elaeocarpus ganitrus (rudraksha), the amazing

www.wjpps.com Vol 5, Issue 9, 2016.

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Tripathy et al. World Journal of Pharmacy and Pharmaceutical Sciences

ELAEOCARPUS GANITRUS (RUDRAKSHA), THE AMAZING

ELECTROMAGNETIC BEAD OF NATURE TO REDEEM MANKIND

FROM DISEASE, SICKNESS AND MEDICINAL PROBLEM

Subhashish Tripathy*1, Anil Middha

2 and Sudhansu Ranjan Swain

3

1,2

Department Pharmaceutical Science OPJS University, Churu, Rajasthan- India.

3Moradabad Educational Trust Group of Institutions Faculty of Pharmacy, Moradabad

Ylrededores, India.

ABSTRACT

Elaeocarpus Ganitrus is a large ever-green tree native to India, Nepal

and Indonesia is famous for its natural electromagnetic bead

commonly known as Rudraksha. According to Hindu Mythology this

tree activates our body energy wheal giving better harmony to body

and mind and better ability to our mental and physical power thereby

we get spiritual illumination. Due to its positive electromagnetic

property it control body bioelectrical energy there by heals chronically

various diseases like BP, Heart Rate and Diabetics, gynecological

problem, neurological disorders, mental problem, spiritual gain,

insomnia, rheumatism, Antiageing and immunomodulatory property.

This present review has been attempting to explain botanical, ethno medicinal,

pharmacological property of Elaeocarpus Ganitrus seed to current medicinal science arena.

KEYWORDS: Elaeocarpus Ganitrus, electromagnetic property, Rudraksha, Antiageing,

immunomodulatory property, bioelectrical energy.

INTRODUCTION

Elaeocarpus ganitrus Beads helps healing various body diseases chronically due to its

electromagnetic property, acupressure and biomagnetic therapy and piezoelectric effect

which mean that it has the ability to generate electric charge in response to applied

mechanical stress. When it touches to human body it control human bioelectric energy and

give the wearer better coordination with his body and mind giving better concentration,

WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

SJIF Impact Factor 6.041

Volume 5, Issue 9, 1079-1099 Review Article ISSN 2278 – 4357

*Corresponding Author

Subhashish Tripathy

Department

Pharmaceutical Science

OPJS University, Churu,

Rajasthan- India.

Article Received on

12 July 2016,

Revised on 01 August 2016,

Accepted on 22 August 2016

DOI: 10.20959/wjpps20169-7684


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mental strength and Antiageing property. According to yoga, meditation and Ayurveda,

There are seven wheel of energy in our body and proper harmony is necessary in these wheel

or energy chakras so that one can unleash true power of his brain.[1-3]

It is widely distributed

from Madagascar in the west through India, Southeast Asia, Malaysia, Southern China and

Japan, through Australia to New Zealand, Fiji and Hawaii in the east with its approximately

350 species.

Rudraksha beads are regarded as the timeless jewels of the gods and find

mention in ancient Purina’s and Upanishads as being the most powerful aid in the path of Self

realization. It shield us against negative energies some time we call as paranormal activity or

something happens beyond our human sensory channel like ghost, sprit, demons or such kind

of malevolent activity. Wearing Rudraksha beads help us activating our energy wheels so that

one can figure out things that are happening beyond human sensory channel like paranormal

activity which is beyond current scientific understanding sometimes actually occur.[4-6]

Fig 1: Elaeocarpus ganitrus plant and its bead Rudraksha

Elaeocarpus Species

Elaeocarpus is a genus belonging to family Elaeocarpaceae contains tropical and subtropical

evergreen trees and shrubs. Nearly 360 species of Elaeocarpus trees are found in different

parts of the world. It is widely distributed from Madagascar in the west through India,

Southeast Asia, Malaysia, Southern China and Japan, through Australia to New Zealand, Fiji,

and Hawaii in the east with its approximately 350 species. Various Phytochemical

investigations shows that the common Phytochemical present in Elaeocarpus sps are

Elaeocarpine, Isoelaeocarpine, Epiiisoelaeocarpiline, Myricitrin, Mearnsetin 3-O-β-D-

glucopyranoside cucurbitacins and Ellagic acid derivatives. The islands of Borneo and New

Guinea have the greatest concentration of species.[7-9]

Some common species with their

occurrence are as follows:

Table.1 Elaeocarpus ganitrus plant species and distribution


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Elaeocarpus ganitrus Roxb.

Taxonomy

Kingdom: Plantae; Subkingdom: Tracheobionta; Superdivison; spermatophyta; Division:

Magnoliophyta; Class: Magnoliopsida; Subclass: Dillenlidae; Order: Malvales; Family:

Elaeocarpaceae; Genus: Elaeocarpus; Species: ganitrus. Botanical Source: Elaeocarpus

ganitrus Roxb.

Table. 2. Vernacular Name(s)

Sr. No. Species of Elaeocarpus Occurrence

1 Elaeocarpus aberrans New Guinea

2 Elaeocarpus acuminatus India

3 Elaeocarpus amoenus Sri Lanka

4 Elaeocarpus angustifolius Queensl and Australia

5 Elaeocarpus apiculatus China, Indonesia, Malaysia, Philippines

6 Elaeocarpus blascoi India. Endangered

7 Elaeocarpus coorangooloo Queensland (Australia)

8 Elaeocarpus coriaceus Sri Lanka

9 Elaeocarpus crassus New Guinea

10 Elaeocarpus dentatus New Guinea

11 Elaeocarpus eumundii Australia

12 Elaeocarpus ganitrus rudraksh tree India, South-East Asia, Indonesia, New Guinea

13 Elaeocarpus gaussenii Southern India. Endangered

14 Elaeocarpus grandiflorus India, Indo-China, Malesia

15 Elaeocarpus hartleyi New Guinea

16 Elaeocarpus hedyosmus Sri Lanka

17 Elaeocarpus hookerianus Pokaka. New Zealand

18 Elaeocarpus holopetalus New South Wales, Victoria (Australia)

19 Elaeocarpus williumsianus NSW, Australia

20 Elaeocarpus variabilis Southern India

21 Elaeocarpus timikensis New guinea

22 Elaeocarpus taprobanicus Sri lanka

23 Elaeocarpus sylvestris Japan, Taiwan, China, Indochina

24 Elaeocarpus stipularis Indochina, malasia

25 Elaeocarpus sikkimensis India, Bhutan

26 Elaeocarpus serratus South asia

27 Elaeocarpus robustus India, Bangladesh

28 Elaeocarpus obovatus Australia

29 Elaeocarpus neobritannicus New Guinea

30 Elaeocarpus photiniaefolius Ogasawara island

31 Elaeocarpus montanus Sri lanka

32 Elaeocarpus miegei New Guinea

33 Elaeocarpus lanceifolius South Asia

34 Elaeocarpus kirtonii Australia

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English Litrasum bead

Bengali Rudrakaya

Hindi Rudraksha

Kannada Rudrakshi

Sanskrit Rudraksha

Tamil Aakkam

Telugu Akkamrudrakai

Greek Elaeocarpus

Elaeocarpus Ganitrus Plant description

Elaeocarpus ganitrus Roxb is the scientific name of Rudraksha plant which ripe blue fruit

yield rudrakhya.[10-11]

This species was named by Dr. William roxburgh and this scientific

name of the plant was taken from Greek words Elaei which means Wild olive, Carous means

fruit. It is a large evergreen broad leave tree found in tropical and subtropical areas at the

altitude ranging from sea cost to 2,000 meter above sea leveal. This tree have perennial

habitat which grows throughout the year. The Tree of Rudrakasha is about 50-200 feet

height. It may grow 14.60 meters to 29.20 meters tall due to the area and the

climate. The diameter of trunk is up to 1.22 meter. The main trunk of the

Rudrakasha tree is cylindrical with a grayish white and rough textured bark. In

Nature and in proper environmental condition leafy crown of a Rudrakasha tree

takes a pyramidal shape. Rudrakasha leaves are like mango plant and length is

about 17.78cm and width is between 2.54cm to 4.45cm. The leaves of Rudrakasha

tree are shinning green on the front side with a dull leathery back side. In the

beginning these leaves are light green in colors and turn into profound green at the

time of adulthood and turn into yellowish red before turning grey coffee color and

falling.[12-13]

This cycle of leaves continues all over the tree throughout the year.

Rudrakasha flowers are white with fringed petals and they come into view in April-

May. Flowers of the plant exhibit soft aroma or fragrance. The flowers of the

Rudrakasha appear in bunch but smaller than that of leaf.[14]

The flowers of the

Rudrakasha appear in bunch but smaller than that of leaf. Most of the Elaeocarpus

ganitrus seeds created from the plants more than 95% are five facets Rudrakasha and these

seeds price are economical, but one facets Elaeocarpus beads and the beads which are above

12 facets are very rare and most of time come with not affordable price.

Table. 3: Macroscopically Examination of leaf


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S. No Leaf Inspection and observation

1 Apex Acute

2 Base symmetric

3 Color Shining green

4 Margin Undulate

5 Shape Ovate

6 Size 5-6 inch in length, 2 inch broad

Table.4 Microscopical Examination of seed

S. No. Seed Inspection and observation

1 Color Blue when ripe

2 Texture Hard

3 Taste Sour

4 Shape Round, Bulbous

5 Size ½ -1 inch

Rudraksha According to Hindu Mythology

The word Rudraksha name comes from Hindu mythology according to summation of two

Sanskrit words "Rudra" meaning Lord Shiva and "Aksha" meaning Teardrops.

Rudraksha so means 'The Tear of Lord Shiva'. In Sanskrit Rudraksha means Rudraksha

fruit as well as Rudraksha tree. Holy Rudraksha beads have been scripted in various religious

Hindu texts like Shivmaha Purana, Shreemaddevibhagwat and Nirnayasindhoo, Padma

Purana, ling Purana, Ashtamalikopnishad and other religious written manuscript. It is believe

that Rudraksha as symbol of link between this earth and heaven. Rudraksha have been worn

by sages and yogis since Vedic times for their profound spiritual significance and powerful

healing properties and consider as divine treasure for mankind and need to be cherished. The

unique properties and divine powers of Rudraksha have been described in the authentic

Shasta’s like the Rudraksha Jabala Upanishad, Padma Purana, Shiva Purana, Devi Purana and

Bhagavat Purana. According to holy religious manuscript it helps human achieve all they

want like a healthy mind, body and soul, a affluent life that many dream of and only some

achieve and a blissful soul.[15-17]


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Fig.2 Rudraksha affecting body energy wheal

Elaeocarpus Ganitrus physical chemical constituent

It shows the presence of epidermis, parenchymatous cells, vascular bundle, lateral vein,

unicellular trichomes calcium oxalate crystals, xylem and phloem. The preliminary

Phytochemical studies for Ethanolic extracts of Elaeocarpus ganitrus show the presence of

Protein, Amino acid Alkaloids, Glycosides, Flavanoids, tannins phytosterols and

carbohydrates. Main chemical constituent is Quercetin and Stigma sterol, Iso palmitic oil, Iso

stearic oil.

The Rudraksha beads are mainly plant product that contains Carbon, Hydrogen, Oxygen,

Nitrogen and different trace elements in a combined form.[18-19]

The gaseous elements in the

following proportion:


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Table. 5 Basic Element of Rudraksha

Elements Percentage

Carbon 50.024%

Hydrogen 17.798%

Nitrogen 0.9461%

Oxygen 30.4531%

Ehthnomedicinal Uses

Rudraksha beads have several amazing powers due to their electromagnetic properties.

Wearing it affects the body and performs healing of various diseases due to its

electromagnetic impulse. As per Ayurvedic system of medicine, wearing Rudraksha beads

relieves strain, insomnia, anxiety, lack of concentration, depression, palpitation, hypertension,

rheumatism, infertility and asthma and has also anti- aging effect.[20-21]

According to mukhi

or natural grooves present in Elaeocarpus beads it possesses different type of

pharmacological effects in our body. In most biological studies undertaken, extracts of

Elaeocarpus ganitrus exhibited wide range of pharmacological activities and are identified as

active against specific biological targets during large scale screening of multiple plant

extracts. Literature reports are available on various pharmacological activities which include

analgesic and anti-inflammatory, CNS activities, typical behavioral actions, sedative,

tranquillizing, hypnosis potentiating, antidepressant, antiasthma tic, anti-diabetic, cardio

stimulation, antihypertensive, anticonvulsant, etc.[22-23]

Theory of Rudraksha bioelectrical energy control by electromagnetism

Magnetic fields upon the body help to energize and boost the rate of circulation stimulating

nutrient rich blood flow thus invigorating our body metabolism by oxygenating the organs


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providing muscle and tissue more oxygen for mental and physical vigor while accelerating

the removal of body waste, flushing out unwanted toxins releasing more endorphins, the body

natural pain killers promoting repair and stimulating faster healing. It also improves the

body’s anti-infective activity and enhancing immunity normalizes endocrine production.[24-26]

Magnetic field al so affect enzyme production and utilization for reducing swelling, stiffness

and acidity from wounds helping in reducing inflammation. Static magnetic fields also

stimulate collagen density in and around the joints heal bones and alleviate chronic pain. In

the absence of a magnetic field the level of charge of subatomic particles diminishes,

resulting in the reduced overall charge of atoms[32]

the beneficial healing properties of

magnets are an established factor. Rudraksha have positive electromagnetic properties. It has

been proved in modern scientific lab that it has both paramagnetic and diamagnetic

properties. It has unique attribute of having capability to change its polarity. This

characteristic is called dynamic polarity. In Rudraksha the magnetic property is due to the

diamagnetism, the ability of any substance to acquire temporary magnetic property in

presence of an external magnetic field. The polarity of the charge induced is meant for

eternity opposite to that of the external field inducing the charge.

The whole human being behaves as a compound bio-electric circuit consisting of nervous

system and other organs.[27-28]

A vast quantity of electrical impulses are generated in the

human body because of continuous blood circulation and conduction of sensory and motor

impulses in nervous system which help contraction and relaxation of muscle fibers. These

electrical impulses are known as bio electrical energy. Harmonically controlled flow of this

bio-electric energy in the body provides better blood circulation. Rudraksha are name

according to natural grove present in it called as mukhi number of mukhi present in

Rudraksha changes electromotive force that influence our bio-electrical system. It resists the

flow of bio-electric current generated owing to potential difference between diverse organs or

parts of the body. This opposition generates an exact ampere of current flow based on the

factor of resistance. This control our heartbeat, reformation it and sending out precise

impulses to brain to influence certain bio-chemicals in the brain which brings positivity and

help us generating better relationship between body and mind.[29-30]


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Table.6 Traditional Use of Rudraksha

Medicinal use of Elaeocarpus beads according to Ayurveda

Types of Rudrakasha Uses

One Face Rudrakasha

It improves the concentration and mental constitution

of the wearer. Use for headache, heart disease, blood

pressure and right eye defect.

Two Faces Rudrakasha

Good for mental peace and pregnancy. Use for left eye

defect, diseases of heart, lung, brain, kidney and

intestine.

Three faces Rudrakasha

Recommended for: Blood defect, plague, small pox,

digestive problems, blood pressure, weakness,

disturbed menstrual cycle, spontaneous abortion and

ulcer.

Four Faces Rudrakasha Recommended for: Mental disease, paralysis, arthritis,

yellow fever and nasal disease.

Five Faces Rudrakasha Recommended for: Bone marrow, liver, kidney, feet,

thigh, ear, diseases of fat and diabetes.

Six Faces Rudrakasha Recommended for: Eyes, reproductive organs, urinary

tract, prostate, mouth and throat.

Seven Faces Rudrakasha

Recommended for: Weakness, colic pain,

handicappers, pain in bone and muscles, paralysis, long

term disease, impotency, worries and hopelessness.

Eight Faces Rudrakasha Recommended for: Lung, feet, skin and eye catarrhisis,

hydrosol, airtracia.

Nine Faces Rudrakasha Recommended for: Lung diseases, fever, eye pain,

bowel pain, skin disease, body pain.

Ten Faces Rudrakasha Recommended for: Pacifying all the bad planets effect

on our body.

Eleven Faces Rudrakasha Recommended for: Maintenance of entire

neurophysiology.

Twelve Faces Rudrakasha Recommended for: Heart, lung and skin disease, hiatus

of stomach, esophagus and bowel problems.

Thirteen Faces Rudrakasha Recommended for: Meditation and spiritual

attainments

Fourteen Faces Rudrakasha Recommended for: Safety and riches, provides

miraculous cures to several ailments.

Fifteen Faces Rudrakasha

It is best for curing diseases like skin diseases,

recurring miscarriage, still birth etc. Fifteen mukhi

Rudraksha is measured as a blessing for women who

are incapable to imagine and in such case both the

partner should wear it for fruitfulness.

Sixteen Faces Rudrakasha It is used for curing the diseases like leprosy,

tuberculosis, cor-pulmonale, lung diseases, etc.

Seventeen Faces Rudrakasha It is best for the treating diseases like memory lapse,

body functional disorders, etc.

Eighteen Faces Rudrakasha Its treatment is best for prevent and curing diseases

like mental in harmonization, loss of power, etc.

Nineteen Mukhi Rudraksha Nineteen Mukhi Rudrakasha eradicate the diseases like

blood disorder, spinal disorder etc.

http://www.rudraksha-world.com/fifteen-face-rudraksha-140-19.html

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Twenty Mukhi Rudrakasha It is used as medical cure for eyesight problem and

snake bites.

Twenty One Mukhi Rudrakasha

Only twenty one Mukhi Rudraksha has deep-rooted

medical healing and it eliminates every form of

diseases.

Trijuti/Tribhagi Rudrakasha Trijuti Rudrakasha is best for keeping diseases like

internal and external body disorders at bark.

Gauri Shankar Rudrakasha It is used for the treatment of diseases like sexual

problems, behavioral disorders, etc.

Ganesh Rudrakasha It is used for wisdom, learning, prudence and power.

Methods for Identification of real Elaeocarpus Ganitrus bead Rudraksha

Rudraksha bead are very rare and precious. Most percentage Rudraksha produce from plant

are five faces but Rudraksha Price are high if no face increase from more than ten or only one

face present. Due to high demand duplicate Rudraksha bead are also present in market and

this replica of Rudraksha bead demand scientific test to identify its originality.[31-32]

Properties Test

This test is mean to give information that whether the beads show properties like inductance,

capacitance, conduction of electric current etc.

Cut Test

It is most reliable and trusted methods but bead get damage no further use. Elaeocarpus

ganitrus bead cut horizontally for this technique. When it will be cut one locate the same

number of section as the number of lines. Drawback of this method is that bead gets spoiled.

Eye test

From time to time the fake or the artificial Elaeocarpus ganitrus seed may seem same as real

one, but these counterfeit Rudraksha facets cannot be made as real as those present on the

real Rudraksha. This is a natural partition on Rudraksha which just like the Natural grove.

One can see these deep linings (facets) with the help of a magnifying glass (Lenses).

Copper Coin Test

Normally it is thought that when an Elaeocarpus ganitrus bead is placed between two copper

coins it will slightly rotate either clockwise or the anticlockwise direction. This phenomenon

occurs due to physical and magnetic properties of the Rudraksha beads.

http://www.rudraksha-world.com/twenty-face-rudraksha-145-19.html

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X-Ray

In X-ray technique one can see the internal structure without destructive the beads. X-ray test

is done without complication for Rudraksha up to nine Mukhi but complex Mukhi beads may

not give 100% accurate results due to overlapping of the internal seeds.

Water test

Some of the rare Rudraksha beads like Gauri Shankar or a trijuti can be made by synthetically

joining two or three Rudraksha with help of glue etc. kept in boiling water for some minutes.

A sharp strip will obtain at the joint in case of synthetic Rudraksha.

CT scanning

CT scanning is sophisticated method for identification of Rudraksha but it is more expensive

than X-ray but clear result can get for higher face Rudraksha.

Pharmacological Study of Elaeocarpus Ganitrus

a) Rudraksha novel evaluation, Nano silver synthesis with Aspects of Variation in

Concentration Antimicrobial activity and in Vitro Biocompatibility study

The extraordinary non-degradable distinctive features of the Rudraksha bead renders

reutilization of its resources and inexhaustibility of its potentiality to mediate countless

silvernanoparticle synthesis. Experimental study was done high prospects of maneuvered

nano silver manufactured for many essential applications. In this nano regime author bring a

glorious green route for flabbergasting silver nanoparticles fabrication with the intervention


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of five faced seed Rudraksha. With the variation in concentration of the precursor as well as

the mediator on the physicochemical nature of silver nanostructure its antimicrobial activity

together with the issue of its biocompatibility is analyzed. The Rudraksha extract were

prepared and biosynthesis of silver nanoparticles were conducted and different parameter

were studied together with various characterization. The silver nanoparticles produced are

mainly spherical with different size. There exists also variation in size and silver content

depending upon the concentration of precursor and mediator. The nano silver produced is

very high and with good biocompatibility so Rudraksha have incessant biocompatible nano

silver production.[33]

b) Evaluation of anti-Parkinson effect of E. ganitrus

Rota rod and catalepsy bar tests method was followed by author for evaluation of anti-

Parkinson effect of E. ganitrus. Assessment of oxidative stress was done by counting the

malondialdehyde (MDA) and reduced glutathione (GSH) levels in the striatal area of the

brain. One-way ANOVA was used to notice statistical importance, followed by post-hoc

Tukey test. Results: E. ganitrus (200 and 400 mg/kg, p.o.) pretreated groups considerably

amplified the retention time in rota rod test (p<0.001) and considerably decreased the latency

period in catalepsy bar test (p<0.001), when compared with haloperidol treated group alone.

E. ganitrus (200 and 400 mg/kg, p.o.) pretreated groups give significant anti-oxidative effect

by affecting a reduction in brain MDA levels (p<0.001) and a significant boost in GSH levels

(p<0.001). The results of the study reveal that E. ganitrus has antioxidant activity and showed

affirmative results in both behavioral parameters (Rota rod test and catalepsy bar test) in

MPTP induce investigational model of Parkinson’s disease. E. ganitrus found to be

successful in increasing Rota rod performance and decreasing catatonic reacts.[34]

c) In vitro antimicrobial activity of aqueous extract of E. ganitrus leaves

Author done the In vitro antimicrobial activity of aqueous extract of E. ganitrus leaves

against clinical isolates of bacteria and fungi. The extract show extensive antimicrobial act as

it show growth inhibition designed for Bacillus cereus, Staphylococcus aureus, Escherichia

coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Aspergillus flavus, Penicillium sp,

Candida albicans and C. tropicalis. Agar well diffusion method is used for determining

antibacterial activity of the crude extracts for that aqueous extract of E. ganitrus leaves was

tested for antibacterial activity against three gram positive (B. cereus S.aureus and M. luteus)

and three gram negative bacteria (P. aeruginosa, E. coli and K. pneumoniae), isolated from


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the experimental sample. The extract exhibited brilliant antibacterial activity next to all the

bacterial cultures excluding M. luteus. Antifungal activity of the crude extracts was examined

through the agar well diffusion method. Antifungal activity of the extract was tested

alongside three molds (Penicillium sp, A. niger and A. flavus) and two yeast (C. albicans and

C. tropicalis), isolated from scientific samples.[35]

d) Evaluation of immunomodulatory effects of methanol extract of Elaeocarpus

ganitrus seeds

The seeds of Rudraksha (Elaeocarpus ganitrus) have been conventionally used in India and

other Asian countries from ancient time. The methanolic extract of Elaeocarpus ganitrus

seeds Rudraksha were evaluated for immunomodulatory activity using in vitro and in vivo

methodologies. Result of the extract at a range of concentrations (832 - 6.5 µg/ml) on

secretion of mediators like nitric oxide, superoxide and lysosomal enzyme from isolated

murine peritoneal macrophages were evaluated. The extract give important stimulation of

release of nitric oxide (at 416, 104, 52 µg/ml), superoxide (at 416, 208 µg/ml) and lysosomal

enzyme (at 208, 104 µg/ml). The extract was also evaluated for in vivo phagocytic activity by

carbon clearance test in mice and it show considerable increase in the phagocytic index at

100 and 200mg/kg dose. The outcome of the extract in delayed type hypersensitivity (DTH)

and antibody titre assay were tested in ovalbumin immunized mice. The extract showed

important stimulation of DTH response at 200 mg/kg dose and antibody titer at 100 and 200

mg/kg dose. The outcome of EGM extract in cyclophosphamide induced myelosuppressed

mice was not noteworthy. The results suggest that EGM influences both non-specific

(phagocytosis) and specific (cell mediated and humoral) arms of body immune structure36

.

e) Anxiolytic effects of Elaeocarpus sphaericus fruits on the elevated plus-maze model

of anxiety in mice

Author do the Anxiolytic effects of Elaeocarpus sphaericus fruits on the elevated plus-maze

model of anxiety in mice by the help of methanolic extract of Elaeocarpus sphaericus fruits at

the dose of 200 mg/kg amplified the percentage of time-spent and the percentage of arm

entries in the open arms of the elevated plus-maze (EPM) and decreased the percentage of

time-spent in the closed arms of EPM. Moreover, it prolonged the ketamine-induced latency

to sleep but had no noteworthy effects on total sleeping time induced by ketamine. in

addition, the locomotor activity was affected but not like the same extent as practical for

diazepam. The anxiolytic effects of methanol extract Elaeocarpus sphaericus fruits may be


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correlated to their content of Flavanoids. This study validates the traditional use of the plant

in control of anxiety.[37]

f) Antihypertensive effect of aqueous extract of Elaeocarpus ganitrus Roxb. Seeds in

renal artery occluded

Aqueous extract of Elaeocarpus ganitrus Roxb. Seeds Rudraksha powder was evaluated

designed for its antihypertensive action in renal artery occluded hypertensive rats. Male

Wistar rats (180-200g) were injected with aqueous extract of E. ganitrus for 6 weeks.

Hypertension was induced in animals by clamping the renal artery with renal bulldog clamp

for 4 h. Ischemia of the kidneys causes rise of blood pressure by launch of the renin-

angiotensin system. Elevated blood pressure of the animals was drastically increase renin-

angiotensin system radically.[38]

g) Evaluation of the Effect of Rudraksha (Elaeocarpus Ganitrus Roxb) In Adrenaline

and Nicotine Induced Hypertension

Author done the study to highlights the action of Rudraksha (Elaeocarpus ganitrus Roxb) in

experimentally induced acute hypertension by adrenaline and nicotine. Study was done in 6

anaesthetized cats having comparable body mass and age. 90% Ethanol extracts of

Elaeocarpus ganitrus Roxb was injected intravenously to cats. Blood pressure was measured

by using Pressure transducer and Polyrite (INCO). Elaeocarpus ganitrus (Roxb) reduces

adrenaline induced hypertension and also normal blood pressure; but it is not effective in

nicotine induced hypertension. The effect of the drug was found when the water soluble

portion of the extract was specified to cats in a dose of 15mg / kg body weight.[39]

h) Phytochemical Investigation of Fruit Extract of Elaeocarpus Ganitrus

Phytochemical Investigation of Fruit Extract of Elaeocarpus Ganitrus the study destined to

examine the qualitative and quantitative phytochemical analysis of Ethanolic fruit extract of

medicinally important plant of Elaeocarpus ganitrus for finding of major bioactive

constituents. Experiment was conceded out in terms of qualitative and quantitative

assessment of phytoconstituent. The phenolic content was examined by using Folin-Ciocalteu

assay. The total Flavanoid was obtained spectro photo metrically by using the aluminum

chloride reagent. The acquiesced extraction value in Ethanolic fruit extracts was 28.65%. The

preliminary Phytochemical analysis outcome indicated the presence of alkaloids, glycosides,

phenolic compounds, Flavanoids, saponins, carbohydrates and fixed oils, excluding protein

and amino acids were missing in this extract. The total phenolic content was 232.24 mg of


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Gallic acid equivalent (GAE) per gram of Ethanolic fruit extract of E. ganitrus. The total

Flavanoid concentration was 91.42 mg of quercetin equivalent (QE) per gram of Ethanolic

extract. Phenolic and Flavanoid compounds have several prevailing biological activity, which

outline the requirement of their determination. Results revealed the occurrence of different

bioactive compounds which could be oppressed for their possible applications for medicinal

purposes.[40]

i) Phytochemical Evaluation and Antihyperglycemic Effects of Elaeocarpus Ganitrus

Roxb (Rudraksha) In Streptozotocin Induced Diabetes

The experimental study was intended for examining the constituents of essential oil of leaves

and evaluation of Phytochemical and Antihyperglycemic effect of methanolic seed extracts of

Elaeocarpus ganitrus Roxb. In Streptozotocin induced diabetes. Essential oil was extracted

from E. ganitrus leaves by Hydrodistilation and purified oil was implemented to GC-FID

analysis. Preliminary Phytochemical screening of various extracts of E. ganitrus seeds was

agreed out and antidiabetic activity of methanolic extract was evaluated in streptozotocin

injected diabetic rats. The results revealed which showed the presence of in total sixteen

constituents. The methanolic seed extract of E. ganitrus display potent antidiabetic activity

similar to the standard drug glybenclamide.[41]

j) Mast Cell Stabilizing Effect of Elaeocarpus sphaericus

Ethanolic extract of the fruits of Elaeocarpus sphaericus Rudraksha was found to have

shielding actions against (i) histamine aerosol induced on broncho constriction (ii) mast cells

degranulation induced by Compound 48/80 and (iii) active anaphylaxis. Author emphasize

that the findings are suggestive of potential use of E. sphaericus in bronchial asthma.[42]

k) Experimental Pathological Study of Cell Phone’s Harmful Effect and Protection by

Natural Electromagnetic seed Rudraksha

Radio frequency electromagnetic fields (RFEMF) produced by mobile phone is lethal to body

because 70% of human body is made of water and due to watery composition of our body the

radiation is absorbed in human body and sometime also cause cancer. But this can be

protected partially by natural electromagnetic bead known as Rudraksha. Author do the

pathological experimental study on four group of male people age 20-40 year person and

studied blood, BP, heart rate to notice mobile phones harmful effect and Rudraksha positive

effect on it.[43]


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l) Hypoglycemic and Antidiabetic Potential of Chitosan Aqueous Extract of

Elaeocarpus Ganitrus

Experimental studies were carried out in our laboratory to establish the antidiabetic potential

of chitosan based Extract of Elaeocarpus ganitrus and antidiabetic activity of aqueous extract

of Elaeocarpus ganitrus. In the experimental study on rats were used for experimental

procedure. It was found that chitosan based leaf extract of Elaeocarpus ganitrus produced

hypoglycemic effect in normal rats. The study indicates clinically important antidiabetic

activity of Elaeocarpus ganitrus in diabetic rats. Study indicates clinically significant

antidiabetic activity of Elaeocarpus ganitrus in diabetic rats. The chitosan based extract

improved the antidiabetic activity of Elaeocarpus ganitrus clearly demonstrating synergism.

This reduction of blood glucose is greater in diabetic rats when compared to normal rats.[44]

m) Estimation of Quercetin, an Anxiolytic Constituent, in Elaeocarpus ganitrus

Quercetin as the anxiolytic constituent of Elaeocarpus ganitrus used to standardize the plant

material. Quercetin was used as a reference standard for determining its content in E. ganitrus

beads by means of TLC densitometry. An HPTLC densitometric technique has been

urbanized to guess quercetin in E. ganitrus beads as a result that plant can be standardized on

the base of its bioactive marker. Two methods were followed projected for preparing the test

samples for determining the quercetin content. Firstly, quercetin was get in the ethanol

extract of the plant material. It was also determined in the acid hydrolyzed ethanol extract, in

order to free quercetin from its O-glycoside. Quercetin content in the hydrolyzed ethanol

extract (0.11% w/w) of E. ganitrus beads was found to be about 4 times more than in the

ethanol extract prepared by direct method (0.03% w/w). Results showed that quercetin occurs

in E. ganitrus beads in the form of glycoside. Found that Rudraksha contains indolizidine

type of Alkaloids.[45]

Two of the alkaloids are alike (-)-isoelaeocarpiline and (+)-

elaeocarpiline eariler isolated from E. dolichostylis. The other alkaloids are Elaeocarpidine,

(+)-Elaeocarpine, (+)-Isoelaeocarpin, (+)- Epiisoelaeocarpiline, (+) – Epiialloelaeocarpiline,

(-) – Alloelaeocarpiline, (+) – Pseudoepiisoelaeocarpiline, Rudrakine.


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1 2 3

4 5 6

7 8

9 10

11

12 13


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1. Elaeocarpidine, 2. (+)–Elaeocarpine, 3. (+)–Isoelaeocarpine, 4. (+)-Epielaeocarpiline, 5.

(-)- Alloelaeocarpiline, 6. (+)-Pseudoepiisoelaeocarpiline, 7.(+)-Epialloelaeocarpiline and

8.Rudrakin (9,10) Tannins(Leaf)- (9) Gallic acid (10) Ellagic acid (11)Flavanoids-Quercetin

1 (12, 13) Fatty acids(Seeds)- (12) Palmitic acid (13) Linoleic acid.

CONCLUSION

After studying all scientific manuscript it is concluded that different species of Elaeocarpus

are very important in the field of medical science due to the presence of their Phytochemical

which give high medicinal values. Most of these chemicals are alkaloids, Flavanoids, tannins,

glycosides and Ellagic acid derivatives. Various Elaeocarpus species have also been widely

studied for their various pharmacological activities like anti asthmatic, antidepressant,

Antianxiety, antidiabetic, ant oxidative, antiviral, antitumor and antihypertensive activities.

Rudraksha although appreciated from ancient time for medicinal property but very little

scientific experiment has done so far to reveal the true potential of Rudraksha. The

widespread investigation of literature exposed that Elaeocarpus ganitrus beads Rudraksha

when a person use like ornament, or jewelry touching the skin of our body it control wearer

bio electrical energy due to its Electromagnetic property. Its medicinal property can be

compare to the effect of Acupressure and magnetic therapy and require further scientific

investigation to revel true potential of this amazing electromagnetic bead.

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elaeocarpus ganitrus (rudraksha), the amazing

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