effects of ionizing radiations & safety measures9 12/21/2018 natural exposure india we are all...
TRANSCRIPT
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Ill Effects of Nuclear Radiations and
Safety Measures
Dr. Sarika Prashar,
Medical Physicist & Radiological Safety Officer PGIMER, Chandigarh
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Nuclear Radiation
Ionizing radiation
X, Beta, Alpha, Gamma,
Neutrons
Non ionizing radiation
Microwaves, Radiofrequency
Radiation Characteristics
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Photons
Most penetrating
Interaction mechanisms
All produce energetic electrons
Photoelectric absorption
Compton scattering
Pair production
Electrons can produce subsequent ionizations
How to measure radiations?
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Radioactivity
• mCi
• Bq
Exposure
• R
• C/Kg
• Gy
Absorbed dose
• Rem
• Sievert or Gy
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Are these Nuclear
Radiations harmful?
Are we living with these harmful
radiation all the time?
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Radiation is everywhere
We live in a sea of radiation…
Cosmic
Inhaled Radon
Rocks Radioactive Elements
Plants Bodies
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About 70 mrem/yr Medical procedures 53 mrems Consumer products 10 mrems One coast to coast airplane flight 2 mrems Watching color TV 1 mrem Weapons test fallout less that 1 mrem Nuclear industry less than 1 mrem
Normal annual exposure from man-made radiation
Normal annual exposure from natural radiation
About 300 mrem/yr
Radon gas 200 mrem
Human body 40 mrem
Rocks, soil 28 mrem
Cosmic rays 27 mrem
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Natural Exposure India
We are all exposed to radiation from natural source,
from earth, sky and natural radionuclides like K-40,
and C-14 in the body.
About 2-3 mSV of radiation is acquired annually from
natural sources New Delhi 700 mGy Bangalore 825 mGy Bombay 424 mGy Kerala 4000 mGy (in narrow coastal strip)
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Introduction
The human body is made up of
many organs, and each organ of the
body is made up of specialized
cells.
Ionizing radiation can potentially
affect the normal operation of these
cells
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Interaction of radiation with cells
2 possibilities
Direct interaction in a cell
Indirect interaction in a cell
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Radiolysis of water
Ionizing radiation+H20H20 + + e-
H20 + H+ + OH (f) cell damage
H20 ++ H20
H3O
+ + OH (f) cell damage
e- + H20 H2O
- OH- + H (f) cell damage
H (f) + Oxygen Hyperoxy free radical
OH- + OH- H2O2 H+ +HO2
-
HO2- + Organic molecule > stable org. peroxide > lacks
essential enzyme > eventual cell death
Significant with low LET radiations: X, Gamma
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EFFECTS OF RADIATION ON CELLS
Biological effect begins with the ionization
of atoms. The mechanism by which
radiation causes damage to human tissue, or
any other material, is by ionization of atoms
in the material
•All cells are not equally sensitive to radiation
damage.
•In general, cells which divide rapidly and/or are
relatively non-specialized tend to show effects at
lower doses of radiation then those which are less
rapidly dividing and more specialized.
Relative Biological Effects
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CELL SURVIVAL
Surviving fraction is a function of plating
efficiency in the untreated control cultures
Plating efficiency is the number of colonies
counted as a percentage of the number of cells
plated
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Generation of Survival curves
Cell culture
Cell free
suspension
Use of Agar gel
Clone formation
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Plating efficiency
PE = No. of clones / No. of cells seeded
( say 30/100 = 0.3)
Surviving fraction = (Colonies counted/Cells seeded)*PE
BIOLOGICAL EFFECTS OF
RADIATION
These effects in humans are caused by
damage to individual cells
1. Somatic effects
2. Genetic effects
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Immediate Delayed
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Radiation sickness
Acute Radiation Syndrome
Leukemia
Carcinogenesis
Fetal developmental anomalies
Shortening of life
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Biological Effects Somatic
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Biological Effects
GENETIC/heritable effects appear in the future
generations of the exposed person as a result of
radiation damage to the reproductive cells
1) Chromosome mutations
2) Point mutations
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Other Biological Effects
Non specific life shortening
No specific data
Leukemia and malignancy
Atomic bomb data – no evidence
Safe radiation practices decreased
incidence of short life span
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Other Biological Effects
Early aging
Enhancement of physiological aging
Fibrosis of skin, heart muscle, endocrine
glands
Chronic lung inflammation
Controversial concept
ICRP Estimate
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A number of human population groups exposed to high levels of radiation have been studied to estimate the risk of radiation induced cancer at low levels of exposure.
The current estimate, suggested by the International Commission on Radiological Protection (ICRP-103, 2007), is that there would be 50 excess cases of cancer per million populations if exposed to 1 mSv of radiation dose.
Estimated Days of Life Expectancy Lost From
Various Risk Factors Industry Type or Activity Estimated Days of Life
Expectancy Lost
Smoking 20 cigarettes a day 2370 (6.5 years)
Overweight by 20% 985 (2.7 years)
Mining and Quarrying 328
Construction 302
Agriculture 277
Government 55
Manufacturing 43
Radiation - 340 mrem/yr for 30 years 49
Radiation - 100 mrem/yr for 70 years 34
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Acute radiation injury
Within 60 days of exposure
General effects: Cellular injury
Vascular changes: dose-rate dependent
Endothelial cells
Dilationcell swelling, disruption
thromboses,
Later, intimal hyperplasia and collagenous
hyalinization with media
thickeningnarrowing/obliteration.
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Acute radiation injury
Skin: Pathway of external radiation
Mild erythema:2-3 days
Edema: 2-3 weeks
Epithelial blistering
4-6wks
Chronic radio-dermatitis
months to years
Skin cancer
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Acute radiation injury
Eyes : cataract formation, 200-600 cGy damage lens, latent period 2-35 yrs
Other Organs
Relatively RR
Functional damage
occur at high dose
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Chronic Radiation effects
Stochastic in nature
Chief concern Cancer induction
Non cancerous effects
Cataract formation 500-800 R
Shortening of life span
Leukemia 50-100 cGy
No conclusive evidence of ill
effects in medical field Skin damage
from prolonged
fluoroscopic
exposure
Factors modifying the biological damge
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• Physical factors
– Dose rate
– Fractionation
– Radiation
quality
– Temperature
• Chemical factors – Radioprotectors
– Radiosensitizers
RADIOPROTECTORS
DRF/DMF= Radiation LD50 in presence of protector
Radiation LD50 in absence of protector with biological end point LD50(30)
Examples :- Thiol protectors (cysteine, cysteamine)
2 mercapto ethylamine (MEA)
mercaptopropionylglycine(MPG)
Nonthiol protectors- cytokines, polysaccharides,
metal compounds,
vitamins, plant products
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RADIOSENSITIZERS
ER= TCD50 in absence of sensitizer
TCD50 in presence of sensitizer
TCD50 is radiation dose to cure 50%of treated tumors.
Examples :-
•Nucleotide analogues- halogenated pyramidines
•Hypoxic cell sensitizers- hyperbaric oxygen
•paranitro aceto phenone PNAP
•nitroimidazole- metronidazole, misonidazole, sanazole
•Bioreactive drugs- mitomycin C
•chemotherapeutic drugs-cisplatin, doxorubicin, vincristine
•antimetabolite glucose analouges- 2-deoxy-D-glucose.
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Radiation Safety Measures
Ionizing radiation needs to be
handled with care rather than
fear and its risks should be kept
in perspective with other risks
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EPIDEMIOLOGICAL DATA FROM: Hiroshima-Nagasaki Patients with ancylosing spondylitis cervical cancer tuberculosis mastitis tinea capitis thymus enlargement thyrotoxicosis hemangiomas and more may come Chernobyl Techa river Semiplatinsk Nevada
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Radiation Safety Measures
Basic radiation safety rule
ALARA
As low as reasonably achievable
Nuclear Radiation Safety Program
Administered by the Radiation Safety Coordinator,
supported by the Senior Management and governed by
the Radiation Safety Committee
•Management control over work practices
•Personnel qualification and training
•Control of occupational and public exposure to
radiation
•Ascertain the quantity and concentration of any
nuclear substance released as a result of the licensed
activity
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Occupational Dose Limits
WB 50 mSv
Extremities 500 mSv
Skin 500 mSv
Eye lens 150 mSv
AERB Annual 20 mSv
General Public 1 mSv
Radiation Safety Awareness Precautions
•Recognize radiation warning signs and labels.
•Do not enter radiation areas without permission of the
radiation safety trained laboratory personnel.
•Do not bring food, drink, empty coffee cups or utensils
into the radiation rooms.
•Stay as far away from the radioactive sources as
possible.
•Do not touch or handle any radioactive materials if you
are not trained to work with it.
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Postings
Areas in which
radioisotopes are used or
stored must be
conspicuously posted with
the CAUTION
RADIOACTIVE
MATERIAL sign.
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LABELING
Any container in which radioactive material is
transported, stored, or used must bear a CAUTION
RADIOACTIVE MATERIAL label.
Special items used with radioisotope procedures which
could be contaminated should be labeled
Radioactive work areas should be neatly covered with
vinyl-backed absorbent paper.
The label must
state the type,
quantity, and
amount of
radioactive
material in the
container, the date
of the
measurement of
the quantities 12/21/2018 64
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Transportation Of Radionuclides
Carry radioisotopes in a container that will
contain inadvertent spills.
Always enclose radioisotopes in liquid-
tight, unbreakable carrying cases
Adequate shielding
Transfer of Radioactive Material Form
must be completed
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Radiation Safety Equipments
Survey instruments
GM instruments
IC instruments
Scintillation instruments
Semiconductor
Proportional counters
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Radiation Safety Equipment
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Area Survey
Regular survey of exposure and removable contamination levels
At start and end of day
Use portable survey meter
Established action levels
Corrective actions
Radioactive Waste Disposal
Fundamental radioactive waste management RWM Principles
Protection of Humans
Protection of Environment
Protection beyond National borders
Burden of on future generations
National Legal frameworks
RW generation and management
Safety of Facilities
Classification
According to activity
High activity
Medium activity
Low activity
According to state
Solid waste
Liquid waste
Gaseous waste
Basic Guidelines Dilute and Disperse Low level
radioactive waste
Delay and Decay Short lived isotopes
Concentrate and Contain Intermediate and
high level waste
Disposal limits for Sanitary sewerage system
RN Max. Activity MBq/day
Av. Monthly discharge
MBq/m3
99mTc 3.7 185
99Mo 3.7 185
131 I & 125 I 3.7 22.2
32P 3.7 18.5
14 C 18.5 740
3H 92.5 3700
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Radiation Safety Equipments
Personnel Dosimeters
Photographic film based dosimeters
Thermo luminescent dosimeters
Pocket dosimeters
Radiation Safety Audit
• Regular review of radiation safety program
• Visual checks of personnel safety practices
• Annual review of dept safety polices by
Medical Physicist
• Discussion with radiation safety committee
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RADIATION HORMESIS
Hypothesis predicts that minute
doses of ionizing radiation will
benefit growth, development,
reproduction and resistance to
radiation
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With the knowledge and understanding
Ionizing radiation can be utilized to its
best in the medical field
The radiation industry is no different
than other industries that have threshold
limit values for worker exposure