endocrine physiology - florida international university
TRANSCRIPT
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Endocrine Physiology
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1. Introduction to Endocrine Principles
Amount of hormone Receptor levels
Half life of hormones
Carrier proteins
Metabolism: activation and inactivation
Chemical messenger
Target cell
Endocrine cell
Hormones are Chemical messenger with a half life and a target cell
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Location of Receptor Classes of Hormones Principle Mechanism of Action
Cell surface
receptors (plasma
membrane)
Proteins and peptides,
catecholamines and
eicosanoids
Generation of second messengers which alter
the activity of other molecules - usually enzymes
- within the cell
Intracellular
receptors (cytoplasm
and/or nucleus)
Steroids and thyroid
hormonesAlter transcriptional activity of responsive
genes
There are TWO major groups of hormones
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Peptide and protein hormones consist of assemblages of amino acids
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Aedes aegypti
1 Mrpsttpmvllsylafvlclacvaygssalgsssgssdqslfgggagggggsasaesdig
61 ddrgqreisqatfqhmlavrspkynfglgkrryiiedvpgrlphynfglgkrarnnll
121 eydddsapswsedyssliprdgldydgdkdksaekrasayryhfglgkrrvydfglgkrv
181 yedkrlpnrynfglgkr
Anopheles gambiae
1 Mlalsayvtlslclsvswslpagggtagssssssndldmddlsrdrvsgqgeistsqfqh
61 mlavrspkynfglgkrryiiedvpgrlphynfglgkrgspmggndyeydglmggnqlg
121 wndndytnlitkdgqfdydaekekdaakrtasgngrgsayryhfglgkrraydfglgkry
181 fdaedfnkrlpnrynfglgkr
SPKYNFGLG Aedes 1
SPKYNFGLG Anopheles 1
LPHYNFGLG Aedes 2
LPHYNFGLG Anopheles 2
ASAYRYHFGLG Aedes 3
GSAYRYHFGLG Anopheles 3
RVYDFGLG Aedes 4
RAYDFGLG Anopheles 4
LPNRYNFGLG Aedes 5
LPNRYNFGLG Anopheles 5
197 AA pre-proprotein. 5 allatostatins (8-11 AA). Allatostatin “A”
Peptidic Hormones can be synthesized as larger pre-prohormones
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Amine hormones are derived from amino acids
Peripheral activation
Deiodinases
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Location of Receptor Classes of Hormones Principle Mechanism of Action
Cell surface
receptors (plasma
membrane)
Proteins and peptides,
catecholamines and
eicosanoids
Generation of second messengers which alter
the activity of other molecules - usually enzymes
- within the cell
Peptide and protein hormones act through cell membrane receptors
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Peptide and protein hormones act through generation of second messengers
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Steroid hormones are derived from cholesterol
glucocorticoidsmineralocorticoids
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Location of Receptor Classes of Hormones Principle Mechanism of Action
Intracellular
receptors (cytoplasm
and/or nucleus)
Steroids and thyroid
hormones
Alter transcriptional activity of responsive
genes
Lypophyllic hormones
Delay of response
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Mechanism of action of Steroid hormones
Activation of transcription
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1. Direct interaction with DNA elements
2. Cross-talk with another DNA-bound transcription factors
3. Interaction with both DNA elements and others TFs
General transcription machinery
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Lypophyllic hormones
Phosphoenolpyruvate
carboxykinase
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Pre-prohormone
Snapshots of insulin synthesis, processing, and packaging
2. Synthesis, Storage, and Release of Hormones
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3. Types of Endocrine glands and cells
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4. Control of Endocrine Systems
AXIS: One endocrine gland acting on another endocrine gland
TRH
TSH
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The vertebrate pituitary gland
Neural control of neurosecretory cells
Action potential --- release hormones
Neurosecretory control of endocrine cells
Release factors --- synthesize hormones.
Neurohypophysis. Adenohypophysis.
Portal system
AXIS: One endocrine gland acting on another endocrine gland
endocrine cells
Neurosecretory cells
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The vertebrate pituitary gland
Effects on nonendocrine glands.
Effects on endocrine glands.
Adenohypophysis.
Thyroid -stimulating
Adrenocorticotropic
Melanocyte-stimulating
Luteinizing Follicule-StimTropins: support and
maintain tissues, regulates
activity
synthesize hormones.
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Neurohypophysis.
The vertebrate pituitary gland
Oxytocin (uterus contraction and milk ejection)
Antidiuretic hormone
(urine production)
release hormones
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Both hormonal and neural mechanisms modulate the action of the HPA (Hypot-pituit-adrenal) axis
Axis: one endocrine gland (EG) modulating another EG
Corticotropin releasing
adenocorticotropin
HPA axis CNS
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There is synergism and antagonism among hormones
Amplify effect
opposite effect
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The mammalian stress response includes two phases
Stress response: respond to a threatening situation
adrenaline
+
+
Corticotropin releasing
adenocorticotropin
Stop Feeding
Stop reproduction
Increase circulation
Increase breathing
Increase metabolism
Increase activity CNS
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The mammalian stress response and blood losses
Adrenaline: + Heart and blood pressure
Wound and blood loss : blood volume and blood pressure
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The CNS and the immune system interact during the stress response
Cytokines
Stress helps to fight
infection.
Reduces inflammation
and modulate immune
response.
neuroimmunomodulation
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Anti diuretic hormone (Vasopressin) regulates
the balance of water
Aquaporin-2 is regulated.
Aquaporin-3 is constitutive.
Endocrine control of salt and Water Balance
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The renin–angiotensin–aldosterone system
Aldosterone stimulates the
conservation of sodiumSodium pumps
and channels
Angiotensinogen : large protein
Angiotensin I : 10 AA
Angiotensin II : 8 AA
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Endocrine & neuroendocrine structures involved in control of insect
reproduction and metamorphosis
3 tissues
2 hormones
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Endocrine control of insect metamorphosis