el citoesqueleto - ii
TRANSCRIPT
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Microtúbulos
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Inestabilidad dinámica
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¿Cómo podemos ver la dinámica de los microtúbulos en una célula viva?
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https://www.youtube.com/watch?v=6t05SXykeYQ
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Osamu Shimomura, Martin Chalfie and Roger Tsien
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GFP tubAADNPromotor
ATG stop
5´capAAAAAAAA
AUG stopARN
Proteína de fusión
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Nucleación de microtúbulos-tubulina y otras proteínas accesorias enriquecidas en
“Centros Organizadores de Microtúbulos”
(Microtubule Organizing Centers)
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El Centrosoma es un MTOC en animales
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Otros MTOC en células especializadas
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Maghelli & Tolic-Norrelykke (2010)
Ejercicio
Ablación laser de microtúbulos en levadura (S. pombe)
Microtúbulos marcados con tubulina-GFP
Tiempo entre imágenes: 5 segundos
¿Qué ocurre tras la ablación?
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Ejercicio
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“MicrotubuleAssociatedProteins“
MAPs
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TauMAP2
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Proteínas motoras - kinesinas
(-)
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Proteínas motoras - dineínas
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https://www.youtube.com/watch?v=hL0USeWjTHQ G / RE
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Axones de hasta 1 m!Más de 2 días de viaje
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Filamentos intermedios
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Ejemplo de pregunta de examen
¿Qué es una proteína motora? De un ejemplo específico de una proteína motora, y describa su
rol en un proceso celular.