editorial polysaccharides for biomedical...

EditorialPolysaccharides for Biomedical Applications

Mingqiang Li ,1,2 Jianxun Ding ,3 Yu Tao ,2,4 Bingyang Shi,5 and Jing-Hua Chen6

1Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA2Laboratory of Biomaterials and Translational Medicine, The Third Affiliated Hospital, Sun Yat-sen University,Guangzhou 510630, China3Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences,Changchun 130022, China4Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA5International Joint Center for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China6School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China

Correspondence should be addressed to Mingqiang Li; [email protected], Jianxun Ding; [email protected],and Yu Tao; [email protected]

Received 18 February 2019; Accepted 18 February 2019; Published 9 April 2019

Copyright © 2019 Mingqiang Li et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Polysaccharides have been recognized and applied as promis-ing candidates for diverse biomedical and biotechnologicalapplications, such as diagnosis, bioactive therapy, controlleddrug delivery, gene therapy, theranostics, cell encapsulation,tissue engineering, and medical devices, as a benefit of theirbiocompatibility, biodegradability, inherently low immuno-genicity, and unique bioactive properties. The current specialissue is motivated by the observed increasing interest andemerging innovative research output shown in the field ofpolysaccharide-based biomaterials. It aims to disseminateresearches and advancements based on the polysaccharides,which can be used alone or applied as part of a hybrid systemfor biomedical researches and applications.

Seventeen original research articles and a review paperhave been collected in this special issue. These articles arethemed on the polysaccharide applied for antitumor, antimi-crobial, antioxidant, anti-inflammation, tissue engineering,treatment of asthma, acute lung injury, rheumatoid arthritis,and so forth.

Seven papers focus on the biomedical applications ofchitosan. S. Kim summarized the biological activities (anti-microbial, antioxidant, anticancer, and anti-inflammatoryactivities) of chitosan and its derivatives. E. Szymańskaet al. developed the β-glycerophosphate-modified chitosanhydrogels for controlled drug release. D.-L. He et al.

applied the hyaluronic acid-conjugated chitosan for theencapsulation of novel anticancer oligopeptide (Perilla seedoligopeptide (PSO)), showing a broad spectrum of anticanceractivities. Guo et al. synthesized a cationic chitosan-basednanogel with an average diameter of 55.8 nm for the deliveryof 10-hydroxycamptothecin. L. Zhang et al. prepared thealphastatin-loaded chitosan nanoparticles that could inhibitthe SphK1-S1P signaling pathway and enhance the antian-giogenic effect of alphastatin. C.-L. Li et al. developed thechitosan-polyethylenimine as an effective gene (pCGRP)transfection system for the early healing of fractures. Nguyenet al. investigated the antibacterial activity of poly(vinyl alco-hol)-chitosan-silver nanoparticle hybrid hydrogels.

Seven articles report the investigations on the biologicalactivities of natural polysaccharides. L. Zhang et al. foundthat Dendrobium officinale polysaccharides (DOPS) couldreduce the pentetrazol-induced brain inflammation and sei-zures by inhibiting the IL-1β, TNF-α, and MAPK signalpathways. J.-M. Wang et al. discovered that Astragalus poly-saccharides could be utilized as potential antioxidative drugsfor renal protection. Q. Sun et al. demonstrated the vaccineimmune effect of Robinia pseudoacacia polysaccharides(RPPS). J. Sun et al. combined anti-IL-5 mAb and Achyr-anthes bidentata polysaccharide (ABPS) to improve airwayfunction in a mouse asthma model. C. Peng et al. studied

HindawiInternational Journal of Polymer ScienceVolume 2019, Article ID 7841836, 2 pageshttps://doi.org/10.1155/2019/7841836

http://orcid.org/0000-0002-5178-4138http://orcid.org/0000-0002-5232-8863http://orcid.org/0000-0001-5087-7474https://creativecommons.org/licenses/by/4.0/https://doi.org/10.1155/2019/7841836

the anticancer effects of nanoyam polysaccharides and theCyclocarya paliurus polysaccharide in prostate cancer andthyroid cancer models, respectively. L. Cao et al. obtainedthe high quality of Astragalus polysaccharide by applyingthe cellulase method and proved its biological featuresagainst rheumatoid arthritis.

Four more studies deal with hydrogel or nanoparticle sys-tems for bone regeneration, controlled drug release, and anti-microbial against skin pathogens.

Overall, this special issue bridges the polysaccharide andbiomedical applications. We expect that related researcherswill get inspired.

Conflicts of Interest

The guest editorial team declares no conflict of interestregarding the publication of this special issue.

Acknowledgments

We greatly appreciate the contributions of all the authorsto the special issue and the constructive critiques, com-ments, and suggestions of all the reviewers and the edito-rial staff members.

Mingqiang LiJianxun Ding

Yu TaoBingyang Shi

Jing-Hua Chen

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