energy production ii. protein cho fat pyruvateamino acids fatty acids acetyl-coa tca cycle and...
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Energy Production II
Protein CHO Fat
PyruvateAmino Acids
Fatty Acids
Acetyl-CoA
TCA Cycle and Electron TS
ATP produced
ATP produced
Carbohydrate
Muscle glycogen (250-300g).
Stored in muscle and used there, it is not transported in the blood.
2. Blood glucose (90 mg/100ml blood) = 5g = 1 tsp.
Not used much by most tissues except after a meal, reserved for the brain and "special" situations
At rest: 250 mg glucose/min = 20 min of glucose in blood at any one time.
.
During long, hard exercise can use 2g blood glucose/min = 2.5 min unless replaced
3. Liver glycogen (60-100g).
Breakdown of
glycogen plus gluconeogenesis
(new glucose formation from amino acids,
lactate), replaces blood glucose being used
to maintain normal blood glucose levels.
glycogen pyruvate lactate + 2ATP
glucose carbon dioxide +
water + 30-36 ATP
blood glucose
glucose glycogen
MUSCLE
LIVER
FAT
Most fatty acids used for exercise are transported from adipose tissue to muscle.
Some fat stored is stored in muscle (intramyocellular lipid or IMCL) and can be mobilized for use.
1. Requires a lot of oxygen A 16 carbon fatty acid requires 23 oxygen molecules vs. 6 O2 for glucose
2. Need to transport from adipose tissue makes fat use minimal early in exercise.
3. Cannot sustain high-intensity exercise.
4. Slow – fat must undergo beta oxidation in order to generate acetyl CoA for TCA cycle.
ProteinOnly 5-10% of energy derived from oxidation of protein. Use of protein depends heavily on:
1. Energy balance (deficit = more PRO used)2. CHO available (low = more PRO used)
Amino acids derived from body protein can be used to produce:
a. energy, via entry into TCA cycleb. glucose, via gluconeogenesis
No true storage of protein. Protein used in excess of dietary intake causes loss of lean body mass.
Consequences of extended reliance on a lot of protein for energy (e.g. for weeks, months)?
Protein CHO Fat
PyruvateAmino Acids
Fatty Acids
Acetyl-CoA
TCA Cycle and Electron TS
ATP produced
ATP produced
SummaryGoal of CHO, fat and protein breakdown is to generate ATP, the body’s energy currency.
Non-oxidative metabolism occurs in the cytosol of the cell, oxidative metabolism occurs in the mitochondria.
Acetyl CoA is the common entry point of all 3energy sources into the TCA cycle (oxidative metabolism)=