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„Gr. T. Popa” University of Medicine and Pharmacy, Iaşi

Faculty of Pharmacy

EDUCATION GUIDE

4

1st

YEAR

MATHEMATICS-INFORMATICS

Course content

1. General notions about information theory. Computer, algorithm, programming

language. The architecture of the computers.

2. Windows operating systems. Characteristics. Windows versions. Working with

folders and files. Windows embedded applications. Antivirus and archiving

applications.

3. Text processing in Windows: Word. Worksheet applications: MS-Excel, MS-

Access.

4. Database general considerations. Extracting statistical information from

databases.

5. Presentation of statistical data. The graphical representation of a statistical

series. Measuring of the data variation.

6. Introduction to the probability theory. Random variables and probability laws.

Elements of the probability theory. Computation of the probability for random

events. Bayes formula.

7. Standard normal distribution. Other probability laws for continuous variables.

8. Statistical tests. Analysis of the relationships between phenomena.

The content of the practical lessons

1. Presentation of the computer network facilities in the computer laboratory and

the programs installed on this computer network. The Windows operating

system.

2. The MS-Word, MS-Access and MS-Excel application.

3. Manipulating the data series using Excel program. Presentation of statistical

date.

4. Computation of the probability of events using Excel program. Formula of total

probability and the Bayes theorem.

5. Computation of the probability of events defined by random variables.

Calculation of probabilities based on PDF and CDF functions.

6. Calculating of the confidence interval.

7. Comparison between sample mean and representative population mean.

8. Statistical hypotheses testing. Linear regression analysis.

PHARMACEUTICAL PHYSICS

Course content

1. Dimensional equation. Motion types.

2. Dynamics principles. Statics notions. General conditions of equilibrium of

bodies.

3. Oscillations and waves. Sound waves; Doppler effect; ultrasounds.

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4. Fluids. Fluids statics. Fluids dynamics. Bernoulli’s equation. Dynamic of real

fluids; Blood viscosity. Sedimentation and centrifugation. Surface phenomena

in liquids. Pressure created by a curved liquid surface; contact phenomena.

5. Surface phenomena at the contact between three media; superficial tension of

solutions; thermal expansion; appreciation of drugs stability. Transport

phenomena.

6. Coulomb’s law; Electrostatic field; Electric dipole; polarization of atoms and

molecules; electric current; Ohm’s law; applications of superconductors;

Joule’s effect; electric networks in permanent regime; motion of charged

particles in electric and magnetic fields.

7. Photometry.

8. X-Ray; photoelectric effect. Atomic nucleus. Natural radioactivity.

Radiopharmaceuticals.


1. Physical quantities. Measurement of the physical quantities. Errors.

Measurement of density for solid and liquids.

2. Determination of: the superficial tension coefficient, the crioscopic point of a

solution, the melting specific latent heat of ice, the specific heat for the solid

substances, the viscosity coefficient, the surface free energy for solids, the

electric resistance, the mechanical equivalent of the calory, the osmotic

pressure, the focal distance of a lens, the refractive index, the optical

microscope qualities.

3. Evaluation of some physical factors, which influence the conservation of the

pharmaceutical products.

4. Tracing of the calibration curve for a thermocouple.

5. Measurement of density for solid and liquids.

6. Subtance identification using spectra in visible domain. Determination of the

concentration of a solution using photocolorimeter.

7. Study of the dialyse phenomenon using Kohlrausch polarimeter bridge.

8. Modification of the superficial tension coefficient by the surface-active

substances. Variation of the viscosity coefficient with temperature.

9. Application of the microscope. Tracing of the calibration curve of the prism

spectroscope.

10. Atomic absorbtion spectrophotometry. IR spectrometry.

GENERAL AND INORGANIC CHEMISTRY

Course content

1. Fundamental concepts. Structure of the atom. The periodic table. The periodic

law.

2. Chemical bonding. Intermolecular bonding.

3. The solid matter. Thermochemistry.

4. Chemical equilibrium. Ionic equilibria of weak electrolytes.

5. Dispersed systems. Oxidation-reduction reactions.

6. Coordination compounds.

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7. A survey of the nonmetals elements and its compounds

8. The chemistry of metals and its compounds

9. The importance of metals for the proper functioning of biological systems


1. Purity criterions. The purity determination of some substances. Determination

of the chemical equivalents, of crystallization water.

2. Thermochemistry. Calorimetry.

3. Chemical equilibrium. The rate of reactions and the influence of different

factors. The process of dissolution.

4. The solutions preparations and preservation. Expressing concentration.

5. pH and pOH. Acid-base indicators.

6. Synthesis of some coordination compounds.

7. The chemistry of nonmetals, metals and its compounds.

VEGETAL AND ANIMAL BIOLOGY – FIRST MODULE

Course content

1. Plant cytology and histology. Organography.

2. Plants as source of drugs.

3. Lower plants and their pharmaceutical importance.

4. Division Pteridophyta, Pinophyta and Magnoliophyta: general characters and

description of pharmaceutically important species.


1. Methods of obtaining smicroscopic sections through vegetal material.

2. Plant cytology. Cellular division.

3. Plant tissues. Vegetative and reproductive tissues.

4. Presentation of main taxonomic groups and their most important medicinal

species.

5. Determination and herborization of medicinal plants.

6. Determination and herborization of medicinal plants.

PHARMACEUTICAL PROPEDEUTICS

Course content

1. Pharmacy as a component of the sanitary system. Pharmaceutical drug

product. ATC classification system for drugs.

2. The Pharmacopoeia and pharmacopoeial standards. Active drugs. Regular and

maximum therapeutic dose. Therapeutic methods.

3. Preparation of dosage forms. Packaging and storage of dosage forms. Quality

control of drug products.

4. Dispensing of drugs. Medical prescription. The administration of drugs.

5. Medicated solutions for oral and topical use. Parenteral preparations.

Preparations for mucosal application. Medicated aerosols. Preparations for

dermal application. Semisolid and solid dosage forms.

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ANALYTICAL CHEMISTRY – FIRST MODULE

Course content

1. Analytical reactions and reagents.

2. Ion properties and their analytical classification.

3. Chemical equilibrium and its importance for the analysis. Acid-basic

equilibrium.

4. Electrolytes in solution. Analytical reactions with formation of insoluble

products.


1. Analytical reactions for the cations - separation and identification.

2. Analytical reactions for the anions.

3. Separation and identification of anion ions from a mixture.

4. General analysis: identification of ions from an unknown mixture.

PSYCHOLOGY

Course content

1. Psychological context of human being and methodology of research in human

sciences.

2. Psychological functions – perception, attention, memory, thinking,

imagination.

3. Affectivity, human activity, will.

4. The human personality. Age psychology human conduct.

5. Psychological stress.

ROMANIAN LANGUAGE


1. Romanian language - Roman language. The characteristics of medical notions.

2. Noun and noun derivates. Romanian verb. The adjective. Adverb. Pronoun.

Conjunctions and prepositions.

3. Aspects of the Romanian nation’s culture and civilization.

4. Family name, plant name.

5. An aspect of the medical act of deontology.

6. Pharmacist’s vow. Elaboration techniques of a scientific paper.

PHYSICAL EDUCATION


1. Initial testing motion abilities.

2. Developing motion abilities.

3. Motion habits of specific types of sports.

4. Applied utilitarian motion habits.

5. Final testing motion abilities.

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ANATOMY

Course content

1. Terminology. Anatomical exploration methods. Surface anatomy of the human

body anatomical, landmarks and reference lines. General information about

tissues; epithelial and connective tissues.

2. The sequence of stages of human ontogeny. Placenta. Teratogenicity.

3. Morpho-functional organization of the musculoskeletal system.

4. Morpho-functional organization of the central and peripheral nervous system.

Morpho-functional organization of sensory organs.

5. Morphofunctional organization of the digestive tract and digestive glands.

6. Morpho-functional organization of the respiratory system, of the circulatory

system, of the endocrine system, of the excretory system and of female and

male genital apparatus.


1. Anatomical terminology. Anatomical exploration methods. Epithelial and

connective tissues. The skin.

2. Human ontogenesis. Teratology data

3. Musculoskeletal anatomy. Nervous system. Anatomy of senses.

4. Structure and function of: digestive system, respiratory system, circulatory

system, urinary system, female and male genital system.

5. Endocrine glands

2nd

YEAR

ANALYTICAL CHEMISTRY – FIRST MODULE

Course content

1. Problems and methods of quantitative analytical chemistry.

2. Experimental errors. Evaluation of quantitative analysis results. Statistics on

analytical data. Evaluation and validation of quantitative analytical methods.

Applications in pharmaceutical practice.

3. Theoretical basis of gravimetry and of titrimetry.

4. Titrimetric analysis methods based on acido-basic reactions and precipitation

reactions.

5. Analytical reactions with formation of complex combinations. Titrimetric

analysis methods based on complexation reactions.

6. Analytical reactions with electron exchange. Titrimetry using redox reactions.

7. Diazotation methods.

8. Analysis of trace elements.

9. Physical and chemical separation techniques.

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10. Optical analysis methods.


1. Gravimetric assay of organic substances and ions.

2. Titrimetric analysis methods based on: acidic-basic reactions in water and

anhydrous medium, ion exchange and redox reactions, reactions with

formation of low solubility products, and methods based on reactions of

complexation and diazotation methods.

3. Solvent Extraction.

4. Ion Exchange Separation.

5. Paper Chromatography. Thin Layer Chromatography.

PHARMACEUTICAL MICROBIOLOGY AND VIROLOGY

Course content

1. Microorganism’ classification and general characters.

2. Bacteria: organization, structure, taxonomy, growth and nutrition. General

properties of selected microorganisms. Bacterial genetics.

3. Introduction to virology. Yeasts and moulds.

4. Principles of microbial pathogenity and epidemiology.

5. Fundamentals of immunology.

6. Antimicrobial agents. Mechanisms of action. Clinical uses. Bacterial resistance

to antimicrobial agents.

7. Production and quality control of imunological products.

8. Vaccination and immunization.

9. Microrganisms that affect pharmaceutical industry. Applications of

microorganisms in the pharmaceutical sciences.

10. Microbial contamination and preservation of pharmaceuticals.

11. Sterile pharmaceutical products. Sterilization and disinfection. Control and

sterility assurance.


1. Decontamination.

2. Isolation and identification of microorganisms. Stains for light microscopy.

Culturing and preserving microorganisms.

3. Identification of Gram positive cocci. Identification of Gram positive bacilli.

Identification of Gram negative cocci and bacilli.

4. Antibiotc susceptibility testing. Laboratory tests for the antiseptics and

disinfectants evaluation.

5. Microbiologycal control of air and water. Methods for evaluation of surfaces

microbial contamination.

6. Sterility control of pharmaceuticals.

7. Determination of preservative efficacy.

8. Immunological and molecular techniques for drug control. Pyrogenity tests.

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ORGANIC CHEMISTRY

Course content

1. Classification of organic reactions. Intermediates in organic chemistry.

2. Saturated, unsaturated and aromatic hydrocarbons.

3. Halogen derivatives. Organometallic compounds.

4. Alcohols and phenols. Ethers and oxonium salts.

5. Carbonyl compounds. Carboxylic compounds. Functional derivatives of

organic acids. Simple function compounds with nitrogen.

6. Stereoisomerism and stereochemical conventions.

7. Compounds containing functions with two or more nitrogen atoms in the

molecule. Mixed functions with nitrogen. Aminoacids.

8. Mixed functions with oxygen. Phenolic aldehydes and ketones. Aldehyde- and

ketone-acids.

9. Monosaccharides, disaccharides and polysaccharides.

10. Heterocycles with 5 atoms: furan, pyrrole, thiophen; indole, isoindole;

oxazole, isoxazole; thiazole, isothiazole; pyrazole, imidazole; their benzo-

derivatives; triazoles, tetrazoles; tetrazolium salts.

11. Heterocycles with 5 and 6 atoms: Pyran and benzopyran. Xanthene’s group.

Pyridine’s group. Quinoline and isoquinoline. Acridine. Phenanthridine.

Pyridazine and benzpyridazine. Pyrimidine and benzpyrimidine. Barbituric

acid. Pyrazine and benzpyrazine. Purine. Uric acid. Pteridine. Folic acid.

Aloxazine and B2 vitamin. Phenazine, phenoxazine and phenothiazine.

Triazine and tetrazine.

12. Natural compounds with polyisopentane chain. Terpenoids. Carotenoids.

Steroids.


1. Separation and purification methods for organic compounds. Physical

constants determination. Organic qualitative elemental analysis.

2. Substitution reactions that take place on the aromatic ring.

3. Nitration: nitrobenzene and m-dinitrobenzene.

4. Synthesis of some organic substances (with simple functions and

heterocyclic); chemical and spectral analysis for the main classes of organic

compounds: alcohols, phenols, carbonyl compounds, amines, hydroxy-acids,

glucides, b-keto-esters, aminoacids, proteins.

MEDICAL DEVICES

Course content

1. Applications of medical devices. Legislation. Classification of products and

units performing specific activities with medical devices. Medical equipment

labeling. Marks of conformity. Medical devices preservation. Materiovigilance.

Materials used in medical devices manufacturing.

2. Main medical devices and parapharmaceutical products. Medical devices for

diagnostic. Insulin pumps.

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3. Instruments used in general surgery. Protective gloves. Medical devices for

injection, infusion, blood transfusion. Medical equipment products for wound

management.

4. Medical devices for patient care. Oral hygiene products. Medical devices for

peripheral vascular disease. Orthesis and prosthetics.

5. Medical devices for puericulture. Mechanic contraceptives.

PHYSIOLOGY

Course content

1. Physiological implications of chemical elements.

2. Cell physiology.

3. The human body internal environment. Blood and lymph; physiology of blood

cells.

4. Heart and vascular physiology.

5. Physiology of respiration. Non-respiratory functions of the lung. Modified

respiratory acts.

6. Physiology of the digestive apparatus. Physiology of the liver.

7. Physiology of excretion. Physiology of the urinary pathways – micturition.

8. Physiology of endocrine glands.

9. Physiology of the nervous system.


1. Transmembrane transport. Osmosis.

2. General and neuromuscular physiology. Cronaximetry in vivo in humans.

3. Physiology of blood. Determination of: hematocrit, erythrocyte sedimentation

rate, and the hemoglobin concentration. Counting of blood cells, determination

of blood groups, bleeding time, coagulation time and prothrombin time.

4. Physiology of the heart: electrocardiographic method; components and

analysis of the electrocardiographic trace. Auscultation of the cardiac sounds.

5. Physiology of circulation: arterial pulse. Determination of arterial pressure.

6. Physiology of respiration: auscultation of respiratory sounds, determination of

respiratory volumes and flow rates.

7. Physiology of excretion: physical properties of urine. Brief urine examination,

renal clearance.

8. Physiology of the digestive apparatus: sampling of gastric and duodenal juices.

Composition and properties of digestive juices.

9. Physiology of endocrine glands: methods for the determination of hormone

concentrations; radioimmunoassay.

10. Physiology of the nervous system: somatic and autonomous reflexes of clinical

importance. Determination of tactile and gustative discrimination threshold,

determination of visual acuity.

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PHYSIOPATHOLOGY

Course content

1. General etiology and pathogenesis of disease. General adaptation syndrome.

2. Acute inflammatory reaction. Alterations in temperature regulation.

3. Pathophysiology of blood cells. Pathophysiology of hemostasis.

4. Pathophysiology of respiratory failure and pathophysiology of lung diseases.

5. Pathophysiology of nefrons, of nephrotic syndrome, of renal failure.

6. Pathohysiology of carbohydrate metabolism: diabetes mellitus, hypoglycemia.

7. Pathophysiology of protein metabolism; Pathohysiology of lipid metabolism.

8. Pathophysiology of pressure hemostasis. Atherosclerosis; Pathophysiology of

ischemic heart disease and heart failure.

9. Pathophysiology of gastrointestinal system. Pathophysiology of intestinal

diseases and malabsorbtion.

10. Pathophysiology of exocrine pancreas and liver.


1. Leukocyte disorders - screening tests; analytical tests and diagnostic tests in

leukemias. Primary hemostasis and secondary hemostasis – diagnostic tests.

Red blood cell disorders: screening tests, analytical tests.

2. Inflammatory response – diagnostic tests.

3. Respiratory system disorders: ventilation control, diagnostic of ventilatory

dysfunctions; bronchomotricity tests.

4. Carbohydrate, proteins and lipid metabolism disorders – diagnostic tests.

5. Renal disorders: static tests, dynamic tests.

6. ECG disorders. Investigation of cardiovascular disorders: investigation of

vessels, phonocardiograms.

7. Esophageal, gastric and intestinal disorders, pancreatic, liver and biliary tract

disorders - diagnostic tests.

8. Renal disorders: static tests, dynamic tests.

MEDICAL AND PHARMACEUTICAL TERMINOLOGY

Course content

1. The definition of the concept: medical and pharmaceutical terminology.

2. Basis components of medical and pharmaceutical terms.

3. The basis rules used in forming terms and applications.

4. Terms that refer to the doctor- chemist- patient relationship.

5. Terms and abbreviations used in writing a recipe.

6. Medical terms that refer to major systems of the human body.

PHYSICAL CHEMISTRY

Course content

1. The physical properties of the substances determined by the structure.

2. Spectra in UV, VIS, IR. Relationship betveen optical properties and structure.

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3. The electric properties of the molecules and the interaction of the molecules

with an external electric field. The magnetic properties of the molecules and

the interaction of the molecules with an external magnetic field.

4. Methods for determining the electric dipole moment and dielectric constant.

Molecular refraction. Applications of electric dipole moment and of the

magnetic dipole moments in the analysis. Parachute. Spectra of electron spin

resonance, nuclear magnetic resonance spectra.

5. Chemical thermodynamics. Physics equilibrium. Chemical kinetics.

6. Theory of the simple reactions. Catalitic reactions in homogeneous and

heterogeneous systems. Photochemical reactions.

7. Electrochemistry. The transport of the ions in solution. The transfer of electric

charge at the interface metal/electrolyte solution. Electrochemical properties of

the substances.


1. Determination of some properties and their relation with the structure of

molecules: determination of extinction in the UV/VIS and molar extinction

coefficient; determining the molecular refraction, parachor and polarimetric

measurements.

2. Determining the specific rate, the half-life and the energy of activation of some

irreversible reactions of first and second order.

3. The study of equilibrium in solutions: determining the repartition and

ionization constants.

4. Conductometry and the potentiometry - relations between electrical properties

and chemical structure. Applications.

5. Aplications of catalysis and adsorbents.

VEGETAL AND ANIMAL BIOLOGY – SECOND MODULE

Course content

1. Biomembranes and the basic concept of the biomembranes. The metabolic

functions for the membranous cell systems and the distribution of the enzymes.

2. The role and permeability of the biomembranes and its implication in the

transport patways.

3. Translocators: porins, ion channels, molecular pumps.

4. Intracellular communication/signaling: signaling proteins, receptors and

ligands. Examples of receptors.

5. Cell signaling over short distances or over large distances and/or scales.

MEDICAL GENETICS

Course content

1. Introduction in medical genetics. DNA – molecular substrate of heredity. Gene

structure and function.

2. Inheritance of genetic information.

3. Genetic disorders. Monogenic disorders.

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4. Multifactorial disorders, congenital anomalies.

5. Prevention of genetic disorders; treatment of genetic disorders.


1. Human chromosomes.

2. Sexual chromatin. Chromosomal anomalies.

3. Normal monogenic traits.

4. Pedigrees, monogenic inheritance – criteria.

5. Genetic counselling, recurrence risk.

LATIN LANGUAGE


1. Concepts of Phonetics; Phonetic exercises.

2. The Noun. First and second declension; The Verb. The Present Indicative.

Third, forth and fifth declension. The Verb sum. The Present Indicative Passive.

The Deponent Verbs. The Gerund. The Periphrastic conjugation. The irregular

verbs. The Adjectives; The Degrees of comparison of Adjectives. The

Imperative mood; Lexical and grammatical exercises

3. The Numeral. The Adverb; The Degrees of comparison of Adverbs; The

Present Active and Passive; The Participle. The Prepositions; The Pronoun and

Pronominal Adjectives; Lexical and grammatical exercises.

4. Creating Latin medical terms through various lexical processes. Word

formation.

PHYSICAL EDUCATION


1. The requirements of the Physical Education course.

2. Initial testing motion abilities. Developing motion abilities

3. Motion habits of specific types of sports

4. Applied utilitarian motion habits

BIOMATERIALS

Course content

1. Classification of the biomaterials; Properties characteristic to the biomaterials.

2. Rules and standards regarding the testing of a biomaterial. Characterization

methods for the surfaces of the biomaterials.

3. Techniques of sterilization and disinfection applied to the biomaterials.

4. Applications of the biomaterials in the biomedical domain.

5. Methods used to improve the surface properties of the biomaterials. Systems

with controlled release; polymeric materials receptive to extern stimuli.

BIOSTATISTICS AND COMPUTER NETWORKS

Course content

1. Hypothesis testing: Test of multiple hypotheses. Application to drug

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bioequivalence.

2. Logistic regression.

3. Qualitative variable association. Alternative variable association. Nominal

variable association. Ordinal variable association. Applications.

4. Computer networks. Unix operating systems. The Internet

COMMUNICATION SKILLS IN ENGLISH FOR PHARMACISTS

Course content

5. Communication Skills in Theory and Practice.

6. Developing the Relationship with the Patient. Skills for the Patient Encounter.

Interacting with the Physician.

7. Developing Language and Communication. Communicating on Sensitive

Issues.

8. Conflict Management: the Angry Patient. Helping Patients with Change.

3rd

YEAR

PHYSICO-CHEMISTRY

Course content

1. The physico-chemistry of the heterogeneous dispersed systems and of the

surfaces.

2. The heterogeneous dispersed systems. Liophobic disperse systems. Soils,

Suspensions, Emulsions.

3. Molecular colloids. Association micellar colloids.

4. Kinetico-molecular, electrical and optical properties of the disperse

heterogeneous systems.

5. General superficial phenomena and the physico-chemistry of the surfaces of

separation. The absorption.


1. Molecular colloids.

2. Association micelar colloids.

3. Liophobic dispersions.

4. The study of the absorption at the interfaces S/L and L/G.

PHARMACEUTICAL BIOCHEMISTRY AND CLINICAL LABORATORY

Course content

1. Mineral elements involved in biochemical processes.

2. Enzymes.

3. Liposoluble and hydrosoluble vitamins.

4. Oxidative metabolism and the energy synthesis.

5. The metabolism of carbohydrates, proteins, aminoacids and lipids.

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6. The metabolism of nucleotides and nucleic acids.

7. Hormones. The relationship between hormones and metabolism.


1. Biological samples used in biochemistry laboratory and the factors that could

modify the results of biochemical tests.

2. Qualitative and quantitative analysis of proteins. Hemoglobin determination.

3. Enzymes: structure, properties. Factors that modify enzymes’ activity.

Evaluation and interpretation of enzymes’ activity: transferases, hydrolases.

4. Analysis of vitamins.

5. Quantitative analysis of: glucose, urea, uric acid, creatinine, bilirubin, lipids,

cholesterol, triglycerides, HDL, LDL, calcium, magnesium and iron.

6. Urine analysis.

PHARMACOGNOSY

Course content

1. Simple phenolic glycosides – generalities. Herbal products containing simple

phenolic glycosides.

2. Polyphenolic acids derivatives– generalities. Herbal products containing

polyphenolic acids derivates.

3. Tannins – generalities. Herbal products containing tannins.

4. Flavonoids – generalities. Herbal products containing flavonoids.

5. Coumarins – generalities. Herbal products containing coumarins.

6. Lignins – generalities. Herbal products containing lignins.

7. Carbohydrates – generalities, Vegetal products/carbohydrates of therapeutical

interest.

8. Alkaloids – generalities. Herbal products/extracts containing alkaloids derived

from: glycocol, tryptophan, phenylalanine, lysine-ornithine, acetyl-CoA.

9. Anthraglycosides – generalities. Herbal products/extracts containing

anthraglycosides.

10. Lipids – generalities. Lipids for therapeutic use.

11. Terpenes – generalities. Essential oils – generalities. Herbal products

containing essential oils.

12. Saponins – generalities. Herbal products containing saponins.

13. Cardiotonic heterosides – generalities. Herbal products containing cardiotonic

glycosides.


1. The pharmacognostic study of herbal products containing: simple phenolic

glycosides, derivatives of polyphenolic acids, tannins, flavonoids, coumarins,

lignans, carbohydrates, alkaloids (derived from glycocol, tryptophan,

phenylalanine, lysine-ornithine and acetyl-CoA), anthraglycosides, essential

oils, nonvolatile terpenes, saponins and cardiotonic glycosides.

2. Pharmacognostic study of vegetal and animal lipids.

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DRUG CHEMISTRY

Course content

1. Antiseptic and disinfectant substances.

2. Chemotherapic substances. Chemotherapic substances active in: urinary

infections, intestinal infections.

3. Antimycobacterial chemotherapic substances.

4. Antimalaric synthetic chemotherapic substances.

5. Chemotherapic substances active in Amoebiase, Trichomoniase, Giardiose.

Antihelminthics.

6. Beta-lactamic antibiotics. Non-beta-lactamic antibiotics. Uncatalogued

Antibiotics.

7. Antimycotics. Antivirals.

8. Antitumorals.


1. Pharmaceutical substance quality determination. Pharmaceutical substance

purity control according with active norms.

2. Pharmaceutical substance monographies.

3. General, specific and differentiation chemical reactions in various classes of

pharmaceutical substances.

4. Synthesis and analysis of pharmaceutical substances from following classes:

antiseptic and disinfectant substances, chemotherapics, beta-lactamic

antibiotics, tetracyclins and phenicols.

5. Identity determination of some pharmaceutical substances from studied

classes.

PHARMACEUTICAL TECHNOLOGY

Course content

1. Concept of Pharmaceutics; aims and importance of Pharmaceutical

technology; evolution of pharmaceutical dosage forms and procedures.

2. Routes of administration of drugs: Medical prescription, Controlled

substances, Calculation of maximum dosage for controlled substances in

prescriptions. Factors affecting stability and storage of drug medications.

3. Pharmaceutical dosage forms as homogenous dispersion systems: Solutions,

Syrups. Limonades. Drinking solutions.

4. Homogenous liquid pharmaceutical preparations for topical mucosal

application: Otic preparations, Nasal preparations, Buccal and pharyngeal

pharmaceutical preparations, Topical solutions.


1. Concept and objectives of Pharmaceutics; Organizing pharmacy. Romanian

Pharmacopoeia. Quantitative evaluation of drug substances by arbitrary

measures. Practical applications in the preparation of extemporaneous, officinal

and/or industrial formula.

2. Oral liquid preparations – Solutions – General Monograph in Romanian

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Pharmacopoeia X-th Ed. and Supplements.

3. Medicated solutions - Simple aqueous solutions, officinal and non-officinal

solutions. Aqueous solution with active substances obtained through

preparation. Aqueous solutions containing controlled drug substances; basic

parts of medical prescription. Titrated solutions.

4. Aqueous solutions containing tinctures and extracts. Aromatic waters.

5. Pharmaceutical syrups. Lemonades – Syrups.

6. Liquid pharmaceutical preparations for topical application. Officinal

Monography. Alcoholic solutions. Solution with anhydrous solvents. Vegetal

oils solutions. Solutions with combined solvents. Otic homogenous liquid

preparations. Nasal homogenous liquid preparations. Homogenous liquid

preparations for mucosal application.

7. Solutions with slightly soluble substances.

ANALYTICAL CHEMISTRY – SECOND MODULE

Course content

1. Mass spectrometry.

2. Electro-analytical methods.

3. Radiometrical and radiochemical methods.

4. Thermal analysis methods.

5. Automated methods of analysis.

Conţnutul laboratorului

1. High Performance Liquid Chromatography. Gas Chromatography.

2. Electrophoresis.

3. Spectrophotometry UV, VIS, IR and Atomic Absorption Spectroscopy

4. Electroanalytical methods: Potentiometric titration, Selective Electrode

Potentiometry, Electrogravimetry, Coulometry.

PHARMACODYNAMICS

Course content

1. Branches of pharmacology. The drug.

2. General pharmacokinetics: pharmacokinetics stages, the availability of the

drugs; drug bioavailability; biopharmacy; Drug passage through biological

membranes; Drug absorption; Drug transport in the blood; Drug diffusion and

distribution in the organism; Drug biotransformation; Drug elimination from

the organism.

3. General pharmacodynamics: Pharmacodynamic action; Parameters of the

pharmacodynamic action; Action site; Type of action; Factors influencing the

action of drugs.


1. Concepts and introductory notions regarding the pharmacodynamics study of

the drug. Experimental methods in pharmacodynamics.

2. Measure units used in drug preparation and administration. Prescription

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writing.

3. General pharmacokinetics. The variation of absorption in relation to the

administered pharmaceutical form. The concept of bioavailability.

Biopharmacy. The variation of drug absorption rate according to the

concentration or the route of administration. Drug elimination. The variation of

drug elimination rate according to the urinary pH.

4. General pharmacodynamics. The variation of pharmacodynamic action

according to various factors depending on the drug. The variation of

pharmacodynamic action in relation to various organism-depending factors.

PHARMACEUTICAL LEGISLATION AND DEONTOLOGY

Course content

1. Information regarding the pharmaceutical legislation.

2. The profession of pharmacist and the professional organization.

Pharmaceutical ethic rules.

3. Pharmaceutical units in the health system.

4. The legal status of medicines.

5. Special medications: narcotics, psychotropic, drug precursors.


1. The healthcare system in Romania - organization and operation.

2. Classification of pharmaceutical products. General information on drug

prescription and circulation.

3. Supplying the pharmaceutical units. The acceptance in the pharmaceutical

units. Dispensing the pharmaceutical products.

4. The evidence and legislation of the management.

5. Establishment of pharmaceutical units. Rules for Good Pharmaceutical

Practice.

6. Patient Rights. The malpractice compulsory insurance.

7. Rules of good wholesaler. Advertising and promotion of medicines.

HISTORY OF PHARMACY

Course content

1. Famous historians. Healing elements in Primitive Commune. The first

remedies.

2. The art of healing in the Ancient World.

3. Hippocrates and Hippocrates conception. Galen and pharmacy development.

4. Pharmacy development in the Middle Ages. Pharmacy in the Renaissance

5. Development of pharmacy in the eighteenth and nineteenth centuries.

Contemporary pharmacy.

HOMEOPATHY

Course content

1. Definition, history and importance of the homeopathy. The principles of the

20

homeopathy.

2. Homeopathic remedies. Homeopathic dynamisation methods. Homeopathic

dilution.

3. The homeopathic remedy duration of action. Remedy Relationships in

Homeopathy.

4. Homeopathic diathesis. Homeopathic pharmaceutical forms. Homeopathic

prescription.

5. Materia medica.

PARASITOLOGY

Course content

1. Human parasitic diseases. Protists. Amebiasis. Leishmaniasis. Giardiasis.

Trypanosomiasis. Trichomoniasis.

2. Plasmodium. Toxoplasma. Balantidium.

3. Helminth parasites of humans.

4. Arthropod-borne diseases.

5. Parasitologic diagnostic.

6. Drug Therapy

4th

YEAR

PHARMACEUTICAL CHEMISTRY

Course content

1. General Anaesthetics: Inhalatory Anesthetics. Intravenous Anesthetics.

2. Sedatives and Hypnotics. Tranquilizers. Antipsychotics. Antiepileptics. Anti-

Parkinsonian Drugs. Antidepressants. Psychmotor Stimulants. Opioid

Analgesics. Analgesic-Antipyretic and Nonsteroid Anti-Inflammatory drugs.

Local Anaesthetics.

3. Gout Medication.

4. The Medication for Autonomic Nervous System: Sympathomimetics,

Sympatholytics, Parasympathomimetics, Parasympatholytics.

5. Pharmaceutical Substances Acting at Autonomic Ganglia. Pharmaceutical

substances acting at Neuromuscular Junction.

6. Pharmaceutical Substances Acting on The Cardiovascular System.

7. Pharmaceutical Substances with diuretic action.

8. Pharmaceutical Substances Acting on Blood.

9. Histamine. Agonists and Antagonists.

10. Pharmaceutical Substances Acting on Digestiv System.

11. Pharmaceutical Substances Acting on Respiratory System.

12. Antidiabetics.

13. Drug Therapy for Hypercholesterolemia and Dyslipidemia.

21

14. Radiodiagnostic Substances.


1. General, Specific and Differentiation Chemical Reactions in Various Classes

of Pharmaceutical Substances.

2. Synthesis and Analysis of Pharmaceutical Substances from different classes:

Hypnotic and sedative, Tranquilizers, Neuroleptics, Local anesthetics,

Analgesic-Antipyretic and Nonsteroid Anti-Inflammatory and Stimulants of

CNS.

3. Synthesis and Analysis of Pharmaceutical Substances from different classes:

Musculo-Spasmolytics, Substances Acting on Digestive System, Antiallergy

drugs, Pharmaceutical Substances with diuretic action, Substances used in the

treatment of Hypercholesterolemia and Dyslipidemia, Radiodiagnostic

Substances and Aminoacids.

PHARMACEUTICAL TECHNOLOGY

Course content

1. Extractive pharmaceutical forms. Maceration, Infusion, Decoction, Tinctures –

manufacturing and examples. Pharmaceutical extracts.

2. Injectable pharmaceutical forms. The advantages and disadvantages. Methods

of sterilization. Quality conditions of solvent for parenterals and of injectable

pharmaceutical forms. Solvents, additives and adjuvants for injectable

medicines. Production of injectable pharmaceutical forms and containers used

fot these. Modern ways for prolongation of action injectable product. Stability

of injectable medicine. Bioavailability of injectable medicine.

3. Perfusions. Pharmaceutical containers. Perfusions manufacturing.

4. Ophtalmic pharmaceutical dosage forms – Formulation, Quality conditions;

Phases of manufacturing process of ophthalmic solutions in pharmacy and

industry. Containers type for eye drops packaging. Bioavailability of eye drops.

5. Sera and vaccines. Radiopharmaceutical dosage forms

6. Pharmaceutical dosage forms as heterogeneous dispersions. Colloidal

solutions. Emulsions. Suspensions. Aerosols.

7. Ointments. Transdermal therapeutical systems.

8. Suppositories.


1. Extractive pharmaceutical forms. Aqueous extractive solutions; decoctions;

tinctures; pharmaceuticals extracts.

2. Sterile pharmaceutical dosage forms. Injectable solutions. Perfusion solutions.

Ophtalmic solutions.

3. Lyophobic colloidal dispersions. Colloidal dispersions in water with cationic

dyes. Hydrophilic colloidal dispersions in water with different polymers.

4. Emulsions. Suspensions.

5. Ointments.

6. Suppositories.

22

PHARMACOLOGY

Course content

1. General pharmacotoxicology.

2. Drugs acting on the central and on the peripheral nervous system: General

anesthetics; Sedative-hypnotic drugs; Anxiolytic drugs, Neuroleptics;

Antiseizure drugs; Drugs for Parkinson’s disease; Central skeletal muscle

relaxants; Opioid analgesics; Antipyretic analgesics (nonopioid analgesics);

Nonsteroidal anti-inflammatory drugs; Central nervous system stimulants;

Antidepressant agents; Local anesthetics.

3. Drugs acting on the autonomic nervous system and on the neuromuscular

junction: Parasympathomymetics; Parasympatholytics; Sympathomimetic

drugs; Sympatholitic drugs; Ganglionic drugs; Neuromuscular blocking drugs.

4. Autacoids and their antagonists: histamine and antihistaminic drugs; serotonin,

serotonin agonists and antagonists; angiotensin and inhibitors of angiotensin;

prostaglandins.

5. Drugs used in respiratory disorders.

6. Drugs used in diseases of the blood.

7. Cardiovascular system drugs: Cardiac glycosides and drugs used in cardiac

arrhythmias; Drugs used in angina pectoris; antihypertensive agents; cerebral

and peripheral vasodilators; Vasoconstrictors; Drugs acting on veins and

capillaries.

8. Drugs acting on the excretory system.

9. Drugs acting on digestive apparatus.

10. Drugs acting on uterine motility.

11. Drug therapy for hypercholesterolemia and dyslipidemia.

12. Drugs acting on the endocrine system.

13. Antibiotics. Synthetic chemotherapeutic drugs. Chemotherapeutic drugs.

Cancer chemotherapeutic drugs.


1. Gradual effects and quantal effects. Quantitative evaluation of drug efficacy

and toxicity; therapeutic index.

2. General pharmacotoxicology.

3. General anesthetics; Sedative-hypnotic drugs; Tranquilizers; Neuroleptics;

Anticonvulsivant, Antiparkinsonians, Myorelaxants with central action; Opioid

analgesics; Antipyretic analgesics; Nonsteroidal anti-inflammatory drugs; CNS

stimulants; Antidepressants; Local anesthetics.

4. Drugs acting on the autonomic nervous system and on the neuromuscular

junction.

5. Autacoids and their antagonists.

6. Drugs used in eye diseases.

7. Drugs used in respiratory diseases.

8. Drugs used to treat diseases of the blood.

9. Cardiovascular system medication.

23

10. Drugs action on renal system.

11. Drugs used in gastrointestinal disorders.

12. Drugs acting on uterine motility.

13. Chemotherapeutic drugs.

ENVIRONMENTAL AND FOOD CHEMISTRY

Course content

1. Water in nature; importance of water for human activity. Properties of water;

Chemical composition of water; Water pollution; Processing of water for

potability purposes; Water related pathology; Wastewater.

2. Chemical composition of air; Pollution of atmospheric air. Soil.

3. Inadequate intake of nutrients: undernutrition and overnutrition; Coefficient of

digestibility; Retention coefficient; Proteins, lipids, sugars, mineral substances

and vitamins - their role in the diet; Dietary fiber.

4. Maturation and Alteration of foodstuffs; Preservation of foods; Toxic

substances naturally present in food products; Pollution of foodstuffs.

5. Food additives; Food quality and food security.


1. Water analysis. Determination of parameters from water. Sanitary expertise of

a sample of drinkable water.

2. Determination of NOx from air. Soil analysis.

3. Determination of nutritive elements from food products. Indicators of

freshness

4. Determination of food additives, toxic metals, pesticides, mycotoxins. Sanitary

expertise of a food product

TOXICOLOGY

Course content

1. General Toxicology. Classification of toxics. Parameters of toxicity.

Classification of intoxications.

2. Toxicokinetics. Factors that influence the toxicity.

3. Toxicodynamics: classification of toxic effects; the action of toxics on

molecular, cellular and tissues level.

4. Treatment and prophylaxis of intoxications. Toxicological expertise.

5. Gaseous toxics. Volatile toxics. Mineral toxics


1. Necessary equipment for air samples’ collection. Expression of toxics

concentration from air.

2. Toxicological analysis of gaseous toxics. 3. Isolation and tpxicological of volatile organic toxics from biological samples. 4. Isolation and toxicological analysis of mineral toxics from biological samples

and corpus delicti. 5. Determination of biotoxicological indicators

24

CLINICAL PATHOLOGY

Course content

1. Clinical pathology of respiratory system.

2. Clinical pathology of cardiovascular system.

3. Clinical pathology of the metabolic system.

4. Clinical pathology of digestive system.

5. Clinical pathology of the renal system.


1. Anamnesis of the patient, basic clinical examination. Routine biological

evaluation of the patient.

2. Symptoms and signs of the respiratory diseases. Principles for chest

radiography interpretation.

3. Electrocardiogram technique and interpretation of electrocardiogram; Correct

measurement of blood pressure and heart rate. Exemplifications and clinical

cases for ischemic heart disease, high blood pressure, valvular diseases, rhytm

troubles, arterial diseases, heart failure.

4. Interactive discussions about active depistation of the diabetes mellitus,

monitorisation and complication prevention.

5. Exemplifications and clinical cases presentations in digestive pathology.

6. Exemplifications and clinical cases discussion in renal pathology.

METHODOLOGY OF PHARMACEUTICAL SCIENTIFIC RESEARCH

Course content

1. History of science development.

2. Scientific Documentation. Editing the scientific paper. Using reproductions

when editing scientific papers.

3. Methods and techniques for research. Obstacles in scientific research.

4. Scientific research ethics.

5. Grants for scientific research.


1. Choosing the research theme; Stages of research.

2. Particular aspects concerning research in the field of medicines.

3. Validation of the specialized literature; Quality control of the experimental

results.

4. Forms of scientific communication; Editing the scientific paper - from

manuscript to „imprimatur”. Presentation of the scientific work.

CLINICAL PHARMACY

Course content

1. Clinical pharmacy: definition, introduction.

2. Attributions of the clinical pharmacist.

3. Clinical pharmacy in “clinically-oriented” community pharmacy.

25

4. Basic parameters of clinical pharmacokinetics and their applications.

5. Bioavailability and therapeutic effect.

6. Types of kinetics and compartmentalized models. Kinetics for single and

multiple dose; treatment regimen

PHYTOTHERAPY

Course content

1. Phytotherapy – general knowledge. Traditional and modern herbal medicine.

Types of vegetal extracts.

2. Phytotherapy of gastro-intestinal disorders, hepatic diseases, dermatologic

disorders and CNS disorders.

3. Vegetal origin immunostimulants

DRUGS USED IN VETERINARY MEDICINE

Course content

1. Veterinary Pharmaceutical Forms Formulation, Preparation and

Administration.

2. Chemical Structure-Pharmacodynamic Effects Relationships of the Drugs.

3. Antiseptics-Disinfectants, Antibacterial Chemotherapy, Anticoccidial

Antibiotics, Antihelminthics, Parasiticide Drugs.

4. Digestive System Medication. Hormonal Medication. Non-specific Stimulant

Therapy.

5. Zoonotic diseases.

DERMATOPHARMACY AND COSMETOLOGY

Course content

1. Elements of morpho-skin histology. Skin functions and correlation with

dermatocosmetics use.

2. Transcutaneous absorption of active substances. Cosmetically skin care.

3. The formulation, preparation and use of dermatocosmetics with nutritional and

moisturizing effect.

4. Cosmetic treatment of some dermal dystrophies.

5. Formulation, preparation and use of antiaging products. Depigmenting

products.

6. Acne: ethiopathology and dermatocosmetic treatment.

7. Dermatocosmetic products for hair and hand care. Deodorant and

antiperspirant products.

26

5th

YEAR

TOXICOLOGY

Course content

1. Toxic effects of drugs: Analgesic-antipyretics, nonsteroidal antiinflammatory.

Analgesics morphinomimetics. Hypnotics. Anxiolytic drugs. Neuroleptics.

Antidepressant drugs. Anticonvulsants. Parkinson’s disease drugs. Cortical

stimulants. Spinal stimulants. Local and general anesthetics. Drugs acting on

autonomic nervous system. Antispasmodic musculotrope. Digitalis glycosides.

Antiarrhythmics. Antihypertensives. Diuretics. Oral antidiabetics. Histamine

and antihistamines. Antibiotics and chemotherapeutics. Oral contraceptives.

2. Drug addiction. Doping. Narcotics. Hallucinogens. Major excitants. Minor

excitants. Inebriantes. Dopant substances.

3. Other toxics: Zootoxins. Toxins produced by micromycetes and macro-

mycetes. Phytopharmaceutical substances.

4. Radiotoxicology.


1. General methods for isolation of organic non-volatile compounds.

2. Toxicological analysis of medicines from biological samples: analgesic-

antipyretics, nonsteroidal anti-inflammatory, barbitals, purine derivatives,

glycosides, ephedrine, opium alkaloids, atropine, pilocarpine, synthetic local

anesthetics, strychnine, colchicine, quinine, ergot alkaloides, benzodiazepines,

phenothiazines, antidepressants, isoniazid.

3. Toxicological analysis of nicotine and phytopharmaceutical substances.

4. Determination of biotoxicological indicators.

5. Application of thin layer chromatography on toxicological analysis.

DRUGS ANALYSIS

Course content

1. Drug quality assurance.

2. The separation, identification and purity of the substances in pharmaceutical

forms.

3. Volumetric and instrumental methods used in the drug analysis.

4. Analysis of labeled substances.

5. Drugs’ stability.

6. Validation of analytical methods used in drug analysis.


1. Sampling for analysis. Organoleptic control.

2. Control limits for inorganic and organic impurities.

3. Determination of constants used in the control of drugs.

4. Analysis and control of drug solutions, syrups, tinctures, injectable

27

preparations.

5. Analysis and control of ointments, suppositories.

6. Analysis and control of drug powders, tablets.

DRUGS INDUSTRY AND PHARMACEUTICAL BIOTECHNOLOGY

Course content

1. Pharmaceutical biotechnology. Discovery, development and production of

biopharmaceuticals

2. Biotechnology overview. Devices and vessels used in biotechnology industry.

3. Biotechnology of antibacterial, antifungal, antitumor, antitubercular antibiotics,

HMG-CoA reductaze inhibitors, vitamins, aminoacids, organic acids,

immunosuppressants and antivirals.

4. Recombinant human insulin, recombinant human growth hormone and

somatostatin, recombinant coagulation factors, recombinant anticoagulants and

recombinants thrombolityc agents, recombinant interferons, recombinant

interleukins, recombinant erythropoietin, recombinant vaccines and monoclonal

antibodies.


1. Synthesis of: phenacetin, nipagin, phenacemide, dihydrostreptomycine and

methicillin.

2. Enzymatic hydrolysis of penicillin G sodium salt.

3. Recrystallization and purification of laboratory synthesized substances

CLINICAL PHARMACY

Course content

1. Clinical general pharmacodynamics.

2. Clinical general pharmacotoxicology.

3. Clinical general pharmacotherapy.

4. Scientific analysis of a prescription.

5. Common and special therapeutic surveillance.

6. Patient information and counseling concerning the therapeutic prescription

writing. Primary symptomatic assista


1. The concept of clinical pharmacy. Clinical issues regarding general

pharmacotherapy. Patients’ profile, working models.

2. Clinical pharmacokinetics. Clinical pharmacodynamics. Clinical

pharmacotoxicology.

3. Clinical issues in pregnancy, childhood and elderly.

4. Topics of clinical pharmacy for a scientifically rational therapy in the

pathology of the respiratory system, cardiovascular system, digestive system,

renal system, pathology of pain, blood disorders. Presentation of clinical cases.

Analysis of therapy.

5. Topics of clinical pharmacy for a scientifically rational therapy in the use of

28

chemotherapy.

6. Topics of clinical pharmacy for a scientifically rational therapy in primary

symptomatic assistance.

INDUSTRIAL PHARMACEUTICAL TECHNOLOGY

Course content

1. Manufacture steps of the industrial dosage forms: Research and development:

pilot scale manufacture and scale-up steps; Components and characteristics of

the pharmaceutical industry. Essential elements in the quality of drug products.

Industrial packaging, storage and shelf life of an industrial dosage form.

Quality assurance and Good Manufacturing Practice in the pharmaceutical

industry. Validation.

2. Solid dosage forms as heterogeneous disperse systems – Dosage forms

composed of individual particles: Powders.

3. Encapsulated dosage forms.

4. Solid dosage forms made by aggregation and agglomeration of particles:

Medicated gums, Soft lozenges. Hard candy lozenges. Medicated lollipops.

Molded tablets. Medicated chocolates, Granules, Pellets.

5. Solid dosage forms made by agglomeration and compaction: Tablets.

6. Coated solid dosage forms.

7. Modified release dosage forms.


1. Solid dosage forms as macro-heterogeneous disperse systems: Oral solid

dosage forms. Pharmaceutical powders. Preparation, unit operations.

2. Powders: Pharmacopoeial standards. Multiple active drug powders. Powders

with potent active drugs. Powders containing lipophilic active drugs, volatile

oils and substances. Topical powders.

3. Capsules: Monographs in the Romanian Pharmacopoeia 10th

edition and

Supplement 2004. Hard gelatin capsules.

4. Granules. Molded tablets. Lozenges.

5. Tablets: Monographs in the Romanian Pharmacopoeia 10th edition, European

Pharmacopoeia 7th

edition. Preparation of tablets. Coated tablets.

6. Interactions occurring in pharmaceutical dosage forms.

BIOPHARMACY

Course content

1. The concept of biopharmacy and bioavailability. The role of biopharmacy in

the drug optimization.

2. The conception of a new drug in term of a better bioavailability.

Preformulation and formulation - the link between the active drugs and

excipients with the aim to prepare a pharmaceutical dosage forms in lab or

industry.

3. Biopharmaceutical factors which influence the bioavailability.

29

4. Biopharmaceutical phase. Bioequivalence of drugs.

5. Drugs bioavailabilily from enteral and parenteral pharmaceutical dosage forms.

6. Drugs bioavailability from respiratory route, from topic and mucosa

pharmaceutical dosage forms and transdermal delivery systems.

PHARMACEUTICAL MANAGEMENT AND MARKETING

Course content

1. Introductory notions upon management. Functions of management. Methods

used in management. The National Sanitary System Management

2. The management of the Pharmaceutical National System.

3. The decision in management. The direction functions. Managers and leading

styles. Human resources management.

4. Specifical problems of the Pharmacy management. Quality standards for

pharmacies.

5. The Management of the actual public phrmacy. The inventory management.

The risk management. Communication & management.

6. The marketing function and the characteristics of the pharmaceutical

management. The market segmentation. The life cycle of the product. The

brand. Publicity for pharmaceutical products and services.


1. The Pharmaceutical Management as a part of the health management. The

pharmaceutical market segmentation.

2. The human resources management in the pharmacy.

3. The decision in the pharmaceutical management. The leader schedule. The

pharmaceutical product mix.

4. The pharmacy authorisation. The life cycle of the pharmaceutical product.

5. Abilities and qualities of a good manager.

6. Statistical indicators used in the pharmaceutical management. The marketing

plan.

SOCIAL PHARMACY AND COMMUNICATION WITH PATIENT

Course content

1. The concept of social pharmacy; methods of pharmacist-patient

communication.

2. Communication concept. Factors which influence communication pharmacist-

patient.

3. Pharmacist – the person, which deliver and counsel about drugs.

4. General and special advises about drugs delivery.

5. The role of pharmacist in self-medication. Concept of self-medication.

Approaches to prevent self-medication.


1. Assessment of communication skills.

2. Pharmacist-patient communication for the nose-ear-throat and cough drugs.

30

3. Pharmacist-patient communication for the antacid drugs, ophthalmic drugs,

contraception drugs, HRT, gastrointestinal drugs.

4. Pharmacist-patient communication for pregnancy and post-partum medication

THE ASSURANCE AND IMPROVEMENT OF QUALITY STANDARDS IN

PHARMACEUTICAL UNITS

Course content

1. Fundamental principles of quality management and explanation of terms used.

2. Steps in the certification of pharmaceutical units.

3. Quality standards in pharmaceutical units.

4. The quality manual in pharmaceutical units.

5. Preparations for meeting the evaluation grid in pharmaceutical units.

INTERACTIONS BETWEEN HERBAL MEDICINES AND PRESCRIBED

DRUGS

Course content

1. Mechanisms of herbal drugs-medicines interactions – modulation of

cytochrom P450 and glycoprotein P; clinical implications.

2. Interactions between herbal drugs and cardiovascular medication, CNS

medication, anti-inflammatory and analgesic medication, hormone medication,

anti-diabetic medication, antiviral medication, cytostatic medication, and

immunosupresive medication.

PRACTICAL LESSONS IN PHARMACY

The content of practical guide

1. Pharmacy organisation.

2. Preparation and liberation of drugs from pharmacy.

3. Financial administration in pharmaceutical network.

4. Management and marketing activities in pharmacy.

5. General and special advices about drugs delivery.

6. Patient counseling.

31

Student evaluation

The teachers will present to the students the rules for periodical and final evaluation.

For the establishment of the final grade the following are taken in consideration:

answers in the written /oral exam (final examination), final answers in the practical

laboratory exam, periodical testing through written paper, continuous testing during

the semester, activities such as homeworks/papers/essays/translation/projects

Promotion from one year to another one is allowed without fully acquirement of

number of credits; exams, which were not passed, must not exceed 15 credits.

Bachelor’s degree in Pharmaceutical Science

The title conferred is Licentiate in Pharmacy/Bachelor’s Degree in Pharmaceutical

Science. The final examination consists of a graduation exam and a diploma paper.

Postgraduate studies

Postgraduate training courses – Teachers of Faculty of Pharmacy organize courses

that usually last for 20 hours. Faculty of Pharmacy offers postgraduate courses for

pharmacists, chemists, biologists, physicians and assistants of pharmacy.

Residency studies – three years postgraduate training in two fields Clinical Laboratory

and Clinical Pharmacy.

Doctoral studies – in pharmaceutical field: Analytical Chemistry, Pharmacognosy,

Pharmaceutical Technology, Drugs Analysis and Toxicology.

Facilities for students

“Gr. T. Popa” U.M.F. Iaşi Central Library

The library offers to students a large number of scientific books in medical field

(252.298 volums) and free acces to scientific database Proquest EMBASE, Oxford

Medical Journals, Science Direct, CSA Research Pack, Springerlink–Journals,

Cambridge University Press Journals, Emerald Journals and Sage Journals.

Students for their preparation could use 3 reading rooms and Internet room with

workstations.

Accomodation

8 hostels, 2 canteens-restaurant, sports hall and grounds

32

Learning outcomes of the programme of study

- Design, formulation, manufacture and conditioning of medicines, food

supplements, cosmetics and other health care products.

- Storage, preservation and distribution of medicines, food supplements, cosmetics

and other health care products.

- Delivery of medicines, food supplements, cosmetics, other health care products

and pharmaceutical care.

- Analysis and control of medicines, food supplements, cosmetics and other health

care products, analysis in biochemistry, toxicology, food and environmental

hygiene laboratories.

- Management, marketing and health care administration.

- Consultancy and expertise in the field of medicines, food supplements, cosmetics

and other health care products.

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