Layer 3: Gingival InterfaceNumerous voids and intercommunicating pathways enhance fi broblast infi ltration and cell attachment.

Layer 2: Inner Surface

Inner labyrinth catches pathways, while internal chambers enable collateral circulation and fl ow of interstitial fl uid in the membrane.

Layer 1: Defect Interface

Limited porosity supports an uptake of fl uid, helps adherence to the tooth surface, and inhibits fi broblast movement.

The Only Synthetic Bioresorbable Matrix with Unique, 3-Layer Technology

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EpiGuide® is a uniquely structured bioresorbable polylactide (PLA) membrane with many applications within guided tissue regeneration (GTR) and guided bone regeneration (GBR).

Actual Size is 18X30 mmEmbossed side faces away from the tooth’s surface.

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High-tech Architecture ––––– Maintains Space / Helps Arrest Epithelial Migration

Synthetic Construction ––––– Avoid Risks of Disease from Biological Products

Completely Resorbable –––– Second Surgery Unnecessary to Remove Membrane

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Histology Confi rms the Effective Action of Epi-Guide®

6 weeksNumerous fronds of connective tissue penetrate the Epi-Guide® barrier and new collagen fi bers begin to form within the matrix, with no evidence of acute infl ammatory response.

13 weeksFronds of connective tissue continue to penetrate the Epi-Guide® barrier and display collagen fi ber formation. The barrier remains functional despite initiation of the resorption process. Surrounding connective tissue is normal in appearance.

Visible Healing in Your Patients1. Forms a natural barrier to promote soft-tissue healing.

2. Maintains architecture and structural integrity for up to 20 weeks after implantation.

3. Complete bioresorption occurs between 6 and 12 months.

4. Regenerates tissue despite fl ap recession or if primary closure is not obtained.

P.O. Box 12339Research Triangle Park, NC 27709-2339P: 1.888.237.2767 (1.888.CERASORB)F: 919.941.9775www.RIEMSERdental.com

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Developed and manufactured byKensey Nash Corp.