elixir europe · elixir europe. andrew smith, head of external relations. personalized nutrition...
TRANSCRIPT
![Page 1: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/1.jpg)
www.elixir-europe.org
ELIXIR EuropeAndrew Smith, Head of External Relations
Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017
Public data infrastructure for microbiome, food and nutrition research: facilitating research and innovation in the era of big data
![Page 2: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/2.jpg)
2
1. Data challenges/barriers
2. Opportunities for data-driven innovation
3. Role of coordinated public data infrastructures as part of the solution
Themes of talk
![Page 3: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/3.jpg)
3
Source: http://omicsmaps.com
• Computer speed and storage capacity is doubling every 18 months and this rate is steady
• DNA sequence data is doubling every 6-8 months over the last 3 years and looks to continue for this decade
Data growth challenge
![Page 4: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/4.jpg)
4
Source: http://omicsmaps.com
• Data production sites increasing across Europe
• Rapid emergence of new technologies: image data, proteomics, metabolomics…
Data distribution challenge
![Page 5: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/5.jpg)
Diversity of data resources in life science
Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2012. MY Galperin, GR Cochrane – Nucleic Acids Research, 2011
~1800molecular biology
data resources
![Page 6: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/6.jpg)
6
• Secure access and governance of human data
• Data often cannot transfer the boundary in which it was generated
• National/regional health systems of vary between regions, languages, providers and technologies
Data security, ethical and legal challenges
![Page 7: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/7.jpg)
7
Open data mandates
![Page 8: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/8.jpg)
Human capital – skills development
• EC estimates 500,000 life scientists in Europe
• wet lab biologists, bioinformaticians to lab technicians….
• Need for ‘user’ training is high
• High level Expert Group on EOSC estimates Europe needs 500,000 ’data scientists’
• Need for training for data scientists and bioinformaticians
![Page 9: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/9.jpg)
Global commodity of users
9
![Page 10: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/10.jpg)
Kafkas S, Kim JH, and McEntyre JR Database Citation in Full Text Articles (May 2013) PLoS One 10.1371/journal.pone.0063184
European Nucleotide Archive
Protein Data Bank
DNA Variations (SNPs)
Gene Expression Studies DOIs (long tail)
Data citation in Europe PMC full text articles
![Page 11: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/11.jpg)
Data-driven innovation - demonstrating impact
*Bousfield D, McEntyre J, et al. Patterns of database citation in articles and patents indicate long-term scientific and industry value of biological data resources. F1000Research 2016
![Page 12: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/12.jpg)
Public data resources as a business model for SMEs
Customisation Aggregation Brokerage
Interaction with public data resources
![Page 13: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/13.jpg)
![Page 14: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/14.jpg)
• ELIXIR on the ESFRI roadmap
• ELIXIR one of three prioritised Research Infrastructures
• ELIXIR defined by GSO as infrastructure with global reach
Aligning national, European and global priorities
"ELIXIR is nominated because it is a world-leading infrastructure, vital for enabling the life sciences to derive maximum knowledge and understanding from biological, medical and environmental 'Big Data'.”
Group of Senior Officials on Global Research Infrastructures Progress Report 2015, October 2015
![Page 15: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/15.jpg)
Other ESFRI Research Infrastructures
• BBMRI – biobanks • EATRIS – translational
medicine• ECRIN – clinical trials• INSTRUCT – structural
biology• INFRAFRONTIER – mouse
models
• EMBRC – marine platforms• EuroBioImaging – medical
and biological imaging • EU-OpenScreen – chemical
screening• MIRRI – microbial resources• ISBE – systems biology • EMPHASIS – plant
phenotyping
Others for Food and Health?
![Page 16: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/16.jpg)
ELIXIR Structure
Five technical platforms for Compute, Data, Tools and Interoperability
Complemented by Use Cases for Marine meta-genomics, Rare diseases, Human data, Plants sciences,
PROTEOMICS
METABOLOMICS
GALAXY
and galaxyproteomics,
metabolomics
![Page 17: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/17.jpg)
ELIXIR Services
Data deposition:ENA, EGA, PDBe, EuropePMC, …
Bioinformatics tools:Bio.tools
Data Interoperability:Standards,Identifiers, Ontologies
Compute:Secure data transfer, cloud computing, AAI
Industry:Innovation and SME programmeBespoke collaborations
Training:TeSS, Data Carpentry, eLearning
Data management:Genome annotationData management plans
Added value data:UniProt, Ensembl, OrphaNet, …
![Page 18: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/18.jpg)
Recommended Deposition Databases
• “Whenever possible, biological research data should be submitted to the recommended community deposition databases”
https://elixir-europe.org/platforms/data/elixir-deposition-databases
![Page 20: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/20.jpg)
Connecting users with specialist training
![Page 21: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/21.jpg)
ELIXIR Training portal (TeSS)
• 230 upcoming events
• 650 online training materials
• 38 content providers
• https://tess.elixir-uk.org/
![Page 22: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/22.jpg)
‘Local’ EGA
• Sensitive data are stored locally
• EGA provides the software platform
• First prototype in 2017 with national partners
![Page 23: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/23.jpg)
Industry engagement
![Page 24: ELIXIR Europe · ELIXIR Europe. Andrew Smith, Head of External Relations. Personalized Nutrition for Better Health, Brussels 10-11 Oct 2017. Public data infrastructure for microbiome,](https://reader034.vdocuments.net/reader034/viewer/2022042621/5f71b0a471027776bd0ec3c6/html5/thumbnails/24.jpg)
www.elixir-europe.org
@ELIXIREurope /company/elixir-europe
Thanks!