edu.umch.de · 1.4 field of study health 1.5 study cycle licence 1.6 study program medicine 2. data...

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Adresa UMFST: Târgu Mureş, str. Gh. Marinescu nr. 38, 540139, judeţul Mureş, România

Web: www.umftgm.ro | Email: [email protected] | Tel: +40 265 215 551 ext. 246 | Fax: +40 265 210 407

FACULTATEA DE MEDICINĂ Faculty of Medicine

SYLLABUS – 3rd YEAR

No.

Educational activities - Objects/Disciplines

1 Pharmacology.

2 Bacteriology. Virusology. Parasitology

3 Pathology

4 Pathophysiology

5 Surgical Semiology (1)

6 Medical Semiology (1)

7 Clinical Biochemistry. Immunology

8 Surgical Semiology (2)

9 Medical Semiology (2)

10 Hygiene, Environmental Health and Food Safety

11 Scientific Research Methodology

12 Medical Biostatistics

13 Optional courses:

Legal Responsibility of the Medical Profession

Alternative Medicine

SYLLABUS

1. Data regarding the program

1.1 Higher education institution UNIVERSITY OF MEDICINE AND PHARMACY OF TÎRGU MUREȘ

1.2 Faculty Medicine

1.3 Department M2

1.4 Field of study Health

1.5 Study cycle Licence

1.6 Study program Medicine

2. Data regarding the discipline 2.1 Name Bacteriology-virology-parasitology 1

2.2 Course coordinator Szekely Edit

2.3 Practical activity coordinator(s) Szekely Edit,

2.4 Study year III 2.5 Semester I 2.6 Type of evaluation Exam 2.7 Type of discipline DF

3. Total estimated time (hours per semester of didactic activities)

3.1 Hours per week 4 3.2 out of which

lecture 2

3.3 laboratory practical

activity 2

3.4 Total hours in the curriculum 56 3.5 out of which

lecture 28


activity 24

Distribution of time pool per week 3

hours

Study of books, lecture materials, bibliography, notes 1

Supplemental documentation at the library, from specialized information portals and in the field 1

Preparation for seminaries/laboratories, homework, reports, portfolios and essays 1

Tutorial activities 0.5

Examinations 0.5

Other activities 1

3.7 Total hours of individual study per

week 5

3.8 Total hours per semester 56

3.9 Credits 4

4. Prerequisites (where applicable) 4.1 curricular

prerequisites

4.2 competency

prerequisites

5. Conditions (where applicable) 5.1 for lectures

5.2 for laboratory and practical

activities

6. Specific competencies acquired

Professional competencies

- suspect/recognize infectious diseases caused by bacteria

- require proper bacteriological analysis to establish etiology

- understanding results provided by the laboratory and using them

accordingly in the management of patients with infectious diseases

- understanding the medical problems caused by the emergence and

spread of antimicrobial resistance and the need for proper antibiotic use in

order to prevent further selection of resistance

- acquire basic knowledge of prophylaxis and treatment of bacterial

infections

- emergent and re-emergent bacterial infections

Transversal competencies

- develop abilities for teamwork, efficient verbal and written

communication skills

- respect for professional values and ethics,

- solving clinical problems and chosing proper therapeutical decisions

7. Objectives of the discipline (based on the grid of specific competencies)

7.1 General objective

To acquire knowledge of the basic biology of bacteria, pathogenesis

of infections caused by them and possibilities of diagnosis,

prevention and treatment.

7.2 Specific objectives

Students should become familiar with the:

- morphology, physiology and genetics of bacteria

- pathogenesis of infections caused by them

- role of immune system in defense against bacterial infections

Students should understand the basic microbiological diagnostic

principles, should know the factors that influence results and

indications for performing microbiology tests.

Students should acquire basic knowledge on the mechanism of

action of antibiotics and development of resistance against

antibiotics. They should familiarize with basic epidemiological and

immunization concepts.

They should gain knowledge about specific medically important

bacteria in respect of associated diseases, mode of transmission,

possibilities of prevention and treatment.

Students should understand the role of the human microbiota, the

concept of colonization, infection and contamination.

They should recognize:

- the importance of infection in special patient categories, such as

immune suppressed, hospitalized patients

- bioterrorism

- the role of vaccines in prevention

- therapeutic and epidemiological impact of antimicrobial resistance

8. Contents Crt. 8.1 Lecture Teaching Hours Observations ICS correlation

no. methods

First semester

1. 1. The object and purpose of medical

microbiology. History of microbiology.

Oral

presentations

PPT

2

History of

microbiology

2.

2. Bacterial morphology. Bacterial cell structure.

Chemical composition of bacteria. Growth and

multiplication of bacteria. Physical, chemical and

biological factors affecting bacteria. Bacterial

genetics.

Oral

presentations

PPT

2

Bacterial

morphology,

bacterial structure,

metabolism,

multiplication,

antimicrobial

resistance

3.

3. Pathogenesis of bacterial infections. Host

defense mechanisms. Prevention of infectious

diseases.

Oral

presentations

PPT

2 Integrated

lecture –

phtysiology,

dermatology,

infectious

diseases

immunisation

immunodeficiency

infection

4.

4. Bacterial classification and nomenclature.

Gram-positive cocci: Staphylococcus genus,

Streptococcus genus, Enterococcus genus

Oral

presentations

PPT

2

bullous/vesicular

eruption, dysuria,

joint pain, joint

swelling, loose

stools, vaginal

discarge; cardiac

valve disease,

chronic renal

disease,

endocarditis,

gastroenteritis;

infectious disease

of childhood,

meningitis, oral

diseases, otitis

media, peritonitis,

respiratory tract

infection,

septicaemia, skin

infections, urinary

tract infections

5.

5. Gram-negative cocci: Neisseria gonorrhoeae,

Neisseria meningitidis; Gram-positive bacilli:

Corynebacterium genus, Bacillus genus, Listeria

genus

Oral

presentations

PPT

2

haemoptysis,

headache, raised

intracranial

pressure, loose

stools, vomiting;

disorders of

prgnancy and

deliver;

meningitis,

respiratory tract

infection,

septicaemia,

sexually

transmitted

disease, skin

infection, skin

ulceration,

pregnancy loss

6.

6 Aerobic, facultative anaerobic Gram-negative

bacilli: Escherichia coli, Shigella genus,

Salmonellagenus, Yersinia genus, Klebsiella

genus, Proteus genus

Oral

presentations

PPT

2

dysuira, loose

stools, vomiting;

gastroenteritis;

peritonitis,

respiratory tract

infections, urinary

tract infection

7.

7. Curved Gram-negative bacilli: Vibrio genus,

Campylobacter genus, Helicobacter genus;

Aerobic non-fermenter Gram-negative bacilli:

Pseudomonas aeruginosa, Acinetobacter

baumannii

Oral

presentations

PPT

2

loose stools,

vomiting;

electrolyte and

water balance,

burns, cystic

fibrosis,

gastroenteritis,

peptic ulcer,

peritonitis, skin

infections

8.

8. Gram-negative coccobacilli: Haemophilus

genus, Gardnerella genus, Bordetella pertussis,

Legionella genus

Oral

presentations

PPT

2

vaginal discharge,

sexually

transmitted

diseases,

meningitis,

respiratory tract

infections,

septicaemia

9. 9. Spore-forming (clostridia) and non-spore-

forming anaerobic bacteria

Oral

presentations

PPT

2

TBL

constipation,

dysphagia, squint,

visual impairment,

acne, oral

disorders,

peripheral nerve

disorders,

peritonitis,

septicaemia

10.

10. Bacteria that are not classified according to

Gram-staining: Mycobacterium genus,

Treponema pallidum, Borrelia burgdorferi,

Leptospira spp., Chlamydia genus, Mycoplasma

genus

Oral

presentations

PPT

2

Integrated

lecture –

phtysiology,

dermatology,

phtysiology

haemoptysis,

icterus, jpoint

pain, raised

intracranial

pressure, red eye,

acute liver

disease/failure,

meningitis,

peripheral nerve

disorders, sexually

transmitted

diseases,

tuberculosis,

urinary tract

infection

11. 11. Normal microbiota of the human body.

Specimen collection.

Oral

presentations

PPT

2

Skin, vaginal,

throat, oral cavity

microbiota,

specimens,

collection

12.

12. Diagnostic principles in infectious diseases

(respiratory tract, urogenital, digestive tract

infections, skin and soft tissue infections). Blood

cultures in bloodstream infections. Infections

caused by anaerobes.

Oral

presentations

PPT

2

TBL

Respiratory tract

infection, sexually

transmitted

diseases, skin

infections, urinary

tract infections,

septicaemia,

gastroenteritis,

candidiasis,

vaginal discharge

13. 13. Antibiotic susceptibility testing.

Antimicrobial resistance.

Oral

presentations

PPT

2

Antimicrobial

resistance

14. 14. Nosocomial infections. Emergent and

reemergent infectious diseases. Bioterrorism.

Oral

presentations

PPT

2

Nosocomial

infections,

hospital strains,

bioterrorism

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Brooks G.F., Butel, J. S., Morse, S.A.: Jawetz, Melnick, Adelberg’s Medical

Microbiology,McGraw-Hill Medical, New York, 25th edition. 2010

2. Fritz H. Kayser, Kurt A. Bienz, Johannes Eckert, Rolf M. Zinkernagel: Medical Microbiology. Georg

Thieme Verlag, Stuttgart, 2005

3.Winn W, Allen S, Janda W, Koneman E, Procop G, Schreckenberger P, Woods G: Koneman's Color

Atlas and Textbook of Diagnostic Microbiology. Lippincott Williams & Wilkins, Philadelphia, 6th

edition, 2006

Crt.

no.

8.1 Seminaries/Laboratories/Practical

activities/Stages

Teaching

methods Hours Observations ICS correlation

First semester

1. 1. Laboratory safety rules. Microbial growth

control.. Decontamination

Practical

activities,

presentation

2

Decontamination,

disinfection,

antisepsis,

asepsis,

sterilisation

2. 2. Diagnostic algorithm in bacteriology. Specimen

collection and shipment.

Practical

activities,

presentation

2

Specimens,

collection,

shipment

3.

3. Study of bacterial morphology. Wet mount.

Smears. Staining techniques (simple stain, Gram

stain, acid-fast stain, Neisser stain)

Practical

activities,

presentation

2

Bacterial

morphology,

cocci, bacilli,

spiral forms,

Gram-positive,

Gram-negative,

smears, acid fast,

Neisser stain

4.

4. Cultivation of bacteria. Culture media.

Inoculation techniques. Colony morphology.

Identification of bacteria according to their

biochemical patterns.

Practical

activities,

presentation

2

Cultivation,

culture media,

colony

morphology,

identification of

bacteria

5.

5. Diagnostic methods based on antigen-antibody

reactions (agglutination, immunofluorescence,

enzyme-linked immunosorbent assay, Western

blot). Detection of bacterial nucleic acid

(hybridization, polymerase chain reaction).

Methods used for bacterial typing.Gene transfer.

Practical

activities,

presentation

2

Antigen-antibody

reactions,

molecular

biology methods,

molecular typing

6. 6. In vitro and in vivo pathogenicity tests.

Antibiotic susceptibility testing.

Practical

activities,

presentation

2

Antimicrobial

resistance,

antimicrobial

susceptibility

testing, MIC, E-

test, disk

diffusion method

7. 7. Practical exam Practical

eexam

2

8.

8. Diagnosis of infections caused by:

Staphylococcus spp., Streptococcus spp. and

Enterococcus spp

Practical

activities,

presentation

2

bullous/vesicular

eruption, dysuria,

joint pain, joint

swelling, loose

stools, vaginal

discharge;

cardiac valve

disease, chronic

renal disease,

endocarditis,

gastroenteritis;

infectious disease

of childhood,

meningitis, oral

diseases, otitis

media,

peritonitis,

respiratory tract

infection,

septicaemia, skin

infections,

urinary tract

infections

9.

9. Diagnosis of infections caused by

Enterobacteriaceae: Escherichia coli, Klebsiella

spp., Proteus spp., Shigella spp., Salmonella spp.,

Yersinia spp. Laboratory diagnosis of cholera.

Practical

activities,

presentation

2

dysuira, loose

stools, vomiting,

gastroenteritis,

peritonitis,

respiratory tract

infections,

urinary tract

infection

10.

10. Diagnosis of infections caused by Gram-

negative non-fermentative rods (Pseudomonas

aeruginosa, Acinetobacter spp.). Diagnosis of

infections caused by Bacillus spp. Diagnosis of

infections caused by anaerobic bacteria (clostridia,

endogenous anaerobes).

Practical

activities,

presentation

2

loose stools,

vomiting,

constipation,

dysphagia,

squint, visual

impairment, acne

burns,

gastroenteritis

peritonitis,

meningitis,

respiratory tract

infections,

septicaemia, skin

infections, skin

ulcerations, oral

disorders,

peripheral nerve

disorders,

peritonitis,

septicaemia

11.

11. Diagnosis of infections caused by

Haemophilus spp. Neisseria spp, Diagnosis of

syphilis. Diagnosis of tuberculosis

Practical

activities,

presentation

2

haemoptysis,

headache, raised

intracranial

pressure, loose

stools, vomiting,

vaginal discharge

disorders of

pregnancy and

deliver -

meningitis,

respiratory tract

infections,

septicaemia,

sexually

transmitted

diseases, skin

infections, skin

ulcerations,

pregnancy loss,

tuberculosis

12.

12. Human microbiota. Diagnosis of infections

(respiratory and digestive tract, urogenital, skin

and soft tissue infections, meningitis and

bloodstream infections). Control of

crosstransmission in hospital setting in order to

prevent nosocomial infections.

Practical

activities,

presentation

2

Throat swab,

sputum, nasal

swab, genital

secretions, CSF,

pus, blood

culture, stool

culture, urine

culture, hospital

flora, nosocomial

infections

13. 13. Review Practical

activities

2

14. 14. Practical exam Exam 2

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Roelme, elearning

2. Online atlas: https://microbiologie.umftgm.ro/atlas

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Due to advances in medicine that lead to frequent use of invasive and/or immune suppressive treatments

there is an increase of the number of patients vulnerable to bacterial infections. Mobility, intense traveling

contributes to the rapid spread of microorganisms. In this context there is a need for well trained

physicians having proper knowledge on infectious agents involved in human diseases, being able to

recognize, diagnose and treat them. The potential to cause epidemics, outbreaks should be recognized in

order to implement specific measures of prevention. On the other hand, emergence and spread of

antimicrobial resistance are of great concern, representing an increasing challenge in the management of

infections. Understanding these medical problems, learning and promoting proper antimicrobial

consumption habits are essential.

10. Evaluation

Type of activity 10.1 Evaluation criteria 10.2 Evaluation

methods

10.3 Percent of

the final grade

10.4 Evaluation

during the semester

Lecture Knowledge of medically important bacteria TBL - evaluation 10%

Practical activities Diagnostic and therapeutical principles in

microbiology Practical exam 20%

10.5 Final evaluation

Theoretical final

exam

suspect/recognize infectious diseases

caused by bacteria

- require proper bacteriological analysis to

establish etiology

Written exam

(multiple choice and

questions)

60%

Practical final

exam

Understanding of bacteriological analyses

and their use in treatment

- understanding antimicrobial resistance

and the importance of prudent use of

antimicrobials

Test 10%

10.6 Minimal performance standards

1. Grade 5 for midterm evaluations

2. Minimum requirements to sit the final exam: grade 5 of evaluations; attendance of all practical classes;

70% attendance of lectures

3. Passing the final exam: 5 is the minimum grade required to pass both the theoretical and practical final

exam

SYLLABUS




1.3 Department M2




2. Data regarding the discipline 2.1 Name Bacteriology-virology-parasitology_2

2.2 Course coordinator Székely Edit

2.3 Practical activity coordinator(s) Szekely Edit,

2.4 Study year II 2.5 Semester II 2.6 Type of evaluation Exam 2.7 Type of discipline DF



lecture 2


activity 2


lecture 28


activity 28


hours





Examinations 0.5

Other activities 1


week 5


3.9 Credits 4


prerequisites

4.2 competency

prerequisites



activities



- suspecting/recognizing infectious diseases caused by viruses, parasites

or fungi with a thorough understanding of their pathogenesis,

transmission patterns

- requiring proper microbiological analysis for establishing etiology

- understanding results provided by the microbiologist and using them

accordingly in the management of patients with infectious diseases

- knowledge of methods used for diagnostic purposes, their advantages

and limitations

- acquiring basic knowledge in prophylaxis and treatment of viral

infections

- understanding the local/national/international epidemiology of major

viral/parasitic/fungal infections

- recognizing special patient population at risk for acquiring

viral/parasitic/fungal infections

- acquiring basic knowledge of tropical and tourism-related infections


- developing abilities for teamwork, efficient verbal and written

communication skills

- respect for professional values and ethics,

- solving clinical problems and chosing proper therapeutical decisions



Providing knowledge of the basic biology of microorganisms

(viruses, parasites and fungi), pathogenesis of infections caused by

them and possibilities of diagnosis, prevention and treatment.


Students should become familiar with the:

- morphology, physiology and genetics of microorganisms (viruses,

fungi and parasites)

- pathogenesis of infections caused by these microorganisms

- role of immune system in defense against infections

Students should understand the basic microbiological diagnostic

principles. They should know the factors that influence results and

indications for performing microbiology tests.

Students should acquire basic knowledge on the mechanism of

action of antimicrobial agents, familiarize with basic

epidemiological concepts.

They should gain knowledge about specific medically important

viruses, fungi and parasites in respect of associated diseases, mode

of transmission, possibilities of prevention and treatment

They should recognize:

- the importance of infection in special patient categories, such as

immunesuppresed patients

- the role of vaccines in prevention

8. Contents Crt. 8.1 Lecture Teaching Hours Observations ICS correlation

no. methods

First semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Second semester

1.

1. General properties of viruses. Virion

structure. Chemical composition of viruses.

Viral replication. Cultivation of viruses.

Oral

presentation,

PPT

2

Virus, virion,

capside, helical

symmetry type,

cubical symmetry

type, viral

replication,

cultivation, cell

cultures

2.

2. Viral genetics. Subviral agents: viroids,

prions. Bacteriophages. Viral vectors, gene

therapy.

Oral

presentation,

PPT

2

Viral genetics,

viroids, prions,

degeneratice CNS

disease, viral

vectors, gene

therapy

3. 3. Cell-virus interactions.

Oral

presentation,

PPT

2

immunization

immunodeficiency

acute infection,

chronic infection,

latent infection,

persistent infection

4.

4. Immunity in viral infections. Chemotherapy

of viral infections. Immunotherapy,

prophylaxis.

Oral

presentation,

PPT

2

Immunity

Immunodeficiency

Immunoprophylaxis,

immunotherapy,

treatment of viral

infections

5. 5 Classification of viruses. DNA viruses: Oral 2

bullous/vesicular

Adenoviridae, Herpesviridae, Parvoviridae,

Papillomaviridae, Polyomaviridae, Poxviridae

presentation,

PPT

skin eruption,

haematuria, loose

stools; carcinoma of

the head and neck,

cervical cancer;

infectious diseases

of childhood,

respiratory tract

infection, sexuallly

transmitted diseases

6.

6 RNA viruses: Arenaviridae, Bunyaviridae,

Caliciviridae, Coronaviridae, Filoviridae,

Flaviviridae, Orthomyxoviridae,

Paramyxoviridae, Picornaviridae, Reoviridae,

Retroviridae, Rhabdoviridae, Togaviridae

Oral

presentation,

PPT

2

loose stools,

gastroenteritis,

infectious diseases

of childhood,

infections of the

respiratory tract

7. 7. Human hepatitis viruses. Human

immunodeficiency virus.

Oral

presentation,

PPT

2

hepatomegaly,

jaundice, acute liver

disease/failure,

chronic liver

disease, HIV

8.

8. Oncogenic viruses. Viral infections

(Respiratory tract infections. Enteric infections.

Infections with mucocutaneous manifestations.

Haemorrhagic fevers. Central nervous system

infections)

Oral

presentation,

PPT

2

bullous/vesicular

skin eruption,

headache, loose

stools,

gastroenteritis,

infectious diseases

of childhood,

meningitis,

respiratory tract

infections

9.

9. Classification of parasites. Clinical

implications of intestinal parasitoses. Protozoa

(Amoebas. Trichomonas spp. Giardia lamblia.

Toxoplasma gondii.)

Oral

presentation,

PPT

2

Integrated

lecture,

pediatrics

loose stools, vaginal

discharge,

malabsorbtion,

pregnancy loss,

sexually transmitted

diseases

10. 10. Flat worms. Round worms.

Oral

presentation,

PPT

2

abdominal

distendion,

abdominal pain,

constipation,

hepatomegaly,

jaundice, loose

stools, pruritus,

weight loss

11. 11. Tropical parasitoses

Oral

presentation,

PPT

2 TBL loose stools malaria,

skin ulcerations

12. 12. General properties and classification of Oral 2

hair disorders, skin

fungi. Pathogenesis of fungal infections.

Dermatophytes. Systemic mycoses

presentation,

PPT

infections

septicaemia,

respiratory tract

infections

13. 13. Opportunistic fungal infections

Oral

presentation,

PPT

2

vaginal discharge

candidosis,

meningitis,

respiratory tract

infections,

septicaemia

14.

14. Infections of the immunocompromised

host. Microbiological diagnosis of various

infections.

Oral

presentation,

PPT

2 TBL Immunodeficiency

Bibliography:

1. Brooks G.F., Butel, J. S., Morse, S.A.: Jawetz, Melnick, Adelberg’s Medical

Microbiology,McGraw-Hill Medical, New York, 25th edition. 2010

2. Fritz H. Kayser, Kurt A. Bienz, Johannes Eckert, Rolf M. Zinkernagel: Medical Microbiology. Georg

Thieme Verlag, Stuttgart, 2005

3.Winn W, Allen S, Janda W, Koneman E, Procop G, Schreckenberger P, Woods G: Koneman's Color

Atlas and Textbook of Diagnostic Microbiology. Lippincott Williams & Wilkins, Philadelphia, 6th

edition, 2006

Crt.

no.


activities/Stages

Teaching


First semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Second semester

1.

1. Microbial growth control. Specimen collection

and shipment for virology. Diagnostic algorithm in

virology. Study of viral morphology.

Practical

activities,

presentation

2

Decontamination,

disinfection,

antisepsis,

asepsis,

sterilisation

Specimens,

collection,

shipment

2. 2. Cultivation of viruses. Antigen-antibody

reaction based methods. Detection of nucleic acids.

Practical

activities,

presentation

2

Viral cultivation

Cell cultures,

viral vectors

3.

3. Laboratory diagnosis of herpetic infections.

Diagnosis of infections caused by human

papillomaviruses. Diagnosis of viral infections of

the respiratory tract.

Practical

activities,

presentation

2

bullous/vesicular

skin eruptions,

hematuria, loose

stools carcinoma

of the head and

neck, cervical

cancer, infectious

diseases of

childhood ,

respiratory tract

infection,

sexually

transmitted

diseases

4. 4. Laboratory diagnosis of viral hepatitis.

Diagnosis of HIV infection

Practical

activities,

presentation

2

hepatomegaly,

jaundice, acute

liver

disease/failure,

chronic liver

disease, HIV

5. 5. EXAM Exam 2

6.

6. Parasitological diagnosis. Protozoa (Entamoeba

spp., Trichomonas vaginalis, Giardia lamblia,

Toxoplasma gondii)

Practical

activities,

presentation

2

loose stools, ,

vaginal

discharge,

malabsorbtion,

pregnancy loss,

sexually

transmitted

diseases

7.

7. Flat worms (Fasciola hepatica,

Diphyllobothrium latum, Dipylidium caninum,

Echinococcus granulosus, Taenia saginata şi

Taenia solium, Hymenolepis spp.)

Practical

activities,

presentation

2

abdominal

distention,

abdominal pain,

constipation,

hepatomegaly,

jaundice, loose

stools, pruritus,

weight loss, acute

liver disease,

allergic

disorders,

anemia, eating

disorders

8.

8. Round worms (Ascaris lumbricoides, Enterobius

vermicularis, Toxocara canis, Ankylostoma

duodenale, Strongyloides stercoralis, Trichinella

spiralis)

Practical

activities,

presentation

2

abdominal

distention,

abdominal pain,

constipation,

hepatomegaly,

jaundice, loose

stools, pruritus,

weight loss, acute

liver disease,

allergic

disorders,

anemia, eating

disorders

9.

9 Laboratory diagnosis of infections caused by

yeasts. Laboratory diagnosis of infections caused

by Pneumocystis jiroveci.

Practical

activities,

presentation

2

vaginal

discharge,

candidosis,

meningitis,

respiratory tract

infection,

septicaemia

10.

10. Laboratory diagnosis of infections caused by

moulds. Laboratory diagnosis of infections caused

by dermatophytes and dimorphic fungi

Practical

activities,

presentation

2

Skin infections,

respiratory tract

infections,

septicaemia

11. 11. Microbiological diagnosis of CNS, respiratory

tract and enteric infections - case reports

Practical

activities,

presentation

2

loose stools,

vomiting, vaginal

discharge,

sputum, disorders

of pregnancy and

delivery,

meningitis,

respiratory tract

infections,

septicaemia,

sexually

transmitted

diseases, skin

infections, skin

ulcerations,

pregnancy loss

12.

12. Microbiological diagnosis of hepatitis and

infections of immunocompromised patients - case

reports

Practical

activities,

presentation

2

hepatomegaly,

jaundice, acute

liver

disease/failure,

chronic liver

disease

13. 13. Review Review 2

14. 14. Exam Exam 2

Bibliography:

www.microumftgm.ro; e-learning, Online atlas: https://microbiologie.umftgm.ro/atlas

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Due to advances in medicine that lead to frequent use of invasive and/or immunsuppressive treatments

there is an increase of the number of patients vulnerable to infections caused by fungi, viruses and

parasites. In this context there is a need for well trained physicians having proper knowledge on infectious

agents involved in human diseases, being able to recognize, diagnose and treat them.

10. Evaluation


methods

10.3 Percent of

the final grade

10.4 Evaluation

during the

semester

Lecture

- Basic knowledge (morphology, pathogenesis,

associated diseases, immunity, transmission,

prevention and treatment) regarding medically

important microorganisms

TBL 10%

Practical

activities

Knowledge of: - morphology, physiology and genetics

of viruses, fungi and parasites - pathogenesis - host

defenses Understanding basic diagnostic principles in

viral, fungal, parasitic infections and factors that can

affect results - indications for diagnostics

Practical exam 20%

10.5 Final

evaluation

Theoretical

final exam

- suspecting/ recognizing infectious diseases caused

by viruses, parasites or fungi - requiring proper

microbiological analysis for establishing etiology

-current problems regarding emergent and re-

emergent infections

- acquiring basic knowledge of tropical and tourism-

related infections

Written exam:

multiple choice

+ questions

60%

Practical final

exam

-înțelegerea rezultatelor obținute și utilizarea acestora

în mod adecvat

în tratamentul pacientului

-dobandirea cunostintelor de baza in profilaxia si

tratamentul infectiilor virale, parazitologice, fungice

Written exam:

multiple choice 10%


Grade 5 for midterm evaluations;

Minimum requirements to sit the final exam: grade 5 of evaluations; attendance of all practical classes;

70% attendance of lectures

Passing the final exam: 5 is the minimum grade required to pass both the theoretical and practical final

exam

SYLLABUS



1.2 Faculty MEDICINE

1.3 Department M2

1.4 Field of study HEALTH CARE


1.6 Study program MEDICINE

2. Data regarding the discipline 2.1 Name Clinical Biochemistry, Immunology

2.2 Course coordinator Prof. Dobreanu Minodora

2.3 Practical activity coordinator(s) Univ Assist. Şular Floredana-Laura,

2.4 Study year III 2.5 Semester 2 2.6 Type of evaluation V 2.7 Type of discipline DD



lecture 1


activity 1


lecture 14


activity 14


hours




Tutorial activities

Examinations

Other activities


week 4


3.9 Credits 2


prerequisites -

4.2 competency

prerequisites -

5. Conditions (where applicable) 5.1 for lectures -


activities -



Professional competences obtained by students are in medical

interpretation of test results obtained in laboratory evaluation of water and

electrolytes balance, carbohydrates, lipids and proteins metabolism,

diagnostic value of serum enzymes analysis, coagulation tests, specific

and non-specific cellular and humoral immun system evaluation. Medical

students will learn modern laboratory methods for investigation of

biological fluids – their quality and limits.


Clinical Biochemistry and Immunology discipline aims to form student

capacity for integration of basic knowledges in biochemistry, physiology

/physiopathology and internal medicine, in producing useful correlations

at patient bedside, in reccomending and analysing laboratory

investigations in clinical context.

Analysis capacity of preanalitical influence (collecting, transportation and

storage of biological fluids) in laboratory test results, is also stimulated.


7.1 General objective General aim of our discipline is to create a logical base in asking and

interpretation of laboratory investigations.


Pathogenic mechanisms in modification of laboratory parameters in

diseases; diagnostic value of laboratory tests, correlations established

between clinical context and laboratory results.

8. Contents Crt.

no. 8.1 Lecture Teaching methods Hours Observations ICS correlation

First semester

Second semester

1.

1. Evaluation of water and

electrolytes balance: natrium and

kalium.

Lecture+

presentation .ppt 1

The main

investigations

will be

presented,

benefits and

limitations

Electrolyte and water

balance, Adrenal

excess, Adrenal failure

2. 2. Evaluation of acid-base

balance of the organism

Lecture+

presentation .ppt

1 The main

investigations

will be

presented,

benefits and

limitations

Acid based disturbance,

Hyperventilation,

Cardiorespiratory arrest

3.

3. Laboratory evaluation of

calcium, phosphorus and

magnesium homeostasis.

Osteoporosis

Lecture+

presentation .ppt

1 The main

investigations

will be

presented,

benefits and

limitations

Disorders of calcium

and vitamin D

metabolism,

Osteoporosis

4. 4. Evaluation of plasma proteins.

Dysproteinemias

Lecture+

presentation .ppt

1 The main

investigations

will be

presented,

benefits and

limitations

Malnutrition,

Malabsorption,

Oedema, Burns,

Chronic liver disease,

Chronic lung disease,

Chronic renal disease

5.

5. Evaluation of lipid and

lipoprotein metabolism –

involvement of dyslipidemias in

atherosclerosis.

Lecture+

presentation .ppt

1 The main

investigations

will be

presented,

benefits and

limitations

Disorders of lipid

metabolism, Ischemic

heart disease,

Cerebrovascular disease

6. 6. Evaluation of carbohydrate

metabolism

Lecture+

presentation .ppt

1 TBL -The main

investigations

will be

presented,

benefits and

Hypoglycaemia,

Diabetes mellitus

limitations

7.

7. Specific and non-specific,

cellular and humoral defense of

the organism

Lecture+

presentation .ppt

1 Basic

immunological

terminology

Immunisation,

Immunodeficiency

8.

8. Antigen and antibody.

Biological identity of superior

organisms– MHC

Lecture+

presentation .ppt

1 Immunological

terminology and

knowledges

Immunisation,

Immunodeficiency

9. 9. Immune cells and lymphoid

tissues

Lecture+

presentation .ppt

1 The main

investigations

will be

presented,

benefits and

limitations

Myeloproliferative

disorders,

Lymphoproliferative

disorders

10. 10.Primary and secondary

specific immune response

Lecture+

presentation .ppt

1 The main

investigations

will be

presented,

benefits and

limitations

Immunisation

Immunodeficiency

11.

11.Pathological immune

reactions. Systemic and organ-

related autoimmune disorders

Lecture+

presentation .ppt

1 TBL -The main

investigations

will be

presented,

benefits and

limitations

Allergic disorders,

Asthma, Drug reactions,

Rhesus haemolytic

disease

12.

12.Primary and secondary

immunodeficiency syndromes.

HIV infection, AIDS

Lecture+

presentation .ppt

1 The main

investigations

will be

presented,

benefits and

limitations

Immunodeficiency.

HIV caused

Immunodeficiency

13. 13.Immune reactions in cancer.

Immune therapy in tumors

Lecture+

presentation .ppt

1 The main

investigations

will be

presented,

benefits and

limitations

Immunisation

Immunodeficiency

14.

14. Immunity of transplant.

Therapeutical means in immune

disorders

Lecture+

presentation .ppt

1 The main

investigations

will be

presented,

benefits and

limitations

Immunisation

Immunodeficiency

Bibliography:

1. Practical Compendium of Clinical Biochemistry and Immunology. Dobreanu Minodora, Alina

Ardelean Mărginean, Anca Bacârea, Simona Cernea, Elena Enache, Liviu Enache, Marta Andrea Fodor,

Oana Oprea, Floredana Șular,2014

2. Basic Concepts in Immunology. Minodora Dobreanu, et al.. 2015

1.William J. Marshall and Stephen K.Bangert - Clinical Chemistry - 7th Ed, MOSBY- ELSEVIER 2012

2.Roderick Nairm, Matthew Helbert - Immunology for Medical students, 2nd Ed, MOSBY- ELSEVIER

2007

3.Abdul Abbas et al -Basic Immunology, 3rd Ed, Saunders ELSEVIER, 2011.

Crt.

no.


activities/Stages

Teaching


First semester

Second semester

1. 1.Safety in Clinical Laboratory. Collecting

blood and body fluid specimens

Practical

demonstrations 1

Major risk in

laboratory

work will be

presented.

Laboratory

safety

Anemia,

Thromboembolic

disease

2.

2.Optical methods for analysis in clinical lab.

Absoption and emission spectrophotometry.

Autoanalyser. Quality control.

Practical

demonstrations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

presented

Hypoglicemia,

Anemia, Jaundice

3.

3.Electroanalytical methods in medical lab.

Laboratory evaluation of Acid-Base balance

of the body

Practical

demonstrations,

case

presentations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

Electrolyte and

water balance,Acid

based disturbance

presented

4. 4.Assessment of carbohydrate metabolism

Practical

demonstrations,

case

presentations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

presented

Diabetes mellitus

5. 5.Laboratory evaluation of lipid metabolism.

Atherogen index

Practical

demonstrations,

case

presentations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

presented

Disorders of lipid

metabolism,

Ischemic heart

disease

6. 6.Serum protein analysis in clinical

laboratory. Dysproteinemic syndromes

Practical

demonstrations,

case

presentations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

presented

Malnutrition,

Malabsorption,

Oedema, Burns,

Chronic liver

disease, Chronic

lung disease,

Chronic renal

disease

7. 7.Chemical examination of urine. Urinary

sediment – microscopic examination

Practical

demonstrations,

case

presentations

1

CBL

Haematuria,

Urinary tract

infection, Urinary

tract obstruction

8. 8.Laboratory diagnosis in hemostasis.

Evaluation of anticoagulant thepary

Practical

demonstrations,

case

presentations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

presented

Purpura,

Thromboembolic

disease,

Coagulation

disease

9.

9.Immunological methods – principles,

classifications: turbidimetry, nephelometry,

aglutination, ELISA, chemiluminiscence

Practical

demonstrations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

presented

Immunisation

10.

10.Evaluation of unspecific cellular immune

response; phagocytosis- chemotactic and

oxidative burst activity of monocytes and

granulocytes

Practical

demonstrations,

case

presentations

1 Actual

techniques

for

investigation

Immunisation,

Immunodeficiency

in modern

laboratory,

will be

presented

11.

11.Evaluation of unspecific humoral immune

response –determination of hsPCR and of

complement factors C3, C4, C1 INH.

Practical

demonstrations,

case

presentations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

presented

Immunisation,

Immunodeficiency

12.

12.Evaluation of specific humoral immune

response : determination of serum and CSF

concentration of immunoglobulins

Practical

demonstrations,

case

presentations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

presented

Immunisation,

Immunodeficiency

13. 13.Evaluation of specific cellular immune

response : TBNK by flowcitometry

Practical

demonstrations,

case

presentations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

presented

Immunisation,

Immunodeficiency,

HIV

14.

14.Molecular biology techniques.

isolation/purification of nucleic acids.

Amplification: PCR, qPCR, RT PCR.

Practical

demonstrations

1 Actual

techniques

for

investigation

in modern

laboratory,

will be

presented

Immunisation,

Immunodeficiency

Bibliography:

1) Dobreanu M. et al - Practical Compendium of Clinical Biochemistry and Immunology, Univ Press,

2014.

2) Mary L. Turgeon, Linne & Ringsrud's Clinical Laboratory Science - The basics and routine techniques,

Ed. 5, MOSBY- ELSEVIER 2007

3)Christine Dorresteyn Stevens -Clinical Immunology and serology -a LABORATORY perspective, Ed.

2, FA Davis, Philadelphia, 2003

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Medical tests performed by clinical laboratories, bring 70% of useful information for diagnosis, prognosis

/ monitoring of patients health status, with less than 2% of total healthcare costs.

10. Evaluation


methods

10.3 Percent of

the final grade

10.4 Evaluation during the

semester

Lecture

Written test 15%

Practical activities

Written test 15%


Theoretical final exam În funcție de specificul

disciplinei Written exam 50%

Practical final exam În funcție de specificul

disciplinei written exam 20%


Threshold of minimum knowledge for passing exam:

1.Water and mineral compartments of the body.

2.Ionogram of serum and biological fluids.

3.Water and electrolytes distribution between different compartments . Isovolemia and isoosmosis.

Disorders of electrolyte balance .

4.Potassium homeostasis: hyper- and hypokalemia.

5.Mechanisms that maintain pH in the extracellular fluid: physiological buffer systems.

6.Physiological and pathological variations of the acid-base balance parameters

7.Mechanisms involved in the phosphorus-calcium balance of the body: parathyroidian hormone,

calcitriol (vitamin D3), calcitonin.

8.Disorders of calcium and phosphorus metabolism.

9.Assessment of calcium and phosphorus metabolism disorders.

10.Bone metabolic disorders: osteoporosis.

11.Magnesium: role in human body, hypo- and hypermagnesiemia states

12.Structure, general properties, biological functions, main characteristics and classification of plasma

proteins.

13.Main plasma proteins: Albumin, a1AT, a2Mg,Transferin,Ceruloplasmin, Haptoglobin,

Immunoglobulins G,A,M

14.Dysproteinemias. Acute phase proteins –hsCRP

15.Serum enzymes. Clasification, diagnostic properties.Izoenzymes

16.Serum lipids: physical, chemical and biological properties, biological roles of lipids.

17.Lipoproteins: structure and classification. Lipid/ lipoprotein metabolism. Lipid metabolism disorders –

dyslipidemias.

18.Atherogenic risk factors – atherosclerosis. Present conception on atherosclerosis pathogenesis

19.Origins of blood carbohydrates: nutritional glucose, glycogenogenesis-glycogenolysis, glucose

formation from other substances – gluconeogenesis.

20.Major glucose metabolic pathways in different cells.

21.Regulating mechanisms of carbohydrate metabolism. Hormonal control of the circulating level of

glucose.

22.Diabetes mellitus – clasification, diagnosis, monitorisation. Diabetes complications.

23.1. Cellular elements of non-specific immune system. Phagocytosis. The complement system.

2. Physical, chemical and biological properties of antigens. Superantigens. Immunoglobulins: structure,

properties, coding, biosynthesis.

3. Cellular markers of biological individuality: major histocompatibility complex class I and class II.

4. T and B lymphocytes, lymphocyte receptors. Primary and secondary lymphoid tissues

5. Antigen recognition, processing and presentation. Clonal selection and proliferation. Primary and

secondary immune response

6. Hereditary and acquired immunodeficiencies. HIV infection, AIDS.

7. Tumor markers. Immune response to neoplasias. Tumor immunotherapy.

8. Gell-Coombs classification of pathologic immune reactions.

9. Autoimmunity. Systemic and organ specific autoimmune diseases

Types of transplant; histocompatibility; immune mechanisms involved in graft rejection.

Immunomodulation: immunostimulation, immunosupression.

SYLLABUS




1.3 Department M2

1.4 Field of study HEALTH

1.5 Study cycle LICENSE


2. Data regarding the discipline 2.1 Name Medical biostatistics

2.2 Course coordinator Olah Peter

2.3 Practical activity coordinator(s) Avram Calin

2.4 Study year 2 2.5 Semester I 2.6 Type of evaluation V 2.7 Type of discipline DC



lecture 1


activity 1


lecture 14


activity 14


hours

Study of books, lecture materials, bibliography, notes 0,5

Supplemental documentation at the library, from specialized information portals and in the field 0,5

Preparation for seminaries/laboratories, homework, reports, portfolios and essays 0,5

Tutorial activities 0,25

Examinations 0,25

Other activities


week 5


3.9 Credits 2


prerequisites -

4.2 competency

prerequisites -



activities -



- The student must demonstrate the ability to understand and to acquire

domain specific terms for biostatistics, respectively glossary of

specialized terms used in this field

- Knowledge of the main types of statistical tests and steps for their

application and selection algorithms of a particular statistical test,

depending on the type of study / experiment

- Demonstrate ability to understand and correctly apply a specific

statististic protocol


- Ability to detect the main sources of systematic and random errors that

may occur in a clinical study / science experiment

- Ability to properly integrate statistical protocol in the context of

scientific work in the biomedical field

- Understanding the role and importance of statistical analysis in the

modern context of "evidence-based medicine evidence-based medicine"



In today's evidence-based medicine, biostatistics has become one of

the essential tools for the practitioner or researcher working in the

biomedical field. Therefore, the main objective of this subject is to

familiarize students in the biomedical field, with specialized

glossary of mathematical statistics in order to assimilate the correct

application of a statistical protocol, depending on the type of clinical

study / science experiment;


- Understanding glossary of specialized terms used in this field of

biostatistics

- Demonstrate, in the context of evidence-based medicine, the

statistical foundations of human homeostasis, namely the necessity

of providing adequate statistical tools for any study or experiment

biomedical

- Knowledge of the main types of statistical tests and steps for their

application and algorithms for selecting a particular statistical test,

depending on the type of study / experiment

- Understanding and application of a specific protocol

8. Contents Crt.

no. 8.1 Lecture

Teaching


First semester

1.

Fundamentals in biostatistics. Introduction. Types of

errors. Exactity and precision. Organisation of data

for statistical processing. Frequency distributions.

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Biological

variability

2. Descriptive statistics

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Homeostasis.

Laboratory

Reference

Ranges in

Healthy Adults

3.

Inferential statistics. Statistical interpretation of the

results from an experiment or a study. Tests for

outliers. Normality tests.

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Clinical trials

4. Inferential statistics. Tests of Statistical

Significance. Parametric versus nonparametric tests

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Clinical trials

5. Analysis of contingency tables

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Epidemiological

studies

6. Correlations and regressions

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

7.

Analysis of variance (ANOVA). Epidemiological

and clinical studies. Statistical indicators used in

epidemiological and clinical studies

Oral +

multimedia

presentation

2

2 hours at

every 2

weeks

Bioequivalence

studies

8.

9.

10.

11.

12.

13.

14.

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Bacârea Vladimir, Ghiga Dana, Măruşteri Marius, Oláh Péter, Petrişor Marius - A Primer in Research

Methodology and Biostatistics, University Press Targu Mures, 2014

2. Motulsky HJ. The InStat Guide to Choosing and Interpreting Statistical Tests, GraphPad Software Inc.,

San Diego California USA, 2001, Available at: www.graphpad.com.

3. Motulsky HJ. GraphPad Prism - Statistics Guide. GraphPad Software Inc., San Diego California USA,

2007, Available at: www.graphpad.com.

4. Cox DR. Principles of statistical inference. Cambridge University Press, 2006.

5. Marusteri M., Bacarea V., Comparing groups for statistical differences: how to choose the right

statistical test?, Biochemia Medica 2010;20(1):15–32, Available at:

http://www.kbsm.hr/klinkemija/HDMB/BiochMed/arhiva.php

6. McHugh ML. Standard error: meaning and interpretation. Biochem Med 2008;18:7-13.

7. Slavkovic A. Analysis of Discrete Data. Available at:

http://www.stat.psu.edu/online/courses/stat504/01_overview/index.html.

8. Simundic AM. Confidence interval. Biochem Med 2008;18:154-61. Available at:


9. Ilakovac V. Statistical hypothesis testing and some pitfalls. Biochem Med 2009;19:10-6. Available at:


Crt.

no.

8.1

Seminaries/Laboratories/Practical

activities/Stages

Teaching methods Hours Observations ICS correlation

First semester

1. Fundamentals in biostatistics. Types

of errors. Exactity and precision

Practical demostrations.

Synchronous/asynchronous

elearning methods

1

Biological

variability

2.

Organisation of data for statistical

processing. Raw (primary) data.

Indexed data. Tabular data.

Contingency tables



elearning methods

1

Biological

variability

3.

Descriptive statistics: Measures of

Central Tendency (mean, median,

mode); Measures of dispersion

(variance, standard deviation,

coefficient of variation);



elearning methods

1

Homeostasis.

Laboratory

Reference

Ranges in

Healthy Adults

4.

Descriptive statistics: Other

statistical indicators in descriptive

statistics. Confidence intervals.



elearning methods

1

Homeostasis.

Laboratory

Reference

Ranges in

Healthy Adults

5. Inferential statistics. Tests for

outliers



elearning methods

1

Clinical trials

6. Inferential statistics. Normality tests



elearning methods

1

Clinical trials

7.

Inferential statistics. Tests of

Statistical Significance. Parametric

versus nonparametric tests: Student t

test and its variants



elearning methods

1

Clinical trials

8.

Inferential statistics. Tests of

Statistical Significance. Parametric

versus nonparametric tests:

Wilcoxon signed-rank test. Mann–

Whitney test.



elearning methods

1

Clinical trials

9.

Analysis of contingency tables. Chi

square test and its variants (Chi

square test with Yates correction,

Fisher exact test)



elearning methods

1

Epidemiological

studies

10. Analysis of contingency tables. Odd-

ratio (OR) and Relative risk (RR).



elearning methods

1

Epidemiological

studies

11. Correlations and regressions.

Correlation coefficient



elearning methods

1

12.

Correlations and regressions.

Coefficient of determination. Linear

regression.



elearning methods

1

13.

Analysis of variance (ANOVA) -

One-way Anova. Repeated measures

Anova. Kruskal-Wallis test.

Friedman test.



elearning methods

1

Bioequivalence

studies

14.

Analysis of variance (ANOVA).

Epidemiological and clinical studies.

Statistical indicators used in

epidemiological and clinical studies



elearning methods

1

Bioequivalence

studies

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Bacârea Vladimir, Ghiga Dana, Măruşteri Marius, Oláh Péter, Petrişor Marius - A Primer in Research

Methodology and Biostatistics, University Press Targu Mures, 2014

2. Marusteri M., Bacarea V., Comparing groups for statistical differences: how to choose the right

statistical test?, Biochemia Medica 2010;20(1):15–32, Available at:


3. Motulsky HJ. The InStat Guide to Choosing and Interpreting Statistical Tests, GraphPad Software Inc.,

San Diego California USA, 2001, Available at: www.graphpad.com.

4. Motulsky HJ. GraphPad Prism - Statistics Guide. GraphPad Software Inc., San Diego California USA,

2007, Available at: www.graphpad.com.

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain The knowledge acquired from the above mentioned curricular content will assure for the students the

proper understanding of basic statistical glossary and of some other terms related to the field of

biostatistics and will enhance their ability to understand and apply a specific statistical protocol for a

particular type of clinical trial/epidemiological study or scientific experiment. It is also provided a

theoretical and practical framework for critically reading of scientific articles published in the biomedical

field, with the proper understanding of statistical protocols used in such articles.

10. Evaluation

Type of activity 10.1 Evaluation criteria 10.2 Evaluation methods 10.3 Percent of

the final grade

10.4 Evaluation

during the semester

Lecture

Correlation between theoretical

and practical notions Capacity of

performing practical work.

Multiple choice test (TBL) 5%

Practical

activities


and practical notions Capacity of

performing practical work.

Practical skills tests during the

semester, to test student's ability to

properly apply a particular type of

statistical test.

20%

10.5 Final

evaluation

Theoretical

final exam

Understanding and integration of

all theoretical concepts

Knowledge of bibliographical

references

Multiple choice test 45%

Practical final

exam


and practical notions

Capacity of performing practical

work

Practical exam at the end of

semester. 30%


Understanding basic glossary of specialized terms in biostatistics

Ability to select and apply a statistical test correctly.

The ability to correctly determine the coordinates of a statistical protocol-specific type for clinical trial or

epidemiological / science experiment.

SYLLABUS




1.3 Department M2




2. Data regarding the discipline 2.1 Name Pharmacology and clinical pharmacology

2.2 Course coordinator Lecturer dr.Ban Erika

2.3 Practical activity coordinator(s) Lecturer dr.Ban Erika

2.4 Study year III 2.5 Semester I si

II 2.6 Type of evaluation Exam 2.7 Type of discipline DF



lecture 2


activity 2

3.4 Total hours in the curriculum 56/sem 3.5 out of which

lecture 28/sem


activity 28/sem


hours



Preparation for seminaries/laboratories, homework, reports, portfolios and essays x

Tutorial activities x

Examinations 1

Other activities x

3.7 Total hours of individual study

per week 8


3.9 Credits 4+4=8


prerequisites -

4.2 competency

prerequisites -



activities



• Understanding/knowledge of indications, contraindications, adverse

effects, pharmacokinetics, dosage, drug associations and interactions for

each drug class

Transversal competencies • Aquisition of skills and knowledge necessary for accurate drug

prescription (compound, precompound, officinal)



Pharmacology is a basic science, included in the curriculum for third

year medical students, which aim is to provide students with the

following knowledge:

• knowledge of the most important drug classes, the organotrophic

medications, the main therapeutic drug classes, correlations between

action and chemical structure


• • Understanding the mechanisms of action of the drug molecule on

the level of cells, tissues, organs and systems, on molecular and

receptorial level, and on the level of the whole human body

• knowledge of indications, contraindications, adverse effects,

pharmacokinetics, dosage, drug associations and interactions for

each drug class

• During the practical activities students learn the general rules of

medical prescriptions ( compound, precompound, officinal), and the

basics of pharmacovigilence

• Understanding of basic concepts of general pharmacology,

pharmacokinetics, pharmacodynamics, pharmacotoxicology and

dosage regardind the following drug cathegories: drugs acting on

peripheral neurotransmission and tissue active substances, drugs

acting on central nervous system, blood, respiratory system,

gastrointestinal system, urinary tract and uterus, endocrine and

metabolic processes, antiinflamatory drugs, antimicrobial and

antiparasitic chemotherapy, anticancer agents

• Aquisition of skills and knowledge necessary for accurate drug

prescription (compound, precompound, officinal)

8. Contents Crt.

no. 8.1 Lecture

Teaching


First semester

1.

1.Introduction: basic principles, importance,

historical development of pharmacology;

generalities about drugs- definitions, effects

Pharmacokinetics: sites of administration, drug

Oral +

multimedia

presentation

2

Acute kidney failure

absorbtion, distribution, metabolism, excretion,

cumulation Pharmacokinetics: sites of

administration, drug absorbtion, distribution,

metabolism, excretion, cumulation

2.

2. Pharmacodynamics: mechanisms of action,

interactions, dosage and administration, drug

safety and effectiveness. Basic and clinical

evaluation of a drug. Pharmacotoxicology:

toxicity, adverse effects, pharmacovigilance.

Oral +

multimedia

presentation

2

Drug effect on fetus

3.

3. Drugs acting on the autonomic nervous

system. Cholinergic agonists : direct and

indirect acting parasympathomimetics.

Oral +

multimedia

presentation

2

Glaucoma

4.

4. Cholinergic antagonists –

parasympatholytics; antispasmodic drugs.

Drugs that act on autonomic ganglia.

Oral +

multimedia

presentation

2

Intestinal obstruction

5. 5. Neuromuscular blocking agents

Oral +

multimedia

presentation

2

Pre-operative care

6. 6. Adrenergic drugs : sympathomimetics

Oral +

multimedia

presentation

2

Cardiorespiratory

arrest

7. 7. Sympatholytic agents : alpha-blockers, beta-

blockers, neurosympatholytics.

Oral +

multimedia

presentation

2

Hypertension

8. 8. Cardiac glycosides, other drugs used in

congestive heart failure

Oral +

multimedia

presentation

2

Acid-base

disturbance

9. 9. Antiarrhythmics

Oral +

multimedia

presentation

2

Cardiac rhythm

disorders

10. 10. Antianginal Drugs. Diuretics. Treatment of

high blood pressure.

Oral +

multimedia

presentation

2

Ischemic heart

disease

11.

11. Agents used in correction of plasma and

blood volume. Antianemic drugs : iron, vitamin

B12, folic acid

Oral +

multimedia

presentation

2

Anemia

12.

12. Antithrombotic drugs: anticoagulants,

antiplatelet agents, fibrinolytic agents.

Haemostatic agents : coagulants,

antifibrinolytics

Oral +

multimedia

presentation

2

Thromboembolic

disease

13.

13.Drugs affecting the respiratory system:

Drugs used for cough, expectorants,

antiasthmatic agents.

Oral +

multimedia

presentation

2

Asthma

14.

14. Drugs affecting the gastrointestinal system.

Stimulants and supplements of digestive

secretions. Digestive enzymes Antacids and

antiulcer drugs. Emetic and antiemetic drugs.

Purgatives, laxatives and antidiarrheal agents.

Oral +

multimedia

presentation

2

Peptic ulcer

Cholagogues and choleretics

Second semester

1. 1. Local anesthetics

Oral +

multimedia

presentation

2

Oral disorders

(caries)

2. 2.General anesthetics : inhaled and intravenous.

Oral +

multimedia

presentation

2

Post-operative care

3.

3. Sedative, hypnotic, anxiolytic drugs:

barbiturates, benzodiazepines, alcohols,

aldehides, etc

Oral +

multimedia

presentation

2

Anxiety/phobia

4.

4. Antipsychotic drugs: phenotiazines,

butyrophenones etc., Psychostimulants and

analeptic drugs.

Oral +

multimedia

presentation

2

Schizophrenia

5. 5. Antiepileptic drugs, anti-Parkinson agents,

central muscle relaxants

Oral +

multimedia

presentation

2

Epilepsy

6. 6. Antidepressants: tricyclic, atypical etc.

Oral +

multimedia

presentation

2

Depression

7. 7. Opioid analgesics and antagonists

Oral +

multimedia

presentation

2

Cerebral palsy

8.

8. Nonsteroidal antiinflammatory drugs,

antirheumatic agents, drugs used in gout

treatment

Oral +

multimedia

presentation

2

Inflammatory

arthritis

9. 9. Corticosteroids and ACTH

Oral +

multimedia

presentation

2

Adrenal failure

10.

10. Antimicrobial agents: penicillins,

cephalosporins, macrolides, chloramphenicol,

tetracyclines, aminoglycozides, polymixin

Antimicrobial chemoterapeutics

(antimycobacterials, sulfonamides and

trimethoprim)

Oral +

multimedia

presentation

2

Infectious disease of

childhood

11.

11. Urinary tract and intestinal antiseptics

(quinolones, nitrofurans, nalidixic acid),

disinfectants. Local and general antifungal

agents. Antiprotozoal agents: chemotherapy of

malaria, amibiazis, trichomoniazis.

Anthelmintic drugs, chemotherapy of

exoparasites. Antiviral agents.

Oral +

multimedia

presentation

2

Urinary tract

infection.Candidiasis

12.

12. Antidiabetic agents: insulin and oral

antidiabetics. Thyroid hormones and

antithyroid drugs.

Oral +

multimedia

presentation

2

Diabetes

13. affecting the phosphocalcic metabolism.

Anticancer drugs and immunosupressants.

Oral +

multimedia

presentation

2

Carcinoma of the

breast

14.

14. Basics of clinical pharmcology.

Introduction of a new drug, phases of the

clinical testing.

Oral +

multimedia

presentation

2

Drug reactions

Bibliography:

1.Pharmacology Course. Brassai Attila, 2014

1. Rang HP, Dale MM, Ritter JM, Moore PK: Pharmacology, Editura Churchill Livingstone, ediţia a 5-a,

(2003)

2. Hardman J, Limbord L, Gilman A: Goodman & Gilman’s – The pharmacological basis of therapeutics,

Editura The McGraw-Hill Companies, Inc. ediţia a 10-a (2001)

3. Katzung BG (red): Basic and clinical pharmacology, Editura McGraw-Hill, Boston, editia a 9-a (2004)

4. Brody TM, Larner J, Minneman KP, Harold CN: Human pharmacology- molecular to clinical, Editura

Mosby, ediţia a 4-a (2005)

Crt.

no.


activities/Stages

Teaching

methods Hours Observations

ICS

correlation

First semester

1.

1. General and official regulation of prescription,

delivery and circulation of drugs. Pharmacopeia.

Pharmacy. Medical prescription – forms, general

rules.

Practical

demonstrations,

lectures

2

2. 2. Solid dosage forms.

Practical

demonstrations,

lectures

2

3. 3. Semisolid and soft dosage forms

Practical

demonstrations,

lectures

2

4. 4. Liquid and gaseous dosage forms.

Practical

demonstrations,

lectures

2

5. 5. Cholinergic-anticholinergic agents

Practical

demonstrations,

lectures

2

6. 6. Adrenergic- antiadrenergic agents

Practical

demonstrations,

lectures

2

7. 7. Cardiac glycosides and antiarrhytmics.

Practical

demonstrations,

lectures

2

8. 8. Vasoactive agents.

Practical

demonstrations,

lectures

2

9. 9. Drugs affecting the respiratory system

Practical

demonstrations,

lectures

2

10. 10. Drugs affecting the gastrointestinal system

Practical

demonstrations,

lectures

2

11. 11. Diuretics

Practical

demonstrations,

lectures

2

12. 12. Hematologic drugs.

Practical

demonstrations,

lectures

2

13. 13. Practical test: general pharmacology and drug

prescription Examination 2

14. 14. Practical test: autonomic nervous system Examination 2

Second semester

1. 1. Local anesthetics

Practical

demonstrations,

lectures

2

2. 2. General anesthetics

Practical

demonstrations,

lectures

2

3. 3. Sedative, hypnotic, anxiolytic drugs : barbiturates,

benzodiazepines, alcohols, aldehides, etc.

Practical

demonstrations,

lectures

2

4.

4. Antipsychotic drugs: phenotiazines,

butyrophenones etc., Psychostimulants and analeptic

drugs

Practical

demonstrations,

lectures

2

5. 5. Antidepressants: tricyclic, atypical etc.

Practical

demonstrations,

lectures

2

6. 6. Opioid analgesics and antagonists

Practical

demonstrations,

lectures

2

7. 7. Nonsteroidal antiinflammatory drugs,

antirheumatic agents, drugs used in gout treatment

Practical

demonstrations,

lectures

2

8. 8. Corticosteroids and ACTH

Practical

demonstrations,

lectures

2

9.

9. Antimicrobial agents: penicillins, cephalosporins,

macrolides, chloramphenicol, tetracyclines,

aminoglycozides, polymixin Antimicrobial

chemoterapeutics (antimycobacterials, sulfonamides

and trimethoprim)

Practical

demonstrations,

lectures

2

10.

10. Urinary tract and intestinal antiseptics

(quinolones, nitrofurans, nalidixic acid),

disinfectants. Local and general antifungal agents.

Antiprotozoal agents: chemotherapy of malaria,

amibiazis, trichomoniazis. Anthelmintic drugs,

chemotherapy of exoparasites. Antiviral agents.

Practical

demonstrations,

lectures

2

11.

11. Antidiabetic agents: insulin and oral

antidiabetics. Thyroid hormones and antithyroid

drugs

Practical

demonstrations,

lectures

2

12. 12. Gonadal hormones and anabolic steroids

Practical

demonstrations,

lectures

2

13. 13. Drugs affecting the phosphocalcic metabolism.

Anticancer drugs and immunosupressants

Practical

demonstrations,

lectures

2

14. 14. Practical test- Central nervous system Examination 2

Bibliography:

1. Pharmacology Course. Brassai Attila, 2014

1. Rang HP, Dale MM, Ritter JM, Moore PK: Pharmacology, Editura Churchill Livingstone, ediţia a 5-a,

(2003)

2. Hardman J, Limbord L, Gilman A: Goodman & Gilman’s – The pharmacological basis of therapeutics,

Editura The McGraw-Hill Companies, Inc. ediţia a 10-a (2001)

3. Katzung BG (red): Basic and clinical pharmacology, Editura McGraw-Hill, Boston, editia a 9-a (2004)

4. Brody TM, Larner J, Minneman KP, Harold CN: Human pharmacology- molecular to clinical, Editura

Mosby, ediţia a 4-a (2005)

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain • • Understanding of basic concepts of general pharmacology, pharmacokinetics, pharmacodynamics,

pharmacotoxicology and dosage regardind the following drug cathegories: drugs acting on peripheral

neurotransmissin and tissue active substances, drugs acting on central nervous system, blood, respiratory

system, gastrointestinal system, urinary tract and uterus, endocrine and metabolic processes,

antiinflamatory drugs, antimicrobial ant antiparasitic chemotherapy, anticancer agents

• Aquisition of skills and knowledge necessary for accurate drug prescription (compound, precompound,

officinal)

10. Evaluation


the final grade

10.4 Evaluation during the semester

Lecture



Theoretical final exam MCQ exam – 100 questions 70%

Practical final exam Written test and experiments 30%


Knowing drugs action mechanism, general rules of medical prescriptions (compound, precompound,

officinal).

SYLLABUS




1.3 Department M2


1.5 Study cycle License


2. Data regarding the discipline 2.1 Name Pathophysiology

2.2 Course coordinator Assoc. Prof. Anca Bacârea, MD, PhD

2.3 Practical activity coordinator(s) Assoc. Prof. Anca Bacârea, MD, PhD

2.4 Study year III 2.5 Semester I 2.6 Type of evaluation Exam 2.7 Type of discipline DF



lecture 2


activity 2


lecture 28


activity 28


hours




Tutorial activities -

Examinations 0.5

Other activities 0.5


week 12


3.9 Credits 8


prerequisites

4.2 competency

prerequisites



activities



• Identification in terms of efficiency and effectiveness of general health

care needs, and treatment.

• Description of functioning of human body and the general mechanisms

of disease production.

• Getting Integrating concepts / situations that apply to the human body in

order to explain signs and symptoms.

• Establishing treatment needs imposed by the existence of signs and

symptoms of disease.

• The practical importance of pathophysiology for understanding the of

medical disciplines.

• Using the acquired notions in scientific research.

• Achieving a work / essay / case presentation - identifying targets.


• Identify objectives to be achieved, the resources available, their closing

conditions, work flow, working time, deadlines and related risks.

• Identifying roles and responsibilities in a multidisciplinary team and

applying effective techniques and working relationships within the team

and the relationship with the patient.

• Effective use of information sources and communication resources and

training to assist (Internet portals, specialized software, databases, online

courses, etc.)


7.1 General objective Presentation of the mechanisms of diseases which are important for

the doctor in its work.


Presentation of the etiopathology and pathophysiological

mechanisms in general and special pathophysiology of the body

systems.

Explaining the mechanisms of action of pharmacological substances

from the pathophysilogical point of view.

Theoretical and practical skills for positive and differential diagnosis

in clinical conditions.

8. Contents Crt.

no. 8.1 Lecture

Teaching

methods Hours

Observa

tions ICS correlation

First semester

1. 1

1

1. Introduction in pathophysiology. The

disease state. The mechanisms involved in

causing disease.

Multimedia /

oral

presentation

1

Cardiorespiratory

arrest

2.

2. Pathophysiology of thermoregulation.

Hyperthermia. Hypothermia. Febrile

syndrome.

TBL 2

PUO-pyrexia of

unknown

origin,Hypothermia

3. 3. The pathophysiology of inflammation. Multimedia / 2

Oedema,Septicaemi

The pathophysiology of infection. oral

presentation

a

4. 4. The pathophysiology of pathological

immune reactions.

Multimedia /

oral

presentation

2

Allergic

disorders,Connectiv

e tissue

disease,Immunodefi

ciency

5. 5.Pathophysiology of blood I - red blood

cell series.

Multimedia /

oral

presentation

2

Tiredness,Anemia,

Rhesus haemolytic

disease

6. 6. Pathophysiology of blood II - leukocyte

series.

Multimedia /

oral

presentation

2

Lymphadenopathy,

Lymphoproliferativ

e

disorders,Splenome

galy

7.

7. Pathophysiology of blood III –

hemostasis, coagulation and fibrinolysis

disorders.

Multimedia /

oral

presentation

2

Purpura,Coagulatio

n disease

8.

8. Pathophysiology of cardiovascular

system I - Congenital heart diseases.

Diseases of the cardiac wall: pericardium,

myocardium, endocardium.

TBL 2

Palpitations,Cardiac

conduction/rhythm

disorder,Cardiac

valve

disease,Endocarditi

s,Malformations of

cardiovascular

system,Pericardial

disease

9. 9. Pathophysiology of cardiovascular

system II – Atherosclerosis.

Multimedia /

oral

presentation

1

Disorders of lipid

metabolism,Ischemi

c heart disease


system III - Systemic hypertension.

Pulmonary hypertension.

Multimedia /

oral

presentation

1

Hypertension

11.

11. The pathophysiology of cardiovascular

system IV - Chronic ischemic heart

disease. Acute myocardial infarction.

Arrhythmias and conduction disorders.

Multimedia /

oral

presentation

1

Chest pain,Ischemic

heart disease

12.

12. Pathophysiology of cardiovascular

system V - Heart failure. Diseases of the

blood vessels: arteries and veins.

Lymphatic circulation disorders.

Multimedia /

oral

presentation

1

Cyanosis,Peripheral

vascular

disease,Thromboem

bolic

disease,Varicose

veins


system VI – the shock.

Multimedia /

oral

presentation

1

Shock

14. 14. Pathophysiology of acid-base

imbalances and fluid and electrolyte

disorders.

Integrative

lecture 1

Acid based

disturbance,Electrol

yte and water

balance

15.

1. The pathophysiology of the respiratory

system I – the pathophysiology of

hypoxemia and hypercapnia. Respiratory

failure. ARDS.

Multimedia /

oral

presentation

1

Breathlessness,Cya

nosis,Haemoptysis,

Hyperventilation

16. 2. Pathophysiology of respiratory system II

- Pathophysiology of restrictive ventilatory

disorders.

TBL 1

Chronic lung

disease,Pleural

effusion,Pneumotho

rax,Respiratory

tract infection

17. 3. Pathophysiology of respiratory system

III - Pathophysiology of obstructive

ventilatory disorders.

Multimedia /

oral

presentation

1

Stridor,Asthma,Chr

onic bronchitis and

emphysema,Chroni

c lung disease

18.

4. Pathophysiology of digestive system I -

Digestive system: oral cavity, pharynx,

esophagus, stomach, small intestine, colon,

rectum.

Multimedia /

oral

presentation

1

Abdominal

pain,Dysphagia,Lo

ose stools,Rectal

bleeding,Vomiting,

Carcinoma of the

colon and

rectum,Carcinoma

of the

stomach,Diverticula

r

disease,Gastroenteri

tis,Hernia,Inflamma

tory bowel

disease,Intestinal

obstruction,Malabs

orption,Malnutritio

n,Peptic ulcer

19. 5. Pathophysiology of digestive system II -

liver and biliary tract. The exocrine

pancreas.

Multimedia /

oral

presentation

1

Abdominal

distension,Abdomin

al pain,Anorectal

pain,Bowel habit

change,Constipatio

n,Haematemesis,He

patomegaly,Jaundic

e,Pruritus,Acute

liver

disease/failure,Carc

inoma of the

pancreas,Chronic

liver

disease,Disorders of

pancreas,Encephalo

pathy,Gall bladder

disease,Splenomega

ly

20.

6. The pathophysiology of metabolic

disorders: carbohydrate, protein and fat

metabolism. Diabetes mellitus and

nutrition disorders.

Multimedia /

oral

presentation

1

Visual

impairment,Diabete

s mellitus,Disorders

of uric acid

metabolism,Hypogl

ycaemia

21. 7. Pathophysiology of urinary system I -

Renal parenchyma. Upper and lower

urinary tract.

Multimedia /

oral

presentation

1

Dysuria,Frequency

of

micturition,Haemat

uria,Urinary

incontinence,Carcin

oma of the kidney

and bladder,Urinary

tract

infection,Urinary

tract obstruction

22. 8. Pathophysiology of urinary system II -

Acute renal failure. Chronic renal failure.

Multimedia /

oral

presentation

1

Polyuria,Retention

of urine,Acute renal

disease/failure,Chro

nic renal


calcium and

vitamin D

metabolism

23. 9. The pathophysiology of male

reproductive system. The pathophysiology

of female reproductive system.

Multimedia /

oral

presentation

1

Breast

lump,Gynaecomasti

a

24. 10. Pathophysiology of the endocrine

system.

Multimedia /

oral

presentation

1

Short

stature,Weight

gain,Weight

loss,Adrenal

excess,Adrenal

failure,Disorders of

calcium and

vitamin D

metabolism,Hypog

onadism,Osteoporo

sis,Pituitary

disorders,Thyroid

disorders

25.

11. Pathophysiology of the central and

peripheral nervous system.

Pathophysiology of organ senses - optical

analyzer. Auditory analyzer.

Multimedia /

oral

presentation

1

Abdominal

pain,Confusion,Dist

urbance of

consciousness,Dizzi

ness,Headache,Rais

ed intracranial

pressure,Visual

impairment,Cerebro

vascular

disease,Migraine,Pe

ripheral nerve

disorders

26. 12. Pathophysiology of loco-motor

apparatus. Pathophysiology of skin - non-

tumor and tumor lesions.

TBL 1

Back pain,Joint

pain,Joint

swelling,Pruritus,Ps

oriasis,Skin cancer

27. 13. Pathophysiology of cancer. Integrative

lecture 1

Weight loss,Bone

malignancy,Carcino

ma of the

breast,Carcinoma of

the

bronchus,Carcinom

a of the

cervix/uterus/ovary,

Disorders of

prostate

28. 14. Particularities in newborn, children,

pregnancy and elderly.

Multimedia /

oral

presentation

1

Disorders of

pregnancy and

deliver

Bibliography:

1.Bacârea Anca, Pathophysiology, Lecture guide, University Press Tîrgu Mureș, 2014

2. McCance KL et al. Pathophysiology. the biologic basis for disease in adults and children, Seventh

Edition, Elsevier 2014.

3. Essentials of Pathophysiology: Concepts of Altered Health States, Carol Mattson Porth, second edition,

Lippincott William Wilkins, 2006

4. Paulev Poul-Erik, Textbook in Medical Physiology and Pathophysiology, Copenhagen Medical

Publishers, 2000

5. Springhouse, Professional guide to pathophysiology 2ed, Ed. Lippincott Williams and Wilkins, 2006

Cr

t.

no

.


activities/Stages Teaching methods Hours

Observa

tions ICS correlation

First semester

1.

1. Work safety in the laboratory of

pathophysiology. Model of case report.

Presenting the way of teaching and

examination.

CBL, case reports 1

2.

2. Pathophysiology of thermoregulation.

Presentation of cases: Case no. 1 -

Hyperthermia; Case. 2 - Hypothermia.

CBL, case reports

1

PUO-pyrexia of

unknown

origin,Hypothermia

3.

3. The pathophysiology of

inflammation. Presentation of cases:

Case no. 1 - Streptococcal angina; Case

2. Fever in paraneoplastic syndrome –

Hodgkin’s lymphoma.

CBL, case reports

1

Oedema,Septicaemi

a

4. 4. The pathophysiology of pathological

immune reactions. Presentation of CBL, case reports

1

Allergic

disorders,Connectiv

cases: Case no. 1 – Allergic rhinitis;

Case. 2 – Incompatibility reaction in

case of unmatched blood group / Rh

transfusion

e tissue

disease,Immunodefi

ciency

5.

5. Pathophysiology of blood I- red

blood cell series. Presentation of cases:

Case no. 1 - Iron-deficiency anemia;

Case. 2 - Polycythemia vera.

CBL, case reports

1

Tiredness,Anemia,

Rhesus haemolytic

disease

6.

6. Pathophysiology of blood II -

leukocyte series. Presentation of cases:

Case no. 1 - Acute myeloid leukemia;

Case. 2 – Infectious mononucleosis/

HIV (SIDA)

CBL, case reports

1

Lymphadenopathy,

Lymphoproliferativ

e

disorders,Splenome

galy

7.

7. Pathophysiology of hemostasis,

coagulation and fibrinolysis disorders.

Case no. 1 - Hemophilia; Case. 2 –

Thrombophilia.

CBL, case reports

1

Purpura,Coagulatio

n disease

8.


cardiovascular system I. Case no. 1 -

Tetralogy of Fallot / Transposition of

the great vessels; Case. 2 – Bacterial

endocarditis.

CBL, case reports

1

Palpitations,Cardiac

conduction/rhythm

disorder,Cardiac

valve

disease,Endocarditi

s,Malformations of

cardiovascular

system,Pericardial

disease

9.


cardiovascular system II. Case no. 1

Ischemic heart disease; Case no.2 –

Chronic obliterative arteritis.

CBL, case reports

1

Disorders of lipid

metabolism,Ischemi

c heart disease

10.


cardiovascular system III. Presentation

of cases: Case no. 1-Essential systemic

hypertension; Case. 2 - Hypertension in

pregnancy / in pheochromocytoma.

CBL, case reports

1

Hypertension

11.


cardiovascular system IV. Case no. 1 -

Acute myocardial infarction; Case. 2 -

Chronic atrial fibrillation..

CBL, case reports

1

Chest pain,Ischemic

heart disease

12.


cardiovascular system V. Case no. 1 -

Congestive heart on the background of

dilated cardiomyopathy / heart

transplant; Case no. 2 - Pulmonary

embolism

CBL, case reports

1

Cyanosis,Peripheral

vascular

disease,Thromboem

bolic

disease,Varicose

veins

13.


cardiovascular system VI. Case no. 1-

Cardiogenic shock; Case no. 2 –

Hypovolemic shock/Anaphylactic

CBL, case reports

1

Shock

shock.

14.

14. Pathophysiology of acid-base

imbalances and fluid and electrolyte

disorders. Case no. 1- Metabolic

acidosis; Case no. 2 – Drug induced

hyperkalemia. Practical exam.

CBL, case reports

1

Acid based

disturbance,Electrol

yte and water

balance

15.

1. The pathophysiology of the

respiratory system I – Case no. 1- Post

transfusion ARDS (TRALI); Case no. 2

– Post traumatic ARDS.

CBL, case reports

1

Breathlessness,Cya

nosis,Haemoptysis,

Hyperventilation

16.

2. The pathophysiology of the

respiratory system I – Case no. 1-

Pneumonia with pleuresia; Case no. 2 –

Pneumothorax.

CBL, case reports

1

Chronic lung

disease,Pleural

effusion,Pneumotho

rax,Respiratory

tract infection

17. 3. The pathophysiology of the

respiratory system I – Case no. 1-

Asthma; Case no. 2 – COPD.

CBL, case reports

1

Stridor,Asthma,Chr

onic bronchitis and

emphysema,Chroni

c lung disease

18.

4. Pathophysiology of digestive system

I- oral cavity, salivary glands, pharynx.

Case no. 1 – Gastric ulcer; Case. 2 –

Crohn Disease.

CBL, case reports

1

Abdominal

pain,Dysphagia,Lo

ose stools,Rectal

bleeding,Vomiting,

Carcinoma of the

colon and

rectum,Carcinoma

of the

stomach,Diverticula

r

disease,Gastroenteri

tis,Hernia,Inflamma

tory bowel

disease,Intestinal

obstruction,Malabs

orption,Malnutritio

n,Peptic ulcer

19.

5. Pathophysiology of digestive system

II - liver and biliary tract; exocrine

pancreas. Case no. 1 - post hepatitis C

cirrhosis / liver transplantation; Case. 2

– Acute pancreatitis.

CBL, case reports

1

Abdominal

distension,Abdomin

al pain,Anorectal

pain,Bowel habit

change,Constipatio

n,Haematemesis,He

patomegaly,Jaundic

e,Pruritus,Acute

liver

disease/failure,Carc

inoma of the

pancreas,Chronic

liver


pancreas,Encephalo

pathy,Gall bladder

disease,Splenomega

ly

20.

6. The pathophysiology of metabolic

disorders: carbohydrate, protein and fat.

Case no. 1 - Hypoglycemic coma in

diabetes mellitus, Case no. 2 -

Hyperglycemic coma in case of insulin

dependent diabetes.

CBL, case reports

1

Visual

impairment,Diabete

s mellitus,Disorders

of uric acid

metabolism,Hypogl

ycaemia

21.

7. Pathophysiology of urinary system I -

renal parenchyma. Case no. 1 –

Multiple myeloma with acute tubular

necrosis Case. 2 – Prostate adenoma

and secondary hydronephrosis.

CBL, case reports

1

Dysuria,Frequency

of

micturition,Haemat

uria,Urinary

incontinence,Carcin

oma of the kidney

and bladder,Urinary

tract

infection,Urinary

tract obstruction

22.

8. Pathophysiology of urinary system II

– Case no. 1 –Prerenal acute renal

failure; Case no. 2 - Chronic renal

failure.

CBL, case reports

1

Polyuria,Retention

of urine,Acute renal

disease/failure,Chro

nic renal


calcium and

vitamin D

metabolism

23.

9. The pathophysiology of male and

female reproductive system. Case no. 1

- Orchiepididymitis; Case no. 2 -

Ruptured ectopic pregnancy.

CBL, case reports

1

Breast

lump,Gynaecomasti

a

24. 10. Pathophysiology of the endocrine

system. Case no. 1 – Hyperthyroidism;

Case no. 2 Hypothyroidism.

CBL, case reports

1

Short

stature,Weight

gain,Weight

loss,Adrenal

excess,Adrenal

failure,Disorders of

calcium and

vitamin D

metabolism,Hypog

onadism,Osteoporo

sis,Pituitary

disorders,Thyroid

disorders

25. 11.Pathophysiology of the central and

peripheral nervous system. Case no. 1 -

Intracranial hypertension; Case 2 - Tetra

CBL, case reports

1

Abdominal

pain,Confusion,Dist

urbance of

paresis by fracture of cervical spinal

column.

consciousness,Dizzi

ness,Headache,Rais

ed intracranial

pressure,Visual

impairment,Cerebro

vascular

disease,Migraine,Pe

ripheral nerve

disorders

26.

12. Pathophysiology of skin and loco-

motor apparatus. Case no.1 – Secondary

osteoporosis in hyperparathyroidism.

Case no. 2 – Psoriasis/ Atopic

dermatitis/ Malignant melanoma of the

skin

CBL, case reports

1

Back pain,Joint

pain,Joint

swelling,Pruritus,Ps

oriasis,Skin cancer

27.

13. Pathophysiology of cancer. Case no.

1 – Cervical cancer/Brest cancer; Case

no. 2 –Colo-rectal cancer/Lung cancer

in never smoker/Prostate cancer.

CBL, case reports

1

Weight loss,Bone

malignancy,Carcino

ma of the

breast,Carcinoma of

the

bronchus,Carcinom

a of the


Disorders of

prostate

28. 14. Practical exam. CBL, case reports 1

Bibliography:

1. Pathophysiology. Practical Work Guide. Anca Bacarea, Bianca Liana Grigorescu, George Claudiu

Costea, 2016, ISBN 978-973-169-460-3

1. Paulev Poul-Erik, Textbook in Medical Physiology and Pathophysiology, Copenhagen Medical

Publishers, 2000

2. Silbernagl S., Lang F.,Color Atlas of Pathophysiology, Thieme, 2000

3. Springhouse, Professional guide to pathophysiology 2ed, Ed. Lippincott Williams and Wilkins, 2006

4. General Practice Notebook http:// .www.gpnotebook.co.uk/homepage.cfm, 2010

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Knowledge of the pathophysiological mechanisms is mandatory for logic understanding of diseases,

allows the understanding of clinical and paraclinical expression of diseases and enables the practical

application of this knowledge in the medical work.

10. Evaluation

Type of activity 10.1 Evaluation

criteria 10.2 Evaluation methods

10.3 Percent of

the final grade

10.4 Evaluation during

the semester

Lecture



Theoretical final

exam

Final

theoretical

exam

Test 1

Test 2

Multiple choice test 40% written test 5% written

test 5% 50%

Practical final

exam

Final practical

exam

Test 1

Test 2

Case report

Oral presentation 30% multiple choice test5%

multiple choice test 5% oral presentation and

multimedia 10%

50%


Passing grade is 5, for both theoretical and practical examination. The student is obliged to attend

practical sessions, courses, recover all absences, promote theoretical and practical exam and to properly

use specialized terminology.

SYLLABUS




1.3 Department M2




2. Data regarding the discipline 2.1 Name Hygiene.Environmental and Food Health

2.2 Course coordinator Prof. Tarcea Monica

2.3 Practical activity coordinator(s) Conf. dr. Nadasan Valentin

2.4 Study year III 2.5 Semester II 2.6 Type of evaluation Exam 2.7 Type of discipline DD



lecture 2


activity 2


lecture 28


activity 28


hours

Study of books, lecture materials, bibliography, notes 0.5

Supplemental documentation at the library, from specialized information portals and in the field 0.5

Preparation for seminaries/laboratories, homework, reports, portfolios and essays 0.5


Examinations 1

Other activities -


week 6


3.9 Credits 2

4. Prerequisites (where applicable) 4.1 curricular prerequisites -

4.2 competency prerequisites -


5.2 for laboratory and practical activities to follow the laboratory guide work and protection instructions



- Description of theories and concepts specific to environmental hygiene

- Analysis of health issues related to the main elements of the

environment: water, air, radiation, food, waste

- Assessment of environmental health risks and develop measures for

controlling environmental risk factors

- Appropriate use of criteria and standardized methods in order to assess

the quality of food and food safety

- Implementation of projects, ability to collect information and to deliver

health education lectures on various topics in school, in order to promote

the population health status


- To identify roles and responsibilities in a multidisciplinary team and

specific projects, with proper evaluation and enforcement of ethics,

professional ethics, and safety at work

- To know how to elaborate the effective use of information sources and

communication, for professional training and personal development.

- To identify life style health risks and the proper ways to prevent them.



- To identify and evaluate the most prevalent environmental hazards, their

effects on human body, to reduce their direct and indirect harmfull effects

and prevent the illnesses related to them, and to promote individual,

community and public health.


- To apply the appropriate methodology for assessing environmental risks

related to air and water pollution.

- To know and apply the methodology for assessing food quality and food

security.

- To implement the principles of health education and promotion

regarding healthy nutrition.

- To know and to apply the health and hygiene standards, in order to

protect the population against illnesses.

8. Contents Crt.

no. 8.1 Lecture

Teaching


First semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Second semester

1.

1. Introduction to hygiene and environmental

health –The importance and objectives of

hygiene and environmental health - Definition

of hygiene, health and environmental health.

The determinants of health.

Oral and

multimedia

presentation

2

Chronic bronchitis

and emphysema, Skin

cancer, Substance

abuse, Depression,

Respiratory tract

infection, Skin

infections/infestations,

Malaria, Malnutrition,


Thyroid disorders,


and vitamin D

metabolism

2.

2. Environmental risk – Risk assessment,

management and communication.

Environmental toxicology and epidemiology

basics.

Oral and

multimedia

presentation

2

Chronic bronchitis

and emphysema, Skin

cancer, Substance

abuse, Depression,

Respiratory tract

infection, Skin

infections/infestations,

Malaria, Malnutrition,


Thyroid disorders,


and vitamin D

metabolism

3.

3. Air quality – Normal air composition.

Sources and effects of the most relevant air

pollutants. Air quality monitoring and air

pollution control measures.

Oral and

multimedia

presentation

2

Dizziness, Headache,

Tiredness, Chronic

bronchitis and

emphysema,

Respiratory tract

infection, Chronic

lung disease

4.

4. Water quality – Water intake and losses.

Water supply, water sources and their

characteristics. The hydrological cicle. Water

self-purification. Natural and man-made water

pollutants.

Oral and

multimedia

presentation

2

Cyanosis, Loose

stools, Abdominal

pain, Vomiting,


balance

5.

5. Water quality – Infectious and

noninfectious water born diseases. Drinking

water standards. Water treatment for

residential consumption. Wastewater.

Oral and

multimedia

presentation

2

Cyanosis, Loose

stools, Abdominal

pain, Vomiting,


balance

6.

6. Ionizing and non-ionizing radiation – The

electromagnetic spectrum. Natural and man-

made sources of ionizing radiation. Types of

exposure and health effects. Radiation

protection. Nonionizing radiations – radio

frequency, microwave and UV radiation.

Oral and

multimedia

presentation

2

Skin cancer, Diarrhea,

vomiting

7.

7. Urban and built environment – health

impact of housing and urban environment.

Environmental noise - sources, effects and

control of noise pollution. Solid waste

management.

TBL

session 2

Formative

evaluation

Dizziness, Headache,

Pruritus, Hearing loss,

Sleep disturbance,

Skin cancer,

Depression

8.

8. Food hygiene – Food - health relationship.

Macronutrients: proteins, lipids,

carbohydrates, dietary fibers; their role, daily

requirements, sources, and deficiencies.

Oral and

multimedia

presentation

2

Weight gain, Weight

loss, Constipation,

Malnutrition,

Disorders of uric acid

metabolism, Disorders

of lipid metabolism

9.

9. Food hygiene – Micronutrients: vitamins,

minerals, their role, daily requirements,

sources, and deficiencies. Phytochemicals.

Oral and

multimedia

presentation

2


and vitamin D

metabolism, Oral

disorders (incl.

Caries), Thyroid

disorders, Anemia,

10.

10. Food hygiene – Foodborne diseases.

Physical and chemical contamination of food.

Food additives and their safety.

Oral and

multimedia

presentation

2

Loose stools,

Abdominal pain,

Vomiting, Diarrhea,

Poisoning

11.

11. Food hygiene – Food borne diseases.

Microbiological contamination of food. Prion

diseases. Food safety. The HACCP system.

TBL

session 2

Formative

evaluation

Poisoning, Diarrhea,

vomiting,

gastroenteritis,

Encephalopathy

12.

12. Promoting healthy nutrition – Food

guides. Food groups – Meat, fish, and meat

products; eggs, milk, and dairy products.

Sources and nutritional value.

Oral and

multimedia

presentation

2

Weight gain,

Diabetes, constipation

13.

13. Promoting healthy nutrition – Food

groups: grains, grain products, fruits,

vegetables, legumes, and nuts. Processed

foods. Sugar products, alcoholic and non-

alcoholic beverages. Sources and nutritional

value.

Oral and

multimedia

presentation

2

Diarrhea, Vomiting,

Food allergies,

Poisoning, Gastric

pathology, Hepatic

disorders,

Inflammatory bowel

disease, Substance

abuse

14.

14. Child and adolescent health – Personal

and school hygiene. Risk behaviors in

children and adolescents. Health education for

preventing risk behaviors in children and

adolescents.

Oral and

multimedia

presentation

2

Immunization,

aggression / violence,

back pain, headache,

contraception,

learning disorders,

normal child

development, sexually

transmitted diseases,

substance abuse,

suicide and self-harm,

fatigue, disorders of

puberty

Bibliography:

References:

1. Tarcea M.: Environmental Hygiene, Edit. University Press Tirgu-Mures, 2014.

2. Frumkin H, Ed. Environmental Health: From Global to Local. San Francisco: Jossey Bass, 2005.

3. Friis RH. Essentials of Environmental Health. Jones & Bartlett Publishers 2011.

Crt.

no.


activities/Stages

Teaching


First semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Second semester

1.

1. Physical properties of the air – standards and

assessment methods. Air pollution assessment: PM,

dusts, and gases. Air quality monitoring.

Lab

practical

applications

2+2

Headache,

Dizziness,

Tiredness,

Pruritus, Sleep

disturbance,

Allergic

disorders,

Learning

disorders

2.

2. Indoor air pollution – environmental tobacco

smoke; measuring breath CO; the brief advice to

quit smoking. Microbiological contamination of the

air. Lighting condition and community noise

Lab

practical

applications

2+2

Chronic

bronchitis and

emphysema,

Respiratory

assessment. tract infection,

Chronic lung

disease,

Hearing loss

3.

3. Drinking water quality – sensory characteristics,

physical and chemical parameters. Drinking water

chemical quality standards: organic pollutants,

nitrites, nitrates. Microbiological analysis of

drinking water. Free residual chlorine measurement.

CBL and

practical

applications

2+2

Loose stools,

Vomiting,

Abdominal

pain,

Electrolyte and

water balance,

Cyanosis

4.

4. Nutritional assessment: BMI, body fat percentage.

Assessment of caloric and nutrient intake. Food

quality assessment: meat, milk, eggs.

Lab

practical

applications

2+2

Weight gain,

Weight loss,

Constipation,

Malnutrition,

Disorders of

calcium and

vitamin D

metabolism,

Oral disorders

(incl. Caries),

Disorders of

uric acid

metabolism,

Disorders of

lipid

metabolism

5.

5. Food quality assessment: grain products, fruits,

vegetables, canned food products, fatty foods,

beverages. Parasitological and microbiological

analysis of food.

Lab

practical

applications

2+2

Loose stools,

Vomiting,

Abdominal

pain,

Constipation

6.

6. Child and adolescent hygiene – Personal and

dental hygiene. School hygiene. Prevention of risk

behaviors in children and adolescents: smoking,

alcohol, drugs.

Lab

practical

applications

2+2+2

Tiredness,

Normal child

development,

Child abuse,

Substance

abuse,

Learning

disorders,

Disorders of

puberty

7. 7. Final test Test 2

8.

9.

10.

11.

12.

13.

14.

Bibliography:

References:

Ábrám Z., Tarcea M., Finta H., Moldovan H., Moldovan G., Nădăşan V., Ferencz J.L. Hygiene Practical

laboratory Guide, UMP Tîrgu Mureş, 2012.

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Coroboration between Hygiene curriculum and expectations of community associations and stakeholders:

Evaluation and analysis of environmental risk factors and proper implementation of health programmes,

preventive measures and education training for population, in order to prevent diseases for each

individual and all community.

10. Evaluation


the final grade

10.4 Evaluation during the semester

Lecture

TBL 20%


CBL 10%


Theoretical final exam


Practical final exam



- To know: the determinants of health and their influence on the human organism; the optimal parameters

of air and water quality; the prevention strategies and measures for air and waterborne diseases; the risks

of exposure to radiation and noise; the principles of healthy nutrition and food safety; the most important

behavioral risk factors in children and adolescents and how to prevent these behaviors.

• The minimum requirements for admission to the final practical exam:

- Attendance to the practical activities of the discipline is mandatory. Unexcused absences are allowed for

a maximum of 20% of the lab total number. Unmotivated absence to more than 2 per semester practical

work entails accepting the practical exam in the first examination session. The test consists of a written

multiple choice type test. The minimum pass mark is 5.

• The minimum requirements for admission to the final theoretical exam:

- Attendance to the course is mandatory and the absences cannot be recovered. Students are required to

take a written multiple choice test, as scheduled. The minimum pass mark is 5.

SYLLABUS




1.3 Department M2


1.5 Study cycle LICENSE


2. Data regarding the discipline 2.1 Name SCIENTIFIC RESEARCH METHODOLOGY

2.2 Course coordinator GHIGA DANA / LECTURER

2.3 Practical activity coordinator(s) GHIGA DANA / LECTURER

2.4 Study year 2 2.5 Semester I 2.6 Type of evaluation V 2.7 Type of discipline DC



lecture 1


activity 1


lecture 14


activity 14


hours




Tutorial activities 1

Examinations 1

Other activities


week 3


3.9 Credits 2


prerequisites -

4.2 competency

prerequisites -



activities -



- The student will need to know the main stages of evaluation and

initiation of a specialized study

- The student must be able to interpret the quality of a study / published

scientific article

- The student must be able to apply the knowledge gained in community

practice, in initiating and conducting a community study, in dissemination

of the obtained results and to assist local and national strategic programs


- Oral and written communication skills with knowledge of the scientific

oral presentation rules and the license paper / PhD thesis structure

- To respect the professional ethics by following the mandatory protocols

used in medical research



Scientific research has a big influence in university area. Applying the

scientific research principles in medical area is a necessity given the

structure of such University – 6 years with the possibility of admission to

a PhD program. The essence of this course is the elaboration of a license

paper at the end of the studies.


Introduce students to techniques of clinical and epidemiological studies.

Learning required protocols to follow in medical research.

Methodology of the medical research studies.

Presentation of results and conclusions in writing (article) and oral

(presentation rules).

8. Contents Crt.

no. 8.1 Lecture

Teaching


ICS

correlation

First semester

1. Methodology of medical scientific research –

generalities

PowerPoint

presentation,

interactive

discussions

1

Medical

research

2. Medical scientific research: Strategies and planning

a research study

PowerPoint

presentation,

interactive

discussions

1

Medical

research

3. Steps of a research study: Study population and

sample

PowerPoint

presentation,

interactive

discussions

1

Sample

4. Steps of a research study: Types and methods of

data collection

PowerPoint

presentation,

interactive

1

Medical

data

collection

discussions

5. Steps of a research study: Data analysis

PowerPoint

presentation,

interactive

discussions

1

Medical

research

6. Steps of a research study: Methodology (descriptive

studies)

PowerPoint

presentation,

interactive

discussions

1

Research

study

7. Steps of a research study: Methodology (cohort

studies) TBL

1

Research

study

8. Steps of a research study: Methodology (case-

control studies)

PowerPoint

presentation,

interactive

discussions

1

Research

study

9. Steps of a research study: Methodology (randomized

clinical trials) TBL

1

Research

study

10. Steps of a research study: Methodology (screening

and diagnostic tests)

PowerPoint

presentation,

interactive

discussions

1

Research

study

11. Steps of a research study: Research study bias

PowerPoint

presentation,

interactive

discussions

1

Medical

research

12. Steps of a research study: Displaying results

PowerPoint

presentation,

interactive

discussions

1

Medical

research

13. The structure of a scientific paper (Evaluation of a

scientific article)

PowerPoint

presentation,

interactive

discussions

1

Scientific

paper

14. Ethics in medical research

PowerPoint

presentation,

interactive

discussions

1

Medical

research

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Bacârea Vladimir, Ghiga Dana, Măruşteri Marius, Olah Peter, Petrişor Marius. A primer in research

methodology and biostatistics. University Press Târgu Mureş, ISBN: 978-973-169-285-2, 2014.

2. Ray M Merrill. Principles of Epidemiology Workbook: Exercises and Activities, Ed. Jones & Bartlett

Learning, ISBN: 978-0-7637-8674-8, 2011.

3. Christensen LB, Burke Johnson R, Turner LA. Research methods, Design, and Analysis, 11th edition,

Ed. Pearson education, ISBN: 978-0-205-81921-8, 2011.

4. Kumar Ranjit. Research Methodology a step-by-step guide for beginners, 3rd edition, Ed. Sage

Publications Ltd., ISBN: 978-1-84920-300-5, 2011.

5. Leon Gordis. Epidemiology, 4th Edition, Ed. Saunders, ISBN: 978-1-4160-4002-6, 2009.

6. Petter Laake, Haakon Breien Benestad, Bjørn Reino Olsen. Research methodology in the medical and

biological sciences, Ed. Academic Press, ISBN: 978-0-12-373874-5, 2007.

7. Jekel JF, Katz DL, Elmore JG, Wild DMG. Epidemiology, Biostatistics and Preventive Medicine, third

edition, Ed. Saunders Elsevier, ISBN: 978-1-4160-3496-4, 2007.

Crt.

no.


activities/Stages

Teaching


ICS

correlation

First semester

1. Online documentation

PowerPoint

presentation,

practical

exercises

1

Medical

research

2. Research studies - generalities, case report study

PowerPoint

presentation,

practical

exercises

1

Research

study

3. Cross sectional study

PowerPoint

presentation,

practical

exercises

1

Research

study

4. Epidemiological measurements

PowerPoint

presentation,

practical

exercises

1

Research

study

5. Recap Practical

exercises

1

6. Test (cross sectional study and epidemiological

measurements)

Real time test

assisted by

computer

1

7. Cohort study

PowerPoint

presentation,

practical

exercises

1

Research

study

8. Case – Control study

PowerPoint

presentation,

practical

exercises

1

Research

study

9. Randomized clinical trials

PowerPoint

presentation,

practical

exercises

1

Research

study

10. Screening and diagnostic tests

PowerPoint

presentation,

practical

exercises

1

Research

study

11. Recap Practical

exercises

1

12. Test (research studies)

Real time test

assisted by

computer

1

13. Medical writing

PowerPoint

presentation,

practical

exercises

1

Scientific

paper

14. Exam

Real time test

assisted by

computer

1

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Bacârea Vladimir, Ghiga Dana, Măruşteri Marius, Olah Peter, Petrişor Marius. A primer in research

methodology and biostatistics. University Press Târgu Mureş, 2014, ISBN: 978-973-169-285-2.

2. Ray M Merrill. Principles of Epidemiology Workbook: Exercises and Activities, Ed. Jones & Bartlett

Learning, ISBN: 978-0-7637-8674-8, 2011.

3. Kumar Ranjit. Research Methodology a step-by-step guide for beginners, 3rd edition, Ed. Sage

Publications Ltd., ISBN: 978-1-84920-300-5, 2011.

4. Petter Laake, Haakon Breien Benestad, Bjørn Reino Olsen. Research methodology in the medical and

biological sciences, Ed. Academic Press, ISBN: 978-0-12-373874-5, 2007.

5. Jekel JF, Katz DL, Elmore JG, Wild DMG. Epidemiology, Biostatistics and Preventive Medicine, third

edition, Ed. Saunders Elsevier, ISBN: 978-1-4160-3496-4, 2007.

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Knowing the steps of a research study

Knowing how to collect patients data for use in research studies

Knowledge of license paper structure in order to develop a PhD thesis

10. Evaluation


methods

10.3 Percent of

the final grade


the semester

Lecture Individual responses Team responses

Responses motivation TBL 10%

Practical activities Correlation between theoretical and

practical notions

Real time test assisted

by computer 30%


Theoretical final

exam

Understanding and integration of all

theoretical concepts Multiple choice test 45%

Practical final exam Correlation between theoretical and

practical notions

Real time test assisted

by computer 15%


Enunciation of the steps of a research study

Medical research study classification

Methods of result presentation

Scientific paper structure

License paper structure

SYLLABUS




1.3 Department M1


1.5 Study cycle LICENCE


2. Data regarding the discipline 2.1 Name MORPHOPATHOLOGY

2.2 Course coordinator Professor Gurzu Simona

2.3 Practical activity coordinator(s) Senior lecturer Turdean Sabin, Senior lecturer Mezei Tibor

2.4 Study year III 2.5 Semester I-II 2.6 Type of evaluation EX 2.7 Type of discipline DF



lecture 2


activity 2


lecture 28


activity 28


hours





Examinations 6

Other activities 4


week 8


3.9 Credits 8


prerequisites

4.2 competency

prerequisites Competenta lingvistica engleza – Examen Profex C1



activities

Semester II - participation at necropsy; digitalized microscopical

slides


Professional competencies - Understanding the basic pathological aspects of the main lesions of the

human body, as a mandatory part of the future clinical studies


- The interactive collaboration of the student with the didactic staff having

as a main objective the proper understanding of the macro- and

microscopical aspects correlated with the clinical ones

- At the necropsy, the student should understand the pathomechanism of

death and, at the same time, should be familiarized with the medical

know-how


7.1 General objective Understanding the basis of the pathological processes and adapting them

to the systemic pathology


Knowing the basic anatomo-clinical disorders

Understanding the morphological disorders and correlating them with

clinical aspects, based on the macro- and microscopical features,

correlated with the theoretical aspects

8. Contents Crt.

no. 8.1 Lecture

Teaching


First semester

1. Disorders of circulation Oral +

multimedia 2

Cerebrovascular

disease, Pleural

effusion


multimedia 2

Peripheral vascular

disease,

Thromboembolic

disease, Shock,

Varicose veins,

Coagulation disease


multimedia 2

Lymphoproliferative

disorders,

Splenomegaly

4. Disorders of metabolism Oral +

multimedia 2

Test-Dis.

circulation

Hypoglycaemia,

Encephalopathy,

Inborn errors of

metabolism, Drug

reactions,

Electrolyte and

water balance


multimedia 2

Disorders of uric

acid metabolism,

Cystic fibrosis,

Disorders of

calcium and vitamin

D metabolism,

Disorders of lipid

metabolism


multimedia 2

Diabetes mellitus

7. Inflammation Oral +

multimedia 2

Asthma


multimedia 2 TBL 1 Allergic disorders


multimedia 2

Immunisation,

Immunodeficiency,

HIV

10. Inflamation and immunopathology Oral +

multimedia 2

Test-

Inflammation

Connective tissue

disease

11. Tumor pathology Oral +

multimedia 2 TBL 2 Bone malignancy


multimedia 2

Skin cancer


multimedia 2

Childhood tumors


multimedia 2

Carcinoma of head

and neck

Second semester

1. Pathology of the cardiovascular system Oral +

multimedia 2

Pericardial disease,

Endocarditis,

Cardiac valve

disease,

Thromboembolic

disease

2. Pathology of the cardiovascular system Oral +

multimedia 2

Ischemic heart

disease,

Hypertension

3. Pathology of the cardiovascular Oral +

multimedia 2

Aortic aneurysm,

Temporal arteritis,

Malformations of

cardiovascular

system

4. Pathology of the respiratory system Oral +

multimedia 2

Test-

cardiovascular

Otitis media,

Pneumothorax,

Chronic bronchitis

and emphysema,

Respiratory tract

infection

5. Pathology of the respiratory system Oral +

multimedia 2

Chronic lung

disease, Carcinoma

of the bronchus,

Asthma

6. Pathology of the gastrointestinal tract Oral +

multimedia 2

Carcinoma of the

oesophagus, Peptic

ulcer,

Gastroenteritis,

Carcinoma of the

stomach

7. Pathology of the gastrointestinal tract Oral +

multimedia 2 TBL 1

Inflammatory bowel

disease,

Appendicitis,

Carcinoma of the

colon and rectum,

Intestinal

obstruction,

Peritonitis,

Diverticular disease,

Hernia

8. Pathology of the liver, gallbladder and pancreas Oral +

multimedia 2

Gall bladder

disease, Disorders

of pancreas,

Carcinoma of the

pancreas

9. Pathology of the kidney and urinary tract Oral +

multimedia 2

Chronic renal

disease, Carcinoma

of the kidney and

bladder

10. Pathology of the female genital system Oral +

multimedia 2 TBL 2

Carcinoma of the


Infertility

11. Pathology of the pregnancy and breast Oral +

multimedia 2

Carcinoma of the

breast

12. Pathology of the male genital system Oral +

multimedia 2

Disorders of

prostate

13. Pathology of the nervous and locomotor

systems

Oral +

multimedia 2

Cerebrovascular

disease,

Degenerative CNS

disease, Meningitis,

Brain tumor,

Peripheral nerve

disorders,

Malformations of

spine/CNS-central

nervous system

14. Pathology of the blood, bone marrow and

endocrine system

Oral +

multimedia 2

Test-Male

genital system

Myeloproliferative

disorders

Bibliography:

Gurzu Simona, Jung Ioan. Basic Concepts of Pathology. Ed. University Press, 2011.

Gurzu Simona, Jung Ioan. Compendium of Systemic Pathology. Ed. University Press, 2012.

Underwood JCE, Cross SS. General and Systematic Pathology. Ed. Churchil Livingstone, 2009.

Crt

.

no.

8.1

Seminaries/Laboratories/Pract

ical activities/Stages

Teaching methods Hour

s Observations ICS correlation

First semester

1. Autopsy technique - Tissue

processing

Digitalized

microscopical

slides +

multimedia/Necrop

sy

2

microscopic and gross

preaparations/museum/auto

psy room

Cardiorespirator

y arrest

2. Disorders of circulation -

Necropsy

Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Shock

3. Disorders of circulation -

Necropsy

Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Aortic aneurysm

4. Disorders of cell and tissue

metabolism - Necropsy

Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Disorders of

lipid metabolism

5. Disorders of cell and tissue

metabolism - Necropsy

Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Disorders of uric

acid metabolism

6. Inflammation - Necropsy

Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Appendicitis


Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Tuberculosis


Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Peritonitis

9. Tumor pathology - Necropsy

Digitalized

microscopical

slides +

2



psy room

Carcinoma of the

bronchus

multimedia/Necrop

sy


Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Carcinoma of the

cervix/uterus/ova

ry


Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Skin cancer


Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Carcinoma of the

colon and rectum

13. Congenital malformations

Digitalized

microscopical

slides +

multimedia/Necrop

sy

2 museum

Malformations

of cardiovascular

system,

Malformations

of spine/CNS-

central nervous

system

14. Review

Digitalized

microscopical

slides +

multimedia/Necrop

sy

2



psy room

Second semester

1. Pathology of the

cardiovascular system

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Ischemic heart

disease

2. Pathology of the

cardiovascular system

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Aortic aneurysm

3. Pathology of the respiratory

system

Digitalized

microscopical

slides +

macroscopical

examination of

2



psy room

Chronic

bronchitis and

emphysema

organs included in

formaline buffer

4. Pathology of the respiratory

system

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Carcinoma of the

bronchus

5. Pathology of the

gastrointestinal tract

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Inflammatory

bowel disease

6. Pathology of the

gastrointestinal tract

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Carcinoma of the

stomach

7. Pathology of the renal system

and genital organs

LDigitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Chronic renal

disease,

Disorders of

prostate

8. Pathology of the renal system

and genital organs

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Carcinoma of the

cervix/uterus/ova

ry

9. Pathology of pregnancy

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Disorders of

pregnancy and

deliver

10. Pathology of the breast

Digitalized

microscopical

slides +

macroscopical

examination of

2



psy room

Carcinoma of the

breast

organs included in

formaline buffer

11.

Pathology of the nervous

system and hematopoietic

system

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Brain tumor

12. Pathology of the endocrine

system

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Thyroid

disorders

13. Review laboratories

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

14. Review laboratories

Digitalized

microscopical

slides +

macroscopical

examination of

organs included in

formaline buffer

2



psy room

Bibliography:

Gurzu Simona, Jung Ioan. Introduction in histopathology. Ed University Press, 2012

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain The medical student should understand, in his preclinical activity, the basic aspects related to the macro-

and microscopical features of the main diseases encountered in the daily diagnosis. It is also mandatory

its familiarizition with the great importance of necropsy in his professional further activity and also the

importance of the medical know-how

10. Evaluation


the final grade


the semester

Lecture Two tests (10% each

30%

and two TBLs - 5%

each)



Theoretical final

exam Multiple choice test Test- semester I Test- semester II 40%

Practical final

exam Practical oral exam

Recognition and description of one

microscopical slide and one

macroscopical lesion

30%


Basic knowledge about the main pathological processes of the human body – sem. I

Knowing the main aspects about systemic pathology – sem. II.

For specific rules, please see the rules of the department on the site www.umftgm.ro - search term:

anatomie patologica

SYLLABUS




1.3 Department M5


1.5 Study cycle BA


2. Data regarding the discipline 2.1 Name SURGICAL SEMIOLOGY

2.2 Course coordinator PROF. DR. SUCIU HORATIU

2.3 Practical activity coordinator(s) ASIST. UNIV. DR. RUSSU CRISTIAN

2.4 Study year III 2.5 Semester I 2.6 Type of evaluation E 2.7 Type of discipline DD



lecture 2


activity 3


lecture 28


activity 42


hours





Examinations 0,5

Other activities 0,5


week 11


3.9 Credits 5


prerequisites -

4.2 competency

prerequisites -



activities -



Students will acquire general and practical knowledge concerning aseptic

and antiseptic, surgical infections, burns and frostbite, hemorrhage and

hemostasis, clinical examination of the abdomen, abdominal trauma,

surgical semiology of the neck, limbs, chest and abdomen, veins and

arteries diseases.

Students will be able to take the history and perform physical

examination and some basic diagnostic maneuvers, requiring appropriate

complementary examinations and a plan for primary secondary and

tertiary prevention, in a given situation.


Students will develop teamwork abilities, oral and written communication

skills, and will develop their professional and ethical values, clinical

problem solving and correct therapeutic decision making .

7. Objectives of the discipline (based on the grid of specific competencies) 7.1 General objective Notions of surgical semiology


To acquire the necessary knowledge about the organization and

functioning of surgery clinics, preparation of clinical observation sheets,

acquisition of necessary notions about performance: clinical examination

equipment and systems, rectal and vaginal examinations, dressings,

bandages, surgical sutures, injections, punctures and biopsies, incision

and drainage, acquision of the necessary knowledge about laboratory

exploration in surgical conditions of the neck, breast, e4sophagus,

stomach, duodenum, smalland large bowel, rectum, liver, gall blader,

pancreas and spleen, acquiring technical knowledge required on clinical

examination of the mammmary region, abdomen, veins and peripheral

artery diseases.

8. Contents Crt.

no. 8.1 Lecture Teaching methods Hours Observations ICS correlation

First semester

1. 1.INTRODUCTION

Multimedia,

interactive,

heuristic

conversation PPT

2

Learning

disorders, Pain

management

2. 2. HISTORY OF SURGERY

Multimedia,

interactive,

heuristic

conversation PPT

2

Learning

disorders, Pre-

operative care

3. 3. ASEPSIS and ANTISEPSIS

Multimedia,

interactive,

heuristic

conversation PPT

2

Septicaemia

4. 4. SOFT TISSUE TRAUMA

Multimedia,

interactive,

heuristic

conversation PPT

2

Abdominal

pain,

Septicaemia

5. 5. OPEN MECHANIC TRAUMATISMS.

WOUNDS

Multimedia,

interactive,

heuristic

conversation PPT

2

Trauma to

chest/abdomen,

Trauma to

head, Trauma

to limbs,

Trauma to

spine

6. 6. SURGICAL INFECTIONS -

INTRODUCTION

Multimedia,

interactive,

heuristic

conversation PPT

2

Trauma to

chest/abdomen,

Trauma to

head, Trauma

to limbs,

Trauma to

spine

7. 7. ACUTE NONSPECIFIC SURGICAL

INFECTIONS

Multimedia,

interactive,

heuristic

conversation PPT

2

Septicaemia

8. 8. ACUTE SPECIFIC SURGICAL

INFECTIONS TBL, PPT 2

Septicaemia

9. 9. HEMORRHAGE AND HEMOSTASIS

Multimedia,

interactive,

heuristic

conversation PPT

2

Transfusion of

blood products

10. 10. PREPARING THE PATIENT FOR

SURGERY TBL, PPT 2

Skin

ulcerations,

Septicaemia

11. 11. PREPARING THE PATIENT FOR

SURGICAL EMERGENCIES

Multimedia,

interactive,

heuristic

conversation, PPT

2

Septicaemia,

Post-operative

care

12. 12. POSTOPERATIVE CARE

Multimedia,

interactive,heuristic

conversation, PPT

2

Septicaemia,

Post-operative

care

13. 13. FIRST AID IN AMBULATORY

Multimedia,

interactive,

heuristic

conversation, PPT

2

Septicaemia,

Post-operative

care

14. 14. OUTPATIENT SURGERY

Multimedia,

interactive, PPT,

heuristic

conversation, PPT

2

Post-operative

care,

Septicaemia

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1. Symptoms and signs of surgical diseases, 3rd edition, Norman Browse, Arnold Publ., 1997

2. Principles of Surgical Management, Oxford University Press, C.Quick and P. Thomas,Oxford

Univ.Press, 2000

3. BASIC SURGERY, H.C. Polk & others, Quality Medical Publ., 1993

4. Tratat de patologie chirurgicala sub redactia N.Anglescu, Editura Medicala, 2001MANUAL DE

5. SEMIOLOGIE SI PRACTICI CHIRURGICALE, S. Simion, Edit. Univ. C. Davila, Bucuresti, 2003

Crt.

no.


activities/Stages

Teaching


First semester

1.

1. The organization of surgical services:

Primary evidences (surgical observation

worksheet, referral letter, discharge letter,

consultation register, the blood request note) -

Definition, structure, completing procedure,

document archiving at the patient discharge.

Presentation 3

Immunodeficiency

2. 2. Sterile equipment dressing. Surgeon’s hands

sterile washing, methods used.

Practical

demonstration 3

Immunodeficiency

3.

3. Surgical instruments. Probes. - cutting

instruments (fixed blade scalpel, with

interchangeable blade, disposable), surgical

scissors - for dressings, dissecting, straight,

curved, Cooper scissors) - grasping and holding

instruments - anatomical and surgical forceps -

hemostatic forceps (Pean, Kocher, Mosquito,

Halstedt) - sponge forceps - Museux forceps(for

uterine cervix) - towel clamps (Schaedel,

Doyen, Bachaus) -

Presentations

and practical

demonstration

3

Pleural effusion

4. 4. Surgical suture, surgical knots. - Definition.

Clarification. Principles. Necessary materials.

Practical

demonstration 3

Coagulation

disease

Indications. Contraindications. Technique.

Complications. Applying Michel clips.

5.

5. Wound dressings. Enswathement techniques

- Definition. Principles. Necessary materials.

Means of fixing the dressing. General rules of

enswathement.

Presentations

and practical

demonstration

3

Burns,

Septicaemia

6.

6. Wound dressings. Enswathement techniques.

- Methods of enswathement. Types of

enswathement for different regions. - The

buttocks leading methods (types of

enswathement) circular, spiral, helical,

overturned in

Presentations

and practical

demonstration

3

Burns,

Septicaemia

7.

7. Injections (i.d., s.c., i.m., i.v., i.a.) -

definition, necessary materials, injections

technique. Incidents, accidentsNecessary

materials. Vena cannulation by surgical

preparation. Vena cannulation by percutaneous

technique. CVP measurement – necessary

materials, measurement technique.

Presentations

and

simulation

3

Coagulation

disease

8. 8. Infusion - Preparing the infusion, infusion

solutions, infusion kit. Incidents, accidents.

Presentations

and

simulation

3

Coagulation

disease

9.

9. Minor outpatient surgery. (incision of a hot

or cold abscess, evacuation of a seroma, nail

removal, excision of benign growths, excision

of a foreign body).

Presentations,

observation

and practical

demonstration

3

Coagulation

disease

10.

10. Incannulation of a vein and CVP measuring.

Indications. Necessary material, measurement

technique.

Presentations,

observation

and practical

demonstration

3

Shock,

Coagulation

disease

11.

11. Anesthesia. Definition, classification. Local

anesthesia, regional anesthesia, Indications,

technique. Incidents, accidents, complications.

Presentations

and

observation

3

Drug reactions

12.

12. Hemostasis. Hemorrhage. - Definition,

classification. Signs. Symptoms. Spontaneous

hemostasis, temporary hemostasis, final

hemostasis (surgical). Used methods.

Presentations 3

Shock,

Coagulation

disease

13.

13. Punctions (pleural, pericardial, bladder,

Douglas space). - Definition. Classification,

principles. Necessary materials. Technique.

Indications. Accidents. Complications.,

Presentations

and

observation in

clinical cases

3

Haemoptysis,

Pericardial

disease,

Pneumothorax

14.

14. Transporting accident victims. - Method of

implementation atthe scene of the accident,

injured delivery in the specialized service,

monitoring during transport.

Presentations

and

observation in

clinical cases

3

Burns, Falls, Back

pain,

Cardiorespiratory

arrest

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:



Univ.Press, 2000




6. Basic of surgical semiology, Horatiu S, Popa D., Mathe Zs.,Russu C., Russu Eliza, UMF Tg Mures,

2015

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Surgical semiology is the basis for any surgical specialization. For future family physicians it provides a

minimum of knowledge enabling them to perform small surgical maneuvers in surgeries.

10. Evaluation


methods

10.3 Percent of

the final grade

10.4 Evaluation during the

semester

Lecture Knowledge TBL 15%

Practical activities Interaction Conversation Dialogues 15%


Theoretical final exam Knowledge of theoretical concepts

presented in the syllabus Multiple choice test 45%

Practical final exam Performance of maneuvers presented in

the syllabus

Practical

examination 25%


Students should know the theoretical and practical subject in proportion of at least 50%

SYLLABUS




1.3 Department M5




2. Data regarding the discipline 2.1 Name SURGICAL SEMIOLOGY

2.2 Course coordinator Dr.Borz Cristian

2.3 Practical activity coordinator(s) Assist Dr. Russu Cristian

2.4 Study year III 2.5 Semester II 2.6 Type of evaluation E 2.7 Type of discipline DD



lecture 2


activity 3


lecture 28


activity 42


hours





Examinations 0,5



week 10


3.9 Credits 5


prerequisites -

4.2 competency

prerequisites -



activities -



Students will acquire general and practical knowledge concerning aseptic

and antiseptic, surgical infections, burns and frostbite, hemorrhage and

hemostasis, clinical examination of the abdomen, abdominal trauma,

surgical semiology of the neck, limbs, chest and abdomen, veins and

arteries diseases.

Students will be able to take the history and perform physical

examination and some basic diagnostic maneuvers, requiring appropriate

complementary examinations and a plan for primary secondary and

tertiary prevention, in a given situation.


Students will develop teamwork abilities, oral and written communication

skills, and will develop their professional and ethical values, clinical

problem solving and correct therapeutic decision making .

7. Objectives of the discipline (based on the grid of specific competencies) 7.1 General objective Notions of surgical semiology


To acquire the necessary knowledge about the organization and

functioning of surgery clinics, preparation of clinical observation sheets,

acquisition of necessary notions about performance: clinical examination

equipment and systems, rectal and vaginal examinations, dressings,

bandages, surgical sutures, injections, punctures and biopsies, incision

and drainage, acquision of the necessary knowledge about laboratory

exploration in surgical conditions of the neck, breast, e4sophagus,

stomach, duodenum, smalland large bowel, rectum, liver, gall blader,

pancreas and spleen, acquiring technical knowledge required on clinical

examination of the mammmary region, abdomen, veins and peripheral

artery diseases.

8. Contents Crt.

no. 8.1 Lecture

Teaching


ICS

correlation

First semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Second semester

1. SURGICAL INFECTIONS

Multimedia,

interactive,

heuristic

conversation

PPT

2

2. LOCAL SURGICAL INFECTIONS

Multimedia,

interactive,

heuristic

conversation

PPT

2

3. GENERAL SURGICAL INFECTIONS

Multimedia,

interactive,

heuristic

conversation

PPT

2

4. ACUTE INFECTIONS OF THE HAND AND

FINGERS

Multimedia,

interactive,

heuristic

conversation

PPT

2

5. ANAEROBIC INFECTIONS. NECROTIC

SURGICAL INFECTIONS

Multimedia,

interactive,

heuristic

conversation

PPT

2

6. ARTERY DISEASES. SYNDROME OF

CHRONIC PERIPHERAL ISCHEMIA

Multimedia,

interactive,

heuristic

conversation

PPT

2

7. VENOUS DISEASES. THE VARICOSE DISEASE

Multimedia,

interactive,

heuristic

conversation

PPT

2

8. THE TROMBO-EMBOLIC DISEASE

Multimedia,

interactive,

heuristic

conversation

PPT

2

9. TUMORS IN SURGERY Multimedia, 2

interactive,

heuristic

conversation

PPT

10. EVALUATION AND TREATMENT OF SEVERE

TRAUMATISMS

Multimedia,

interactive,

heuristic

conversation

PPT

2

11. HISTORY OF SURGERY

Multimedia,

interactive,

heuristic

conversation

PPT

2

12. ASEPTIC AND ANTISEPTIC

Multimedia,

interactive,

heuristic

conversation

PPT

2

13. TRAUMA OF THE BONES AND

JOINTS.FRACTURES AND SPRAINES

Multimedia,

interactive,

heuristic

conversation

PPT

2

14. HAEMORRHAGES

Multimedia,

interactive,

heuristic

conversation

PPT

2

Bibliography:



Univ.Press, 2000




Crt.

no.


activities/Stages

Teaching


ICS

correlation

First semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Second semester

1.

1. Osteoarticular trauma. Temporary restraining

techniques. - Definition. Classification (fractures,

dislocations, sprains). Temporary immobilization

technique at the accident scene.

Presentations

and

demonstration

3

2.

2. Surgical drainage. - Definition. Clasification.

Necessary materials. Indications. Principles.

Incidents. Accidents. Complications. Technique.

The drainage of superficial collections.

Presentations

and observation

in clinical cases

3

3.

3. Tracheostomy. - Definition. Indications.

Principles. Necessary materials. Technique. High

tracheotomy. Low tracheotomy. Minitraheotomy.

Indications. Accidents. Complications.

Presentations

and observation

in clinical cases

3

4. 4. Cerebro-cardio-pulmonary resuscitation. -

Definition. Basic Life Support.

Presentations

and simulations 3

5.

5. Urinary bladder catheterization - Definition.

Indications. Contraindications. Principles. Necessary

materials. Technique. Incidents. Accidents. Minimal

cystostomy

Presentations

and observation

in clinical cases

3

6.

6. Enemas. Definition. Indications.

Contraindications. Principles. Necessary materials

Technique incidents. Accidents.

Presentations

and observation

in clinical cases

3

7.

7. Gastric intubation and gastric lavage. Definition.

Indications. Contraindications. Principles. Necessary

materials. Technique.Iincidents. Accidents.

Presentations,

simulations and

observation in

clinical cases

3

8.

8. Chest and breast examination - Minimal

pleurostomia. Passive and active pleural drainage.

Intercostal nerve infiltration. - Clinical signs in the

benign and malignant breast tumors.

Presentations,

simulations and

observation in

clinical cases

3

9.

9. Examination of the abdomen - Abdominal

syndromes, topography, clinical examination and

peritoneal puncture.

Presentations

and

demonstration

3

10. 10. Examination of the neck, limbs, varicose veins

clinical tests.

Presentations

and

demonstration

3

11. 11. Description of a tumor and ulceration. Rectal

and vaginal digital examination (indications, Presentations

3

contraindications, technique).

12. 12. General recapitulation.

3

13. 13. General recapitulation.

3

14. 14. Evaluation

Bibliography:



Univ.Press, 2000




6. Basic of surgical semiology, Horatiu S, Popa D., Mathe Zs.,Russu C., Russu Eliza, UMF Tg Mures,

2015

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Surgical semiology is the basis for any surgical specialization. For future family physicians it provides a

minimum of knowledge enabling them to perform small surgical maneuvers in surgeries.

10. Evaluation


the final grade

10.4 Evaluation

during the semester

Lecture Knowledge of theoretical concepts


Practical

activities

Knowledge of theoretical concepts

and performance of maneuvers

presented in the syllabus

Multiple choice test and

practical examination(TBL) 10%


Theoretical final

exam



Practical final

exam


and performance of maneuvers

presented in the syllabus

Practical examination 20%


Students should know the theoretical and practical subject in proportion of at least 50%

SYLLABUS




1.3 Department M3




2. Data regarding the discipline

2.1 Name SEMIOLOGIE MEDICALĂ /MEDICAL SEMIOLOGY/modul

limba engleză

2.2 Course coordinator Lecturer dr. GERMÁN-SALLÓ MÁRTA

2.3 Practical activity coordinator(s) Lecturer dr. GERMÁN-SALLÓ MÁRTA, Lecturer dr. NEGOVAN

ANCA,

2.4 Study year III 2.5 Semester I 2.6 Type of evaluation EXAMEN 2.7 Type of discipline DD



lecture 2


activity 3


lecture 28


activity 42


hours





Examinations 1

Other activities 1


week 11


3.9 Credits 5


prerequisites

4.2 competency

prerequisites



activities -



1. Understanding the basic knowledges of medical semiology-theories

and concepts.

2. Capacity of describing and recognizing the characteristic symptoms

and signs of different illnesses ,and obtaining the complete history of the

patient's illness.

3. Correct interpretation of symptoms and signs based on basic medical

semiology knowledges,assessing the patient's responses to the illness and

to the diagnostic and therapeutic ideas

4. Aquiring psychomotor skills to conduct a complete physical

examination on adult patients

5. Performing the comprehensive physical examination of a patient-basic

examination skills

6. Organizing a good clinical record

Minimum standard for competence evaluation: performing history,

physical examination, some specific diagnostic maneuvers, soliciting

adequate investigations, developing a problem list and plan, establishing a

presumed diagnosis, create the patient’s record


1. Adequate use of basic knowledges of medical semiology in

professional communication with the patient and with the medical staff

2. Clinical tkinking and reasoning:Capacity of analyzing and sintethysing

symptoms, signs and investigations to establish a presumed diagnosis-,

from data base to plan

3. Organizing informations gathered from effective patient-centered

interwiews into a standard written format integrating health history and

phsychosocial data.

4. Learning to apply Travistock principles of medical ethics.



Gathering and using basic knowledges regarding correct interpretation of

clinical symptoms and signs and investigations in order to develop a

problem list and plan, establish a presumed diagnosis and create the

patient’s record


Learning and recognizing clinical symptoms and signs

Learning and performing the clinical history-obtain and document a

complete history for adult patients ,practicing oral presentation skills

Learning and performing the physical examination –perform and

document a complete physical examination for adult patients, practice and

present comprehensive physical examination

Learning and performing some specific diagnostic maneuvers

Identifying common medical problems, developing a problem list and

plan based on history and physical examination, in order to establish a

presumed diagnosis

8. Contents Crt.

no. 8.1 Lecture

Teaching


First semester

1. 1. Introduction to medical semiology-about

medical profession, communication skils

Powerpoint

presentation 2

somatization,

affective disorders

2. 2. Medical chart. Taking history Powerpoint

presentation

2

Infectious disease

of childhood

3. 3. General symptoms Powerpoint

presentation

2

dizzines,

headache, weight

loss

4. 4. Phisical examination Powerpoint

presentation

2

movement

disorders,

disturbance of

conciousness

5. 5. Inspection of skin,nails, mucosa Powerpoint

presentation

2

anemia, jaundice,

cyanosis

6. 6. Semiology of subcutaneous tissue,

muscles,bone, joints, lymph nodes

Powerpoint

presentation

2

joint pain,

lymphadenopathy,

oedema

7. 7. Symptoms of respiratory diseases Powerpoint

presentation

2

breathlessness,

chest pain

8. 8. Alveolar condensation syndrome TBL 2

hyperventilation

9.

9. Physical examination of the respiratory system:

auscultation of the lungs. Normal respiratory

sounds. Added respiratory sounds.

Powerpoint

presentation

2

respiratory tract

infection

10. 10. Semiological importance of paraclinical

examinations in respiratory diseases

Powerpoint

presentation

2

chronic lung

disease,

hyperventilation

11. 11.Obstructive respiratory diseases Powerpoint

presentation

2

asthma, chronic

bronchitis,

emphysema

12. 12. Syndromes of the lung parenchima Powerpoint

presentation

2

tuberculosis,

carcinoma of the

bronchus

13. 13. Diseases of the pleura, Mediastinal syndrome.

Acute and chronic respiratory failure syndrome.

Powerpoint

presentation

2

pleural effusion,

pneumothorax

14. 14. Symptomatology of metabolic diseases TBL 2

diabetes

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1.Basics of Diagnosis: History Taking Physical Examination and Investigations vol I. Germán-Salló

Márta, 2014

1. Thomas James, Monaghan Tanya: Oxford Handbook of Clinical Examination and Practical Skills,

Oxford University Press 2007

FACULTATIVE

2. Barbara Bates: A Guide to Physical Examination and History Taking,sixth Edition, J.B Lippincott

Company Philadelphia, 7 th Edition, 1999

3.Huw Llewelyn, Hock Aun Ang, Keir Lewis, Anees Al-Abdullah: Oxford Handbook of Clinical

Diagnosis, Oxford University Press , second Edition 2009

4. Mark H. Swartz: Textbook of physical dagnosis history and examination. W.B. Saunders Company

2002

Crt.

no.


activities/Stages

Teaching


First semester

1. 1 Presenting the medical chart. bedsided

practice 3

infectious disease

of childhood

2.

2 Physical examination skills: -health history-

presenting the framework, model of written

recording

ppt,

demonstration,

patient

examination

3 allergic disorders

3.

3 Physical examination skills: general survey,

level of consciousness, build, height, weight,

dress, grooming, personal hygiene, odors of the

body and breath, posture, stance, gait, motor

acitivity

ppt,

demonstration,

patient

examination

3 movement

disorders,

4.

4 Physical examination skills: inspection and

palpation of skin, hair, nails, inspection of

mucous membranes , assessment of oedema,

clinical signs of swelling

ppt,

demonstration,

patient

examination

3 jaundice,

cyanosis

5. 5. Physical examination skills: examination of

locomotor system

ppt,

demonstration,

patient

examination

3 joint pain, joint

swelling

6.

6. Physical examination skills: examination of

lymph nodes, thyroid gland and breast

examination

ppt,

demonstration,

patient

examination

3 lymphadenopathy

7. 7.Semiology of respiratory system- symptoms

ppt,

demonstration,

patient

examination

3 breathlessness,

chest pain

8. 8. Anamnesis CBL 3 hyperventilation

9. 9. Semiology of respiratory system-clinical

examination of respiratory system

case

presentation,

patient

examination

3 respiratory tract

infections

10. CBL SESSION case

presentation 3

chronic

bronchitis and

emphysema

11. 11. Semiology of respiratory system -

syndromes

case

presentation 3 asthma

12. 12 Semiology of respiratory system -

syndromes demonstrations 3

tuberculosis,

carcinoma of

bronchus

13. 13 Semiology of respiratory system -

syndromes demonstrations, 3

pleural effusion,

pneumotorax

14. 14 13 Semiology of respiratory system -

syndromes CBL 3 cyanosis, stridor

Second semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Bibliography:

1.Basics of Diagnosis: History Taking Physical Examination and Investigations vol I. Germán-Salló

Márta, 2014



FACULTATIVE






2002

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Recognizing, analyzing and synthethysing the symptoms and signs of medical diseases, obstaining a

complet history and performing a comprehensive physical examination , integration of investigations

findings and the capacity of developing a problem list are essential steps in establishing a final correct

clinical diagnosis in order to recommend the most appropiate, individualized treatment for each patient.

10. Evaluation


the final grade


the semester

Lecture

TBL 15%


CBL 15%


Theoretical final

exam

În funcție de specificul

disciplinei, minim 60% Final test-multiple choice 40%

Practical final exam În funcție de specificul

disciplinei

Practical exam, history taking,

physical examination of the patient 30%


• Writting a medical chart

•Clinical examination of respiratory sistem

Minimum admission requirements for the final examination:

- 14 anamneses (with their description in the workbook) completed with the patient's general inspection

- 10 clinical examinations (inspection, palpation, percussion, auscultation) of the respiratory sistem with

detailed description of each patient

Must seen clinical situations

- Pallor,Cyanosis, cutaneous erythema, rash

- Jaundice

- Bilateral gambia edema, collateral vein circulation

- Cutaneous bleeding

- Bronchial syndromes (acute bronchitis, chronic bronchitis, asthma)

- Pulmonary condensation syndrome

- Pleural syndromes (exudative pleuritis)

- Respiratory failure

- Palpable peripheral adenopathy

SYLLABUS




1.3 Department M3




2. Data regarding the discipline 2.1 Name MEDICAL SEMIOLOGY_2

2.2 Course coordinator Lecturer Dr. NEGOVAN ANCA,

2.3 Practical activity coordinator(s) Lecturer Dr. GERMÁN-SALLÓ MÁRTA, Lecturer Dr.

NEGOVAN ANCA

2.4 Study year III 2.5 Semester II 2.6 Type of evaluation E 2.7 Type of discipline DD



lecture 2


activity 3


lecture 28


activity 42


hours





Examinations 0,5



week 11


3.9 Credits 5


prerequisites -

4.2 competency

prerequisites -

5. Conditions (where applicable)

5.1 for lectures -

5.2 for laboratory and practical activities -



1. Understanding the basic knowledges of medical semiology-theories

and concepts.

2. Capacity of describing and recognizing the characteristic symptoms

and signs of different illnesses ,and obtaining the complete history of the

patient's illness.

3. Correct interpretation of symptoms and signs based on basic medical

semiology knowledges,assessing the patient's responses to the illness and

to the diagnostic and therapeutic ideas

4. Aquiring psychomotor skills to conduct a complete physical

examination on adult patients

5. Performing the comprehensive physical examination of a patient-basic

examination skills

6. Organizing a good clinical record

Minimum standard for competence evaluation: performing history,

physical examination, some specific diagnostic maneuvers, soliciting

adequate investigations, developing a problem list and plan, establishing a

presumed diagnosis, create the patient’s record


1. Adequate use of basic knowledges of medical semiology in

professional communication with the patient and with the medical staff

2. Clinical thinking and reasoning:Capacity of analyzing and sintethysing

symptoms, signs and investigations to establish a presumed diagnosis-,

from data base to plan

3. Organizing informations gathered from effective patient-centered

interwiews into a standard written format integrating health history and

phsychosocial data.

4. Learning to apply Travistock principles of medical ethics.



Gathering and using basic knowledges regarding correct interpretation of

clinical symptoms and signs and investigations in order to develop a

problem list and plan, establish a presumed diagnosis and create the

patient’s record


Learning and performing the physical examination –perform and

document a complete physical examination for adult patients, practice and

present comprehensive physical examination

Learning and performing some specific diagnostic maneuvers

Identifying common medical problems, developing a problem list and

plan based on history and physical examination, in order to establish a

presumed diagnosis

8. Contents Crt.

no. 8.1 Lecture

Teaching


First semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Second semester

1. 1. Cardiovascular symptoms. Powerpoint

presentation 2

chest pain,

palpitation

2. 2. Physical examination of cardiovascular

system-inspection, palpation, percution

Powerpoint

presentation 2

hypertension,

varicose vein

3. 3. The auscultation of heart and vessels Powerpoint

presentation 2

cardiac valve

disease

4. 4. The role of investigations in cardiovascular

semiology

Powerpoint

presentation 2

cardiac

conduction/rhythm

disorders

5. 5. Semiology of valvular cardiopathy (mitral,

aortic, pulmonary, tricuspid) TBL 2

cardiac valve

diseases

6. 6. Semiology of congenital heart disease. Powerpoint

presentation 2

Malformations of

cardiovascular

system

7. 7. Myocardial, endocardial and pericardial

syndromes

Powerpoint

presentation 2

endocarditis,

pericardial

diseaseIchemic

heart disease

8. 8.Semiology of vascular diseases Powerpoint

presentation 2

varicose veine,

peripheral

vascular diseases

9. 9.Gastrointestinal symptoms Powerpoint

presentation 2

dysphagia,

abdominal pain

10. 10.Physical examination of abdomen Powerpoint

presentation 2

hepatomegaly,

splenomegaly

11. 11Upper and lower gastrointestinal syndrome Powerpoint

presentation 2

bowel habits

change

12. 12.Semiology of liver, biliary tree and pancreas Powerpoint 2

jaundice

presentation

13. 13. Semiology of urinary tract TBL 2

dysuria

14. 14.Haematological disorders Powerpoint

presentation 2

myeloproliferative

disorders, purpura

Bibliography:

1. Basics of Diagnosis: History Taking Physical Examination and Investigations vol II. Germán-Salló

Márta



FACULTATIVE






2002

Crt.

no.


activities/Stages

Teaching


First semester

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

Second semester

1. 1. Semiolgy of cardiovascular Symptoms of

cardiovascular diseases

demonstration,

patient

examination

3 chest pain,

palpitations

2. 2.Physical examination of cardiovascular

system-

ppt, patient

examination

3 cyanosis

3. 3 Investigation of cardiovascular system-

methods

case

presentation,

patient

3 hypertension

examination

4. 4 ECG interpretations/basics

case

presentation,

patient

examination

3

cardiac

conduction/rhythm

disorder

5. 5 Semiology of cardiovascular diseases

case

presentation,

patient

examination

3

cardiac valve

disease


demonstration,

case

presentation

3

ischemic heart

disease

7. 7 Pericardial syndromes. Myocardial

syndromes. Endocardial syndromes. CBL

3 pericardial disease


demonstration,

case

presentation

3 palpitation

9. 9 Semiology of cardiovascular diseases demonstration 3

breathlessness,

endocarditis

10. 10.Semiology of cardiovascular diseases

case

presentation,

patient

examination

3

angina pectoris

11. 11 Digestive syndromes. case

presentation

3 splenomegaly

12. 12 Ichteric syndrome. Liver and gall bladder

diseases CBL

3

bowel habit

change

13. 13 Semiology of urinary system. Clinical

examination.

demonstration,

case

presentation,

ppt

3

dysuria,

haematuria

14. 14 Hematological disorders-syndromes

demonstration,

case

presentation,

ppt

3

purpura

Bibliography:

1. Basics of Diagnosis: History Taking Physical Examination and Investigations vol II. Germán-Salló

Márta



FACULTATIVE






2002

9. Correlations between the contents of the discipline and the expectations of the community representatives, professional associations and representative employers in the domain Recognizing, analyzing and synthethysing the symptoms and signs of medical diseases, obstaining a

complet history and performing a comprehensive physical examination , integration of investigations

findings and the capacity of developing a problem list are essential steps in establishing a final correct

clinical diagnosis in order to recommend the most appropiate, individualized treatment for each patient.

10. Evaluation

Type of activity 10.1 Evaluation

criteria 10.2 Evaluation methods

10.3 Percent of

the final grade


the semester

Lecture

TBL 15%


CBL 15%


Theoretical final

exam Final test-multiple choice 40%

Practical final exam Case report -taking history, clinical

examination, case presentation, interpretation 30%


Minimum admission requirements for the final examination: • 14 anamneses (with their description in the workbook)

• 12 clinical examinations (inspection, palpation, percussion auscultation) of the cardiovascular system

with detailed description of each patient,

• 6 clinical examinations (inspection, palpation, percussion auscultation) of the digestive system with

detailed description of each patient,

• 4 clinical examinations (inspection, palpation, percussion auscultation) of the renal apparatus with

detailed description of each patient,

Must seen clinical situations Patient with coronary syndrome

Patient with valvular cardiopathy (mitral, aortic, pulmonary, tricuspid)

Pericardial syndromes

Arterial hypertension syndrome

Heart failure syndrome.

Signs, symptoms in peripheral arterial disease

Signs, symptoms in venous diseases

Gastro-duodenal ulcer syndrome

Intestinal syndromes

Urinary Tract Infection

Urinary tract obstruction

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