et al. antimicrobial and antibiofilm activity of ...dunman, paul m., krysan, damian j., flaherty, d....

Torres N S et al Antimicrobial and Antibiofilm Activity of Synergistic Combinations of a

Commercially Available Small Compound Library With Colistin Against Pseudomonas

aeruginosa Frontiers in Microbiology |9 1ndash12 (2018)

httpdoiorg103389fmicb201802541

Zeinab Mamouei Abdullah Alqarihi Shakti Singh Shuying Xu Michael Mansour Ashraf S

Ibrahim Priya Uppuluri Alexidine dihydrochloride has broad spectrum activities against

diverse fungal pathogens (2018) httpdoiorg101128mSphere00539-18

Luke John Alderwick Panchali Kanvatirth Gurdyl Besra Rose E Jeeves Joanna Bacon

Utilisation of the Prestwick Chemical Library reg to identify drugs that inhibit the growth of

Mycobacteria 1ndash40 (2018) httpsdoiorg101101357897

Chakraborty M Sellier C Ney M Pascal V amp Charlet-berguerand N Daunorubicin

reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac

dysfunctions in a Drosophila model of myotonic dystrophy 1 1ndash12 (2018)

httpsdoiorg101242dmm032557

Aviolat H Nomineacute Y Gioria S amp Bonhoure A SynAggreg  A Multifunctional High-

Throughput Technology for Precision Study of Amyloid Aggregation and Systematic

Discovery of Synergistic Inhibitor Compounds 1ndash23 (2018)

httpsdoi101016jjmb201809009

Gina Wall Ashok K Chaturvedi Floyd L Wormley Jr Nathan P Wiederhold Hoja P Patterson Thomas F Patterson J L L-R Screening a Repurposing Library for Inhibitors of Multidrug-Resistant Candida auris Identifies Ebselen as a Repositionable Candidate for Antifungal Drug Development Antimicrob Agents Chemother (2018) httpsdoi101128AAC01084-18

Fernandez M et al Toxic Colors  The Use of Deep Learning for Predicting Toxicity of

Compounds Merely from Their Graphic Images Introduction The discovery of new chemicals

and materials plays a key role in technological innovation and (2018)

httpsdoi101021acsjcim8b00338

Palandri A Martin E Russi M amp Rera M Identification of cardioprotective drugs by

medium-scale in vivo pharmacological screening on a Drosophila cardiac model of

Friedreichrsquo s ataxia Disease Models amp Mechanisms (2018) httpsdoi101242dmm033811

Tauziede-Espariat A et al High-Throughput Drug Screening Identifies Pazopanib and

Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors Report High-

Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising

Treatments for Malignant Rhabdoid Tumors 1737ndash1745 (2017)

httpsdoi101016jcelrep201710076

Tione Buranda Catherine Gineste Yang Wu Virginie Bondu Dominique Perez Kaylin R

Lake Bruce S Edwards Larry A Sklar A High-Throughput Flow Cytometry Screen

Identifies Molecules That Inhibit Hantavirus Cell Entry Slas Discovery Vol 23 Issue 7 2018

(2018) httpsdoiorg1011772472555218766623

Melissa Conte Josselin Lupette Khawla Seddiki Coline Meiuml Lina-Juana Dolch Valeacuterie

Gros Caroline Barette Fabrice Reacutebeilleacute Juliette Jouhet Eric Mareacutechal Screening for

biologically annotated drugs that trigger triacylglycerol accumulation in the

diatomPhaeodactylum Plant Physiology (2018) httpsdoi101104pp1701804

Coutard B et al Toward the identi fi cation of viral cap-methyltransferase inhibitors by

fluorescence screening assay Antiviral Research 144 330ndash339 (2017) httpdxdoiorg101016jantiviral201706021

Jung H et al Amodiaquine improves insulin resistance and lipid metabolism in diabetic

model mice Diabetes Obes Metab 1ndash14 (2018) httpdoi101111dom13284

Sandra M W van de Wiel D Rudi de Waart Ronald P J Oude Elferink and Stan F J van

de Graaf Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the

Organic Solute Transporter a-b Cell Mol Gastroenterol Hepatol 5223ndash237 (2018)

httpdoi101016jjcmgh201711011

Astol A et al Pharmacophore-Based Repositioning of Approved Drugs as Novel

Staphylococcus aureus NorA Efflux Pump Inhibitors JMedChem 60 1598minus1604 (2017)

httpdoi101021acsjmedchem6b01439

Eren R O et al Development of a semi-automated image-based high-throughput drug

screening system Front Biosci 242ndash253 (2018)

Jones C L Njomen E Dexheimer T S amp Tepe J J Small Molecule Enhancement of 20S

Proteasome Activity Targets Intrinsically Disordered Proteins ACS Chem Biol 12

2240minus2247 (2017) httpdoi101021acschembio7b00489

O L M Meijer P van den Biggelaar R Ofman F A Wijburg N van Vlies High-

Throughput Screen Fails to Identify Compounds That Enhance Residual Enzyme Activity of

Mutant N- Acetyl- a -Glucosaminidase in Mucopolysaccharidosis Type JIMD Reports

(2017) httpdoi1010078904

Reis S Dos et al Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two

Unrelated Antiprion Drugs 35 e2174 PLoS ONE (2008)

httpdoi101371journalpone0002174

Gug F Oumata N amp Blondel M Synthesis of Conjugates of 6-Aminophenanthridine and

Guanabenz Two Structurally Unrelated Prion Inhibitors for the Determination of Their

Cellular Targets by Affinity Chromatography Bioconjugate Chem 279ndash288 (2010)

httpdoi101021bc900314n

Dos S et al Biochimie Mode of action of the antiprion drugs 6AP and GA on ribosome

assisted protein folding Biochimie 93 1047ndash1054 (2011)

httpdoi101016jbiochi201103002

Nguyen P et al Structure minus Activity Relationship Study around Guanabenz Identifies Two

Derivatives Retaining Antiprion Activity but Having Lost α 2- Adrenergic Receptor Agonistic

Activity ACS Chem Neurosci 2014 5 1075minus1082 (2014)

httpdxdoiorg101021cn5001588

Dunman Paul M Krysan Damian J Flaherty D P Methods and composition for treating

infections (2017) Patent US 20170065540A1

Dong J et al Biochimica et Biophysica Acta Bisacodyl and its cytotoxic activity on human

glioblastoma stem-like cells Implication of inositol 1 4 5-triphosphate receptor dependent

1864 1018ndash1027 (2017) httpdxdoiorg101016jbbamcr201701010

Smith C N J et al Identifying ligands at orphan GPCRs  current status using structure-

based approaches Tables of Links British Journal of Pharmacology 173 2934-2951 (2016)

httpdoi101111bph13452

Jones L H amp Bunnage M E Applications of chemogenomic library screening in drug

discovery Nat Publ Gr 16 285ndash296 (2017) httpdxdoiorg101038nrd2016244

Varbanov H P Kuttler F Banfi D Turcatti G amp Dyson J Repositioning approved drugs

for the treatment of problematic cancers using a screening approach 1ndash16 (2017)


Arvidsson P I Sandberg K Forsberg-Nilsson K

Open for collaboration an academic platform for drug discovery and development at

SciLifeLab Drug Discovery Today 2016 21(10)1690-1698

httpdoiorg101016jdrudis201606026

Bastin J Djouadi F

Resveratrol and Myopathy Nutrients 2016 8(5) 254 httpdoiorg103390nu8050254

Cappato S Tonachini L Giacopelli F Tirone M Galietta L J V Sormani M Bocciardi

R

High-throughput screening for modulators of ACVR1 transcription discovery of potential

therapeutics for fibrodysplasia ossificans progressiva Disease Models amp Mechanisms 2016

9(6) 685ndash696 httpdoiorg101242dmm023929

Chen G Masuda A Konishi H Ohkawara B Ito M Kinoshita M Ohno K

Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG

RNA foci in a mouse model of myotonic dystrophy Scientific Reports 2016 6(April) 25317

httpdoiorg101038srep25317

Cheng H Chen T Tor M Park D Zhou Q Huang J B Zhou G

A High-Throughput Screening Platform Targeting PDLIM5 for Pulmonary Hypertension

Journal of Biomolecular Screening 2016 21(4) 333ndash34

httpdoiorg1011771087057115625924

Chneiweiss H Junier M-P Etienne V

Recycler un anti-hypertenseur pour combattre les tumeurs du cerveau Communiqueacute de Presse

National (2016 April 15) Paris httpdoiorg1015252emmm201505421

Chypre M Seaman J Cordeiro O G Willen L Knoop K A Buchanan A Mueller C

G

Characterization and application of two RANK-specific antibodies with different biological

activities Immunology Letters 2016 216 171 5ndash14

httpdoiorg101016jimlet201601003

Coleman D T Gray A L Stephens C A Scott M L Cardelli J A

Repurposed drug screen identifies cardiac glycosides as inhibitors of TGF-β-induced cancer-

associated fibroblast differentiation Oncotarget 2016 7(22) 1ndash10

httpdoiorg1018632oncotarget8609

Cordeiro O G Chypre M Brouard N Rauber S Alloush F Romera-Hernandez M

Mueller C G

Integrin-alpha IIb identifies murine lymph node lymphatic endothelial cells responsive to

RANKL PLoS ONE 2016 11(3) 1ndash16 httpdoiorg101371journalpone0151848

Druzhyna N Szczesny B Olah G Moacutedis K Asimakopoulou A Pavlidou A Szabo C

Screening of a composite library of clinically used drugs and well-characterized

pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a

drug potentially suitable for repurposing for the experimental therapy of colon

Pharmacological Research 2016 113 18ndash37 httpdoiorg101016jphrs201608016

Ekins S Mietchen D Coffee M Stratton T Freundlich J Freitas-Junior L Andrade C

Open drug discovery for the Zika virus F1000Research 2016 5(0) 150

httpdoiorg1012688f1000research80131

Fattahi F Steinbeck J A Kriks S Tchieu J Zimmer B Kishinevsky S Studer L

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

Nature 2016 531(7592) 105ndash9 httpdoiorg101038nature16951

Gofshteyn J Caacuterdenas A M Bearden D

Treatment of chronic enterovirus encephalitis with fluoxetine in a patient with X-linked

agammaglobulinemia Pediatric Neurology 2016

httpdoiorg101016jpediatrneurol201606014

Guetschow E D Kumar S Lombard D B Kennedy R T

Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter

volume samples Analytical and Bioanalytical Chemistry 2016 408(3) 721ndash731

httpdoiorg101007s00216-015-9206-0

Hasegawa S Kitoh H Ohkawara B Mishima K Matsushita M Masuda A Ohno K

Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters

Biochemical and Biophysical Research Communications 2016 470(2) 356ndash361

httpdoiorg101016jbbrc201601044

Holler C J Taylor G McEachin Z T Deng Q Watkins W J Hudson K Kukar T

Trehalose upregulates progranulin expression in human and mouse models of GRN

haploinsufficiency a novel therapeutic lead to treat frontotemporal dementia Molecular

Neurodegeneration 2016 11(1) 46 httpdoiorg101186s13024-016-0114-3

Iglesias A Lage S Cadavid M I Loza M I Brea J

Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-

HT2A Receptors and Identification of Active Compounds by High-Throughput Screening

Journal of Biomolecular Screening 2016 httpdoiorg1011771087057116644162

Kang J Hsu C-H Wu Q Liu S Coster A D Posner B A Wu L F

Improving drug discovery with high-content phenotypic screens by systematic selection of

reporter cell lines Natural Biotechnology 2016 34(1) 70ndash77 httpdoiorg101038nbt3419

Koppel J Jimenez H Adrien L Greenwald B S Marambaud P Cinamon E Davies P

Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of

Alzheimerrsquos disease Alzheimerrsquos and Dementia Translational Research and Clinical

Interventions 2016 2(2) 121ndash130 httpdoiorg101016jtrci201605003

Koschmann J Poroikov V Wingender K E

Multi-omics ldquoUpstream Analysisrdquo of regulatory genomic regions helps identifying targets

against methotrexate resistance of colon cancer EUPROT 2016

httpdoiorg101016jeuprot201609002

Lopez L C Varea O Navarro S Carrodeguas J A Sanchez de Groot N Ventura S

Sancho J

Benzbromarone Quercetin and Folic Acid Inhibit Amylin Aggregation International Journal

of Molecular Sciences 2016 17(6) httpdoiorg103390ijms17060964

Nogueira U Dominguez E Loza M I Blanco F J Carames B

Identification of novel molecules targeting cartilage aging as osteoarthritis therapeutics

Osteoarthritis and Cartilage 2016 24 S18ndashS19 httpdoiorg101016jjoca201601062

Prado S Beltraacuten M Coiras M Bedoya L M Alcamiacute J Gallego J

Bioavailable inhibitors of HIV-1 RNA biogenesis identified through a Rev-based screen

Biochemical Pharmacology 2016 107 14ndash28 httpdoiorg101016jbcp201602007

Rhim J heon Luo X Gao D Xu X Zhou T Li F Xia X

Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural

progenitor cells Scientific Reports 2016 6(May) 26547 httpdoiorg101038srep26547

Sakano D Choi S Kataoka M Shiraki N Uesugi M Kume K Kume S

Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass Stem Cell Reports

2016 7(1) 95ndash109 httpdoiorg101016jstemcr201605015

Samantaray S Correia J N Garelnabi M Voelz K May R C Hall R A

Novel cell-based in vitro screen to identify small-molecule inhibitors against intracellular

replication of Cryptococcus neoformans in macrophages International Journal of

Antimicrobial Agents 2016 48(1) 69ndash77 httpdoiorg101016jijantimicag201604018

Sapi J

In Memoriam Professor Camille-Georges Wermuth European Journal of Medicinal

Chemistry 2016 108 741 httpdoiorg101016jejmech201511017

Shah E T Upadhyaya A Philp L K Tang T Skalamera D Gunter J Hollier B G

Repositioning ldquooldrdquo drugs for new causes identifying new inhibitors of prostate cancer cell

migration and invasion Clinical amp Experimental Metastasis 2016 33(4) 385ndash399

httpdoiorg101007s10585-016-9785-y

Timiri Shanmugam P S Nair R P De Benedetti A Caldito G Abreo F Sunavala-

Dossabhoy G

Tousled kinase activator gallic acid promotes homologous recombinational repair and

suppresses radiation cytotoxicity in salivary gland cells Free Radical Biology and Medicine

2016 93 217ndash226 httpdoiorg101016jfreeradbiomed201512029

Torres N S Abercrombie J J Srinivasan A Lopez-Ribot J L Ramasubramanian A K

Leung K P

Screening a Commercial Library of Pharmacologically Active Small Molecules Against

Staphylococcus aureus Biofilms Antimicrobial Agents and Chemotherapy 2016 July

AAC00377-16 httpdoiorg101128AAC00377-16

Ulferts R de Boer S M van der Linden L Bauer L Lyoo H R Mateacute M J van

Kuppeveld F J M

Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication

Inhibitors That Target Viral Protein 2C Antimicrobial Agents and Chemotherapy 2016 60(5)

2627ndash38 httpdoiorg101128AAC02182-15

Aggarwal C Jimenez J C Lee H Chlipala G E Ratia K Federle M J

Identification of quorum-sensing inhibitors disrupting signaling between Rgg and short

hydrophobic peptides in streptococci mBio 2016 6(3) 1ndash11

httpdoiorg101128mBio00393-15

Ai N Wood R D Welsh W J

Identification of Nitazoxanide as a Group I Metabotropic Glutamate Receptor Negative

Modulator for the Treatment of Neuropathic Pain An In Silico Drug Repositioning Study

Pharmaceutical Research 2015 32(8) 2798ndash807 httpdoiorg101007s11095-015-1665-7

Bergamo A Riedel T Dyson P J Sava G

Preclinical combination therapy of the investigational drug NAMI-A+ with doxorubicin for

mammary cancer Investigational New Drugs 2015 33(1) 53ndash63

httpdoiorg101007s10637-014-0175-5

Bharadwaj U Eckols T Kolosov M Kasembeli T Adam A Torres D Zhang X

Dobrolecki L Wei Wei Michael T Lewis Bhuvanesh Dave Jenny C Chang Melissa D

Landis Chad J Creighton M A Mancini and D J T

DRUG-REPOSITIONING SCREENING IDENTIFIED PIPERLONGUMINE AS A DIRECT

STAT3 INHIBITOR WITH POTENT ACTIVITY AGAINST BREAST CANCER Oncogene

2015 34(11) 1341ndash1353 httpdoiorg101038onc201472

Chrsquong J-H Moll K Quintana M del P Chan S Moles E Liu J Wahlgren M

Cell-based Screening Identifies a Rosette-Disrupting Antimalarial for the Treatment of

Plasmodium falciparum Malaria Complications Blood 2015 (February) 1ndash13


Cheung L Yu D M T Neiron Z Failes T W Arndt G M Fletcher J I

Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-

throughput bioluminescence screen Biochemical Pharmacology 2015 93(3) 380ndash388

httpdoiorg101016jbcp201411006

Corbel C Zhang B Le Parc A Baratte B Colas P Couturier C Bach S

Tamoxifen inhibits CDK5 kinase activity by interacting with p35p25 and modulates the pattern

of tau phosphorylation Chemistry and Biology 2015 22(4) 472ndash482

httpdoiorg101016jchembiol201503009

Demishtein A Porat Z Elazar Z Shvets E

Applications of flow cytometry for measurement of autophagy Methods 2015 75 87ndash95

httpdoiorg101016jymeth201412020

Diener S Schorpp K Strom T-M Hadian K Lorenz-Depiereux B

Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling

ASSAY and Drug Development Technologies 2015 13(8) 476ndash487

httpdoiorg101089adt2015653

Diener S Schorpp K Strom T Hadian K Lorenz-depiereux B Mu H Universita T


ASSAY and Drug Development Technologies 2015 (October) 476ndash487


Divorty N Mackenzie A E Nicklin S A Milligan G

G protein-coupled receptor 35 An emerging target in inflammatory and cardiovascular disease

Frontiers in Pharmacology 2015 6(MAR) 1ndash13 httpdoiorg103389fphar201500041

Grover P Shi H Baumgartner M Camacho C J Smithgall T E

Fluorescence polarization screening assays for small molecule allosteric modulators of ABL

kinase function PLOS ONE 2015 10(7) 1ndash26 httpdoiorg101371journalpone0133590

Huynh T P Barwe S P Lee S J McSpadden R Franco O E Hayward S W

Rajasekaran A K

Glucocorticoids Suppress Renal Cell Carcinoma Progression by Enhancing NaK-ATPase

Beta-1 Subunit Expression PLOS ONE 2015 10(4) e0122442

httpdoiorg101371journalpone0122442

Keillor J W Apperley K Y P Akbar A

Inhibitors of tissue transglutaminase Trends in Pharmacological Sciences 2015 36(1) 32ndash40

httpdoiorg101016jtips201410014

Lasserre J-P Dautant A Aiyar R S Kucharczyk R Glatigny A Tribouillard-Tanvier

D di Rago J-P

Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies

Disease Models amp Mechanisms 2015 8(6) 509ndash526 httpdoiorg101242dmm020438

Malergue F van Agthoven a Scifo C Egan D Strous G J

Automation of a Phospho-STAT5 Staining Procedure for Flow Cytometry for Application in

Drug Discovery Journal of Biomolecular Screening 2015 20(3) 416ndash421

httpdoiorg1011771087057114555477

Nath A K Ryu J H Jin Y N Roberts L D Dejam A Gerszten R E Peterson R T

PTPMT1 inhibition lowers glucose through succinate dehydrogenase phosphorylation Cell

Reports 2015 10(5) 694ndash701 httpdoiorg101016jcelrep201501010

Oprea T I Sklar L A Agola J O Guo Y Silberberg M Roxby J Wandinger-Ness A

Novel activities of select NSAID renantiomers against Rac1 and Cdc42 GTPases PLOS ONE

2015 10(11) 1ndash32 httpdoiorg101371journalpone0142182

Park C Y Zhou E H Tambe D Chen B Lavoie T Dowell M Krishnan R

High-throughput screening for modulators of cellular contractile force Integrative Biology 

Quantitative Biosciences from Nano to Macro 2015 7(10) 1ndash16

httpdoiorg101039c5ib00054h

Pedram Fatemi R Salah-Uddin S Modarresi F Khoury N Wahlestedt C Faghihi M A

Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using

AlphaScreen Journal of Biomolecular Screening 2015 20(9) 1132ndash41

httpdoiorg1011771087057115594187

Porcu G Serone E De Nardis V Di Giandomenico D Lucisano G Scardapane M

Ragnini-Wilson A

Clobetasol and halcinonide act as smoothened agonists to promote myelin gene expression and

RxRγ receptor activation PLOS ONE 2015 10(12) 1ndash22


Preuett B Leeder J S Abdel-Rahman S

Development and Application of a High-Throughput Screening Method to Evaluate Antifungal

Activity against Trichophyton tonsurans Journal of Biomolecular Screening 2015 20(9)

1171ndash1177 httpdoiorg1011771087057115594751

Raneri M Sciandrone B Briani F

A whole-cell assay for specific inhibitors of translation initiation in bacteria Journal of

Biomolecular Screening 2015 20(5) 627ndash33 httpdoiorg1011771087057114566376

Ratajewski M Grzelak I Wisniewska K Ryba K Gorzkiewicz M Walczak-Drzewiecka

A Dastych J

Screening of a chemical library reveals novel PXR-activating pharmacologic compounds

Toxicology Letters 2015 232(1) 193ndash202 httpdoiorg101016jtoxlet201410009

Rauthan M Pilon M

A chemical screen to identify inducers of the mitochondrial unfolded protein response in C

Elegans Worm 2015 4(4) e1096490 httpdoiorg1010802162405420151096490

Ren X-R Wang J Osada T Mook R A Morse M A Barak L S Chen W

Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor

growth Breast Cancer Research 2015 17(20) 1ndash11 httpdoiorg101186s13058-015-0528-

9

Rybniker J Vocat A Sala C Busso P Pojer F Benjak A Cole S T

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1 Nature Communications

2015 6(7659) 1ndash8 httpdoiorg101038ncomms8659

Seguin A Monnier V V Palandri A Bihel F F Rera M Schmitt M Lesuisse E

A YeastDrosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency

Oxidative Medicine and Cellular Longevity 2015 ID 565140 1ndash11

httpdoiorg1011552015565140

Srivastava G Matta A Fu G Somasundaram R T Datti A Walfish P G Ralhan R

Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens

and xenograft model Implications for oral cancer therapy Molecular Oncology 2015 9 1720ndash

1735 httpdoiorg101016jmolonc201505005

Stolp Z D Smurthwaite C A Reed C Williams W Dharmawan A Djaballah H

Wolkowicz R

A Multiplexed Cell-Based Assay for the Identification of Modulators of Pre-Membrane

Processing as a Target against Dengue Virus Journal of Biomolecular Screening 2015 20(5)


Takeuchi M Yamamoto T

Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner

Experimental Cell Research 2015 335(1) 62ndash67 httpdoiorg101016jyexcr201505019

Teixeira-Castro A Jalles A Esteves S Kang S Da Silva Santos L Silva-Fernandes A

Maciel P

Serotonergic signaling suppresses ataxin 3 aggregation and neurotoxicity in animal models of

Machado-Joseph disease Brain 2015 138 3221ndash3237 httpdoiorg101093brainawv262

Tsai S Y Maass K Lu J Fishman G I Chen S Evans T

Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling Stem

Cell Reports 2015 4 1089ndash1102 httpdoiorg101016jstemcr201504015

Vidalain P Lucas-hourani M

Activation de la reacuteponse inneacutee antivirale par des inhibiteurs de la biosynthegravese des pyrimidines

Les surprises drsquoun criblage Med Sci 2015 30(4) 98ndash104

Wasko M J Pellegrene K A Madura J D Surratt C K

A role for fragment-based drug design in developing novel lead compounds for central nervous

system targets Frontiers in Neurology 2015 6(SEP) 1ndash11

httpdoiorg103389fneur201500197

Watari A Hashegawa M Muangman T Yagi K Kondoh M

Use of cell-based screening to identify small-molecule compounds that modulate claudin-4

expression Biotechnology Letters 2015 37 1177ndash1185 httpdoiorg101007s10529-015-

1791-7

Yi N Y He Q Caligan T B Smith G R Forsberg L J Brenman J E Sexton J Z

Development of a Cell-Based Fluorescence Polarization Biosensor Using Preproinsulin to

Identify Compounds That Alter Insulin Granule Dynamics Assay and Drug Development

Technologies 2015 13(9) 558ndash569 httpdoiorg101089adt2015665

Zeniou M Fegraveve M Mameri S Dong J Salomeacute C Chen W Heeschen C

Chemical library screening and structure-function relationship studies identify bisacodyl as a

potent and selective cytotoxic agent towards quiescent human glioblastoma tumor stem-like

cells PLOS ONE 2015 1ndash35 httpdoiorg101371journalpone0134793

Ahn H J Glickman J F Poon K L Zamolodchikov D Jno-Charles O C Norris E H

Strickland S

A novel A-beta-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive

decline in Alzheimerrsquos disease mice J Exp Med 2014 211(6) 1049ndash1062

Aiyar R S Bohnert M Duvezin-Caubet S Voisset C Gagneur J Fritsch E S

Steinmetz L M

Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders Nature

Communications 2014 5(5585) 1ndash9 httpdoiorg101038ncomms6585

Alekseev S Ayadi M Brino L Egly J M Larsen A K amp Coin F

A small molecule screen identifies an inhibitor of DNA repair inducing the degradation of

TFIIH and the Chemosensitization of tumor cells to platinum Chemistry and Biology 2014

21 398ndash407 httpdoiorg101016jchembiol201312014

Allali-Hassani A Kuznetsova E Hajian T Wu H Dombrovski L Li Y Vedadi M A

Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro Journal of


Andreux P a Mouchiroud L Wang X Jovaisaite V Mottis A Bichet S Auwerx J

A method to identify and validate mitochondrial modulators using mammalian cells and the

worm C Elegans Scientific Reports 2014 4(5285) 1ndash10 httpdoiorg101038srep05285

Baell J Walters M A

Chemical con artists foil drug discovery Nature 2014 513 481ndash483

httpdoiorg101038513481a

Balsera B Mulet J Fernaacutendez-Carvajal A Torre-Martiacutenez R D La Ferrer-Montiel A

Hernaacutendez-Jimeacutenez J G Criado M

Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors A new

target for a privileged structure European Journal of Medicinal Chemistry 2014 86 724ndash739

httpdoiorg101016jejmech201409039

Bernardo S M Allen C P Waller A Young S M Oprea T Sklar L A Lee S A An

automated high-throughput cell-based multiplexed flow cytometry assay to identify novel

compounds to target Candida albicansvirulence-related proteins PLOS ONE 2014 9(10

e110354) 1ndash11 httpdoiorg101371journalpone0110354

Bharadwaj U Eckols T K Kolosov M Kasembeli M M Adam a Torres D Tweardy

D J

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with

potent activity against breast cancer Oncogene 2014 34 1341ndash1353

httpdoiorg101038onc201472

Bhuvanagiri M Lewis J Putzker K Becker J P Leicht S Krijgsveld J Kulozik A E

5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion EMBO

Molecular Medicine 2014 6(12) 1593ndash1609 httpdoiorg1015252emmm201404461

Blatt J Farag S Corey S J Sarrimanolis Z Muratov E Fourches D Janzen W P

Expanding the scope of drug repurposing in pediatrics the Childrenrsquos Pharmacy Collaborative

Drug Discovery Today 2014 19(11) 1696ndash1698 httpdoiorg101016jdrudis201408003

Chang Q Berdyshev E Cao D Bogaard J D White J J Chen S Grassi M A

Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of

photoreceptors Journal of Biological Chemistry 2014 289(12) 8337ndash8352

httpdoiorg101074jbcM113507152

Denicolaiuml E Baeza-Kallee N Tchoghandjian A Carreacute M Colin C Jiglaire C J

Figarella-Branger D Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor

xenograft growth in vivo Oncotarget 2014 5(21) 10934ndash10948


Donohue E Balgi A D Komatsu M Roberge M

Induction of covalently crosslinked p62 oligomers with reduced binding to polyubiquitinated

proteins by the autophagy inhibitor verteporfin PLOS ONE 2014 9(12) 1ndash30


Filgueira C S Benod C Lou X Gunamalai P S Villagomez R A Strom A Webb P

A screening cascade to identify ERβ ligands Nuclear Receptor Signaling 2014 12 1ndash13

httpdoiorg101621nrs12003

Garciacutea-Alcover I Colonques-Bellmunt J Garijo R Tormo J R Artero R Aacutelvarez-Abril

M C Peacuterez-Alonso M

Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput

screening in myotonic dystrophy type 1 Disease Models amp Mechanisms 2014 7(11) 1297ndash

1306 httpdoiorg101242dmm016592

Geer M A Fitzgerald M C

Energetics-based methods for protein folding and stability measurements Annual Review of

Analytical Chemistry (Palo Alto Calif) 2014 7(1) 209ndash28 httpdoiorg101146annurev-

anchem-071213-020024

Gutierrez A Pan L Groen R W J Baleydier F Kentsis A Marineau J Aster J C

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

Journal of Clinical Investigation 2014 124(2) 644ndash655 httpdoiorg101172JCI65093

Hall C J Wicker S M Chien A-T Tromp A Lawrence L M Sun X Crosier P S

Repositioning drugs for inflammatory disease-fishing for new anti-inflammatory agents

Disease Models amp Mechanisms 2014 7 1069ndash1081 httpdoiorg101242dmm016873

Kawahara G Gasperini M J Myers J A Widrick J J Eran A Serafini P R Kunkel

L M

Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling Human

Molecular Genetics 2014 23(7) 1869ndash1878 httpdoiorg101093hmgddt579

Liu C Lou W Zhu Y Nadiminty N Schwartz C T Evans C P Gao A C

Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide

resistance in castration-resistant prostate cancer Clinical Cancer Research 2014 (Vol 20)

httpdoiorg1011581078-0432CCR-13-3296

Mech L D

Chemical Genetic Identification of the Histamine H1 Receptor as a Stimulator of Insulin-

Induced Adipogenesis Chemistry amp Biology 2014 11 907ndash913 httpdoiorg101016j

Meneely K M Luo Q Riley A P Taylor B Roy A Stein R L Lamb A L

Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to

enzymes of a similar scaffold or mechanism Bioorganic and Medicinal Chemistry 2014 22

5961ndash5969 httpdoiorg101016jbmc201409010

Normand A Riviegravere E Renodon-Corniegravere A

Identification and characterization of human Rad51 inhibitors by screening of an existing drug

library Biochemical Pharmacology 2014 91 293ndash300


Nyleacuten F Miraglia E Cederlund A Ottosson H Stroumlmberg R Gudmundsson G H

Agerberth B

Boosting innate immunity Development and validation of a cell-based screening assay to

identify LL-37 inducers Innate Immunity 2014 20(4) 364ndash376

httpdoiorg1011771753425913493338

Patten S a Armstrong G a B Lissouba A Kabashi E Parker J A amp Drapeau P

Fishing for causes and cures of motor neuron disorders Disease Models amp Mechanisms 2014

7 799ndash809 httpdoiorg101242dmm015719

Pytel D Seyb K Liu M Ray S S Concannon J Huang M Glicksman M A

Enzymatic Characterization of ER Stress-Dependent Kinase PERK and Development of a

High-Throughput Assay for Identification of PERK Inhibitors J Biomol Screen 2014 2(2)

1024ndash1034 httpdoiorg1014440jbm201554A

Roumlhrig U F Majjigapu S R Chambon M Bron S Pilotte L Colau D Michielin O

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 23-

dioxygenase 1 (IDO1) inhibitors European Journal of Medicinal Chemistry 2014 84 284ndash

301 httpdoiorg101016jejmech201406078

Tegos G P Evangelisti A M Strouse J J Ursu O Bologa C Sklar L A

A high throughput flow cytometric assay platform targeting transporter inhibition Drug

Discovery Today Technologies 2014 12 e95ndashe103

httpdoiorg101016jddtec201403010

Theorell J Gustavsson A L Tesi B Sigmundsson K Ljunggren H G Lundbaumlck T

Bryceson Y T

Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural

killer cell activation Cancer Immunology Immunotherapy 2014 63 627ndash641

httpdoiorg101007s00262-014-1539-6

Voisset C Daskalogianni C Contesse M-A Mazars A Arbach H Le Cann M Blondel

M

A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr

virus Disease Models amp Mechanisms 2014 7 435ndash444 httpdoiorg101242dmm014308

Voisset C Garciacutea-Rodriacuteguez N Birkmire A Blondel M Wellinger R E

Using yeast to model calcium-related diseases Example of the Hailey-Hailey disease

Biochimica et Biophysica Acta - Molecular Cell Research 2014 1843(10) 2315ndash2321

httpdoiorg101016jbbamcr201402011

Walzl A Unger C Kramer N Unterleuthner D Scherzer M Hengstschlaumlger M

Dolznig H

The Resazurin Reduction Assay Can Distinguish Cytotoxic from Cytostatic Compounds in

Spheroid Screening Assays Journal of Biomolecular Screening 2014 19(7) 1047ndash1059

httpdoiorg1011771087057114532352

Wang J Cheng H Ratia K Varhegyi E Hendrickson W G Li J Rong L

A Comparative High-Throughput Screening Protocol to Identify Entry Inhibitors of Enveloped

Viruses Journal of Biomolecular Screening 2014 19(1) 100ndash107

httpdoiorg1011771087057113494405

Wolter J K Wolter N E Blanch A Partridge T Cheng L Morgenstern D A Irwin

M S

Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma

Oncotarget 2014 5(1) 161ndash172 httpdoiorg1018632oncotarget1083

Yang Y H C Vilin Y Y Roberge M Kurata H T Johnson J D

Multiparameter screening reveals a role for Na+ channels in cytokine-induced β-cell death

Molecular Endocrinology 2014 28(3) 406ndash417 httpdoiorg101210me2013-1257

Zhang M Luo G Zhou Y Wang S Zhong Z

Phenotypic Screens Targeting Neurodegenerative Diseases Journal of Biomolecular

Screening 2014 19(1) 1ndash16 httpdoiorg1011771087057113499777

Podolska K Sedlak D Bartunek P Svoboda P

Fluorescence-Based High-Throughput Screening of Dicer Cleavage Activity Journal of


Ahmad S Hughes M a Johnson G L Scott J E

Development and validation of a high-throughput intrinsic ATPase activity assay for the

discovery of MEKK2 inhibitors Journal of Biomolecular Screening 2013 18(4) 388ndash399

httpdoiorg1011771087057112466430

Antoniani D Rossi E Rinaldo S Bocci P Lolicato M Paiardini A Landini P

The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule

cyclic-di-GMP by interfering with intracellular nucleotide pool availability Applied

Microbiology and Biotechnology 2013 97 7325ndash7336 httpdoiorg101007s00253-013-

4875-0

Audran E Dagher R Gioria S Tsvetkov P O Kulikova A A Didier B Haiech J

A general framework to characterize inhibitors of calmodulin Use of calmodulin inhibitors to

study the interaction between calmodulin and its calmodulin binding domains Biochimica et

Biophysica Acta - Molecular Cell Research 2013 1833(7) 1720ndash1731


Bharat A Blanchard J E Brown E D

A high-throughput screen of the GTPase activity of Escherichia coli EngA to find an inhibitor

of bacterial ribosome biogenesis Journal of Biomolecular Screening 2013 18(7) 830ndash836

httpdoiorg1011771087057113486001

Blatt J Corey S J

Drug repurposing in pediatrics and pediatric hematology oncology Drug Discovery Today

2013 18(1ndash2) 4ndash10 httpdoiorg101016jdrudis201207009

Cederlund A Nyleacuten F Miraglia E Bergman P Gudmundsson G H Agerberth B

Label-Free Quantitative Mass Spectrometry Reveals Novel Pathways Involved in LL-37

Expression Journal of Innate Immunity 2013 365ndash376 httpdoiorg101159000355931

Chartier A Simonelig M

Animal models in therapeutic drug discovery for oculopharyngeal muscular dystrophy Drug



Choulier L Nomineacute Y Zeder-Lutz G Charbonnier S Didier B Jung M L Altschuh

D

Chemical library screening using a SPR-based inhibition in solution assay Simulations and

experimental validation Analytical Chemistry 2013 85 8787ndash8795

httpdoiorg101021ac4019445

Dahlin J L Sinville R Solberg J Zhou H Han J Francis S Zhang Z

A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone

acetylation PLOS ONE 2013 8(11) httpdoiorg101371journalpone0078877

Goldman R C

Why are membrane targets discovered by phenotypic screens and genome sequencing in

Mycobacterium tuberculosis Tuberculosis 2013 93 569ndash588

httpdoiorg101016jtube201309003

Gozalbes R Mosuleacuten S Ortiacute L Rodriacuteguez-Diacuteaz J Carbajo R J Melnyk P Pineda-

Lucena A

Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches

Bioorganic and Medicinal Chemistry 2013 21 1944ndash1951

httpdoiorg101016jbmc201301033

Gupta V A Kuwada J Y Beggs A H

P411 Developing therapies for congenital myopathies by high throughput chemical screening

in ryanodine receptor 1 mutant zebrafish Neuromuscular Disorders 2013 23(9ndash10) 762ndash763

httpdoiorg101016jnmd201306449

Jiang X Sun L Qiu J J Sun X Li S Wang X Dong S

A Novel Application of Furazolidone Anti-Leukemic Activity in Acute Myeloid Leukemia

PLOS ONE 2013 8(8-e72335) 1ndash9 httpdoiorg101371journalpone0072335

Jin S Sarkar K S Jin Y N Liu Y Kokel D Van Ham T J Peterson R T

An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of

action Journal of Biomolecular Screening 2013 18(1) 108ndash115

httpdoiorg1011771087057112458153

Kawahara G amp Kunkel L M

Zebrafish based small molecule screens for novel DMD drugs Drug Discovery Today

Technologies 2013 10(1) e91ndashe96 httpdoiorg101016jddtec201203001

Kourtesi C Ball A R Huang Y-Y Jachak S M Vera D M a Khondkar P Tegos G

P

Microbial efflux systems and inhibitors approaches to drug discovery and the challenge of

clinical implementation The Open Microbiology Journal 2013 7 34ndash52

httpdoiorg1021741874285801307010034

Kumagai H Suemori H Uesugi M Nakatsuji N Kawase E

Identification of small molecules that promote human embryonic stem cell self-renewal

Biochemical and Biophysical Research Communications 2013 434 710ndash716


Liu M Lin Y ling Chen X R Liao C C Poo W K

In vitro assessment of Macleaya cordata crude extract bioactivity and anticancer properties in

normal and cancerous human lung cells Experimental and Toxicologic Pathology 2013 65

775ndash787 httpdoiorg101016jetp201211004

McCormick A V Wheeler J M Guthrie C R Liachko N F Kraemer B C

Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity Biological

Psychiatry 2013 73 464ndash471 httpdoiorg101016jbiopsych201208027

Ozawa M Shimojima M Goto H Watanabe S Hatta Y Kiso M Kawaoka Y

A cell-based screening system for influenza A viral RNA transcriptionreplication inhibitors

Scientific Reports 3 2013 1106 httpdoiorg101038srep01106

Reipas K M Law J H Couto N Islam S Li Y Li H Dunn S E

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling

by blocking the activation of Y-box binding protein-1 (YB-1) Oncotarget 2013 4(2) 329ndash

345 httpdoiorg1018632oncotarget834

Robinson T J W Liu J C Vizeacoumar F Sun T Maclean N Egan S E Zacksenhaus

E

RB1 status in triple negative breast cancer cells dictates response to radiation treatment and

selective therapeutic drugs PLOS ONE 2013 8(11)


Sadikot T Swink M Eskew J D Brown D Zhao H Kusuma B R Vielhauer G A

Development of a high-throughput screening cancer cell-based luciferase refolding assay for

identifying Hsp90 inhibitors Assay and Drug Development Technologies 2013 11(8) 478ndash

488 httpdoiorg101089adt2012498

Salani B Marini C Rio A Del Ravera S Massollo M Orengo A M Sambuceti G

Metformin impairs glucose consumption and survival in Calu-1 cells by direct inhibition of

hexokinase-II Scientific Reports 2013 3 (2070) 1ndash8 httpdoiorg101038srep02070

Shanks E J

Reduce reuse recycle How drug repositioning is finding its niche in drug discovery European

Pharmaceutical Review 2013 18(3) 31ndash34

Siles S A Srinivasan A Pierce C G Lopez-Ribot J L Ramasubramanian A K

High-throughput screening of a collection of known pharmacologically active small

compounds for identification of candida albicans biofilm inhibitors Antimicrobial Agents and

Chemotherapy 2013 57(8) 3681ndash3687 httpdoiorg101128AAC00680-13

Wrench A P Gardner C L Gonzalez C F Lorca G L

Identification of a Small Molecule That Modifies MglASspA Interaction and Impairs

Intramacrophage Survival of Francisella tularensis PLOS ONE 2013 8(1 (e54498)) 1ndash14


Zeder-Lutz G Renau-Ferrer S Aguieacute-Beacuteghin V Rakotoarivonina H Chabbert B

Altschuh D Reacutemond C

Novel surface-based methodologies for investigating GH11 xylanase-lignin derivative

interactions The Analyst 2013 138(22) 6889ndash99 httpdoiorg101039c3an00772c

Zeidler U Bougnoux M E Lupan A Helynck O Doyen A Garcia Z drsquoEnfert C

Synergy of the antibiotic colistin with echinocandin antifungals in candida species Journal of

Antimicrobial Chemotherapy 2013 68(6) 1285ndash1296 httpdoiorg101093jacdks538

Ahmad S Hughes M A Yeh L-A Scott J E

Potential Repurposing of Known Drugs as Potent Bacterial -Glucuronidase Inhibitors Journal

of Biomolecular Screening 2012 17(7) 957ndash965 httpdoiorg1011771087057112444927

Colliandre L Le Guilloux V Bourg S Morin-Allory L

Visual characterization and diversity quantification of chemical libraries 2 Analysis and

selection of size-independent subspace-specific diversity indices Journal of Chemical

Information and Modeling 2012 52(2) 327ndash342 httpdoiorg101021ci200535y

Conesa C Doss M X Antzelevitch C Sachinidis A Sancho J Carrodeguas J A

Identification of Specific Pluripotent Stem Cell Death-Inducing Small Molecules by Chemical

Screening Stem Cell Reviews and Reports 2012 8 116ndash127 httpdoiorg101007s12015-

011-9248-4

De Chassey B Meyniel-Schicklin L Aublin-Gex A Andreacute P Lotteau V

New horizons for antiviral drug discovery from virus-host protein interaction networks Current

Opinion in Virology 2012 2(5) 606ndash613 httpdoiorg101016jcoviro201209001

Ding Z German P Bai S Feng Z Gao M Si W Jonasch E

Agents that stabilize mutated von Hippel-Lindau (VHL) protein results of a high-throughput

screen to identify compounds that modulate VHL proteostasis Journal of Biomolecular


Flusin O Saccucci L Contesto-Richefeu C Hamdi A Bardou C Poyot T Iseni F

A small molecule screen in yeast identifies inhibitors targeting protein-protein interactions

within the vaccinia virus replication complex Antiviral Research 2012 96(2) 187ndash195

httpdoiorg101016jantiviral201207010

Giacomotto J Seacutegalat L Carre-Pierrat M Gieseler K

Caenorhabditis elegans as a chemical screening tool for the study of neuromuscular disorders

Manual and semi-automated methods Methods 2012 56(1) 103ndash113


Gupte J Swaminath G Danao J Tian H Li Y Wu X

Signaling property study of adhesion G-protein-coupled receptors FEBS Letters 2012 586

1214ndash1219 httpdoiorg101016jfebslet201203014

Holmes A R Keniya M V Ivnitski-Steele I Monk B C Lamping E Sklar L A

Cannon R D

The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC

and MFS transporter efflux pump activities which reverses the azole resistance of Candida

albicans and Candida glabrata clinical isolates Antimicrobial Agents and Chemotherapy 2012

56(3) 1508ndash1515 httpdoiorg101128AAC05706-11

Li Y-J Zhao X Vecchiarelli-Federico L M Li Y Datti A Cheng Y Ben-David Y

Drug-mediated inhibition of Fli-1 for the treatment of leukemia Blood Cancer Journal 2012

2(e54) 1ndash9 httpdoiorg101038bcj201152

Libraries O

Drug Repurposing development strategy 2012 90(40) 1ndash8

Oprea T I Mestres J

Drug Repurposing Far Beyond New Targets for Old Drugs The AAPS Journal 2012 14(4)

759ndash763 httpdoiorg101208s12248-012-9390-1

Park S J Shin J H Kim E S Jo Y K Kim J H Hwang J J Cho D H

Mitochondrial fragmentation caused by phenanthroline promotes mitophagy FEBS Letters

2012 586(24) 4303ndash4310 httpdoiorg101016jfebslet201210035

Polireddy K Khan M M T Chavan H Young S Ma X Waller A Krishnamurthy P

A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette

transporter ABCB6 PLOS ONE 2012 e4005 7 1ndash14


Reynolds R C Ananthan S Faaleolea E Hobrath J V Kwong C D Maddox C Secrist

J A

High throughput screening of a library based on kinase inhibitor scaffolds against

Mycobacterium tuberculosis H37Rv Tuberculosis 2012 92(1) 72ndash83


Sachlos E Risuentildeo R M Laronde S Shapovalova Z Lee J H Russell J Bhatia M

Identification of drugs including a dopamine receptor antagonist that selectively target cancer

stem cells Cell 2012 149 1284ndash1297 httpdoiorg101016jcell201203049

Shin J H Park S J Jo Y K Kim E S Kang H Park J H Cho D H

Suppression of autophagy exacerbates Mefloquine-mediated cell death Neuroscience Letters

2012 515 162ndash167 httpdoiorg101016jneulet201203040

Tomasini-Johansson B R Johnson I A Hoffmann F M Mosher D F

Quantitative microtiter fibronectin fibrillogenesis assay Use in high throughput screening for

identification of inhibitor compounds Matrix Biology 2012 31 360ndash367

httpdoiorg101016jmatbio201207003

Villalta-Romero F Gortat A Herrera A E Arguedas R Quesada J De Melo R L

Peacuterez-Payaacute E

Identification of new snake venom metalloproteinase inhibitors using compound screening and

rational peptide design ACS Medicinal Chemistry Letters 2012 3 540ndash543

httpdoiorg101021ml300068r

Walker S R Frank D a

Screening approaches to generating STAT inhibitors Allowing the hits to identify the targets

Jak-Stat 2012 1(4) 292ndash299 httpdoiorg104161jkst22662

Wang Y Davidow L Arvanites A C Blanchard J Lam K Xu K McMahon A P

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity

Chemistry and Biology 2012 19(8) 972ndash982 httpdoiorg101016jchembiol201206012

Zeder-Lutz G Choulier L Besse M Cousido-Siah A Figueras F X R Didier B

Altschuh D

Validation of surface plasmon resonance screening of a diverse chemical library for the

discovery of protein tyrosine phosphatase 1b binders Analytical Biochemistry 2012 421(2)

417ndash427 httpdoiorg101016jab201109015

Ahmad S Hughes M a Lane K T Redinbo M R Yeh L-A Scott J E

A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors Current

Chemical Genomics 2011 5 13ndash20 httpdoiorg1021741875397301105010013

Allen J A Roth B L

Strategies to discover unexpected targets for drugs active at G protein-coupled receptors

Annual Review of Pharmacology and Toxicology 2011 51 117ndash144

httpdoiorg101146annurev-pharmtox-010510-100553

Chen M H Yang W L R Lin K T Liu C H Liu Y W Huang K W

Huang C Y F

Gene expression-based chemical genomics identifies potential therapeutic drugs in

hepatocellular carcinoma PLOS ONE 2011 6(11)


Chigaev A Wu Y Williams D B Smagley Y Sklar L A

Discovery of Very Late Antigen-4 (VLA-4 α4β 1 integrin) allosteric antagonists Journal of

Biological Chemistry 2011 286(7) 5455ndash5463 httpdoiorg101074jbcM110162636

Chopra S Matsuyama K Hutson C Madrid P

Identification of antimicrobial activity among FDA-approved drugs for combating

Mycobacterium abscessus and Mycobacterium chelonae Journal of Antimicrobial

Chemotherapy 2011 66 1533ndash1536 httpdoiorg101093jacdkr154

Couplan E Aiyar R S Kucharczyk R Kabala A Ezkurdia N Gagneur J Blondel M

A yeast-based assay identifies drugs active against human mitochondrial disorders PNAS USA

2011 108(29) 11989ndash11994 httpdoiorg101073pnas1101478108

Dengler M A Staiger A M Gutekunst M Hofmann U Doszczak M Scheurich P van

der Kuip H

Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon

induction of excessive aerobic glycolysis PLOS ONE 2011 6(9)


Dey R Chen L

In search of allosteric modulators of α7-nAChR by solvent density guided virtual screening

Journal of Biomolecular Structure amp Dynamics 2011 28(5) 695ndash715

httpdoiorg10108007391102201110508600

Ekins S Williams A J Krasowski M D Freundlich J S

In silico repositioning of approved drugs for rare and neglected diseases Drug Discovery

Today 2011 16(7ndash8) 298ndash310 httpdoiorg101016jdrudis201102016

Fonslow B R Stein B D Webb K J Xu T Choi J Kyu S Iii J R Y

A High Content Screen Identifies Inhibitors of Nuclear Export of Forkhead Transcription

Factors 2011 10(1) 54ndash56 httpdoiorg101038nmeth2250Digestion

Gohil V M Offner N Walker J A Sheth S A Fossale E Gusella J F Mootha V K

Meclizine is neuroprotective in models of Huntingtonrsquos disease Human Molecular Genetics

2011 20(2) 294ndash300 httpdoiorg101093hmgddq464

Hubert Jr L Lin Y Dion V Wilson J H

Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat

contraction in human cells Molecular and Cellular Biology 2011 31(15) 3105ndash3112

httpdoiorg101128MCB05158-11

Hundeshagen P Hamacher-Brady A Eils R Brady N R

Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry

in a high-content screen for inducers of autophagy BMC Biology 2011 9(1) 38

httpdoiorg1011861741-7007-9-38

Jo Y K Park S J Shin J H Kim Y Hwang J J Cho D H Kim J C

ARP101 a selective MMP-2 inhibitor induces autophagy-associated cell death in cancer cells



Kawahara G Karpf J

Drug screening in a zebrafish model of Duchenne muscular dystrophy Pnas 2011 108(13)

5331ndash6 httpdoiorg101073pnas1102116108

Kawahara G Karpf J A Myers J A Alexander M S Guyon J R Kunkel L M

Drug screening in a zebrafish model of Duchenne muscular dystrophy Proceedings of the

National Academy of Sciences of the United States of America 2011 108(13) 5331ndash6

httpdoiorg101073pnas1102116108

Kumar E A Charvet C D Lokesh G L Natarajan A

High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein

tyrosine kinase interactions Analytical Biochemistry 2011 411(2) 254ndash260

httpdoiorg101016jab201011038

Le Guilloux V Colliandre L Bourg S Gueacutenegou G Dubois-Chevalier J Morin-Allory

L

Visual characterization and diversity quantification of chemical libraries 1 Creation of

delimited reference chemical subspaces Journal of Chemical Information and Modeling 2011

51(8) 1762ndash1774 httpdoiorg101021ci200051r

Lee Y J Burlet E Wang S Xu B Huang S Galiano F J Witt S N

Triclabendazole protects yeast and mammalian cells from oxidative stress Identification of a

potential neuroprotective compound Biochemical and Biophysical Research Communications

2011 414(1) 205ndash208 httpdoiorg101016jbbrc201109057

MacKenzie A E Lappin J E Taylor D L Nicklin S A Milligan G

GPR35 as a novel therapeutic target Frontiers in Endocrinology 2011 1ndash10

httpdoiorg103389fendo201100068

Milligan G

Orthologue selectivity and ligand bias Translating the pharmacology of GPR35 Trends in

Pharmacological Sciences 2011 32(5) 317ndash325 httpdoiorg101016jtips201102002

Moorwood C Lozynska O Suri N Napper A D Diamond S L Khurana T S

Drug discovery for duchenne muscular dystrophy via utrophin promoter activation screening

PLOS ONE 2011 6(10) 1ndash11 httpdoiorg101371journalpone0026169

Peal D S Mills R W Lynch S N Mosley J M Lim E Ellinor P T Milan D J

Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen

Circulation 2011 123(1) 23ndash30 httpdoiorg101161CIRCULATIONAHA110003731

Sexton J Z Danshina P V Lamson D R Hughes M House A J Yeh L-A Williams

K P

Development and Implementation of a High Throughput Screen for the Human Sperm-Specific

Isoform of Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDHS) Current Chemical

Genomics 2011 5 30ndash41 httpdoiorg1021741875397301105010030

Spitzer M Griffiths E Blakely K M Wildenhain J Ejim L Rossi L Wright G D

Cross-species discovery of syncretic drug combinations that potentiate the antifungal

fluconazole Molecular Systems Biology 2011 7(1) 499 httpdoiorg101038msb201131

Takakura A Nelson E A Haque N Humphreys B D Zandi-Nejad K Frank D A

Zhou J

Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling

pathways Human Molecular Genetics 2011 20(21) 4143ndash4154

httpdoiorg101093hmgddr338

Wermuth C G

Are pyridazines privileged structures MedChemComm 2010 2(10) 935

httpdoiorg101039c1md00074h

Andrews P D Becroft M Aspegren A Gilmour J James M J McRae S Andrews P

W

High-content screening of feeder-free human embryonic stem cells to identify pro-survival

small molecules The Biochemical Journal 2010 432(1) 21ndash33

httpdoiorg101042BJ20101022

Antoniani D Bocci P MacIag A Raffaelli N amp Landini P

Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell

assays suitable for high-throughput screening of biofilm inhibitors Applied Microbiology and

Biotechnology 2010 85(4) 1095ndash1104 httpdoiorg101007s00253-009-2199-x

Barbaric I Gokhale P J Jones M Glen A Baker D amp Andrews P W

Novel regulators of stem cell fates identified by a multivariate phenotype screen of small

compounds on human embryonic stem cell colonies Stem Cell Research 2010 5(2) 104ndash119

httpdoiorg101016jscr201004006

Buckley C E Marguerie A Roach A G Goldsmith P Fleming A Alderton W K

Franklin R J M

Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination

effects Neuropharmacology 2010 59(3) 149ndash159

httpdoiorg101016jneuropharm201004014

Carme Mulero M Orzaez M Messeguer J Messeguer A Peacuterez-Paya E Peacuterez-Riba M

A fluorescent polarization-based assay for the identification of disruptors of the RCAN1-

calcineurin A protein complex Analytical Biochemistry 2010 398(1) 99ndash103


Colton C K Kong Q Lai L Zhu M X Seyb K I Cuny G D Glenn Lin C-L

Identification of Translational Activators of Glial Glutamate Transporter EAAT2 through Cell-

Based High-Throughput Screening An Approach to Prevent Excitotoxicity Journal of


Dearmond P D West G M Anbalagan V Campa M J Patz E F Fitzgerald M C

Discovery of novel cyclophilin A ligands using an HD exchange- and mass spectrometry-based

strategy Journal of Biomolecular Screening 2010 15(9) 1051ndash62

httpdoiorg1011771087057110382775

Doughty-Shenton D Joseph J D Zhang J Pagliarini D J Kim Y Lu D Casey P J

Pharmacological targeting of the mitochondrial phosphatase PTPMT1 The Journal of

Pharmacology and Experimental Therapeutics 2010 333(2) 584ndash92

httpdoiorg101124jpet109163329

Feng R Rios J A Onishi T Lokshin A Gorelik E Lentzsch S

Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma

agents Leukemia Research 2010 34(7) 917ndash924

httpdoiorg101016jleukres200912002

Gui C Obaidat A Chaguturu R Hagenbuch B

Development of a cell-based high-throughput assay to screen for inhibitors of organic anion

transporting polypeptides 1B1 and 1B3 Current Chemical Genomics 2010 4 1ndash8

httpdoiorg1021741875397301004010001

Insa R

Drug Repositioning Filling the Gap European Biopharmaceutical Review 2010 retrieved

from httpwwwsamedanltdcommagazine12issue132article2698

Jadhav A Ferreira R S Klumpp C Mott B T Austin C P Inglese J Simeonov A

Quantitative analyses of aggregation autofluorescence and reactivity artifacts in a screen for

inhibitors of a thiol protease Journal of Medicinal Chemistry 2010 53(1) 37ndash51

httpdoiorg101021jm901070c

Jasenosky L D Neumann G Kawaoka Y

Minigenome-based reporter system suitable for high-throughput screening of compounds able

to inhibit Ebolavirus replication andor transcription Antimicrobial Agents and Chemotherapy

54(7) 2010 3007ndash3010 httpdoiorg101128AAC00138-10

Johnson R M Allen C Melman S D Waller A Young S M Sklar L A Parra K J

Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-

throughput screening flow cytometry Analytical Biochemistry 2010 398(2) 203ndash211


Kokel D Bryan J Laggner C White R Cheung C Y Mateus R Peterson R T

Rapid behavior-based identification of neuroactive small molecules in the zebrafish Nat Chem

Biol 2010 6(3) 231ndash237 httpdoiorg101038nchembio307

Kuhn I Kellenberger E Said-Hassane F Villa P Rognan D Lobstein A Muller-

Steffner H

Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD+

catabolizing enzyme Bioorganic and Medicinal Chemistry 2010 18(22) 7900ndash7910


Leonardi R Zhang Y M Yun M K Zhou R Zeng F Y Lin W Jackowski S

Modulation of pantothenate kinase 3 activity by small molecules that interact with the

substrateallosteric regulatory domain Chemistry and Biology 2010 17(8) 892ndash902


Lipinski R J Bushman W

Identification of Hedgehog signaling inhibitors with relevant human exposure by small

molecule screening Toxicology in Vitro 2010 24(5) 1404ndash1409

httpdoiorg101016jtiv201004011

Manuscript A amp Leads P D NIH Public Access Tuberculosis 2010 89(5) 331ndash333

httpdoiorg101016jtube200907007Discovery

Manuscript A amp Syndromes G P NIH Public Access 2010 48(Suppl 2) 1ndash6

httpdoiorg101097MPG0b013e3181a15ae8Screening

Ouertatani-Sakouhi H Liu M El-Turk F Cuny G D Glicksman M A Lashuel H A

Kinetic-Based High-Throughput Screening Assay to Discover Novel Classes of Macrophage

Migration Inhibitory Factor Inhibitors Journal of Biomolecular Screening 2010 15(4) 347ndash

358 httpdoiorg1011771087057110363825

Peluso J Muller C D

Advances in flow cytometry for drug screening Expert Opinion on Drug Discovery 2010 5(9)

827ndash833 httpdoiorgDoi 101517174604412010509395

Rodgers A D Zhu H Fourches D Rusyn I Tropsha A Hill C Carolina N

Modeling Liver-Related Adverse Effects of Drugs Using k Nearest Neighbor Quantitative

Structure - Activity Relationship Method Chemical Research in Toxicology 2010 23 724ndash

732 httpdoiorg101021tx900451r

Schaertl S Prime M Wityak J Dominguez C Munoz-Sanjuan I Pacifici R E

Macdonald D

A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors Journal of

Biomolecular Screening  The Official Journal of the Society for Biomolecular Screening 2010

15(5) 478ndash487 httpdoiorg1011771087057110366035

Shahinas D Liang M Datti A Pillai D R

A repurposing strategy identifies novel synergistic inhibitors of plasmodium falciparum heat

shock protein 90 Journal of Medicinal Chemistry 2010 53(9) 3552ndash3557

httpdoiorg101021jm901796s

Shum D Smith J L Hirsch A J Bhinder B Radu C Stein D A Djaballah H

High-content assay to identify inhibitors of dengue virus infection Assay and Drug

Development Technologies 2010 8(5) 553ndash70 httpdoiorg101089adt20100321

Talele T T Arora P Kulkarni S S Patel M R Singh S Chudayeu M Kaushik-Basu

N

Structure-based virtual screening synthesis and SAR of novel inhibitors of hepatitis C virus

NS5B polymerase Bioorganic amp Medicinal Chemistry 2010 18(13) 4630ndash4638


Vedadi M Arrowsmith C H Allali-Hassani A Senisterra G Wasney G A

Biophysical characterization of recombinant proteins A key to higher structural genomics

success Journal of Structural Biology 2010 172(1) 107ndash119

httpdoiorg101016jjsb201005005

Yeyeodu S T Witherspoon S M Gilyazova N Ibeanu G C

A rapid inexpensive high throughput screen method for neurite outgrowth Current Chemical


Zhao P Sharir H Kapur A Cowan A Geller E B Adler M W Abood M E

Targeting of the orphan receptor GPR35 by pamoic acid a potent activator of extracellular

signal-regulated kinase and β-arrestin2 with antinociceptive activity Molecular Pharmacology

2010 78(4) 560ndash568 httpdoiorg101124mol110066746

Ananthan S Faaleolea E R Goldman R C Hobrath J V Kwong C D Laughon B E

White E L

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv Tuberculosis

89(5) 2009 334ndash353 httpdoiorg101016jtube200905008

Auld D S Zhang Y Q Southall N T Rai G Landsman M MacLure J Inglese J A

basis for reduced chemical library inhibition of firefly luciferase obtained from directed

evolution Journal of Medicinal Chemistry 2009 52(5) 1450ndash1458

httpdoiorg101021jm8014525

Calmels N Seznec H Villa P Reutenauer L Hibert M Haiech J Puccio H

Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug

screen BMC Neurology 2009 9(1) 46 httpdoiorg1011861471-2377-9-46

Charpentier X Gabay J E Reyes M Zhu J W Weiss A Shuman H A

Chemical genetics reveals bacterial and host cell functions critical for type IV effector

translocation by Legionella pneumophila PLoS Pathogens 2009 5(7)

httpdoiorg101371journalppat1000501

Chen S Borowiak M Fox J L Maehr R Osafune K Davidow L Melton D

A small molecule that directs differentiation of human ESCs into the pancreatic lineage Nature

Chemical Biology 2009 5(4) 258ndash265 httpdoiorg101038nchembio154

Conn P J Jones C K Lindsley C W

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS

disorders Trends in Pharmacological Sciences 2009 30(3) 148ndash155


Damoiseaux R Sherman S P Alva J a Peterson C Pyle A D

Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells

Stem Cells 2009 27(3) 533ndash542 httpdoiorg101634stemcells2008-0596

DrsquoElia M A Millar K E Bhavsar A P Tomljenovic A M Hutter B Schaab C Brown

E D

Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among

Diverse Processes in Bacterial Cell Wall Biogenesis Chemistry and Biology 2009 16(5) 548ndash

556 httpdoiorg101016jchembiol200904009

Du L Damoiseaux R Nahas S Gao K Hu H Pollard J M Gatti R

Nonaminoglycoside compounds induce readthrough of nonsense mutations The Journal of

Experimental Medicine 2009 206(10) 2285ndash2297 httpdoiorg101084jem20081940

Dubreuil P Letard S Ciufolini M Gros L Humbert M Casteacuteran N hellip Hermine O

(2009) Masitinib (AB1010) a potent and selective tyrosine kinase inhibitor targeting KIT

PLoS ONE 4(9) httpdoiorg101371journalpone0007258

Ewald J A Peters N Desotelle J A Hoffmann F M amp Jarrard D F

A High-Throughput Method to Identify Novel Senescene-Inducing Compounds J Biomol

Screen 2009 14(7) 853ndash858 httpdoiorg1011771087057109340314A

Gozalbes R Mosuleacuten S Carbajo R J amp Pineda-Lucena A

Development and NMR validation of minimal pharmacophore hypotheses for the generation of

fragment libraries enriched in heparanase inhibitors Journal of Computer-Aided Molecular

Design 2009 23(8) 555ndash569 httpdoiorg101007s10822-009-9269-0

Haiech J Heizmann C W amp Krebs J

The 10th European symposium on calcium-binding proteins in normal and transformed cells

Biochimica et Biophysica Acta 2009 1793(6) 931ndash2


Haynes M K Strouse J J Waller A Leitao A Curpan R F Bologa C Thompson T

A

Detection of intracellular granularity induction in prostate cancer cell lines by small molecules

using the HyperCyt high-throughput flow cytometry system Journal of Biomolecular


Hibert M F

FrenchEuropean academic compound library initiative Drug Discovery Today 2009 14(15ndash

16) 723ndash725 httpdoiorg101016jdrudis200905012

Huang X Setola V Yadav P N Allen J a Rogan S C Hanson B J Roth B L

Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-

Hydroxytryptamine 2B Receptor Agonists  Implications for Drug Safety Assessment

Molecular Pharmacology 2009 5(4) 710ndash722 httpdoiorg101124mol109058057

Iorns E Lord C J amp Ashworth A

Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen

sensitization The Biochemical Journal 2009 417 361ndash370


Kemmer D McHardy L M Hoon S Rebeacuterioux D Giaever G Nislow C Roberge M

Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical

inhibition of sphingolipid biosynthesis BMC Microbiology 2009 9(1) 9

httpdoiorg1011861471-2180-9-9

Lagunin A Filimonov D Zakharov A Xie W Huang Y Zhu F Poroikov V

Computer-aided prediction of rodent carcinogenicity by PASS and CISOC-PSCT QSAR and

Combinatorial Science 2009 28(8) 806ndash810 httpdoiorg101002qsar200860192

Langer T Hoffmann R Bryant S Lesur B

Hit finding towards ldquosmarterrdquo approaches Current Opinion in Pharmacology 2009 9(5)

589ndash593 httpdoiorg101016jcoph200906001

Larsen R S Zylka M J amp Scott J E

A high throughput assay to identify small molecule modulators of prostatic acid phosphatase

Current Chemical Genomics 2009 3 42ndash9 httpdoiorg1021741875397300903010042

Livingstone M Larsson O Sukarieh R Pelletier J Sonenberg N

A Chemical Genetic Screen for mTOR Pathway Inhibitors Based on 4E-BP-Dependent Nuclear

Accumulation of eIF4E Chemistry and Biology 2009 16(12) 1240ndash1249


MacArthur R Leister W Veith H Shinn P Southall N Austin C P Auld D S

Monitoring Compound Integrity with cytochrome P450 assays and qHTS wwwsbsonlineorg

2009 1ndash9 httpdoiorg1011771087057109336954

Manuscript A amp Formation H T F NIH Public Access 2009 358(1) 1ndash6

httpdoiorg101016jbbrc200703056High

Mulero M C Aubareda A Orzaacuteez A Messeguer J Serrano-Candelas E Martiacutenez-

Hoyer S Peacuterez-Riba M

Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a

regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase

activity Journal of Biological Chemistry 2009 284(14) 9394ndash9401


Norton J T Titus S A Dexter D Austin C P Zheng W Huang S

Automated high-content screening for compounds that disassemble the perinucleolar

compartment Journal of Biomolecular Screening 2009 14(9) 1045ndash1053

httpdoiorg1011771087057109343120

Orzaacuteez M Mondragoacuten L Garciacutea-Jarentildeo A Mosuleacuten S Pineda-Lucena A Peacuterez-Payaacute

E (2009) Deciphering the antitumoral activity of quinacrine Binding to and inhibition of Bcl-

xL Bioorganic and Medicinal Chemistry Letters 2009 19(6) 1592ndash1595

httpdoiorg101016jbmcl200902020

Perne A Muellner M K Steinrueck M Craig-Mueller N Mayerhofer J Schwarzinger

I Mayerhofer M

Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis

PLOS ONE 2009 4(12) httpdoiorg101371journalpone0008292

Porotto M Orefice G Yokoyama C C Mungall B A Realubit R Sganga M L

Moscona A

Simulating henipavirus multicycle replication in a screening assay leads to identification of a

promising candidate for therapy Journal of Virology 2009 83(10) 5148ndash5155

httpdoiorg101128JVI00164-09

Pyeon D Pearce S M Lank S M Ahlquist P Lambert P F

Establishment of human papillomavirus infection requires cell cycle progression PLoS

Pathogens 2009 5(2) httpdoiorg101371journalppat1000318

Sanders B D Jackson B Brent M Taylor A M Dang W Berger S L Marmorstein

R

Identification and characterization of novel sirtuin inhibitor scaffolds Bioorganic and

Medicinal Chemistry 2009 17(19) 7031ndash7041 httpdoiorg101016jbmc200907073

Sung J C Jensen N H Kurome T Kadari S Manzano M L Malberg J E Kozikowski

A P

Selective 5-hydroxytryptamine 2c receptor agonists derived from the lead compound

tranylcypromine Identification of drugs with antidepressant-like action Journal of Medicinal

Chemistry 2009 52(7) 1885ndash1902 httpdoiorg101021jm801354e

Wible B A

Incidence and specificity of drug-induced trafficking inhibition of cardiac ion channels Journal

of Pharmacological and Toxicological Methods 2009 60(2) 223

httpdoiorg101016jvascn200904068

Zhu P J Hobson J P Southall N Qiu C Thomas C J Lu J Liu S

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

Bioorganic and Medicinal Chemistry 2009 17(14) 5139ndash5145


Cascales L Mas-Moruno C Tamborero S Acentildea J L Sanz-Cervera J F Fustero S


Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-α

production in the cell Chemical Biology and Drug Design 2008 72(4) 320ndash328

httpdoiorg101111j1747-0285200800703x

Desbordes S C Placantonakis D G Ciro A Socci N D Lee G Djaballah H Studer

L

High-Throughput Screening Assay for the Identification of Compounds Regulating Self-

Renewal and Differentiation in Human Embryonic Stem Cells Cell Stem Cell 2008 2(6) 602ndash

612 httpdoiorg101016jstem200805010

Garcia-Lopez A Monferrer L Garcia-Alcover I Vicente-Crespo M Alvarez-Abril M

C Artero R D

Genetic and chemical modifiers of a CUG toxicity model in Drosophila PLOS ONE 2008

3(2) httpdoiorg101371journalpone0001595

Hoffmann H H Palese P Shaw M L

Modulation of influenza virus replication by alteration of sodium ion transport and protein

kinase C activity Antiviral Research 2008 80(2) 124ndash134


Hutchinson D Ho V Dodd M Dawson H N Zumwalt A C Colton C A

NIH Public Access 2008 148(4) 825ndash832 httpdoiorg101038jid2014371

Ivnitski-Steele I Larson R S Lovato D M Khawaja H M Winter S S Oprea T I

Edwards B S

High-throughput flow cytometry to detect selective inhibitors of ABCB1 ABCC1 and ABCG2

transporters Assay and Drug Development Technologies 2008 6(2) 263ndash276


Johnson R L Huang W Jadhav A Austin C P Inglese J Martinez E D

A quantitative high-throughput screen identifies potential epigenetic modulators of gene

expression Analytical Biochemistry 2008 375(2) 237ndash248


Krysan D J Didone L

A High-Throughput Screening Assay for Small Molecules Journal of Biomolecular Screening

2008 13(7) 657ndash664 httpdoiorg1011771087057108320713

Lai T S Liu Y Tucker T Daniel K R Sane D C Toone E Greenberg C S

Identification of Chemical Inhibitors to Human Tissue Transglutaminase by Screening Existing

Drug Libraries Chemistry and Biology 2008 15(9) 969ndash978


Mangat C S Brown E D

Known Bioactive Small Molecules Probe the Function of a Widely Conserved but Enigmatic

Bacterial ATPase YjeE Chemistry and Biology 2008 15(12) 1287ndash1295


Nakamura K Zawistowski J S Hughes M a Sexton J Z Yeh L-A Johnson G L

Scott J E

Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of

PhoxBem1p (PB1) domain heterodimerization Journal of Biomolecular Screening 2008


Patnaik D Xian J

Molecule Inhibitors of the Mitotic Kinase Haspin By High-Throughput Screening Using a

Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer Assay Journal of

Biomolecular Screening 2008 13(10) 1025ndash1034

httpdoiorg1011771087057108326081Identification

Senisterra G a Soo Hong B Park H-W Vedadi M

Application of high-throughput isothermal denaturation to assess protein stability and screen

for ligands Journal of Biomolecular Screening 2008 13(5) 337ndash42

httpdoiorg1011771087057108317825

Seyb K I Schuman E R Ni J Huang M Michaelis M L Glicksman M A

Identification of Small Molecule Inhibitors of βndashAmyloid Cytotoxicity through a Cell-based

High-Throughput Screening Platform Journal of Biomolecular Screening 2008 13(9) 870ndash

878 httpdoiorg1011771087057108323909Identification

Simeonov A Jadhav A Sayed A A Wang Y Nelson M E Thomas C J Austin C P

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox

cascade PLoS Neglected Tropical Diseases 2008 2(1)

httpdoiorg101371journalpntd0000127

Simeonov A Jadhav A Thomas C J Wang Y Huang R Southall N T Inglese J

Fluorescence spectroscopic profiling of compound libraries Journal of Medicinal Chemistry

2008 51(8) 2363ndash2371 httpdoiorg101021jm701301m

Simeonov A Yasgar A Jadhav A Lokesh G L Klumpp C Michael S Inglese J

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein

interaction Analytical Biochemistry 2008 375(1) 60ndash70


Stoilov P Lin C-H Damoiseaux R Nikolic J Black D L

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing

modulators Proceedings of the National Academy of Sciences 2008 105(32) 11218ndash11223


Tribouillard-Tanvier D Beacuteringue V Desban N Gug F Bach S Voisset C Blondel M

Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions


Winter S S Lovato D M Khawaja H M Edwards B S Steele I D Young S M

Larson R S

High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone

furoate as a novel ABCB1-reversal agent Journal of Biomolecular Screening 2008 13(3)


Wu Z Liu D Sui Y

Quantitative assessment of hit detection and confirmation in single and duplicate high-

throughput screenings Journal of Biomolecular Screening 2008 13(2) 159ndash67

httpdoiorg1011771087057107312628

Xu G W Mawji I A Macrae C J Koch C A Datti A Wrana J L Schimmer A D

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

Apoptosis 2008 13(3) 413ndash422 httpdoiorg101007s10495-007-0175-4

Antczak C Shum D Escobar S Bassit B Seshan V E Wu N Djaballah H

High-Troughput Identification of Inhibitors of Human Mitochondrial Peptide Deformylase J

Biomol Screen 2007 12(4) 521ndash535 httpdoiorg1011771087057107300463

Azzaoui K Hamon J Faller B Whitebread S Jacoby E Bender A Urban L

Modeling promiscuity based on in vitro safety pharmacology profiling data ChemMedChem

2007 2(6) 874ndash880 httpdoiorg101002cmdc200700036

Bender A Scheiber J Glick M Davies J W Azzaoui K Hamon J Jenkins J L

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target

effects from chemical structure ChemMedChem 2007 2(6) 861ndash873

httpdoiorg101002cmdc200700026

Breger J Fuchs B B Aperis G Moy T I Ausubel F M Mylonakis E

Antifungal chemical compounds identified using a C elegans pathogenicity assay PLoS

Pathogens 2007 3(2) 0168ndash0178 httpdoiorg101371journalppat0030018

Chong C Sullivan D J

New uses for old drugs Nature 2007 448(7154) 645

httpdxdoiorg101038448645anhttpwwwnaturecomnaturejournalv448n7154full44

8645ahtml

Crisman T J Parker C N Jenkins J L Scheiber J Thoma M Kang Z Bin Glick M

Understanding false positives in reporter gene assays In silico chemogenomics approaches to

prioritize cell-based HTS data Journal of Chemical Information and Modeling 2007 47(4)

1319ndash1327 httpdoiorg101021ci6005504

Crowe A Ballatore C Hyde E Trojanowski J Q Lee V M-Y

High throughput screening for small molecule inhibitors of heparin-induced tau fibril

formation Biochemical and Biophysical Research Communications 2007 358(1) 1ndash6


Davis R E Zhang Y-Q Southall N Staudt L M Austin C P Inglese J Auld D S A

Cell-Based Assay for I κ B α Stabilization Using A Two-Color Dual Luciferase-Based Sensor



Donahue C P Ni J Rozners E Glicksman M a Wolfe M S

Identification of Tau Stem Loop RNA Stabilizers Journal of Biomolecular Screening 2007





Feng B Y Simeonov A Jadhav A Babaoglu K Inglese J Shoichet B K Austin C P

A high-throughput screen for aggregation-based inhibition in a large compound library Journal

of Medicinal Chemistry 2007 50(10) 2385ndash2390 httpdoiorg101021jm061317y

Fischer H Kansy M Avdeef A amp Senner F Permeation of permanently positive charged

molecules through artificial membranes-Influence of physico-chemical properties European

Journal of Pharmaceutical Sciences 2007 31(1) 32ndash42

httpdoiorg101016jejps200702001

Honson N S Johnson R L Huang W Inglese J Austin C P Kuret J

Differentiating Alzheimer disease-associated aggregates with small molecules Neurobiology

of Disease 2007 28(3) 251ndash260 httpdoiorg101016jnbd200707018

Hurtado-Guerrero R van Aalten D M F

Structure of Saccharomyces cerevisiae Chitinase 1 and Screening-Based Discovery of Potent

Inhibitors Chemistry and Biology 2007 14(5) 589ndash599


Ivey F D Wang L Demirbas D Allain C Hoffman C S

Development of a Fission Yeast-Based High-Throughput Screen to Identify Chemical

Regulators of cAMP Phosphodiesterases Journal of Biomolecular Screening 2007 13(1) 62ndash

71 httpdoiorg1011771087057107312127

Rezza G Nicoletti L Angelini R Romi R Finarelli A Panning M Cassone A

Infection with chikungunya virus in Italy an outbreak in a temperate region The Lancet 2007

370(9602) 1840ndash1846 httpdoiorg101016S0140-6736(07)61779-6

Sprous D G Salemme F R

A comparison of the chemical properties of drugs and FEMAFDA notified GRAS chemical

compounds used in the food industry Food and Chemical Toxicology 2007 45(8) 1419ndash1427

httpdoiorg101016jfct200702004

Tsetsarkin K A Vanlandingham D L Mcgee C E Higgs S

A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential

PLOS Phatogens 2007 3(12) httpdoiorg101371journalppat0030201

White E L Southworth K Ross L Cooley S Gill R B Sosa M I Fletcher T M A

Novel Inhibitor of Mycobacterium tuberculosis Journal of Biomolecular Screening 2007


Bandyopadhyay S

A High-Throughput Drug Screen Targeted to the 5rsquoUntranslated Region of Alzheimer Amyloid

Precursor Protein mRNA Journal of Biomolecular Screening 2007 11(5) 469ndash480

httpdoiorg1011771087057106287271

Broom W J Auwarter K E Ni J Russel D E Yeh L-A Maxwell M M Brown R

H

Two approaches to drug discovery in SOD1-mediated ALS Journal of Biomolecular


Dagher R Pigault C Bonnet D Boeglin D Pourbaix C Kilhoffer M C Haiech J Use

of a fluorescent polarization based high throughput assay to identify new Calmodulin ligands



Fara D C Oprea T I Prossnitz E R Bologa C G Edwards B S Sklar L A

Integration of virtual and physical screening Drug Discovery Today Technologies 2006 3(4)

377ndash385 httpdoiorg101016jddtec200611003

Hergenrother P J

Obtaining and screening compound collections a userrsquos guide and a call to chemists Current

Opinion in Chemical Biology 2006 10(3) 213ndash218 httpdoiorg101016jcbpa200604005

Inglese J Auld D S Jadhav A Johnson R L Simeonov A Yasgar A Austin C P

Quantitative high-throughput screening a titration-based approach that efficiently identifies

biological activities in large chemical libraries Proceedings of the National Academy of

Sciences of the United States of America 2006 103(7) 11473ndash11478


Kinobe R T Dercho R a Vlahakis J Z Brien J F Szarek W A Nakatsu K

Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs The

Journal of Pharmacology and Experimental Therapeutics 2006 319(1) 277ndash284

httpdoiorg101124jpet106102699adjunctive

Monge A Arrault A Marot C Morin-Allory L

Managing profiling and analyzing a library of 26 million compounds gathered from 32

chemical providers Molecular Diversity 2006 10(3) 389ndash403 httpdoiorg101007s11030-

006-9033-5

Ogawa Y Mizumoto N Tanaka H Matsushima H Takashima A

Identification of novel pharmacological activities of an antifungal agent nystatin to promote

dendritic cell maturation J Invest Dermatol 2006 126(2) 349ndash353

httpdoiorg101038sjjid5700081

Peters U Cherian J Kim J H Kwok B H Kapoor T M

Probing cell-division phenotype space and Polo-like kinase function using small molecules

Nature Chemical Biology 2006 2(11) 618ndash626 httpdoiorg101038nchembio826

Schuffenecker I Iteman I Michault A Murri S Frangeul L Vaney M C Brisse S

Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak PLoS

Medicine 2006 3(7) 1058ndash1070 httpdoiorg101371journalpmed0030263

Severson W E Shindo N Sosa M Fletcher T White E L Ananthan S Jonsson C B

Development and Validation of a High-Throughput Screen for Inhibitors of SARS CoV and Its

Application in Screening of a 100000-Compound Library Journal of Biomolecular Screening


Urbaniak M D Tabudravu J N Msaki A Matera K M Brenk R Jaspars M Ferguson

M A J

Identification of novel inhibitors of UDP-Glc 4rsquo-epimerase a validated drug target for african

sleeping sickness Bioorganic and Medicinal Chemistry Letters 2006 16(22) 5744ndash5747


Wang J K T Portbury S Thomas M B Barney S Ricca D J Morris D L Lo D C

Cardiac glycosides provide neuroprotection against ischemic stroke discovery by a brain slice-

based compound screening platform Proceedings of the National Academy of Sciences of the

United States of America 2006 103(27) 10461ndash6 httpdoiorg101073pnas0600930103

Wermuth C G

Similarity in drugs reflections on analogue design Drug Discovery Today 2006 11(7ndash8) 348ndash

354 httpdoiorg101016jdrudis200602006

Wermuth C G

Selective optimization of side activities The SOSA approach Drug Discovery Today 2006

11(3ndash4) 160ndash164 httpdoiorg101016S1359-6446(05)03686-X

Wu X Zhong H Song J Damoiseaux R Yang Z Lin S

Mycophenolic acid is a potent inhibitor of angiogenesis Arteriosclerosis Thrombosis and

Vascular Biology 2006 26(10) 2414ndash2416

httpdoiorg10116101ATV000023836107225fc

Yip K W Mao X Au P Y B Hedley D W Chow S Dalili S Liu F F

Benzethonium chloride A novel anticancer agent identified by using a cell-based small-

molecule screen Clinical Cancer Research 2006 12(18) 5557ndash5569

httpdoiorg1011581078-0432CCR-06-0536

Yip K W Ito E Mao X Au P Y B Hedley D W Mocanu J D Liu F-F

Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent

Molecular Cancer Therapeutics 2006 5(9) 2234ndash40 httpdoiorg1011581535-7163MCT-

06-0134

Zotchev S B Stepanchikova A V Sergeyko A P Sobolev B N Filimonov D A

Poroikov V V

Rational design of macrolides by virtual screening of combinatorial libraries generated through

in silico manipulation of polyketide synthases Journal of Medicinal Chemistry 2006 49(6)

2077ndash2087 httpdoiorg101021jm051035i

Bakshi P Liao Y-F Gao J Ni J Stein R Yeh L-A Wolfe M S

A High-Throughput Screen to Identify Inhibitors of Amyloid beta-Protein Precursor

Processing Journal of Biomolecular Screening 2005 10(1) 1ndash12

httpdoiorg1011771087057104270068

Case A Ni J Yeh L A Stein R L

Development of a mechanism-based assay for tissue transglutaminase - Results of a high-

throughput screen and discovery of inhibitors Analytical Biochemistry 2005 338(2) 237ndash244


Edwards B S Bologa C Young S M Balakin K V Prossnitz E R Savchuck N P

Oprea T I

Integration of Virtual Screening with High-Throughput Flow Cytometry to Identify Novel

Small Molecule Formylpeptide Molecular Pharmacology 2005 68(5) 1301ndash1310

httpdoiorg101124mol105014068phenylalanine

Mizumoto N Gao J Matsushima H Ogawa Y Tanaka H Takashima A

Discovery of novel immunostimulants by dendritic-cell ndash based functional screening Blood

2005 106(9) 3082ndash3090 httpdoiorg101182blood-2005-03-1161

OrsquoConnor K A Roth B L

Finding New Tricks For Old Drugs An Efficient Route For Public-Sector Drug Discovery Nat

Rev Drug Discov 2005 4(12) 1005ndash1014 httpdoiorg101038nrd1900

Rao F V Andersen O A Vora K A DeMartino J A Van Aalten D M F

Methylxanthine drugs are chitinase inhibitors Investigation of inhibition and binding modes


Ray S S Nowak R J Brown R H Lansbury P T

Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked

superoxide dismutase mutants against unfolding and aggregation Proceedings of the National

Academy of Sciences of the United States of America 2005 102(10) 3639ndash3644


Razonable R R Henault M Watson H L Paya C V

Nystatin induces secretion of interleukin (IL)-1β IL-8 and tumor necrosis factor alpha by a

toll-like receptor-dependent mechanism Antimicrobial Agents and Chemotherapy 2005 49(8)


Wible B A Hawryluk P Ficker E Kuryshev Y A Kirsch G Brown A M HERG-

Litereg A novel comprehensive high-throughput screen for drug-induced hERG risk Journal of

Pharmacological and Toxicological Methods 2005 52(1) 136ndash145


Young S M

High-Throughput Screening with HyperCyt(R) Flow Cytometry to Detect Small Molecule

Formylpeptide Receptor Ligands Journal of Biomolecular Screening 2005 10(4) 374ndash382

httpdoiorg1011771087057105274532

Ahn J S

Development of an Assay to Screen for Inhibitors of Tau Phosphorylation by Cdk5 Journal of


Doan T

High-throughput target validation in model organisms Drug Discovery Today TARGETS

2004 3(5) 191ndash197 httpdoiorg101016S1741-8372(04)02452-1

Edwards B S Oprea T Prossnitz E R Sklar L A

Flow cytometry for high-throughput high-content screening Current Opinion in Chemical

Biology 2004 8(4) 392ndash398 httpdoiorg101016jcbpa200406007

Gaud A Simon J M Witzel T Carre-Pierrat M Wermuth C G amp Seacutegalat L

Prednisone reduces muscle degeneration in dystrophin-deficient Caenorhabditis elegans

Neuromuscular Disorders 2004 14(6) 365ndash370 httpdoiorg101016jnmd200402011

Wermuth C G

Selective Optimization of Side Activities Another Way for Drug Discovery Journal of

Medicinal Chemistry 2004 47(6) 1303ndash1314 httpdoiorg1010029781118098141ch11

Rushton D N

Functional Electrical Stimulation and rehabilitationmdashan hypothesis Medical Engineering amp

Physics 2003 25 75ndash78 httpdoiorg101016S

Oprea T I

Virtual screening in lead discovery A viewpoint Molecules 2002 7(1) 51ndash62

httpdoiorg10339070100051

Poroikov V V Filimonov D A

How to acquire new biological activities in old compounds by computer prediction Journal of

Computer-Aided Molecular Design 2002 16(11) 819ndash824

httpdoiorg101023A1023836829456

biologically annotated drugs that trigger triacylglycerol accumulation in the

diatomPhaeodactylum Plant Physiology (2018) httpsdoi101104pp1701804

Coutard B et al Toward the identi fi cation of viral cap-methyltransferase inhibitors by

fluorescence screening assay Antiviral Research 144 330ndash339 (2017) httpdxdoiorg101016jantiviral201706021

Jung H et al Amodiaquine improves insulin resistance and lipid metabolism in diabetic

model mice Diabetes Obes Metab 1ndash14 (2018) httpdoi101111dom13284

Sandra M W van de Wiel D Rudi de Waart Ronald P J Oude Elferink and Stan F J van

de Graaf Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the

Organic Solute Transporter a-b Cell Mol Gastroenterol Hepatol 5223ndash237 (2018)

httpdoi101016jjcmgh201711011

Astol A et al Pharmacophore-Based Repositioning of Approved Drugs as Novel

Staphylococcus aureus NorA Efflux Pump Inhibitors JMedChem 60 1598minus1604 (2017)

httpdoi101021acsjmedchem6b01439

Eren R O et al Development of a semi-automated image-based high-throughput drug

screening system Front Biosci 242ndash253 (2018)

Jones C L Njomen E Dexheimer T S amp Tepe J J Small Molecule Enhancement of 20S

Proteasome Activity Targets Intrinsically Disordered Proteins ACS Chem Biol 12

2240minus2247 (2017) httpdoi101021acschembio7b00489

O L M Meijer P van den Biggelaar R Ofman F A Wijburg N van Vlies High-

Throughput Screen Fails to Identify Compounds That Enhance Residual Enzyme Activity of

Mutant N- Acetyl- a -Glucosaminidase in Mucopolysaccharidosis Type JIMD Reports

(2017) httpdoi1010078904

Reis S Dos et al Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two

Unrelated Antiprion Drugs 35 e2174 PLoS ONE (2008)


Gug F Oumata N amp Blondel M Synthesis of Conjugates of 6-Aminophenanthridine and

Guanabenz Two Structurally Unrelated Prion Inhibitors for the Determination of Their

Cellular Targets by Affinity Chromatography Bioconjugate Chem 279ndash288 (2010)

httpdoi101021bc900314n

Dos S et al Biochimie Mode of action of the antiprion drugs 6AP and GA on ribosome

assisted protein folding Biochimie 93 1047ndash1054 (2011)

httpdoi101016jbiochi201103002

Nguyen P et al Structure minus Activity Relationship Study around Guanabenz Identifies Two

Derivatives Retaining Antiprion Activity but Having Lost α 2- Adrenergic Receptor Agonistic

Activity ACS Chem Neurosci 2014 5 1075minus1082 (2014)

httpdxdoiorg101021cn5001588


















Bastin J Djouadi F



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Young S M



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