P. ,71 SERUH lI1WRl.L AlCD TRACE-ELBXEIIT LEVELS III HCISF'ITALIZBD PATIEITS VITH IIIFLAX'MATORY BOVBL DISEASE (IED). F. M.D. Hingorancel,

C. Do& E. Cabre, II. Lachica' ,

A. Abad-Lacruz , A.Gi12, I[. Bstevs , 1. Barenys, N. A. Gassull. Dept. of Gaatroenterology, Hospital de Bellvitge, L’Hospitalet, Barcelona. ‘CSIC, Exper. Stat. ‘Zaidin’, Granada. =Research Dept. UIIIASA, Granada, Spain.

Serum levels of Ca, P, Fe, Mg, Zn, Cu, En, Cr, Ho, and Se were prospectively measured in 89 healthy subjects (36 mea, 53 women, aged 34f2 yrs) and in 23 patients (13 ima. 10 women, aged 33*3 yrs) with acute or subacute attacks of IBD, ‘at admission in hospital. Fifteen patients (group A) had extensive acute colitis (Ulcerative or Crohn’s Colitis), and 8 cases (group B) had ileal or ileocolic Crohn’s Disease. TSF, HA&C, and Serum Albumin CBA) were used to assess protein-energy nutritional status. TSF, MAX, and SA were lower in group A than in controls (p<O.O5 to p<O, 001). SA was

the only decreased parameter in group B (p<O.OOl). Levels of Nn, Cr, and Ifo showed no differences among the three groups studied. The values of the reibaining micronutrients studied are shown in the Table. Unlike the location of the disease, the presence of malnutrition did not influence micronutrient serum levels (ABOVA 2F). The number of cases at risk of deficiency (below the P15 of healthy controls) was )50X for Fe, 2, and Ca in group A, and for Fe, Zn, Ca, and Mg in group B. These results should be taken into account in planning nutritional therapy in IBD patients.

Group A (n 15) = Group B (n 8) I I Ca (mmol/L) 2.19 f 0.03 l 2.27 * 0.03 tX 2.38 f 0.01 P tmmol/L) 1.18 f 0.06 1.31 f 0.12 tX 1.16 i 0.02 Ng &g/L) 20.7 f 0.70 18.3 t 1.30 t# 20.8 f 0.30 Fe (tsg/L) 0.45 f 0.06 t 0.43 i 0.12 t 0.94 * 0.04 Zn (w/L) 0.84 f 0.05 t 0.91 * 0.07 t 1.02 f 0.02 cu (xg/L) 1.31 f 0.09 t 1.20 f 0.10 1.11 f 0.03

) 53.7 i 0.10 t 51.2 i 11.3 41.1 f: 2.40 AEOVA 1F + Scheffe test. t:p<O.Ol vs Control; #:p<O.Ol vs group A.

P.72 EFFECT OF DIFFERENT NUTRITIONAL REGIMES ON TUMOR GROWTH IN CANCER BEARING PATIENTS. F.Rossi Fanelli, C.Cangiano, A.Cascino, R. Cavaliere*, F.Ceci++, F.Franchi,

M.PluscaritoIi. Clin. Nutr. Unit, III Dept. Intern. Medicine, University 'La Sapienza' and * Istituto Regina Elena; Rome, ITALY. t+Fellow of the Italian Association fnr Cancer Research (AIRC).

The differences in substrate utilization between normal and neoplastic tissue may be used in the nutritional manipulation of cancer. In tumor-bearing rats, a fat-based

TPN regimen was reported to increase host weight without stimulating tumor growth. The present study was aimed at verifying this finding in human cancer. Twenty-seven

patients with tumors of the esophagus (9), stomach (9) and colon (9) were randomly

assigned to receive, for 14 days, one of three different nutritional regimes: A) TPN

aminoacids (AA) + 100% glucose; 8) TPN AA + 20% glucose + 80% lipids; C) isocaloric,

isonitrogenous diet (Controls). The tumor cell replication rate was calculated on

bioptic specimens obtained before and after each 14 day regime period using the

labelling index (LI) technique, which is based on the incorporation rate of tritiated

thimidine by the replicating cancer cells. Anthropometric, biochemical and

immunological parameters were used to carefully assess host nutritional state at

identical time intervals. The table below shows the percent variation of LI with re- soect to baseline values, after each nutritional regime:

100% GLUCOSE 80% FAT DIET

ALI + 254 0 - 1% + 15%

Nutritional indices did not change significantly during any of the three regimes. This study confirms that in human cancer, lipid-based nutritional regimes may help in

at least maintaining host nutritional state with no stimulation of tumor growth.

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