enteric defensins are essential regulators of intestinal micorbial ecology nita salzman nature...
TRANSCRIPT
Enteric defensins are essential regulators of intestinal micorbial
ecology
Nita Salzman
Nature immunolgy 11, 76-83
The problem
Friendly bacteria
?
??
Background
Mucous membrane
Lumen
Friendly bacteria
Lamina
Propria
DC
Innate proinflamatory response
Il-1, a,B-befensins
TL5,9 Cytokines
IgA
Tcell
IL-17
Previously
DEFA-5
Protection against Salmonella
Hypothesis
• Addition of DEFA5, kills Salmonella directly, therefore providing protection, or,
• DEFA5 alters intestinal flora which in turn provides protection against the pathogen.
Expression
Bacterial colonisation mRNA
So ..?
• So far,
• mice expressing functional DEFA5, have a different microbiological ecology. Which is not due to other paneth cell functions.
Recipricating data
SFB
Total numbers
Th-17 cells
The problem refined
Friendly bacteria
IL-17 T cells
Implications
• Crohns type diseases
• Probiotics
• Allergies
• Antibiotic treatments!