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Endometrial Preparation for Frozen Embryo Transfer (FET)
Zitao Liu MD PhD
New Hope Fertility Center NY
Natural Cycle
FET Protocol for endometrial preparation
bull N FET including modified N FET
bull HRT FET Estrogen Progesterone
Priming Estrogen in HRT FET
bull 075 mg of micronized estradiol (oral administration)
bull 125 g of estradiol gel (transdermal administration)
bull 1 mg of estradiol valerate (oral or vaginal administration)
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) I
Borini A et al Effect of duration of estradiol replacement on the outcome of oocyte donation J Assist Reprod Genet 2001 Apr18(4)185-90
Conclusions bull Endometrial receptivity a
wide duration of E2 treatment (until 2 months)
bull Breakthrough bleeding gt40 day 72
bull SAB le10 d significant higher
bull The best results 11 to about 40 days
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) II
Soares SR et al Age and uterine receptiveness predicting the outcome of oocyte donation cycles J Clin Endocrinol Metab 2005904399ndash4404
Endometrial preparation estrogen therapy lasting more than 7 wk is associated with reduced PR and IR (P = 001 and P = 002 respectively)
N FET vs modified N FET
Criteria for HCG administration included (i) visualization of a leading follicle gt17 mm in diameter by TVS (ii) serum oestradiol concentration gt150 pgml and (iii) serum progesterone concentration lt1 ngml
Criteria for ovulation detection included (i) fall in serum oestradiol concentration compared with the previous test (ii) rise in serum progesterone concentration gt15 ngml and (iii) disappearance or typical change in the shape of the lead follicle
Weissman A et al What is the preferred method for timing natural cycle frozen-thawed embryo transfer Reprod Biomed Online 20091966ndash71
GnRH agonist to prevent ovulation in FET
Glujovsky D et al Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes Cochrane Database Syst Rev 20101art no CD006359
Elevated Progesterone before trigger in N FET (I)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (II)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Natural Cycle
FET Protocol for endometrial preparation
bull N FET including modified N FET
bull HRT FET Estrogen Progesterone
Priming Estrogen in HRT FET
bull 075 mg of micronized estradiol (oral administration)
bull 125 g of estradiol gel (transdermal administration)
bull 1 mg of estradiol valerate (oral or vaginal administration)
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) I
Borini A et al Effect of duration of estradiol replacement on the outcome of oocyte donation J Assist Reprod Genet 2001 Apr18(4)185-90
Conclusions bull Endometrial receptivity a
wide duration of E2 treatment (until 2 months)
bull Breakthrough bleeding gt40 day 72
bull SAB le10 d significant higher
bull The best results 11 to about 40 days
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) II
Soares SR et al Age and uterine receptiveness predicting the outcome of oocyte donation cycles J Clin Endocrinol Metab 2005904399ndash4404
Endometrial preparation estrogen therapy lasting more than 7 wk is associated with reduced PR and IR (P = 001 and P = 002 respectively)
N FET vs modified N FET
Criteria for HCG administration included (i) visualization of a leading follicle gt17 mm in diameter by TVS (ii) serum oestradiol concentration gt150 pgml and (iii) serum progesterone concentration lt1 ngml
Criteria for ovulation detection included (i) fall in serum oestradiol concentration compared with the previous test (ii) rise in serum progesterone concentration gt15 ngml and (iii) disappearance or typical change in the shape of the lead follicle
Weissman A et al What is the preferred method for timing natural cycle frozen-thawed embryo transfer Reprod Biomed Online 20091966ndash71
GnRH agonist to prevent ovulation in FET
Glujovsky D et al Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes Cochrane Database Syst Rev 20101art no CD006359
Elevated Progesterone before trigger in N FET (I)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (II)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
FET Protocol for endometrial preparation
bull N FET including modified N FET
bull HRT FET Estrogen Progesterone
Priming Estrogen in HRT FET
bull 075 mg of micronized estradiol (oral administration)
bull 125 g of estradiol gel (transdermal administration)
bull 1 mg of estradiol valerate (oral or vaginal administration)
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) I
Borini A et al Effect of duration of estradiol replacement on the outcome of oocyte donation J Assist Reprod Genet 2001 Apr18(4)185-90
Conclusions bull Endometrial receptivity a
wide duration of E2 treatment (until 2 months)
bull Breakthrough bleeding gt40 day 72
bull SAB le10 d significant higher
bull The best results 11 to about 40 days
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) II
Soares SR et al Age and uterine receptiveness predicting the outcome of oocyte donation cycles J Clin Endocrinol Metab 2005904399ndash4404
Endometrial preparation estrogen therapy lasting more than 7 wk is associated with reduced PR and IR (P = 001 and P = 002 respectively)
N FET vs modified N FET
Criteria for HCG administration included (i) visualization of a leading follicle gt17 mm in diameter by TVS (ii) serum oestradiol concentration gt150 pgml and (iii) serum progesterone concentration lt1 ngml
Criteria for ovulation detection included (i) fall in serum oestradiol concentration compared with the previous test (ii) rise in serum progesterone concentration gt15 ngml and (iii) disappearance or typical change in the shape of the lead follicle
Weissman A et al What is the preferred method for timing natural cycle frozen-thawed embryo transfer Reprod Biomed Online 20091966ndash71
GnRH agonist to prevent ovulation in FET
Glujovsky D et al Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes Cochrane Database Syst Rev 20101art no CD006359
Elevated Progesterone before trigger in N FET (I)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (II)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Priming Estrogen in HRT FET
bull 075 mg of micronized estradiol (oral administration)
bull 125 g of estradiol gel (transdermal administration)
bull 1 mg of estradiol valerate (oral or vaginal administration)
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) I
Borini A et al Effect of duration of estradiol replacement on the outcome of oocyte donation J Assist Reprod Genet 2001 Apr18(4)185-90
Conclusions bull Endometrial receptivity a
wide duration of E2 treatment (until 2 months)
bull Breakthrough bleeding gt40 day 72
bull SAB le10 d significant higher
bull The best results 11 to about 40 days
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) II
Soares SR et al Age and uterine receptiveness predicting the outcome of oocyte donation cycles J Clin Endocrinol Metab 2005904399ndash4404
Endometrial preparation estrogen therapy lasting more than 7 wk is associated with reduced PR and IR (P = 001 and P = 002 respectively)
N FET vs modified N FET
Criteria for HCG administration included (i) visualization of a leading follicle gt17 mm in diameter by TVS (ii) serum oestradiol concentration gt150 pgml and (iii) serum progesterone concentration lt1 ngml
Criteria for ovulation detection included (i) fall in serum oestradiol concentration compared with the previous test (ii) rise in serum progesterone concentration gt15 ngml and (iii) disappearance or typical change in the shape of the lead follicle
Weissman A et al What is the preferred method for timing natural cycle frozen-thawed embryo transfer Reprod Biomed Online 20091966ndash71
GnRH agonist to prevent ovulation in FET
Glujovsky D et al Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes Cochrane Database Syst Rev 20101art no CD006359
Elevated Progesterone before trigger in N FET (I)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (II)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) I
Borini A et al Effect of duration of estradiol replacement on the outcome of oocyte donation J Assist Reprod Genet 2001 Apr18(4)185-90
Conclusions bull Endometrial receptivity a
wide duration of E2 treatment (until 2 months)
bull Breakthrough bleeding gt40 day 72
bull SAB le10 d significant higher
bull The best results 11 to about 40 days
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) II
Soares SR et al Age and uterine receptiveness predicting the outcome of oocyte donation cycles J Clin Endocrinol Metab 2005904399ndash4404
Endometrial preparation estrogen therapy lasting more than 7 wk is associated with reduced PR and IR (P = 001 and P = 002 respectively)
N FET vs modified N FET
Criteria for HCG administration included (i) visualization of a leading follicle gt17 mm in diameter by TVS (ii) serum oestradiol concentration gt150 pgml and (iii) serum progesterone concentration lt1 ngml
Criteria for ovulation detection included (i) fall in serum oestradiol concentration compared with the previous test (ii) rise in serum progesterone concentration gt15 ngml and (iii) disappearance or typical change in the shape of the lead follicle
Weissman A et al What is the preferred method for timing natural cycle frozen-thawed embryo transfer Reprod Biomed Online 20091966ndash71
GnRH agonist to prevent ovulation in FET
Glujovsky D et al Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes Cochrane Database Syst Rev 20101art no CD006359
Elevated Progesterone before trigger in N FET (I)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (II)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
HRT FET Effect of Duration of Estradiol Priming (Donor Oocyte) II
Soares SR et al Age and uterine receptiveness predicting the outcome of oocyte donation cycles J Clin Endocrinol Metab 2005904399ndash4404
Endometrial preparation estrogen therapy lasting more than 7 wk is associated with reduced PR and IR (P = 001 and P = 002 respectively)
N FET vs modified N FET
Criteria for HCG administration included (i) visualization of a leading follicle gt17 mm in diameter by TVS (ii) serum oestradiol concentration gt150 pgml and (iii) serum progesterone concentration lt1 ngml
Criteria for ovulation detection included (i) fall in serum oestradiol concentration compared with the previous test (ii) rise in serum progesterone concentration gt15 ngml and (iii) disappearance or typical change in the shape of the lead follicle
Weissman A et al What is the preferred method for timing natural cycle frozen-thawed embryo transfer Reprod Biomed Online 20091966ndash71
GnRH agonist to prevent ovulation in FET
Glujovsky D et al Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes Cochrane Database Syst Rev 20101art no CD006359
Elevated Progesterone before trigger in N FET (I)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (II)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
N FET vs modified N FET
Criteria for HCG administration included (i) visualization of a leading follicle gt17 mm in diameter by TVS (ii) serum oestradiol concentration gt150 pgml and (iii) serum progesterone concentration lt1 ngml
Criteria for ovulation detection included (i) fall in serum oestradiol concentration compared with the previous test (ii) rise in serum progesterone concentration gt15 ngml and (iii) disappearance or typical change in the shape of the lead follicle
Weissman A et al What is the preferred method for timing natural cycle frozen-thawed embryo transfer Reprod Biomed Online 20091966ndash71
GnRH agonist to prevent ovulation in FET
Glujovsky D et al Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes Cochrane Database Syst Rev 20101art no CD006359
Elevated Progesterone before trigger in N FET (I)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (II)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
GnRH agonist to prevent ovulation in FET
Glujovsky D et al Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes Cochrane Database Syst Rev 20101art no CD006359
Elevated Progesterone before trigger in N FET (I)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (II)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Elevated Progesterone before trigger in N FET (I)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (II)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Elevated Progesterone before trigger in N FET (II)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Elevated Progesterone before trigger in N FET (III)
Modified N FET (hCG trigger) blastocyst transfer no luteal phase support
Groenewoud ER et al The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles Reprod Biomed Online 201734546ndash554
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
hCG supplement with progesterone supplement in FET
250 unit of hCG at progesterone initial supplement
Ben-Meir A et al The benefit of human chorionic gonadotropin supplementation throughout the secretory phase of frozen-thawed embryo transfer cycles Fertil Steril 201093351ndash354
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Endometrial Thickness in FET
El-Toukhy T et al The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles Fertil Steril 200889832ndash839
HRT FET
Clinical Pregnancy
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (I)
day 3 FET with luteal support using 25ndash50 mgd IMP or 8 Crinone twice daily
Kaser DJ et al Intramuscular progesterone versus 8 Crinone vaginal gel for luteal phase support for day 3 cryopreserved embryo transfer Fertil Steril 2012981464ndash1469
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Luteal Phase Support in FET Progesterone Vaginal Cream vs IM (II)
Blastocyst transfer after Crinone 8 (90 mg twice a day) or IMP (50 mg once daily) started on Day 15 of estrogen therapy
Shapiro DB et al Progesterone replacement with vaginal gel versus im injection cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts Hum Reprod 204291706ndash1711
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Luteal phase support in ET oral vs pv progesterone
bull oral dydrogesterone 30 mg daily (10mg TID) vs micronized vaginal progesterone (MVP) 600 mg daily (200mg TID) (Phase III)
bull Progesterone start at the date of OPU
Tournaye H et al A Phase III randomized controlled trial comparing the efficacy safety and tolerability of oral ydrogesterone versus micronized vaginal progesterone for luteal support in in vitro fertilization Hum Reprod 2017 321019ndash1027
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
HRT FET Progesterone level (I)
Serum progesterone at the date of blastocyst transfer intramuscular (IM) P4 at a constant 50 or 75 mg per day
Kofinas JD et al Serum progesterone levels greater than 20 ngdl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates J Assist Reprod Genet 2015321395ndash1399
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
HRT FET Progesterone level (II)
Blastocyst FET after vaginal progesterone pessary Progesterone level 2-3 days after FET
Yovich JL et al Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement Reprod Biomed Online 201531180ndash191
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
HRT FET vs N FET
Groenewoud ER et al A randomized controlled non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer Hum Reprod 2016311483ndash1492
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
HRT FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
N FET timing
Maken S et al embryo transfer a review on the optimal endometrial preparation and timing Hum Reprod 201732(11)2234-2242
Clinical practice proposal for embryo transfer timing in the different preparation methods tOR theoretical oocyte retrieval E2 estradiol P progesterone NC natural cycle
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Endometrial Receptivity transcriptomic signature (134 selected genes)
Diacuteaz-Gimeno P et al A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature Fertil Steril 20119550ndash60
Thank You
Questions
Thank You
Questions