BW, England

Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, New York 10523, USA.