Instrumentation catalog

ELISA & BLOT INSTRUMENTS

by

RIA & INSTRUMENTS

by

TABLE OF CONTENTSOur Company p. 3

To contact us p. 4

ELISA instruments Stratec Gemini p. 5Stratec Gemini Combo p. 8ELISA Shaker p. 9ELISA Washer p. 10 - 11ELISA Reader p. 12 - 13

Dynex technologies p. 14Agility® DS2 DSX

BLOT instruments Microblot - Array Reader p. 23 Neptune Blot / Dot work - processor p. 24

RIA Instruments CoNEXT 125 p. 25Heidolph Titramax 1000 p. 26Heratherm™ p. 26

Custom Diagnostic Laboratory p. 27 services & Sales Conditions

Eric MaesBusiness Segment Manager ELISA, Instruments & Antibodies DIAsource ImmunoAssays S.A.

OUR COMPANY 30 YEARS OF EXPERIENCE IN IVD (KITS AND INSTRUMENTATION)

DIAsource ImmunoAssays (a Biovendor Group company), an international diagnostic company (Belgium), develops, manufactures and markets clinical diagnostic products in the field of endocrinology and infectious diseases. Core products are based on RIA - and ELISA technology and also include reagents to be ran on open ELISA automated analyzers as well as antibodies for use in in-vitro diagnostic assays. DIAsource has specific development and manufacturing programs for Vitamin D, Renin, Calcitonin and many others parameters. We also provide selected instrumentation : we offer ELISA reader, - washer and - shaker, along with open and closed fully automated ELISA platforms helping our customers to automate their tests. It is our ambition to use our 30 years of expertise in Antibody - and Assay development to remain a well-known company of diagnostic immunoassays and instrumentation for the IVD market.

MISSIONOur mission is to develop, manufacture and market a complete panel of quality immunoassays and instrumentation as accurate, reliable, diagnostic tools to detect and monitor endocrine disorders and infectious diseases. We are dedicated to provide highly reliable quality assays and instrumentation to deliver uncompromising support to our customers. We strive to meet for meeting our customers needs through a long-term professional relationship and by offering a real added value. Our company is driven by commitment to quality of products and services.

PRODUCT RANGEDuring the last 30 years, we develop manual ELISA - and RIA immunoassays for the diagnosis and monitoring of a wide variety of endocrine disorders. We constantly rework and develop specific antibodies for use in our diagnostic assays. In addition we offer these antibodies also to other diagnostic companies. Constantly looking for new technologies and applications, we put our expertise in the development of new antibodies (patent pending) and assays to measure 25OH Total Vitamin D (D2+D3). We strengthen our position in the diagnostic market by validating our ELISA assays on our open and closed automates. This innovation marks a turning point for our company, and makes of DIAsource, already renowned in the RIA market, a complete diagnostic provider. The interest in Vitamin D is rising rapidly. Since more than 10 years DIAsource manufactures immunoassays for 25OH Vitamin D3 and 1,25 (OH)2 Vitamin D. In our assay development program, we are focusing specifically on new Vitamin D assays. We introduced a new Total Vitamin D (D2 + D3) RIA and ELISA assay, an innovative free 25OH Vitamin D ELISA kit, together with a Rat 25OH Vitamin D ELISA kit for clinical research studies. The ELISA versions can also be applied on our instruments.

COMMITMENT TO QUALITYWe believe that the quality of products and services finds its origin in scientific expertise, good organization of all operational activities and in well-structured decision processes. These principles are laid out in our ISO 13485:2003 quality manual. Through the integration of product quality in our development and manufacturing processes and a specific customer-oriented approach, we have directed our quality system to comply with the harmonized standard for quality systems within the context of the European Directive for In Vitro Diagnostics. Our internal quality management system is designed to pursue a continuous improvement of our customer service, our product quality and the efficiency of our operations. All our kits and instruments for in-vitro diagnostics (IVD) carry the CE mark and comply with IVD Directive requirements.

Beatrice de BormanCEODIAsource ImmunoAssays S.A.

TO CONTACT US Our people, our professional and experienced Customer Service and Technical Support teams are dedicated to ensure complete customer satisfaction. We take pride in providing helpful and accurate information in a 24-hour turnaround time.Ordering : please see below and consult the ‘How to order’ section for your local contact.

SHIPPING SUPERVISOR

Luciana FrassonTel. : +32 (0)10 84 99 69 Fax : +32 (0)10 84 99 95 luciana.frasson@diasource.be

Customer & Supplier ManagerNathalie DierickxTel. : +32 (0)10 84 99 16 nathalie.dierickx@diasource.be

TECHNICAL SUPPORT SPECIALIST

Valérie Preud’hommeTel. : +32 (0)10 84 99 23valerie.preudhomme@diasource.be

Aurélie BernardTel. : +32 (0)10 84 99 32aurelie.bernard@diasource.be

REGULATORY AFFAIRS COORDINATOR

SERVICE ENGINEER- INSTRUMENTS

Albert Rosell Tel. : +32 (0)10 84 99 76 albert.rosell@diasource.be

Isabelle DehartTel. : +32 (0)10 84 99 04 Fax :: +32 (0)10 84 99 94 isabelle.dehart@diasource.be

PRODUCT DEVELOPMENT, QUALITY & REGULATORY AFFAIRS MANAGER

SALES & MARKETING International Sales Director & Business Segment Manager RIAPeter KerckxMobile : +32 (0)475 57 76 86 peter.kerckx@diasource.be

Business Segment ManagerELISA & Instrumentation and AntibodiesEric MaesMobile : +32 (0)479 70 00 71 eric.maes@diasource.be

Sales- and Business Development Manager Vitamin DJan WautersMobile: +32 (0)479 94 34 78 jan.wauters@diasource.be

Sales Director for Spain & Export Manager LatAmAlberto RosellMobile SP : +34 696 271 518 Fax SP : +34 934 107 866 alberto.rosell@diasource.be

Sales Manager LatinoamericaOlga Lucia Guayacan Mobile : +57 31 030 390 03 olga.guayacan@diasource.be

Product ManagerDavid DegelsTel. : +32 (0)10 84 99 05 david.degels@diasource.be

CUSTOMER SERVICE - ORDERINGTel. : +32 (0)10 84 99 00 - Fax : +32 (0)10 84 99 90-96 - customer.service@diasource.beBelgium Free Phone : 0800 159 59 - France Free Phone: 0800 908 443 - France Free Fax : 0800 902 588

Sales Manager France & District Manager WalloniaLaurent AugisTel. : +32 (0)479 70 00 72 Mobile : +33 6 85 60 17 85laurent.augis@diasource.be

Marketing Project CoordinatorJoëlle BockTel. : +32 (0)10 84 99 13 joelle.bock@diasource.be

Product Manager & Principal Scientist Vitamin DNicolas HeureuxTel. : +32 (0)10 84 99 40 nicolas.heureux@diasource.be

Customer Service ManagerMuriel Hirsoux

CustomerService Representative

Sabrina Baio Isabelle Rosman

M-F Sanchez Tania Cabrera

CEOBéatrice de Borman

Tel. : +32 (0) 10 84 99 07beatrice.deborman@diasource.be

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ELISA INSTRUMENTS STRATEC GEMINI : THE RIGHT COMBINATION• Fully automated microplate processor for low throughput applications

• Total walk away system

• Flexible time management with LIS connectivity

• Modularity – open system

• Ease of use, installation and maintenance

• Assay performance with disposable tips

• High process safety with triple pipetting control

• Convenient programming of assay protocols

• Proven reliability

• The system is in compliance with the In-vitro diagnostic directive 98/79/EC

STRATEC GEMINI Fully automated microplate processor for low throughput applications. Easy integration, no limits.

CAT# : GEM10041566

All values are achieved under optimal conditions and can vary depending on environmental conditions, instrument status and processing conditions. Specifications are subject to change with notice according to STRATEC’s “Change control system”.

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Reader

Photometric range 0 to 3.0 OD

Spectral range 400 nm to 700 nm (up to 8 filters)

Read time < 15 sec single, < 30 sec dual

Precision 1% CV at 1.0 OD

Accuracy ± 0.005 OD or 2.5% (whichever is greater)

Wavelenght reading Single or dual

Assay protocol type End point and kinetics

Shaking Yes

Pipettor

Disposable tips 300 μl or 1100 μl

Min. - Max. volumes10 μl to 300 μl with 300 μl tip 301 μl to 1000 μl with 1100 μl tip

Precision (single dispense) < 3% CV at 20 μl < 3% CV at 100 μl

Precision (multi dispense)< 10% CV at 16 x 20 μl < 3% CV at 8 x 100 μl

Features Flexibly programmable for single pipetting, multiple pipetting, multiple dilution steps, mixing and archiving. Pipetting pressure monitoring, capacitive liquid level detection.

Capacity and throughput

Sample and reagent Initial loading of up to 192 samples, e.g. 144 samples + 8 reagents + 16 controlsContinuous loading of samples and resourcesThree disposable tip rack positionsTwo deep-well plate positions for pre-dilution and /or archiving

Incubator

Temperature range Up to 45° C

Temperature uniformity ± 1.5° C (with in-process temperature monitoring)

Shaking Up to 20 Hz

ChambersTwo independently controlled incubator chambers (RT- 45° C) with shaking (5-20 Hz) Three room temperature incubation chambers

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Ease and Flexibility

Flexible scheduling of up to three platesGraphical assay protocol editorCombination of multiple assays on one plateProven software reliabilityBi-directional LIS connectivity, ideal with random access instrumentsBased on established EIA software platform with more than 4,500 placements worldwide

Safety and in-Process Control

Pipetting pressure monitoringCapacitive liquid level detection for optimal identification of insufficient volume and fibrin clotsColorimetric dispense verificationPositive identification of barcoded samples and reagent

All values are achieved under optimal conditions and can vary depending on environmental conditions, instrument status and processing conditions Specifications are subject to change with notice according to STRATEC's 'Change Control System'

Washer

Channel 2 x 8-channel washer (aspirate and dispense)

Precision 10% CV at 300 μl

Residual volume < 2.5 μl in U-bottom (mean) < 4 μl in flat bottom (mean)

Wash buffer capacity 3 wash buffers

Modes Sweep mode, soak, top and bottom wash, variable pump speed

Dimensions & weight

Width x Depth x Height 97 cm x 66 cm x 75 cm 38.2” x 26.0” x 29.5”

Weight 151 kg (Gross weight), 115 kg (net weight)

Additional functionality through middleware software

Easy integration Wide range of interfaces allows consolidation of results from other instruments

Connects instruments Operates with single or multiple GEMINI installations

Connects host Provides smooth real time bi-directional communication between device and LIS

Additional benefits

Short/long term data storage Can operate with local dbase or SQL server

Retest management User definable retest and reflex management

Drill down Extensive drill down capability on sample or plate data

Open and definable Use functions (e.g. reporting) definable allows maximum flexibility

Closed and secure Software can be locked to operate as a secure closed system

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STRATEC GEMINI COMBO • Efficient dual technology – IFA and EIA – on a single instrument

• Processing of up to 16 IFA slides

• Quick and reliable : No risk of cross-contaminationty

• Flexible and intuitive slide designer

CAT# : GEM10041560

Specification

Capacity Processing of up to 16 IFA slides per run

Features IFA application without hardware modificationFlexible and intuitive slide designerQuick and reliable: no risk of cross-contaminationFlexible slide tray for different types and layout

CONSUMABLES AND SPARE PARTS Access to consumables and spare parts Stratec Gemini + Gemini Combo • Racks

• Adapters

• Conductive tips

• Dilution plate

• Maintenance kit and tools

• Spare parts

Assays Protocols available

Diasource can provide fully support in the adaptation of assays on the Stratec Gemini

For more information, please contact : IVDInstrumentation.support@diasource.be

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ELISA SHAKER The ELISA Shaker, allows shaking and incubation simultaneously.

CAT# : DIA4000

Special Features

• Simultaneous shaking & incubation operation.

• Buzzer indication on completion of incubation

• Indication of Remaining time

• Current temperature of incubation on display, on pressing TEMP Key.

• Separate Timer ON indication on Keypad

Technical Specification

Operating Modes Shaker, Incubator, Shaking & Incubator

Temperature Control

Temperature Range 37° C to 42° C

Resolution 1° C

Incubation Time 1 to 999 min

Shaker

Frequency 400 to 700 RPM

Amplitude 2 mm

Operating Position On horizontal flat, rigid and vibration free surface

Operating Conditions

Temperature From + 18° C to 32° C

Relative Humidity Up to 80%

Storage Conditions

Temperature From -10° C to 35° C

Relative Humidity Up to 80%

Enclosure ABS Fire retardant

Size (cm) 28 X 25 X 16 (l X b X h)

Weight 3 Kgs (Approx)

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ELISA WASHER Plate Washer is a versatile, user friendly & rugged instrument designed by keeping both quality and price in view. The instrument is simple, yet versatile as it uses the state of art hardware for its components.

CAT# : DIA3000

Special Features

• Built in two plate ELISA incubator

• User programmable soak time, wash cycles and dispensing volume

• Battery backed up memory for 50 tests

• Waste bottle full indicator with audible alarm

• Built-in stabilizer

• State of art equipment with versatile software

• Real time clock

• Continuous aspiration to prevent overflow

• Loosely held Manifold to prevent scratching of well bottoms

• Uses special software to aspirate “U” shaped, “V” shaped, and wide wells

• On switching ‘OFF’ the instrument, it performs RINSE operation first and then instrument automatically gets off

Technical Specification

Manifold 8 Way Manifold autoclavable

Dispensing

Method Specially designed Peristaltic Pump

Volume 50 - 500 μl

Aspirating

Method Continuous through diaphragm pump while dispensing hence preventing overflow

Residual Volume < 5 μl

Bottle

Waste 1X(2L) with audible alarm when bottle is completely filled in with waste solution

Wash 1X(2L)

Rinse 1X(2L)

Display

16 digit alphanumeric fluorescent

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Liquid contact materials

Silicon, stainless steel, decline

Memory

8 KB Non volatile RAM Battery backup, supporting 35Open channels

Programming Modes

Plate Wash, Strip Wash, Bottom Wash , Overflow Wash ,RinsingPriming, Disinfect

Shaking

Time 1 to 59 Seconds

Speed 8 Steps

Incubator For two ELISA Plates, 37° +/- 10° C

Timer Individually Programmable 2 Nos.

Power

Wattage 50 Watts

Voltage 115-240 Volts ± 10%, 50 /60 Hz

Operating Position On horizontal, rigid, flat and vibration free surface

Operating Conditions

Temperature +18° C to 35° C

Humidity Up to 85 %

Storage Conditions

Temperature - 10° C to 60° C

Humidity Up to 85 %

Enclosure ABS Fire retardant

Size (cms) 35 x 35 x 13 (l x b x h)

Weight 6 Kg (Approx)

12

ELISA READER The ELISA Plate Reader is a user friendly micro plate Analyser. It is compact & lightweight. It is designed to measure and interpret enzyme immunoassay results, both monochromatically and Bi-chromatically. It is intended for in vitro diagnostics.

CAT# : DIA2000

Special Features

The ELISA Reader can accommodate a flat bottom as well as a round configuration.

The carriage is designed in a way that the plate automatically moves smoothly and positions itself accurately in the optical measurement path. Readings are taken continuously. The average value is calculated and results are presented according to the option selected.

The ELISA Reader has a special provision, which allows it to be used even when a printer is not available. Readings can be conveniently noted down manually.

The other special features of ELISA Reader are as follows:

• Option of Lamp saving mode

• Selection of both primary and secondary filters

• Latest technology with battery back-up for 250 tests with QC, more than 2500 result

• Robust built in 52-column thermal printer with 384 stationary heads

• Unique circuitry for long lamp life

• Alphanumeric Patients ID entry

• Setting of saved tests

• Human machine user interface: Touch panel, Keypad

• Multi-standard curve up to 12 standard calibrations with one blank optional

• Access to test by touch of key

• Capability to connect to 80-column printer for direct report printout

• Blank is optional

• Etting of the Date and Time

• Capable of storing, deleting and recalling tests

• Multiple calibrator modes

• Selection of duplicates for both calibrators and samples

• Extensive software for cut off mode

• Selection of Positive, Equivocal, Negative cut-off

• Several pre-programmed calculation modes will help to facilitate data processing of enzyme immunoassays. These are menu driven modes for simple and error free operations:

- Absorbance mode

- Cut-off mode

- Multi-standard mode (full calibration mode)

- Single calibration mode

- % Absorbance mode

- Uptake and Kinetic mode

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Technical Specification

Human Machine Interface Touch panel / Keypad

Linear measurement range Spectral Range

0.000 to 3.000 Absorbance Units

Filters Type of filter: narrow band InterferenceWave Length: 405nm, 450nm, 492nm, 630nm, 560nmHalf Bandwidth: 10nm ± 2nmSelection: narrow band Interference

Drift <0.005A/hr

Photometric Linearity 2.5A

Photometric Accuracy +/- 2% or 0.007 (0 to 1.5 A), +/- 3% from 1.5 A to 3.0 A

Optical measurement 8 channels

Light Source Tungsten halogen lamp, 20 Watts

Display 6” Graphics LCD, Negative Blue, STN

Curve Plotting Graphical representation on printer

Printer Built in thermal printer 52 columns

Curve Plotting Graphical Representation on Printer

Analysis Mode Absorbance, Single Standard, Cut-off, Multi-Standard, % Absorbance, Uptake, Kinetic

Connectivity RS232 Serial Port / USB

9600 baud, 8 data, 1 stop, no parity bits / USB

Size (cm) 36 x 36 x 22 (lxbxh)

Weight (Approx.) 10 Kgs

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DYNEX TECHNOLOGIES*

AGILITY® • Fully automated ELISA processor

• Compatible with SmartKits-format

CAT# : DSA67000

Physical Specifications

Dimensions W x D x H <1250 mm x < 900 mm x < 1230 mm

Footprint < 1200 x 650 mm

Bench/Ship Weigh 213 kg (max.)/296 kg (max.)

Noise Noise output < 80 dB

Power Requirements

Voltage 100 – 240 V automatic switching

Frequency 50/60 Hz

Power Consumption Typically 400 VA (online UPS required)

Incubator

Temperature range Up to 45° C

Temperature uniformity ± 1.5°C (with in-process temperature monitoring)

Shaking Up to 20 Hz

*Instruments not for distribution/sales in Russia

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Reader Specifications

Photometric Range 0.000 to 3.500 OD

Spectral Range 405 nm to 690 nm

Precision ± 0.010 OD at 0.000 to 0.500 OD < 1% CV at 0.501 to 2.000 OD< 1.5% CV at 2.001 to 2.500 OD

Accuracy ± 0.01 or 2.5% (0.000 to 3.000 OD) whichever is greater

Read Time < 30 seconds, single wavelength < 50 seconds, dual wavelength

Washer Specifications

Manifold Configuration 8-way wash head

Programmable Volumes 50-999 μl

Wash Containers 4 wash bottles at 3.0 L, with quantitative level sensing

Clean Container 1 wash bottle at 3.0 L, with quantitative level sensing

Waste Container 10 L with quantitative level sensing

Residual Wash Volume < 3 μl per well with dual-axis sweep in a at bottom well

Dispense Precision ≤ 5% CV (with 300 μl in a 96 well plate)

Incubator Specifications

Number of Incubators Up to 12 (6 Ambient / 6 Elevated)

Temperature RangRT + 4° C to 45° C (Elevated Incubator) RT + 4° C (Ambient Incubator)

Temperature Accuracy ± 1° C

Shaking 14 Hz periodic or continuous

System Specifications

Number of Plates 12 (additional continuous load capability)

Number of Sample Tubes 200 (additional continuous load capability)

Number of Reagents Up to 16 different SmartKit™ Reagent Packs simultaneously (additional packs can be added using continuous load capability)

Number of Pipettes 2 (sample + reagent)

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Sample Pipetting Specifications

Sample Tip Size 300 μl

Sample Pipetting Volume 10-300 μl

Time to Dispense 11 minutes (typical) 50 μl of 96 samples to plate from sample tubes or deep well plates

Sample Pipetting Precision ≤ 3% CV (at any operating volume above 10 μl)

Sample Pipetting Accuracy ± 2% of target volume

Dilution Range 1 part in 199 one-stage dilution 1 part in 39,601 two-stage dilution

Numbe Number of Sample 20 racks of 112 tips (additional racks can be added using continuous load capability)

Sample Tube Dimensions 10-17 mm diameter external dimension, 45-100 mm depth

Reagent Pipetting Specifications

Reagent Tip Size 1200 μl

Reagent Pipetting Volume 20-1200 μl

Number of Reagent Tips 1 rack of 98 tips (additional racks can be added using continuous load capability) Reagent Pipetting

Precision ≤ 3% CV at 10 shots at any volume in operating range Reagent Pipetting

Accuracy ± 2% of target volume (single shot mode)

Regulatory Compliance

Certified ISO13485Electromagnetic

Perturbation EMC Directive 2004/108/EC : EN 61326-2-6:2006, IEC 61326-1:2006

Electrical Safety BS EN 61010-1:2001, IEC 61010-1:2001, IEC 61010- 2-101, ETL marked

Lead-free All components are RoHS compliant

IVDD CE marked per IVD 98/79/EC Directive

Smart kit

• Gold – ready to use

• Silver – need to transfer reagent bottles and print barcodes

• Bronze – need to pour off reagents to special bottles, print barcodes and save caps (does not contain cap holder)

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DS2® • 2-Plate ELISA

• Processing System

• Compact.

• Easy to Use.

• Innovative.

• A Perfect Combination

CAT# : DS262010

Physical Specifications

Dimensions Width: 54 cm 21 inDepth: 68 cm 27 inHeight: 66 cm 26 inWeight (net): 48 kg 105 lbShipping weight: 78 kg 170 lb

Power Supply

Voltage 100 – 240 V auto-switching

Frequency 50/60 Hz

Power consumption < 300 VA

General Specifications

Number of plates 2

Sample capacity 100 per load

Continuous load Yes

Sample-tube sizer 10 – 16 mm diameter 40 – 100 mm height

Reagent-fluid capacity: 8 x 25 mL bottles, 10 x 15 mL bottles

Control-fluid capacity: 24 x 2 mL vials

Dilution capacity (96) 12 x 8 deep-well strips

Sample-tip capacity 216 tips

Reagent-tip capacity 20 tips

Assays per plate Up to 12

Temperature Accuracy ± 1° C

Selftest at startup Yes

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Reader Specifications

Dynamic range -0.100 – 3.0 OD

Spectral range 405 – 690 nm

Filter slots 6

Reading channels 12 plus reference channel

Read time < 30 sec (single wavelength)

Precision < 1% CV (<2.0 OD) < 2% CV (2.0 – 3.0 OD)

Accuracy +/- 0.005 OD or 2.5% (whichever is greater)

Washer Specifications

Manifold Configuration 8-way

Dispense-volume range 50 – 1000 μL

Wash cycles 1 – 9 (repeatable)

Residual volume < 3 μL

Super aspirate mode Yes

Wash-buer capacity 2 x 2 L

Low-buer alarm Yes

Soak time 0 – 999 seconds

Dispense pressure Pre-set

Rinse function Input connector for user’s external bottle, any size

Waste-water container 1 x 1.5 L

Incubator Specifications

Temperature range Ambient + 4° C to 40° C

Temperature uniformity +/- 1° C across plate @ 37° C

Shaking Independent linear motion 14-20 Hz (periodic or continuous)

Incubation time Programmable

Time to set temperature < 1 min

Temperature monitoring Yes

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Pipetting Specifications

Type Disposable tips (2 types)

Sample-tip range Tip type 300 μL (10 – 250 μL dispense range)

Reagent-tip range Tip type 1,300 μL (20 – 1,000 μL dispense range)

Maximum dilution 1 to 5,000

Replicates Up to 96 samples, standards and controls

Precision, sample tip < 3% CV at any operating volume above 10 ul (single shot mode)

Precision, reagent ti < 3% CV at any operating volume above 20 ul (single shot mode)

Process Security

Liquid-level sensing Yes (reagents, controls and samples)

Level-sensor system Pressure diferential

Clot detection Yes

Dispense-anom aly de tection Yes

Tip detection Yes

Well-fill verification Yes

Alarms Yes

Software

Controlling software DS-Matrix™

Work protocols (assays) Unlimited

Data processing Quantitative and qualitative

Levey-Jennings Yes

Westgard rules Yes

Process reporting Event log + error log

Automatic error recovery Yes

Password access contro Yes

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DSX® • 4-Plate ELISA

• Processing System

• Modular

• Flexible

• Reliable

• A Perfect Combination

CAT# : DSX65400

Physical Specifications

Dimensions Width: < 1060 mm 42 inDepth: < 910 mm 36 inHeight: < 800 mm 32 inFootprint: < 1060 x 610 mm 42 x 24 inBench weight: 136 kg (max) 300 lbs (max)Ship weight: 244 kg (max) 537 lbs (max)

Power Supply

Voltage 100 – 240 V automatic conversion

Frequency 50/60 Hz

Power consumption < 800 VA “online” UPS recommended

Reader Specifications

Photometric range 0.000 to 3.000 OD

Spectral range 405 nm to 690 nm

Precision ± 0.010 OD at 0.000 to 0.500 OD < 1% CV at 0.501 to 2.000 OD< 1.5% at 2.001 to 2.500 OD

Accuracy ± 0.01 OD or 2.5% (0.000 to 3.000 OD) whichever is greater

Read time < 10 seconds, single wavelength# < 20 seconds, dual wavelength#

21

Washer Specifications

Manifold configuration 8-way

Programmable volumes 50 – 999 μL

Waste container 8 L with waste full sensor

Wash container 4 wash bottles at 2.0 L with level-sensing

Residual wash volume < 3 μl per well with dual-axis sweep in a flat-bottom plate

Dispense precision ≤ 5% CV (with 300 μl in a 96 well plate)

Incubator Specifications

Number of incubators Up to 4

Temperature range RT + 7° C to 50° C

Temperature accuracy ± 1° C

Shaking > 15 Hz periodic or continuous

Pipetting Specifications

Number of plates 4

Number of assays 1 assay per strip or up to 12 assays per plate

Number of sample tables 96

Number of reagents 24

Number of standard/control bottles

33 control

Number of pipettes 1

Reagent Pipetting

Reagent tip size 1300 μl

Number of reagent tips 41

Reagent pipetting volume 25 – 1000 μl

Reagent pipetting precision 3% CV at 10 shots at any volume in operating range above 50

Reagent pipetting accuracy +/- 2% of target volume at 50 uL or greater in operating range (single-shot mode)

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Process Security

Liquid-level sensing Yes (reagents, controls and samples)

Level-sensor system Pressure di rential

Clot detection Yes

Dispense-anom aly de tection Yes

Tip detection Yes

Well-fill verification Yes

Alarms Yes

Process Security

Sample tip size 300 μ

Sample pipetting volume 10 – 250 μl 10 – 250 μl single-shot25 – 100 μl multi-shot

Estimated cycle time for sample < 8 seconds pickup to delivery on plate

Time to dispense 19 minutes (typical) 50 μl of 96 samples to plate from sample tubes or deep well plates

Sampling time w/dilutions < 26 minutes (typical)

Example 2 stage dilution, 20 μl sample to 400 μl bu in < 26 minutesSingle-shot sample 3% CV at any operating pipetting precision: volume above 10 μl Single-shot sample ± 2% of target volume at pipetting accuracy: any operating volumeabove 10 μl

Dilution range 1 part in 190 one-stage dilution, 1 part in 36, 100 two-stage dilution

Number of sample tips loaded 4 racks of 108

Sample tube dimensions Sample Rack Options

Short 40-75 mm Tubes

Long 75-100 mm Tubes

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BLOT INSTRUMENTS MICROBLOT - ARRAY READER

Multiplex diagnostics in microtiter plate format.

CAT# : MBARCX

Advantages

• Low sample consumption

• Antigens spotted in triplicate – minimizing statistical variation

• Fully automatic assay processing and results evaluation

• Parallel testing of multiple markers simultaneously

• High sensitivity

Microblot-Array reader

• The colorimetric reader provides high-quality scanning and it is optimized for a 96-well microtiter plates format

• Fast 2 minutes per full plate

• Scanning of selected wells/strips

• Automated spot localization and image analysis

• 5 MPx CMOS Color Camera, Resolution 2592 x 1944 px

Microblot-Array software

• Developed for intuitive and user friendly guiding throughout the process of testing, enabling complex image analysis including results evaluation and connectivity to LIS

• Automated well centering and imaging

• Optional manual control of spot localization

• Detailed results comparison within single wells and spots

• Evaluation of the validity test through control spots

• Clear view of results

R

R

R

R

TC TC TC C1 C1 C1 C2 C2 C2

C3C3 C3 R C4 C4 C4

CG

CG

CG

CM

CM

CM

A1A1 A1

A8A8 A8

A2A2 A2

A3A3 A3

A4A4 A4

A5A5 A5

A6A6 A6

A7A7 A7

A9 A9 A9

A16 A16 A16

A10 A10 A10

A11 A11 A11

A12 A12 A12

A13 A13 A13

A14 A14 A14

A15 A15 A15

A17

A18

A19

A20

A21

A22

A17

A18

A19

A20

A21

A22

A17

A18

A19

A20

A21

A22

R R

R

R

R

TC

TC

TC

C1

C1

C3

C3

C3

C4

C4

C4

C1

C2

C2

C2

A2

A2

A2

A1

CG CG CG CA CA CACM CM CM

A17

A1

A8

A8

A8

A17

A6

A6

A17

A3

A3

A3

A9

A4

A4

A4

A9

A5

A5

A5

A9 A10

A10

A10

A1

A7

A7

A7

A16

A16

A16

A11

A11

A11

A12

A12

A12

A13

A13

A13 A14

A14

A14

A15

A15

A15

A20

A20

A20

A21

A21

A21 A22

A22

A22A18

A18

A18

A19

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NEPTUNE BLOT / DOT WORK - PROCESSORAllows automation of DIAspot Neptune, DIAspot MultiQUANT Neptune and Immuno-Blot strips : more than 30 differents kits available. Up to 24 identical or completely different strips can be loaded on the moving arm.

CAT# : DIA1000

Special Features

• The moving arm moves from back to front and dives sequentially the strips in the wells of individual cartridges

• Each cartridge contains the ready-to-use reagents for a strip (no extra reagents or consumables !)

• Classic DOT (DIAspot) and BLOT strips can be mixed with Microarray strips (DIAspot MultiQUANT Neptune ) in the same run - total flexibility

• Bar code system control the right association strip/cartridge traceability of the test

• No mismatch of reagents and tests

• No priming, no tedious washing or disinfection steps, easy maintenance : save on time

• No dead volume : no extra volume of reagent to order allows small series or single tests to be run economically

• All the strips are loaded on the same moving arm

• Same incubation conditions for all the strips, no drift

• Small Instrument : space saving instrument

• No pumps, no valves, no liquid & tubing inside instrument

• No daily, weekly and monthly maintenance for lab technician

• No maintenance contract means no additional cost

Physical Specifications

Weight 9,5 kg

Size 30 x 30 x 55 cm

Number of kits different per run Up to 24

Number of psamples per run Up to 24

Volume of sample 10 µL

Preparation time 15 minutes

Running time 45 minutes

Maximum results per run 288 (DIASpot) - 600 (DIASpot MultiQUANT)

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RIA INSTRUMENTS CoNEXT 125 • Semi-automatic LAB solution

• The open all-round system for automated pipetting combined with shaker, incubator and wash offers a perfect solution for medium and high throughput RIA labs

CAT# : AMPCONEXT125R

Specifications

Number of Needles 8 (4 x Dispense Reagent and Sample, 4 x Wash Coated Tubes)

Pipetting volume 3 µl to 5000 µl

Precision100µl = CV 0,5%10µl = CV 3,0%

Barcode specifications (optional)

Barcodes Standards ANSI X3.182 and DIN EN 1635 Code 128, Code 39, Codabar, Interleaved 2 of 5 Module width 5 - 15 mils (0.127 - 0.381 mm) Quiet zone ≥ 5 mm Print Contrast Ratio PCS > 70% Barcode height ≥ 8 mm Barcode length max. 64 mm (without quiet zone) Number of characters max. 32 Black code on white background

Technical Data

Voltage: 110 240 V Frequency: 50 – 60 Hz Output: 800 VA Small version (1500X830X780mm) Medium version (1000X830X780mm)Large version (2000X830X780mm)

Reagent Rack14 Pos for different diameter (50 and 100 ml included)2 x 8 Pos. Universal Rack for all diameter

Waste1 x Bottle 10 L for Non Radioactive Waste1 x Bottle 10 L for Radioactive Waste

Sample RackMax.Capacity: 160 SamplesRack 16 Pos.Tube: 10x75mm,13x75mm,16x100mm

Coated Tube RackMax. Capacity: 192 Coated TubesRack 96 Coated TubesDiasource Rack 2 x 48 Coated Tubes

Wash Solution 2 x Wash Solution bottle 10 L

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HEIDOLPH TITRAMAX 1000 with top frame - CAT# : AMPHMT1001

Specifications

Supply voltage 230 V / 50 Hz or 115 V / 60 Hz

Protection class (DIN EN 60529) IP 30

Drive EC-motor

Overheat protection Self-resetting

Speed control Analog

Operation mode Timer / continuous

Ambient temperature 5 – 31° C at 80% relative humidity

Motion Circular vibration

Orbit (mm) 1,5

Rotation speed (rpm) 150 – 1350

Supply power (W) 31

Dimensions (WxHxD) / Weight 270 mm x 316 mm x 98 mm / 6,5 kg

HERATHERM™ Compact Microbiological Incubators - CAT# : 50129111

Specifications

Convection Technology Mechanical convection

Volume (Metric) Chamber 18 L

Voltage / Hertz / Wattage 100 – 240 V / 50 – 60 Hz / 45 w

Weight (Metric) 7.2 kg

Amperage 0.45 to 0.85 A

Control LED display

Temperature Uniformity ± 1.2° C

Temperature Stability ± 0.2° C

Shelves 2 supplied / 3 max.

Temperature Range (Metric) 17° to 40° C

Certifications / Compliance cCSAus, CE

Dimensions (L x W x H) Exterior 18.5 x 10.2 x 16.3 in. (47 x 26 x 41.5 cm)

Dimensions (D x W x H) Interior 11.4 x 7.1 x 12.2 in. (29 x 18 x 31cm)

Electrical Requirements 100 – 240 V / 50 – 60 Hz

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CUSTOM DIAGNOSTIC LABORATORY SERVICES & SALES CONDITIONS

ISO 9001 AND ISO 13485 APPROVED The scientists at DIAsource have extensive experience in the development of antibodies and related enzymatic or radioactive assays. They can help guide you through each step in the process of purifying, fragmenting, coating and labeling antibodies. High level technicians can be consulted at any time to discuss other services like filling and freeze-drying. We can offer specific and flexible suggestions to enhance the performance of your final product. All services are manufactured under strict ISO-9001 guidelines.

SERVICES AVAILABLE • Adaptation of the assay on the different instruments and technologies

• Full training (application and technical) in-house and on-site for all our portfolio of instruments

• After-sales service (Mo-Fri from 8AM to 4:30PM)

• Installation and maintenance service

GENERAL CONDITIONS OF SALES

Article 1 – ApplicationUnless there is an explicit deviation agreed upon in writing, the present general terms and conditions apply to every DIAsource offer as well as every contract that is formed on the basis of such an offer or an order confirmed by DIAsource. The client waives explicitly and fully the application of its own general terms and conditions by virtue of its relationship with DIAsource. Contracts that have been concluded through the staff or representatives of DIAsource and that do not observe these general terms and conditions do not bind DIAsource.

Article 2 – Conclusion of the contractAn offer from DIAsource is only binding if it is accompanied by a period of acceptance and only if this period has not yet expired. A client’s order can only be considered accepted by DIAsource after DIAsource’s express written confirmation of that acceptance. As any order has its own specific characteristics and, therefore, the products ordered by one client cannot be redirected to another client, the client cannot cancel an accepted order whether in full or in part. If the client would cancel an accepted order, it will still have to pay the full price of the relevant order. DIAsource reserves the right to (i) refuse requests for customized orders, or requests for modifications of accepted orders; and/or to (ii) charge such modifications or customizations to the client at the then-prevailing actual cost, with a minimum of 25 EUR (excl. VAT). Without prejudice to the third paragraph of this article 2, an administrative fee of 25 EUR (excl. VAT) will be charged by DIAsource for any order with a value of less than 500 EUR (excl. VAT).

Article 3 – Price and related costsUnless agreed otherwise in writing, all of DIAsource’s set prices apply to packaged products that are delivered Ex Works (in the sense of Incoterms 2010) to the registered seat of DIAsource. The following, on top of the stipulated price, are to be paid by the client, unless there is any explicit written deviation from this rule: (i) All costs of insurance, security, loading, transport, and

unpacking of the products.(ii) All taxes and levies (including VAT and customs duties) related

to the delivered products or the items mentioned under (i), including the taxes and levies that are applied or adapted only after the conclusion of the contract.

(iii) All additional costs for DIAsource that have been incurred as a result of differences in the currency exchange rates that are detrimental to DIAsource. Every cost that is charged for execution of payments must always be borne by the client ultimately.

Article 4 – PaymentUnless agreed on otherwise, (i) if DIAsource sends a pro forma invoice to the client, such pro forma invoice must be paid before the confirmed shipment date and (ii) if DIAsource does not send a pro forma invoice to the client, all invoices should be paid upon receipt. The payment of a (pro forma) invoice may not be refused or postponed for any reason whatsoever. Any late payment will make all debts of the client to DIAsource immediately due upon notification to that effect by DIAsource. An interest on late payment will be charged—ex officio and without notice—on the

unpaid balance of all debts of the client to DIAsource which are due and payable, and the rate of it will be equal to the interest rate calculated according to Article 5, paragraph 2 of the Act of 2 August 2002 on combating late payments in commercial transactions, increased by 3.5% per year. On top of this, a compensation of 15% of the unpaid balance will be charged to cover the administrative costs associated with late payments, and this at a minimum of EUR 100 per invoice that is paid late. All of this is without prejudice to (i) the possibility for DIAsource to prove the actual damage it suffered and to demand compensation for it, or (ii) the possibility for DIAsource to suspend the further performance of its obligations under this or any other contract with the client, or apply any other common law sanction.

Article 5 – Reservation of ownership – transfer of riskThe ownership of every sold product only passes to the client after the client has fully paid the price and related costs for this product, as well as the late interest and compensation that would be due by virtue of late payment of this price. Before full payment is made, and unless explicitly agreed otherwise in writing, the client may not alienate the product, encumber it with securities, or transform it or attach it to an immovable property in any way; in that time span, the client will conserve the product safely and have it insured; it will also conserve it in a way it can be identified individually, with a legible and visible mark on it, explicitly confirming that it is property of DIAsource. The risk of loss, destruction, or damage to the product (also if caused by force majeure) will nevertheless pass to the client as soon as the product is delivered to the client.

Article 6 – Delivery PeriodEvery agreed upon delivery term is only (and is to be considered) indicative. Not observing this term does not entitle the client to any remedy, unless the parties agree explicitly in writing that the delivery term is binding (in that event, not observing the delivery term can only give way to indemnification for the damage that is actual, proven, and established in such a way that both parties are able to submit observations, or to the termination of the sale, any of which can only be sought at the earliest 1 month from the date of a notice demanding delivery).

Article 7 – HardshipIf, beyond the will of DIAsource, unforeseen circumstances (e.g., strike, accidents, weather conditions, material defects, etc.) materialize in the procurement-, production-, distribution- or any other necessary type of process that make the delivery or timely delivery or the performance of any other obligation impossible (or strongly impede this), then DIAsource, depending on the nature of the circumstances, has the right to terminate the contract or suspend the performance of its obligations. DIAsource will not incur any liability if this occurs.

Article 8 – ComplaintsComplaints regarding visible defects or non-conformity are only admissible if (i) the product has not been used yet, and (ii) the complaint is in writing and is sent to the commercial services department of DIAsource in Louvain-La-Neuve no later than 3 working days from the date of delivery. After that, the products

will irrefutably be considered accepted. Following complaints are also non-receivable: anonymous complaints, claims related to results dating more than a year before the introduction of the same complaint, complaints linked to a "mistake" of the customer "(ex: mishandling, error in following the protocol, etc.), claims related to facts that are not within the competence of DIAsource, claims relating to a failure to provide information by the client, claims related to a subjective nature of the said claim.

Article 9 – Liability/SecurityDIAsource will only be liable for hidden defects if the client notifies DIAsource thereof by registered letter within 7 business days after such hidden defects are discovered by the client. This term is to be considered a term unable to be suspended or reset (“délai de déchéance” / “vervaltermijn”). In that event, the client will not be entitled to claim the dissolution of the sale of the relevant product, and DIAsource will only be liable for (i) the decrease in value of the product, and, to the extent DIAsource can be held liable for it, and (ii) the additional damage suffered by the client, it being understood that the client bears the burden of proof. This indemnity (i & ii) will in any event be limited to the price paid by the client for the relevant product. The client must conform strictly with the directives regarding the good distribution practices (GDP) applicable to medical devices marked ‘CE’. The client must use the products in a professional way and in accordance with the instructions of DIAsource. The client must inform DIAsource immediately of any dysfunction or any alteration of the properties and/or performances of the product he has bought from DIAsource. If the products are resold by the client to a third party outside of Belgium, the client must provide all documents and necessary instructions to that third party in the language(s) of the country of destination. DIAsource must only accept returned goods to the extent that they are the subject of a complaint which DIAsource has declared admissible and well-founded.

Article 10 – Netting in case of insolvency of the clientIn case the client is declared bankrupt, or in case any other insolvency or insolvency-like procedure is initiated in respect of the client, any amounts reciprocally due by and between DIAsource and the client shall be netted automatically and by force of law on the date of the opening of the insolvency procedure, regardless of whether such amounts are already due or determined (“vaststaand”/“liquide”) on the date of the opening of the insolvency procedure, and even if they are not entirely certain.

Article 11 – No assignmentThe client may not assign its rights and obligations against DIAsource to any third party (through a sale, a capital contribution, a donation or any other transaction, including the sale or contribution of a division (“bedrijfstak”/“branche d’activité”) or of a business as a whole (“algemeenheid/ “universalité”), or a merger, spin-off, split-up or other corporate restructuring) without the prior written consent of DIAsource.

Article 12 – Applicable law and competent courtBelgian law applies to all agreements to which the present general terms and conditions apply, but with the exclusion of the application of Belgian private international law and the Convention on the International Sale of Goods of Vienna dated 11 April 1980 (except for the Convention on the Limitation Period in the International Sale of Goods of 14 June 1974, whose application remains). The courts of Walloon Brabant, Belgium are exclusively competent to hear all disputes arising out of or in connection with contracts concluded by DIAsource (including the pre-contractual disputes) to which the present general terms and conditions apply.

Article 13 – Discrepancies between language versionsThe present general terms and conditions have been drafted in Dutch, English, French and Spanish. In case of discrepancies between the different language versions, the French version will prevail.

Article 14 – GDPR & Privacy policyDIAsource is compliant to the General Data Protection Regulation. Our policy for privacy and data protection is available on our website www.diasource-diagnostics.com. Any questions can be sent to: GDPR@diasource.be

VITAMIN D • RIA Product:

- 25OH Vitamin D3- 25Oh Vitmain D Total- 1,25 (OH)2 Vitmain D

• Raw material for Vitamin D Assays

• ELISA product:- 25OH Vitamin D Total- 25OH Vitamin D Total 90'- Free 25Oh Vitamin D- 1,25 (OH)2 Vitmain D

MULTI - SPECIES ASSAYS

PRODUCT OVERVIEW

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ANTIBODIES • Bone Metabolism • Cancer Markers • Cardiovascular & Salt Balance • Diabetes & Metabolism

• Fertility • Growth Factors • Thyroid Function

ANTIBODIES & ANTIGENS

PRODUCT OVERVIEW

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OUR OTHER AVAILABLE PRODUCT CATALOGS

MULTI - SPECIES• Allergy• Endocrinology & Metabolism• Infectious Disease

MANUFACTURED BY : DIAsource ImmunoAssays® S.A.rue du Bosquet 2 - BE 1348 Louvain-la-Neuve - Belgium Tel. : +32 (0)10 84 99 11 - Fax : +32 (0)10 84 99 90 info@diasource.be - customer.service@diasource.be

FOR MORE INFORMATION : www.diasource-diagnostics.com

DISTRIBUTED BY :

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A BioVendor group company

VITAMIN DPRODUCT OVERVIEW

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RIAPRODUCT OVERVIEW

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ELISA & INSTRUMENTSPRODUCT OVERVIEW

by IMMUNOASSAYS • Autoimmunity

• Biogenic Amines

• Bone Metabolism

• Cancer Markers

• Cardiovascular & Salt Balance

• Diabetes & Metabolism

• Fertility

• Gastrointestinal

• Infectious Disease Metabolism

• Growth Factors

• Immunology Markers

• Thyroid Function