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Emit® Drugs of Abuse Urine Assays Cross-Reactivity List

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Cross-Reactivity Book

ContentsEmit® II Plus – Amphetamines..... ...............................................................4

Emit® II Plus – Barbiturate .......................................................................8

Emit® II Plus – Benzodiazepine ................................................................ 12

Emit® II Plus – Cannabinoid .................................................................... 16

Emit® II Plus – Cocaine Metabolite ........................................................20

Emit® II Plus – Ecstasy ............................................................................. 24

Emit® II Plus – LSD .................................................................................... 28

Emit® II Plus – Methadone ...................................................................... 32

Emit® II Plus – Methaqualone ................................................................. 36

Emit® II Plus – Opiate ...............................................................................40

Emit® II Plus – Phenylcyclidine ..............................................................44

Emit® II Plus – Propoxyphene ..................................................................48

Emit® II Plus – Absorbance Flags ............................................................ 52

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Emit® II Plus – Amphetamines

The information contained in this document was compiled from the Package Inserts (IFUs) for each Emit® Drugs of Abuse assay, as well as additional cross-reactivity testing performed internally. The Package Insert (IFU) should always be consulted for the most recent information on specificity and cross-reactivity.

Definitions of CategoriesPositive The concentration in ng/mL of the listed drug that gives an assay response equal to the cutoff calibrator. The

concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, Phenmetrazine is listed at 2300 for the Amphetamines assay at 300 ng/mL cutoff. This means that it takes a concentration of 2300 ng/mL Phenmetrazine in urine to produce an instrument response equal to the 300 ng/mL d-methamphetamine calibrator. This concentration of drug in urine may be achieved in patients taking Phenmetrazine.

Negative - Structurally Related Concentration in μg/mL of listed drug that gives an assay response equal to the cutoff calibrator. The concentration of the listed compound is NOT clinically significant, and is not generally encountered in individuals taking the listed drug. For example, Bupropion is listed as 250 for the Amphetamines assay at 300 ng/mL cutoff. This means that it takes 250 μg/mL ( 250,000 ng/mL) of Bupropion to produce an instrument response equal to the 300 ng/mL d-Amphetamine calibrator. This concentration of drug in urine is higher than normally seen in patient taking this drug.

Negative Concentration of drug tested in μg/mL that gave an assay response less than the cutoff calibrator. The concentration of the listed compound is higher than normally seen in patients taking this drug.

User Notes

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The Amphetamines Assay has three cutoffs: 300 ng/mL, 500 ng/mL, and 1000 ng/mL d-Methamphetamine.

Positive– The drugs listed are in ng/mL at which they will cross-react equivalent to the d-Methamphetamine cutoff.

300 Cutoff 500 Cutoff 1000 Cutoffd,l-Amphetamine 625 1050 2150l-Amphetamine 3450 3750 11500Benzphetamine * 400 700 1000d,l-Methamphetamine 450 700 2100l-Methamphetamine 725 1325 3650MDA (Methylenedioxyamphetamine) 1100 1700 (see below)MDEA (Methylenedioxyethamphetamine) 4400 6800 (see below)MDMA (Methylenedioxymethamphetamine) 5200 9150 (see below)Phenmetrazine 2300 3500 13000Selegiline # # #

* Benzphetamine metabolizes to amphetamine and methamphetamine.# Selegiline metabolizes to l-amphetamine and l-methamphetamine. Patients taking Selegiline may

test positive by amphetamine assays.

Negative — Structurally Related – The drugs listed are in µg/mL at which they will cross-react equivalent to the d-Methamphetamine cutoff.

300 Cutoff 500 Cutoff 1000 CutoffBupropion 250 500 2220Cathinone >100 >100 >1004-Chloramphetamine 2.6 4.5 12.2Chloroquine 2100 2200 4500l-Ephedrine 400 800 3500Fenfluramine 25 40 150MDA (Methylenedioxyamphetamine) (see above) (see above) 6.5MDEA (Methylenedioxyethamphetamine) (see above) (see above) 27.2MDMA (Methylenedioxymethamphetamine) (see above) (see above) 34.3Mephentermine 8 15 60Methcathinone >100 >100 >100Methoxyphenamine 90 160 360Phentermine 5.8 9 25Phenylpropanolamine 700 1000 2000PMA (p-Methoxyamphetamine) 4 7 34PMMA (p-Methoxymethamphetamine) 8 14 81Propranolol 100 125 500d,l-Pseudoephedrine 1400 2600 8300nor-Pseudoephedrine 40 70 170Quinacrine 2500 3800 16500Tranylcypromine 30 60 200Tyramine 150 200 600

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NegativeThe compounds below were negative for the Amphetamines 300, 500, and 1000 cutoffs at the concentrations shown except where noted. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 1000Alprazolam 10005-Aminosalicyclic Acid 1000Amitriptyline 1000Amlodipine 750Amoxicillin 1000Atenolol 1000Atomoxetine 1000Atorvastatin 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benzoylecgonine 10001-Benzylpiperazine @ 300 3001-Benzylpiperazine @ 500 4601-Benzylpiperazine @ 1000 460Buprenorphine 1000Caffeine 1000Carbamazepine 250Carisoprodol 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpheniramine 1000Chlorpromazine 200Cimetidine 1000Ciprofloxacin 1000Citalopram 1000Clomipramine 2.5Clonazepam 1000Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Codeine 500l-Cotinine 100Cyclobenzaprine 1000Desipramine @300 300Desipramine @ 500 500Desipramine @ 1000 800Dextromethorphan 1000Dextrorphan 280Diazepam 1000Diclofenac 1000Diethylpropion 1000Diltiazem 1000

Diphenhydramine 1000Dobutamine 1000Doxepin 1000Doxycycline 1000Doxylamine 1000EDDP (2-Ethylidene-1,5-dimethyl- 3,3-diphenylpyrrolidine) 1000Enalapril Maleate 1000Ephedrine 125l-Epinephrine 1000Escitalopram 1000Escomeprazole 1000Eszopiclone 1000Ezetimibe 1000Fenoprofen 150Fentanyl 75Fexofenadine 1000Fluoxetine 500Fluticasone Proprionate 1000Furosemide 1000Gabapentin 1000Glutethimide 500Glyburide 1000Griseofulvin 1000Haloperidol @ 300 500Haloperidol @ 500 700Haloperidol @1000 1000Hydrochlorothiazide 1000Hydrocodone 1000Hydromorphone 1000Ibuprofen 1000Imipramine 750d,l-Isoproterenol 1000Isoxsuprine @ 300 300Isoxsuprine @ 500 500Isoxsuprine @ 1000 500Ketamine 100Ketoprofen 1000Ketorolac Tromethamine 1000LAAM(l-α-Acetylmethadol) 25dinorLAAM(α-Acetyl-N, N-dinormethadol) 25norLAAM(Noracetylmethadol) 25Labetalol 750Lamotrigine 1000Lansoprazole 1000Levofloxacin 1000Lidocaine 1000

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Negative (continued)

Lisinopril 1000LSD (Lysergic acid diethylamide) 2.5MEGX (Monoethylglycinexylidide) 1000Meloxicam 1000Meperidine 1000Meprobamate 1000Mescaline @ 300 1000Mescaline @ 500 1500Mescaline @ 1000 1500Metaproterenol 500Metformin 1000Methadone 1000Methaqualone 1500d,l-Methyldopa 1000l-Methyldopa 1000Methylphenidate 1000Metoprolol Tartrate 1000Metronidazole 1000Morphine 1000Nalmefene 20Naloxone 500NAPA(N-Acetylprocainamide) 400Naproxen 1000Nefazodone 1000NicotinicAcid 500Nortryptyline 750Nylidrin 750Ofloxacin 100Omeprazole 1000Oxazepam 300Oxycodone 1000Oxymorphone 1000PABA (p-Aminobenzoic Acid) 1000Paroxetine 1000PCA (1-Phenylcyclohexylamine) 50PCC (1-Piperidinocyclohexane Carbonitrile) 50PCP (Phencyclidine) 1000Phenelzine @ 300 50Phenelzine @ 500 100Phenelzine @ 1000 100Phenethylamine @ 300 15Phenethylamine @ 500 20Phenethylamine @ 1000 20

Phenylephrine 1000Phenytoin (DPH) 1000Phthalic Acid 1000Pioglitazone 1000Pravastatin 1000Prednisone 1000Procainamide 1000Promethazine 1000Propofol 1000Propoxyphene 1000Propylhexedrine @ 300 20Propylhexedrine @ 500 30Propylhexedrine @ 1000 50Quetiapine Fumerate 1000Quinapril 1000Rabeprazole 1000Ramipril 1000Ranitidine 1000Risedronate 1000Risperidone 1000Rofecoxib 1000Scopolamine 500Secobarbital 1000Sertraline 1000Sildenafil 1000Simvastatin 100011-nor-∆9-THC-9-COOH 100Thioridazine 100Thyroxine 1000Tolmetin Sodium 2000Topiramate 1000Tramadol 1000Tranylcypromine 16Trazodone 1000Trifluoperazine 1000Trihexylphenidyl 1000Trimethobenzamide 500Trimethoprim 10003-OH-Tyramine 300Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100

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Emit® II Plus – Barbiturate



concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, Butalbital is listed as 304 for the Barbiturate assay at 200 ng/mL cutoff. This means that it takes a concentration of 304 ng/mL Butalbital in urine to produce an instrument response equal to the 200 ng/mL Secobarbital calibrator. This concentration of drug in urine may be achieved in patients taking Butalbital.


User Notes

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The Barbiturate Assay has two cutoffs: 200 ng/mL and 300 ng/mL Secobarbital.

Positive– The drugs listed are in ng/mL at which they will cross-react equivalent to the Secobarbital cutoff.

200 Cutoff 300 CutoffAllobarbital 345 744Alphenal 284 978Amobarbital 348 923Aprobarbital 275 478Barbital 1278 41485-Ethyl-5-(4-hydroxyphenyl) barbituric acid 927 4719Butabarbital 274 523Butalbital 304 475Butobarbital 349 875Cyclopentobarbital 304 527Pentobarbital 252 447Phenobarbital 509–971 2386–4624Talbutal 194 262Thiopental 16400 80400

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NegativeThe compounds below were negative for the Barbiturate 200 and 300 cutoffs at the concentrations shown. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 1000Alprazolam 10005-Aminosalicyclic Acid 1000Amitriptyline 1000Amlodipine 1000d-Amphetamine 1000Amoxicillin 1000Atomoxetine 1000Atorvastatin 1000Azathioprine 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benzoylecgonine 1000Buprenorphine 1000Bupropion 1000Caffeine 1000Carbamazepine 1000Carbamazepine 10,11-Epoxide 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpheniramine 1000Chlorpromazine 1000Cimetidine 1000Ciprofloxacin 1000Citalopram 1000Clomipramine 2.5Clonazepam 1000Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Codeine 500Cotinine 100Cyclobenzaprine 1000Desipramine 800Dextromethorphan 1000Diazepam 1000Diclofenac 1000Diltiazem 1000Diphenhydramine 1000Doxepin 1000Doxycycline 1000Doxylamine 1000EDDP (2-Ethylidene-1,5-dimethyl- 3, 3-diphenylpyrrolidine) 1000Enalapril Maleate 1000Ephedrine 1000Escitalopram 1000Escomeprazole 1000Eszopiclone 1000

Ezetimibe 1000Fentanyl 1000Fexofenadine 1000Fluoxetine 1000Fluticasone Proprionate 1000Furosemide 1000Gabapentin 1000Glutethimide 300Glyburide 1000Griseofulvin 1000Hydrochlorothiazide 1000Hydrocodone 1000Hydromorphone 1000Ibuprofen 1000d,l-Isoproterenol 1000Isoxsuprine 1000Ketamine 100Ketoprofen 1000Ketorolac Tromethamine 1000LAMM(l-α-Acetylmethadol) 25dinorLAAM(α-Acetyl-N, N-dinormethadol) 25Lamotrigine 1000Lansoprazole 1000Levofloxacin 1000Lidocaine 1000Lisinopril 1000Lorazepam 250Lormetazepam 1LSD (Lysergic acid diethylamide) 0.01Meloxicam 1000Meperidine 1000Meprobamate 1000Metaproterenol 1000Metformin 1000Methadone 100d-Methamphetamine 35Methaqualone 1500MDA (Methylenedioxyamphetamine) 5MDMA (Methylenedioxy- methampheamine) 200Metoprolol Tartrate 1000Metronidazole 1000Morphine 1000Myoglobin 287NAPA(N-Acetylprocainamide) 400Naproxen 1000Nefazodone 1000Nortriptyline 1000Nylidrin 1000

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Omeprazole 1000Oxazepam 300Oxycodone 1000Oxymorphone 1000Paroxetine 1000PCP (Phencyclidine) 1000Phenytoin (DPH) 1000Pioglitazone 1000Pravastatin 1000Prednisone 1000Promethazine 1000Propofol 1000Propoxyphene 1000Propranolol 1000Pseudoephedrine 1000Quetiapine Fumerate 1000Quinapril 1000Rabeprazole 1000Ramipril 1000Ranitidine 1000Risedronate 1000Risperidone 1000Rofecoxib 1000

Scopolamine 500Sertraline 1000Sibutramine HCl 1000Sildenafil 1000Simvastatin 1000Terbutaline 100011-nor-∆9-THC-9-COOH 100Thioridazine 100Thyroxine 1000Tolmetin Sodium 1000Topiramate 1000Tramadol 1000Tranylcypromine 1000Trazadone 1000Trifluoperazine 1000Trihexylphenidyl 1000Trimethoprim 1000Tyramine 100Valproic Acid 1000Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100

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Emit® II Plus – Benzodiazepine



concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, Alprazolam is listed as 65 for the Benzodiazipine assay at 200 ng/mL cutoff. This means that it takes a concentration of 65 ng/mL Alprazolam in urine to produce an instrument response equal to the 200 ng/mL Lormetazepam calibrator. This concentration of drug in urine may be achieved in patients taking Alprazolam.


User Notes

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The Benzodiazipine Assay has two cutoffs: 200 ng/mL and 300 ng/mL Lormetazepam.

Positive – The drugs listed are in ng/mL at which they will cross-react equivalent to the Lormetazepam cutoff.

200 Cutoff 300 CutoffAlprazolam 65 797-Aminoclonazepam 5700 110007-Aminoflunitrazepam 590 14007-Aminonitrazepam 365 1000Bromazepam 630 1400Chlordiazepoxide 3300 7800Clobazam 260 350Clonazepam 260 500Clorazepate # #Clotiazepam 250 420Demoxepam 850 2200N-Desalkylflurazepam 130 160N-Desmethyldiazepam 110 140Diazepam 44 120Estazolam 55 72Flunitrazepam 140 190Flurazepam 190 250Halazepam 110 160α-Hydroxyalprazolam 100 150α-Hydroxyalprazolamglucuronide 110 1201-N-Hydroxyethlylflurazepam 150 150α-Hydroxytriazolam 130 190Ketazolam 180 290Lorazepam 600 890Lorazepam glucuronide >10000 >10000Medazepam 150 210Midazolam 130 160Nitrazepam 140 220Norchlordiazepoxide 2600 4900Oxazepam 250 350Oxazepam glucuronide >10000 >10000Prazepam 90 130Sertraline + +Temazepam 140 210Temazepam glucuronide 6900 11000Tetrazepam 41 54Triazolam 130 180

# Clorazepatedegradesrapidlyinstomachacidtonordiazepam.Nordiazepamhydroxylates to oxazepam.

+ Therapeutic doses of sertraline may produce a positive result with this assay

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NegativeThe compounds below were negative for the Benzodiazepine 200 and 300 cutoffs at the concentrations shown except where noted. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 10005-Aminosalicyclic Acid 1000Amitriptyline 1000Amlodipine 1000Amoxicillin 1000d-Amphetamine 1000Atomoxetine 1000Atorvastatin 1000Azathioprine 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benzoylecgonine 1000Buprenorphine 1000Bupropion 1000Caffeine 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpheniramine 1000Chlorpromazine 1000Cimetidine 1000Ciprofloxacin 1000Citalopram 1000Clomipramine 2.5Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Clozapine 50ClozapineN-Oxide 50Codeine 500Cotinine 100Cyclobenzaprine 1000Desipramine 800N-Desmethylsertraline 500Dextromethorphan 1000Diclofenac 1000Diltiazem 1000Diphenhydramine 1000Doxepin 1000Doxycycline 1000Doxylamine 1000EDDP (2-Ethylidene-1,5-dimethyl- 3, 3-diphenylpyrrolidine) 1000Enalapril Maleate 1000Ephedrine 1000Escitalopram 900Escomeprazole 1000Eszopiclone 1000

Ezetimibe 1000Fentanyl 1000Fexofenadine 1000Fluoxetine 1000Fluticasone Proprionate 1000Fluvoxamine 1000Furosemide 1000Gabapentin 1000Glutethimide 500Glyburide 1000Griseofulvin 1000Hydrochlorothiazide 1000Hydrocodone 1000Hydromorphone 900Ibuprofen 1000d,l-Isoproterenol 1000Isoxsuprine 1000Ketamine 100Ketoprofen 1000Ketorolac Tromethamine 1000LAMM(l-α-Acetylmethadol) 25dinorLAAM(α-Acetyl-N, N-dinormethadol) 25Lamotrigine 1000Lansoprazole 1000Levofloxacin 1000Lidocaine 1000Lisinopril 1000Loratadine 1000LSD Lysergic acid diethylamide 0.01MDA (Methylenedioxyamphetamine) 5MDMA (Methylenedioxy- methampheamine) 200Meloxicam 1000Meperidine 1000Meprobamate 1000Metaproterenol 1000Metformin 1000Methadone 100d-Methamphetamine 35Methaqualone 1500Metoprolol Tartrate 1000Metronidazole 1000Morphine 1000Myoglobin 287Nabumetone 1000NAPA(N-Acetylprocainamide) 400Naproxen 1000Nefazodone1000Nortriptyline 1000Nylidrin 1000

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Olanzapine @ 300 1000Omeprazole 1000Oxycodone 900Oxymorphone 1000Paroxetine 1000PCP (Phencyclidine) 1000Phenytoin (DPH) 1000Pioglitazone 1000Pravastatin 1000Prednisone 1000Promethazine 1000Propofol 1000Propoxyphene 1000Propranolol 1000Pseudoephedrine 1000Quetiapine Fumerate 500Quinapril 1000Rabeprazole 1000Raloxifene 1000Ramipril 1000Ranitidine 1000Risedronate 1000Risperidone 1000Rizatriptan Benzate 1000

Rofecoxib 1000Scopolamine 500Secobarbital 1000Sibutramine HCL 1000Sildenafil 1000Simvastatin 100011-nor-∆9-THC-9-COOH 100Thioridazine 100Thyroxine 1000Tolmetin Sodium 1000Topiramate 1000Tramadol 1000Tranylcypromine 1000Trazadone 1000Trifluoperazine 1000Trihexylphenidyl 1000Trimethoprim 1000Tyramine 100Valerian Root 10000Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100Zopiclone 1000

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Emit® II Plus – Cannabinoid



concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, 11-Hydroxy-∆8-THC is listed as 67 for the Cannabinoid assay at 50 ng/mL cutoff. This means that it takes a concentration of 67 ng/mL 11-Hydroxy-∆8-THC in urine to produce an instrument response equal to the 50 ng/mL 11-nor-∆9-THC-9-COOH calibrator. This concentration of drug in urine may be achieved in patients taking THC.


User Notes

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The Cannabinoid Assay has three cutoffs: 20 ng/mL, 50 ng/mL and 100 ng/mL 11-nor-∆9-THC-9-COOH.

Positive – The drugs listed are in ng/mL at which they will cross-react equivalent to the 11-nor-∆9-THC-9-COOH cutoff.

20 Cutoff 50 Cutoff 100 Cutoff9-Carboxy-11-nor-∆9-THC-glucuronide 79 95 3288-β-11-Dihydroxy-∆9-THC 24 58 10911-Hydroxy-∆8-THC 43 67 12911-Hydroxy-∆9-THC 42 77 1248-β-Hydroxy-∆9-THC 26 68 146

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NegativeThe compounds below were negative for the Cannabinoid 20, 50, and 100 cutoffs at the concentrations shown except where noted. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 1000Alprazolam 10005-Aminosalicyclic Acid 1000Amitriptyline 1000Amlodipine 1000Amoxicillin 1000d-Amphetamine 1000Atomoxetine 1000Atorvastatin 1000Azathioprine @ 50 1000Azathioprine @ 100 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benzoylecgonine 1000Buprenorphine 1000Bupropion 1000Caffeine 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpheniramine 1000Chlorpromazine 1000Cimetidine 1000Ciprofloxacin 1000Citalopram 1000Clomipramine 2.5Clonazepam 1000Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Codeine 500Cotinine 100Cyclobenzaprine 1000Desipramine 800Dextromethorphan 1000Diazepam 1000Diclofenac 1000Diltiazem 1000Diphenhydramine 1000Doxepin 1000Doxycycline 1000Doxylamine 1000EDDP (2-Ethylidene-1,5-dimethyl- 3, 3-diphenylpyrrolidine) 1000Efavirenz 1000Enalapril Maleate 1000Ephedrine 1000

Escitalopram 1000Escomeprazole 1000Eszopiclone 1000Ezetimibe 1000Fentanyl 1000Fexofenadine 1000Fluoxetine 1000Fluticasone Proprionate 1000Furosemide 1000Gabapentin 1000Glutethimide 500Glyburide 1000Griseofulvin 1000Hydrochlorothiazide 1000Hydrocodone 1000Hydromorphone 1000Ibuprofen 1000d,l-Isoproterenol 1000Isoxsuprine 1000Ketamine 100Ketoprofen 1000Ketorolac Tromethamine 1000LAMM(l-α-Acetylmethadol) 25dinorLAAM(α-Acetyl-N, N-dinormethadol) 25Lamotrigine 1000Lansoprazole 1000Levofloxacin 1000Lidocaine 1000Lisinopril 1000Lormetazepam 1LSD (Lysergic acid diethylamide) 0.01MDA (Methylenedioxyamphetamine) 5MDMA (Methylenedioxy- methampheamine) 200Meloxicam 1000Meperidine 1000Meprobamate 1000Metaproterenol 1000Metformin 1000Methadone 100d-Methamphetamine 35Methaqualone 1500Metoprolol Tartrate 1000Metronidazole 1000Morphine 1000Myoglobin @ 50 287Myoglobin @ 100 287NAPA(N-Acetylprocainamide) 400Naproxen 1000Nefazodone 1000

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Nortriptyline 1000Nylidrin 1000Omeprazole 1000Oxazepam 300Oxycodone 1000Oxymorphone 1000Pantoprazole 1000Paroxetine 1000PCP (Phencyclidine) 1000Phenytoin (DPH) 1000Pioglitazone 1000PotassiumNitrite@50 5000PotassiumNitrite@100 5000Pravastatin 1000Prednisone 1000Promethazine 1000Propofol 1000Propoxyphene 1000Propranolol 1000Pseudoephedrine 10004-Pyridoxic Acid @ 100 1000Quetiapine Fumerate 1000Quinapril 1000Rabeprazole 1000Ramipril 1000

Ranitidine 1000Risedronate 1000Risperidone 1000Rofecoxib 1000Scopolamine 500Secobarbital 1000Sertraline 1000Sibutramine HCL @ 100 1000Sildenafil 1000Simvastatin 1000Thioridazine 100Thyroxine 1000Tolmetin Sodium 1000Topiramate 1000Tramadol 1000Tranylcypromine 1000Trazadone 1000Trifluoperazine 1000Trihexylphenidyl 1000Trimethoprim 1000Tyramine 100Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100

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Emit® II Plus – Cocaine Metabolite



concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, Cocaine is listed as 40–119 for the Cocaine Metabolite assay at 300 ng/mL cutoff. This means that it takes a concentration of 40–119 ng/mL Cocaine in urine to produce an instrument response equal to the 300 ng/mL benzoylecgonine calibrator. This concentration of drug in urine may be achieved in patients taking Cocaine.


User Notes

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The Cocaine Metabolite Assay has two cutoffs: 150 ng/mL and 300 ng/mL benzoylecgonine.

Positive – The drugs listed are in ng/mL at which they will cross-react equivalent to the benzoylecgonine cutoff.

150 Cutoff 300 CutoffCocaine 18–53 40–119Ecgonine 2–6 7–20

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NegativeThe compounds below were negative for the Cocaine Metabolite 150 and 300 cutoffs at the concentrations shown except where noted. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 1000Alprazolam 10005-Aminosalicyclic Acid 1000Amitriptyline 1000Amlodipine 1000Amoxicillin 1000d-Amphetamine 100Atomoxetine 1000Atorvastatin 1000Azathioprine 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benztropine 1000Bupivicaine 1000Buprenorphine 1000Bupropion 1000Caffeine 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpheniramine 1000Chlorpromazine 1000Cimetidine 1000Ciprofloxacin 1000Citalopram 1000Clomipramine 2.5Clonazepam 1000Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Codeine 500Cotinine 100Cyclobenzaprine 1000Desipramine 800Dextromethorphan 1000Diazepam 1000Diclofenac 1000Diltiazem 1000Diphenhydramine 1000Doxepin 1000Doxycycline 1000Doxylamine 1000EDDP (2-Ethylidene-1,5-dimethyl- 3, 3-diphenylpyrrolidine) 1000Enalapril Maleate 1000Ephedrine 1000

Escitalopram 1000Escomeprazole 1000Eszopiclone 1000Ezetimibe 1000Fentanyl 1000Fexofenadine 1000Fluoxetine 1000Fluticasone Proprionate 1000Furosemide 1000Gabapentin 1000Glutethimide 500Glyburide 1000Griseofulvin 1000Hydrochlorothiazide 1000Hydrocodone 1000Hydromorphone 1000Ibuprofen 1000d,l-Isoproterenol 1000Isoxsuprine 1000Ketamine 100Ketoprofen 1000Ketorolac Tromethamine 1000LAAM(l-α-Acetylmethadol) 25dinorLAAM(α-Acetyl-N, N-dinormethadol) 25Lamotrigine 1000Lansoprazole 1000Levofloxacin 1000Lidocaine 1000Lisinopril 1000Lormetazepam 1LSD (Lysergic acid diethylamide) 0.01MDA (Methylenedioxyamphetamine) 5MDMA (Methylenedioxy- methampheamine) 200Meloxicam 1000Meperidine 1000Meprobamate 1000Metaproterenol 1000Metformin 1000Methadone 1000d-Methamphetamine 35Methaqualone 1500Metoclopramide 1000Metoprolol Tartrate 1000Metronidazole 1000Morphine 1000Myoglobin 287NAPA(N-Acetylprocainamide) 400Naproxen 1000

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Nefazodone 1000Nortriptyline 1000Nylidrin 1000Omeprazole 1000Oxazepam 300Oxycodone 1000Oxymorphone 1000Paroxetine 1000PCP (Phencyclidine) 1000Phenytoin (DPH) 1000Pioglitazone 1000Pravastatin 1000Prednisone 1000Promethazine 1000Propofol 1000Propoxyphene 1000Propranolol 1000Pseudoephedrine 1000Quetiapine Fumerate 1000Quinapril 1000Rabeprazole 1000Ramipril 1000Ranitidine 1000Risedronate 1000Risperidone 1000

Rofecoxib 1000Scopolamine 500Secobarbital 1000Sertraline 1000Sibutramine HCl 1000Sildenafil 1000Simvastatin 1000Tetracaine 100011-nor-∆9-THC-9-COOH 100Thioridazine 100Thyroxine 1000Tolmetin Sodium 1000Topiramate 1000Tramadol 1000Tranylcypromine 1000Trazadone 1000Trifluoperazine 1000Trihexylphenidyl 1000Trimethoprim 1000Tyramine 100Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100

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Emit® II Plus – Ecstasy



concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, BDB is listed as 220 for the Ecstasy assay at 300 ng/mL cutoff. This means that it takes a concentration of 220 ng/mL BDB in urine to produce an instrument response equal to the 300 ng/mL MDMA calibrator. This concentration of drug in urine may be achieved in patients taking BDB.

Negative - Structurally Related Concentration in μg/mL of listed drug that gives an assay response equal to the cutoff calibrator. The concentration of the listed compound is NOT clinically significant, and is not generally encountered in individuals taking the listed drug. For example, Bupropion is listed as 2000 for the Ecstasy assay at 300 ng/mL cutoff. This means that it takes 2000 μg/mL ( 2,000,000 ng/mL) of Bupropion to produce an instrument response equal to the 300 ng/mL MDMA calibrator. This concentration of drug in urine is higher than normally seen in patients taking this drug.


User Notes

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The Ecstasy Assay has two cutoffs: 300 ng/mL and 500 ng/mL MDMA.

Positive – The drugs listed are in ng/mL at which they will cross-react equivalent to the MDMA cutoff.

300 Cutoff 500 CutoffBDB (3,4-methenedioxy-alpha-ethyl-phenethylamine) 220 780HMMA (4-hydroxy-3-methoxy-methamphetamine) 50000 50000MBDB(N-Methyl-1-(3,4-Methylenedioxyphenyl)- 2-Butanamine) 200 430MDA (Methylenedioxyamphetamine) 280 578MDEA (Methylenedioxyethamphetamine) 290 528PMA (paramethoxyamphetamine) 13000 22000PMMA (paramethoxymethamphetamine) 1900 3600Haloperidol 8000 (see below)Trazodone 7000 (see below)

Negative — Structurally Related – The drugs listed are in µg/mL at which they will cross-react equivalent to the MDMA cutoff.

300 Cutoff 500 Cutoffd-Amphetamine 160 430l-Amphetamine 220 685d,l-Amphetamine 32 83Benzphetamine 36 88Buproprion 2000 44004-Chloramphetamine 9 60Chloroquine 2000 2000Dobutamine 37 130l-Ephedrine 230 2200Fenfluramine 5 22Haloperidol (see above) 85Isoxsuprine 22 165Labelatol 35 80Mephentermine 180 380d-Methamphetamine 37 130l-Methamphetamine 30 87d,l-Methamphetamine 200 430Methoxyphenamine 6900 13400Nylidrin 24 70Phenmetrazine 3400 7400Phentermine 700 1700PPA (Phenylpropanolamine) 700 2200Propanolol 440 1500d-Pseudoephedrine 450 1600nor-Pseudoephedrine 830 7600Quinacrine 4000 4000Tranylcypromine 420 2800Trazodone (see above) 24Tyramine 3200 7000

26



NegativeThe compounds below were negative for the Ecstasy 300 and 500 cutoffs at the concentrations shown. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 1000Alprazolam 10005-Aminosalicyclic Acid 1000Amitriptyline 10Amlodipine 1000Amoxicillin 1000Atenolol 1000Atomoxetine 1000Atorvastatin 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benzoylecgonine 1000Buprenorphine 1000Bupropion 1000Caffeine 1000Carbamazepine 250Carisoprodol 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpheniramine 500Chlorpromazine 500Cimetidine 1000Ciprofloxacin 1000Citalopram 1000Clomipramine 2.5Clonazepam 1000Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Codeine 500l-Cotinine 100Cyclobenzaprine 125Desipramine 800Dextromethorphan 1000Dextrorphan 280Diazepam 1000Diclofenac 1000Diethylpropion HCl 1000Diltiazem 1000Diphenhydramine 1000Doxepin 250Doxycycline 1000Doxylamine 1000EDDP (2-Ethylidene-1,5-dimethyl-3, 3-diphenylpyrrolidine) 1000Enalapril Maleate 1000

Ephedrine 62.5l-Epinephrine 1000Escitalopram 1000Escomeprazole 1000Eszopiclone 1000Ezetimibe 1000Fenoprofen 1000Fentanyl 75Fexofenadine 1000Fluoxetine 125Fluticasone Proprionate 1000Furosemide 1000Gabapentin 1000Glutethimide 500Glyburide 1000Griseofulvin 1000Hydrochlorothiazide 1000Hydrocodone 1000Hydromorphone 1000Ibuprofen 1000Imipramine 750d,l-Isoproterenol 1000Ketorolac Tromethamine 350Ketamine 100Ketoprofen 1000LAMM(l-α-Acetylmethadol) 25dinorLAAM(α-Acetyl-N, N-dinormethadol) 25Lamotrigine 1000Lansoprazole 1000Levofloxacin 1000Lidocaine 1000Lisinopril 1000LSD (Lysergic acid diethylamide) 0.15MEGX (Monoethyl- glycinexylidide) 1000Meloxicam 1000Meperidine HCl 1000Meprobamate 1000Mescaline 1500Metaclopramide 1000Metaproterenol 250Metformin 1000Methadone 1000Methaqualone 1500l-Methyldopa 1000d,l-Methyldopa 1000Methylphenidate 1000

27



Metoprolol Tartrate 1000Metronidazole 1000Morphine 1000Nalmefene 20Naloxone 500NAPA(N-Acetylprocainamide) 400Naproxen 1000Nefazodone 16NicotinicAcid 500Nitroglycerin 1000Noracetylmethadol 25Nortriptyline 1000Ofloxacin 100Omeprazole 1000Oxazepam 300Oxycodone 1000Oxymorphone 1000PABA (p-Aminobenzoic Acid) 1000Paroxetine 5PCA (1-Phenylcyclohexylamine) 50PCC (1-Piperidinocyclohexane Carbonitrile) 50PCP (Phencyclidine) 1000Phendimetrazine 400Phenelzine 100Phenethylamine 20Phenylephrine 20Phenytoin (DPH) 1000Phthalic Acid 1000Pioglitazone 1000Pravastatin 1000Prednisone 1000Procainamide 1000Promethazine 1000

Propofol 1000Propoxyphene 1000Propranolol 250Propylhexedrine 125Quetiapine Fumerate 1000Quinapril 1000Rabeprazole 1000Ramipril 1000Ranitidine 1000Risedronate 1000Risperidone 16Rofecoxib 1000Scopolamine 500Secobarbital 1000Sertraline 125Sildenafil 1000Simvastatin 100011-nor-∆9-THC-9-COOH 100Thioridazine 100Thyroxine 1000Tolmetin Sodium 2000Topiramate 1000Tramadol 1000Tranylcypromine 125Trifluoperazine 1000Trihexylphenidyl 1000Trimethobenzamide 500Trimethoprim 10003-OH-Tyramine 300Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100


28


Emit® II Plus – LSD



concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, Fentanyl is listed as 3 for the LSD assay at 0.5 ng/mL cutoff. This means that it takes a concentration of 3 ng/mL Fentanyl in urine to produce an instrument response equal to the 0.5 ng/mL LSD calibrator. This concentration of drug in urine may be achieved in patients taking Fentanyl.

Negative – Equivalent Concentration Concentration in μg/mL of listed drug that gives an assay response equal to the cutoff calibrator. The concentration of the listed compound is NOT clinically significant, and is not generally encountered in individuals taking the listed drug. For example, d-Amphetamine is listed as 500 for the LSD assay. This means that it takes 500 μg/mL (500,000 ng/mL) of d-Amphetamine to produce an instrument response equal to the 0.5 ng/mL LSD calibrator. This concentration of drug in urine is higher than normally seen in patients taking this drug.


User Notes

29


The LSD Assay has one cutoff: 0.5 ng/mL LSD.

Positive – The drugs listed are in ng/mL at which they will cross-react equivalent to the LSD cutoff.

0.5 CutoffAmbroxol 60Amitriptyline 7800Chlorpromazine 1410Clomipramine 2560Dicyclomine 22300Diltiazem 390Doxepin 7800Ergonovine 1000Fentanyl 3Fluoxetine 3800Flurazepam 130Haloperidol 240Lysergol 10300Maprotiline 25100Methysergide 3000Metoclopramide 350Nortriptyline 15600Norverapamil 13300Nylidrin 156002-oxo-3-hydroxy-LSD 21Risperidone 1950Sertraline 390Thioridazine 7100Thiothixene 14500Verapamil 7800

Negative – Equivalent Concentration - The drugs listed are in µg/mL at which they will cross-react equivalent to the LSD cutoff.

0.5 Cutoffd-Amphetamine 500Cyclobenzaprine 29Diphenhydramine 71Dothiepin 17d,l Ephedrine 272Fenfluramine 46MDMA (Methylenedioxymethampheamine) 80Mephentermine 57Methadone 400d-Methamphetamine 100Nicotine 500Norfluoxetine 50Paroxetine 100PCP (Phencyclidine) 30Perphenazine 5Prochlorperazine 11Propoxyphene 1000Trazodone 24


30



NegativeThe compounds below were negative for the LSD 0.5 cutoff at the concentrations shown. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alprazolam 1005-Aminosalicyclic Acid 1000Amlodipine 1000Amobarbital 100Amoxetine 62.5Amoxicillin 100d,l-Amphetamine 100Aprobarbital 100Atenolol 100Atorvastatin 1000Barbituric Acid 100Benazepril 1000Benzoylecgonine 1000Bromazepam 100Buprenorphine 1000Buproprion 15.6Butalbital 100Caffeine 100Captopril 500Carbamazepine 250Carbamazepine 10,11 Epoxide 500Celecoxib 1000Cetirizine 62.5Chlordiazepoxide 100Chlorpheniramine 1000Cimetidine 100Ciprofloxacin 1000Citalopram 125Clonazepam 100Clorazepate 100Clotrimazole 1000Codeine 100Cotinine 100Desmethyldiazepam 100Dextromethorphan 1255,5’-Diallylbarbituric Acid 100Diazepam 20Diclofenac 1000Dihydrocodeine 100Dihydroergotamine 100Doxylamine 500Ecgonine 100Ecgonine Methyl Ester 100Ephedrine 250l-Epinephrine 20

α-Ergocryptine 20Ergotamine 100Ethylmorphine 100Ezetimibe 1000Fenprofen 100Glyburide 1000Griseofulvin 1000Hexobarbital 100o-Hydroxyhippuric acid 500Ibuprofen 100Ipratropium bromide 100d,l-Isoproterenol 1000Isoxsuprine 31Ketamine 100Ketoprofen 1000Lamotrigine 1000Levofloxacin 1000Lidocaine 500Lysergic Acid 100Medazepam 100Mefenamic Acid 100Mephobarbital 100Meprobamate 1000Metaproterenol 1000Methaqualone 1000Metoprolol 1000Metronidazole 1000Morphine 1000Morphine-3-Glucuronide 100Morphine-6-Glucuronide 100Nalbuphine 100Naproxen 100Nefazodone 15.6Nifediipine 500Nitrazepam 100Nornicotine 100d-Norpropoxyphene 100Omeprazole 1000Oxazepam 250Oxycodone 100Penicillin 1000Pentobarbital 100Phenothiazine 100Phentermine 100Phenylpropanolamine 1000Phenytoin 1000Prazepam 100Pioglitazone 1000

31




Promethazine 6.8Propofol 1000Propranolol 7.8Pseudoephedrine 100Psilocin 100Psilocybin 100Quinapril 1000Rabeprazole 7.8Ramipril 1000Ranitidine 500Risedronate 1000Rofecoxib 1000Secobarbital 1000Serotonin 1000

Sibutramine HCL 250Sildenafil 1000Temazepam 10011-nor-∆9-THC-9-COOH 150Tolmetin Sodium 1000Tramadol 500Tranylcypromine 125Trifluoperazine 16Trihexylphenidyl 62.5Trimethoprim 1000Tryptamine 100l-Tryptophan 100Tyramine 1000Zolpidem 100

32


Emit® II Plus – Methadone


Definitions of CategoriesNegative Concentration of drug tested in μg/mL that gave an assay response less than the cutoff calibrator. The concentration of

the listed compound is higher than normally seen in patients taking this drug.

User Notes

33


The Methadone Assay has two cutoffs: 150 ng/mL and 300 ng/mL methadone.

Positive

For Methadone only.


34



NegativeThe compounds below were negative for the Methadone 150 and 300 cutoffs at the concentrations shown except where noted. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 1000Alprazolam 10005-Aminosalicyclic Acid 1000Amitriptyline @ 150 25Amitriptyline @ 300 50Amlodipine 1000Amoxicillin 1000d-Amphetamine 1000Atomoxetine 500Atorvastatin 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benzoylecgonine 1000Bromphenirmaine 1929Buprenorphine @ 150 100Buprenorphine @ 300 1000Bupropion 1000Caffeine 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpheniramine 500Chlorpromazine 125Cimetidine 1000Ciprofloxacin 1000Citalopram 125Clomipramine 2.5Clonazepam 1000Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Codeine 500Cotinine 100Cyclobenzaprine @ 150 28Cyclobenzaprine @ 300 62.5Desipramine 800Dextromethorphan 1000Diazepam 1000Diclofenac 1000Diltiazem 1000Diphenhydramine @ 150 250Diphenhydramine @ 300 500Doxepin @ 150 10Doxepin @ 300 125Doxycycline 1000Doxylamine @ 150 100Doxylamine @ 300 250EDDP (2-Ethylidene-1,5-dimethyl- 3, 3-diphenylpyrrolidine) 1000

Enalapril Maleate 1000Ephedrine 1000Escitalopram 125Escomeprazole 1000Eszopiclone 1000Ezetimibe 1000Fentanyl 1000Fexofenadine 1000Fluoxetine 500Fluticasone Proprionate 1000Furosemide 1000Gabapentin 1000Glutethimide 500Glyburide 1000Griseofulvin 1000Hydrochlorothiazide 1000Hydrocodone 1000Hydromorphone 1000Ibuprofen 1000d,l-Isoproterenol 1000Isoxsuprine 1000Ketamine 100Ketoprofen 1000Ketorolac Tromethamine 1000LAAM(l-α-Acetylmethadol)@150 2LAAM(l-α-Acetylmethadol)@300 5dinorLAAM(α-Acetyl-N, N-dinormethadol) 25Lamotrigine 1000Lansoprazole 1000Levofloxacin 1000Lidocaine 1000Lisinopril 1000Lormetazepam 1LSD (Lysergic acid diethylamide) 0.01L-α-Methadol 2MDA (Methylenedioxyamphetamine) 5MDMA (Methylenedioxy- methampheamine) 200Meloxicam 1000Meperidine @ 150 250Meperidine @ 300 500Meprobamate 1000Metaproterenol 1000Metformin 1000d-Methamphetamine @ 150 2d-Methamphetamine @ 300 35Methaqualone 1500Metoprolol Tartrate 1000Metronidazole 1000

35




Myoglobin 287Morphine 1000NAPA(N-Acetylprocainamide) 400Naproxen 1000Nefazodone 1000Nortriptyline 750Nylidrin 1000Omeprazole 1000Oxazepam 300Oxycodone 1000Oxymorphone 1000Paroxetine 750PCP (Phencyclidine) 1000PPA (Phenylpropanolamine) 100Phenytoin (DPH) 1000Pioglitazone 1000Pravastatin 1000Prednisone 1000Promethazine @ 150 37Promethazine @ 300 75Propofol 1000Propoxyphene 1000Propranolol 1000Pseudoephedrine 1000Quetiapine Fumerate 1000Quinapril 1000Rabeprazole 1000Ramipril 1000Ranitidine 1000

Ranitidine @ 150 900Risedronate @ 300 1000Risperidone 1000Rofecoxib 1000Scopolamine 500Secobarbital 1000Sertraline 500Sibutramine HCL 1000Sildenafil 1000Simvastatin 100011-nor-∆9-THC-9-COOH @ 150 0.211-nor-∆9-THC-9-COOH @ 300 100Thioridazine 100Thyroxine 1000Tolmetin Sodium 1000Topiramate 1000Tramadol @ 150 100Tramadol @ 300 1000Tranylcypromine 1000Trazadone 1000Trifluoperazine 250Trihexylphenidyl 1000Trimethoprim 1000Tyramine 100Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100

36


Emit® II Plus – Methaqualone



concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, 3’-Hydroxy-methaqualone is listed as 438 for the Methaqualone assay. This means that it takes a concentration of 438 ng/mL 3’-Hydroxy-methaqualone in urine to produce an instrument response equal to the 300 ng/mL Methaqualone calibrator. This concentration of drug in urine may be achieved in patients taking Methaqualone.


User Notes

37



The Methaqualone Assay has one cutoff: 300 ng/mL methaqualone.

Positive – The drugs listed are in ng/mL at which they will cross-react equivalent to the methaqualone cutoff.

300 Cutoff3’-Hydroxy-methaqualone 4384’-Hydroxy-methaqualone 2332’-Hydroxymethyl-methaqualone 1670Mecloqualone 290

38



NegativeThe compounds below were negative for the Methaqualone 300 cutoff at the concentrations shown. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 1000Alprazolam 1000Amitriptyline 1000Amlodipine 1000Amoxicillin 1000d-Amphetamine 1000Atomoxetine 1000Atorvastatin 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benzoylecgonine 1000Buprenorphine 1000Bupropion 1000Caffeine 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpromazine 1000Cimetidine 1000Ciprofloxacin 1000Citalopram 1000Clomipramine 2.5Clonazepam 1000Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Codeine 500Cotinine 100Cyclobenzaprine 1000Desipramine 800Dextromethorphan 1000Diazepam 1000Diclofenac 1000Diltiazem 1000Diphenhydramine 1000Doxepin 1000Doxycycline 1000Doxylamine 1000Enalapril Maleate 1000Ephedrine 1000Escitalopram 1000Escomeprazole 1000Eszopiclone 1000Ezetimibe 1000Fentanyl 1000

Fexofenadine 1000Fluoxetine 1000Fluticasone Proprionate 1000Furosemide 1000Gabapentin 1000Glutethimide 500Glyburide 1000Griseofulvin 1000Hydrochlorothiazide 1000Hydrocodone 1000Hydromorphone 1000Ibuprofen 1000d,l-Isoproterenol 1000Isoxsuprine 1000Ketamine 100Ketoprofen 1000Ketorolac Tromethamine 1000LAAM(l-α-Acetylmethadol) 25dinorLAAM(α-Acetyl-N,N-dinormethadol) 25Lamotrigine 1000Lansoprazole 1000Levofloxacin 1000Lidocaine 1000Lisinopril 1000Lormetazepam 1LSD (Lysergic acid diethylamide) 0.01MDA (Methylenedioxyamphetamine) 5MDMA (Methylenedioxymethampheamine) 200Meloxicam 1000Meperidine 1000Meprobamate 1000Metaproterenol 1000Metformin 1000Methadone 1000d-Methamphetamine 35Metoprolol Tartrate 1000Metronidazole 1000Morphine 1000NAPA(N-Acetylprocainamide) 400Naproxen 1000Nefazodone 1000Nortriptyline 1000Nylidrin 1000Omeprazole 1000Oxazepam 300Oxycodone 1000Oxymorphone 1000Paroxetine 1000PCP (Phencyclidine) 1000

39




Phenytoin (DPH) 1000Pioglitazone 1000Pravastatin 1000Prednisone 1000Promethazine 1000Propofol 1000Propoxyphene 1000Propranolol 1000Pseudoephedrine 1000Quetiapine Fumerate 1000Quinapril 1000Rabeprazole 1000Ramipril 1000Ranitidine 1000Risedronate 1000Risperidone 1000Rofecoxib 1000Scopolamine 500Secobarbital 1000Sertraline 1000

Sibutramine HCl 1000Sildenafil 1000Simvastatin 100011-nor-∆9-THC-9-COOH 100Thioridazine 100Thyroxine 1000Tolmetin Sodium 1000Topiramate 1000Tramadol 1000Tranylcypromine 1000Trazadone 1000Trifluoperazine 1000Trihexylphenidyl 1000Trimethoprim 1000Tyramine 100Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100

40


Emit® II Plus – Opiate



concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, 6-Acetylmorphine is listed as 435 for the Opiate assay at 300 ng/mL cutoff. This means that it takes a concentration of 435 ng/mL 6-Acetylmorphine in urine to produce an instrument response equal to the 300 ng/mL morphine calibrator. This concentration of drug in urine may be achieved in patients taking Heroin.

Negative - Structurally Related Concentration in μg/mL of listed drug that gives an assay response equal to the cutoff calibrator. The concentration of the listed compound is NOT clinically significant, and is not generally encountered in individuals taking the listed drug. For example, Oxymorphone is listed as 9.3 for the Opiate assay at 300 ng/mL cutoff. This means that it takes 9.3 μg/mL (9,300 ng/mL) of Oxymorphone to produce an instrument response equal to the 300 ng/mL morphine calibrator. This concentration of drug in urine is higher than normally seen in patients taking this drug.


User Notes

41



The Opiate Assay has two cutoffs: 300 ng/mL and 2000 ng/mL morphine.

Positive – The drugs listed are in ng/mL at which they will cross-react equivalent to the morphine cutoff.

300 Cutoff 2000 Cutoff6-Acetylmorphine 435 4182Codeine 102–306 660–1980Dihydrocodeine 291 1872Hydrocodone 247 1545Hydromorphone 498 5349Levofloxacin 125000 –Levorphanol 1048 4700Morphine-3-Glucuronide 626 6167Nalorphine 5540 (see below)Naloxone 11000 (see below)Normorphine 1200 –Ofloxacin 330 –Oxycodone 1500 (see below)Pholcodine 320 1400

Negative — Structurally Related – The drugs listed are in µg/mL at which they will cross-react equivalent to the morphine cutoff.

300 Cutoff 2000 CutoffLevallorphan >5 >120Meperidine >15 >400Nalorphine (see above) >100Naloxone (see above) >350Oxycodone (see above) 48Oxymorphone 9.3 >100

42



NegativeThe compounds below were negative for the Opiate 300 and 2000 cutoffs at the concentrations shown except where noted. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 1000Alprazolam 10005-Aminosalicyclic Acid 1000Amitriptyline @ 300 500Amitriptyline @ 2000 1000Amlodipine 1000Amoxicillin 1000d-Amphetamine 1000Atomoxetine 1000Atorvastatin 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benzoylecgonine 1000Buprenorphine 1000Bupropion 1000Caffeine 1000Carisoprodol 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpheniramine 1000Chlorpromazine 125Cimetidine 1000Ciprofloxacin 1000Citalopram 1000Clomipramine 2.5Clonazepam 1000Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Cotinine 100Cyclobenzaprine 63Desipramine 800Dextromethorphan 63Dezocine 1000Diazepam 1000Diclofenac 1000Dihydroergotamine 1000Diltiazem 1000Diphenhydramine 1000Dothiepin 100Doxepin 10Doxycycline 1000Doxylamine 500Droperidol 1000EDDP 2-Ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidine 1000

EMDP 100Enalapril Maleate 1000Ephedrine 1000Escitalopram 1000Escomeprazole 1000Eszopiclone 1000Ezetimibe 1000Fentanyl 1000Fexofenadine 1000Fluoxetine 900Fluticasone Proprionate 1000Furosemide 1000Gabapentin 1000Glutethimide 500Glyburide 1000Goldenseal tea solutionGriseofulvin 1000Hydrochlorothiazide 1000Ibuprofen 1000d,l-Isoproterenol 1000Isoxsuprine 1000Ketamine 100Ketoprofen 1000Ketorolac Tromethamine 1000LAAM(l-α-Acetylmethadol) 25dinorLAAM(α-Acetyl-N, N-dinormethadol) 25Lamotrigine 1000Lansoprazole 1000Lidocaine 1000Lisinopril 1000Loperamide 1000Lormetazepam 1LSD (Lysergic acid diethylamide) 0.01MDA (Methylenedioxyamphetamine) 5MDMA (Methylenedioxymeth ampheamine) 200Meloxicam 1000Meprobamate 1000Metaproterenol 1000Metformin 1000Methadone 100d-Methamphetamine 35Methaqualone 1500Metoprolol Tartrate 1000Metronidazole 1000Myoglobin 287Naltrexone 1000NAPA(N-Acetylprocainamide) 400Naproxen 1000Nefazodone 1000Nortriptyline 250Nylidrin 1000

43




Omeprazole 1000Oxazepam 300Paroxetine 1000PCP (Phencyclidine) 1000Phenytoin (DPH) 1000Pioglitazone 1000Pravastatin 1000Prednisone 1000Promethazine @ 300 143Promethazine @ 2000 1000Propofol 1000Propoxyphene 1000Propranolol 1000Pseudoephedrine 1000Quetiapine Fumerate 1000Quinapril 1000Rabeprazole 1000Ramipril 1000Ranitidine 900Risedronate 1000Risperidone 1000Rofecoxib 1000

Scopolamine 500Secobarbital 1000Sertraline 250Sibutramine HCL 1000Sildenafil 1000Simvastatin 100011-nor-∆9-THC-9-COOH 100Thioridazine 100Thyroxine 1000Tolmetin Sodium 1000Topiramate 1000Tramadol 1000Tranylcypromine 1000Trazadone 1000Trifluoperazine 500Trihexylphenidyl 1000Trimethoprim 1000Tyramine 100Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100

44


Emit® II Plus – Phenylcyclidine



concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, PCM is listed as 41 for the Phencyclidine assay. This means that it takes a concentration of 41 ng/mL PCM in urine to produce an instrument response equal to the 25 ng/mL Phencyclidine calibrator. This concentration of drug in urine may be achieved in patients taking PCM.

Negative - Structurally Related Concentration in μg/mL of listed drug that gives an assay response equal to the cutoff calibrator. The concentration of the listed compound is NOT clinically significant, and is not generally encountered in individuals taking the listed drug. For example, Dextromethorphan is listed as 120 for the Phencyclidine assay. This means that it takes 120 μg/mL (120,000 ng/mL) of Dextromethorphan to produce an instrument response equal to the 25 ng/mL Phencyclidine calibrator. This concentration of drug in urine is higher than normally seen in patients taking this drug.


User Notes

45



The Phencyclidine Assay has one cutoff: 25 ng/mL phencyclidine.

Positive – The drugs listed are in ng/mL at which they will cross-react equivalent to the phencyclidine cutoff.

25 Cutoff1-(1-Phenylcyclohexyl)morpholine (PCM) 411-(1-Phenylcyclohexyl)pyrrolidine (PCPy) 541-(4-Hydroxypiperidino)phenylcyclohexane 4201-[1-(2-Thienyl)-cyclohexyl]morpholine (TCM) 801-[1-(2-Thienyl)-cyclohexyl]piperidine (TCP) 371-[1-(2-Thienyl)-cyclohexyl]pyrrolidine (TCPy) 834-Phenyl-4-piperidinocyclohexanol 32N,N-Diethyl-1-phenylcyclohexylamine (PCDE) 234Chlorpromazine #

# While chlorpromazine does not cross- react, patients taking chlorpromazine may produce positive results with this assay.

Negative — Structurally Related – The drugs listed are in µg/mL at which they will cross-react equivalent to the phencyclidine cutoff.

25 CutoffDextromethorphan 120Dextrorphan 97Meperidine 67Mesoridazine 50

46



NegativeThe compounds below were negative for the Phencyclidine 25 cutoff at the concentrations shown. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 1000Alprazolam 10005-Aminosalicyclic Acid 1000Amitriptyline 125Amlodipine 1000Amoxicillin 1000d-Amphetamine 1000Atomoxetine 1000Atorvastatin 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benzoylecgonine 1000Buprenorphine 1000Bupropion 1000Caffeine 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpheniramine 125Cimetidine 1000Ciprofloxacin 1000Citalopram 750Clomipramine 2.5Clonazepam 1000Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Codeine 500Cotinine 100Cyclobenzaprine 62Desipramine 800Diazepam 1000Diclofenac 1000Diltiazem 1000Diphenhydramine 1000Doxepin 250Doxycycline 1000Doxylamine 1000EDDP (2-Ethylidene-1,5-dimethyl- 3, 3-diphenylpyrrolidine) 1000Enalapril Maleate 1000Ephedrine 1000Escitalopram 750Escomeprazole 1000Eszopiclone 1000Ezetimibe 1000Fentanyl 1000

Fexofenadine 1000 Fluoxetine 1000Fluticasone Proprionate 1000Furosemide 1000Gabapentin 1000Glutethimide 500Glyburide 1000Griseofulvin 1000Hydrochlorothiazide 1000Hydrocodone 250Hydromorphone 500Ibuprofen 1000d,l-Isoproterenol 1000Isoxsuprine 1000Ketamine 100Ketoprofen 1000Ketorolac Tromethamine 1000LAMM(l-α-Acetylmethadol)25dinor LAAM (α-Acetyl-N,N-dinormethadol)15Lamotrigine 1000Lansoprazole 1000Levofloxacin1000Lidocaine 1000Lisinopril 1000Lormetazepam 1LSD (Lysergic acid diethylamide) 0.01MDA (Methylenedioxyamphetamine) 5MDMA (Methylenedioxymethampheamine) 200Meloxicam 1000Meprobamate 1000Metaproterenol 1000Metformin 1000Methadone 1000d-Methamphetamine 35Methaqualone 1500Metoprolol Tartrate 1000Metronidazole 1000Morphine 58NAPA(N-Acetylprocainamide)400Naproxen1000Nefazodone1000Nortriptyline1000Nylidrin1000Omeprazole 1000Oxazepam 300Oxycodone 1000Oxymorphone 1000Paroxetine 1000Phenethylamine 1000Phenytoin (DPH) 1000Pioglitazone 1000

47




Pravastatin 1000Prednisone 1000Promethazine 170Propofol 1000Propoxyphene 1000Propranolol 1000Pseudoephedrine 1000Quetiapine Fumerate 1000Quinapril 1000Rabeprazole 1000Ramipril 1000Ranitidine 900Risedronate 1000Risperidone 1000Rofecoxib 1000Scopolamine 500Secobarbital 1000Sertraline 1000Sibutramine HCL 1000

Sildenafil 1000Simvastatin 100011-nor-∆9-THC-9-COOH 50Thioridazine 48Thyroxine 1000Tolmetin Sodium 1000Topiramate 1000Tramadol 1000Tranylcypromine 1000Trazadone 1000Trifluoperazine 1000Trihexylphenidyl 125Trimethoprim 1000Tyramine 100Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100

48


Emit® II Plus – Propoxyphene



concentration of the listed compound is clinically significant, and may be encountered in individuals taking the listed drug. For example, Norpropoxyphene is listed as 800 for the Propoxyphene assay. This means that it takes a concentration of 800 ng/mL Norpropoxyphene in urine to produce an instrument response equal to the 300 ng/mL Propoxyphene calibrator. This concentration of drug in urine may be achieved in patients taking Propoxyphene.

Negative – Equivalent Concentration Concentration in μg/mL of listed drug that gives an assay response equal to the cutoff calibrator. The concentration of the listed compound is NOT clinically significant, and is not generally encountered in individuals taking the listed drug. For example, Imipramine is listed as 30 for the Propoxyphene assay. This means that it takes 30 μg/mL ( 30,000 ng/mL) of Imipramine to produce an instrument response equal to the 300 ng/mL Propoxyphene calibrator. This concentration of drug in urine is higher than normally seen in patients taking this drug.


User Notes

49



The Propoxyphene Assay has one cutoff: 300 ng/mL propoxyphene.

Positive – The drugs listed are in ng/mL at which they will cross-react equivalent to the propoxyphene cutoff.

300 CutoffChlorpromazine 7800Norpropoxyphene 800

Negative – Equivalent Concentration - The drugs listed are in µg/mL at which they will cross-react equivalent to the propoxyphene cutoff.

300 CutoffEDDP (2-Ethylidene-1,5-dimethyl-3, 3-diphenylpyrrolidine) 5000Imipramine 30

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NegativeThe compounds below were negative for the Propoxyphene 300 cutoff at the concentrations shown. Concentrations listed are in µg/mL.

Acetaminophen 1000Acetylsalicylic Acid 1000Albuterol 1000Alendronate 1000Alprazolam 10005-Aminosalicyclic Acid 1000Amitriptyline 125Amlodipine 1000Amoxetine 31Amoxicillin 1000d-Amphetamine 1000Atomoxetine 1000Atorvastatin 1000Azathioprine 1000Azithromycin 1000AZT (Zidovudine) 2000Benazepril 1000Benzoylecgonine 1000Buprenorphine 1000Bupropion 1000Caffeine 1000Celecoxib 1000Cephalexin 1000Cetirizine 1000Chlorpheniramine 500Cimetidine 1000Ciprofloxacin 1000Citalopram 1000Clomipramine 2.5Clonazepam 1000Clonidine 1000Clopidogrel Hydrogen Sulfate 1000Clotrimazole 1000Codeine 500Cotinine 100Cyclobenzaprine 7.8Desipramine 5Dextromethorphan 1000Diazepam 1000Diclofenac 1000Diltiazem 1000Diphenhydramine 1000Doxepin 31Doxycycline 1000Doxylamine 500Enalapril Maleate 1000Ephedrine 1000Escitalopram 1000

Escomeprazole 1000Eszopiclone 1000Ezetimibe 1000Fentanyl 1000Fexofenadine 1000Fluoxetine 125Fluticasone Proprionate 1000Furosemide 1000Gabapentin 1000Glutethimide 500Glyburide 1000Griseofulvin 1000Hydrochlorothiazide 1000Hydrocodone 900Hydromorphone 1000Ibuprofen 1000d,l-Isoproterenol 1000Isoxsuprine 1000Ketamine 100Ketoprofen 1000Ketorolac Tromethamine 1000LAMM(l-α-Acetylmethadol)25dinor LAAM (α-Acetyl-N,N-dinormethadol)25Lamotrigine 1000Lansoprazole 1000Levofloxacin1000Lidocaine 1000Lisinopril 1000Lormetazepam 1LSD (Lysergic acid diethylamide) 0.01MDA (Methylenedioxyamphetamine) 5MDMA (Methylenedioxymethampheamine) 200Meloxicam 1000Meperidine 1000Meprobamate 1000Metaproterenol 1000Metformin 1000Methadone 100d-Methamphetamine 35Methaqualone 1500Metoprolol Tartrate 1000Metronidazole 1000Morphine 1000Myoglobin 287NAPA(N-Acetylprocainamide)400Naproxen1000Nefazodone1000Nortriptyline31Nylidrin1000

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Omeprazole 1000Oxazepam 300Oxycodone 1000Oxymorphone 1000Paroxetine 1000PCP (Phencyclidine) 250Phenytoin (DPH) 1000Pioglitazone 1000Pravastatin 1000Prednisone 1000Promethazine 125Propofol 1000Propranolol 1000Pseudoephedrine 1000Quetiapine Fumerate 1000Quinapril 1000Rabeprazole 1000Ramipril 1000Ranitidine 1000Risedronate 1000Risperidone 1000Rofecoxib 1000

Scopolamine 500Secobarbital 1000Sertraline 31Sibutramine HCL 1000Sildenafil 1000Simvastatin 100011-nor-∆9-THC-9-COOH 100Thioridazine 100Thyroxine 1000Tolmetin Sodium 1000Topiramate 1000Tramadol 1000Tranylcypromine 1000Trazadone 1000Trifluoperazine 125Trihexylphenidyl 1000Trimethoprim 1000Tyramine 100Venlafaxine 1000Verapamil 1000Warfarin 1000Zolpidem 100

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Emit® II Plus – Absorbance Flags

Absorbance Flags

The compounds listed below may cause absorbance flags with any of the Emit® II Plus Drug of Abuse assays.

Amiordarone OfloxacinCiprofloxacin PyridiumDiflunisal SolindacGriseofluvin SulfasalazineMefenamic Acid Tolmetin SodiumMetronidazole Zomepiral

Call your local Technical Solutions Center if instrument errors or flags are encountered in the presence of these compounds.

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