european oncology conference · 2019-12-27 · result: some countries (peru, cuba & mexico) are...

Dear participants of Euro Oncology 2020 and colleagues around the World!

Please, receive our warmest greetings from the “Euro Oncology Conference 2020”, the inspiring scientific event to be held during March 30-31, 2020, in Paris, France.

Our theme relates to the “Advancements in Oncology and Cancer Science”, a challenging trending topic in the research field. We all know that cancer is not one disease, it is more than 200 diseases, and most of them are unique and quite different one another. Consequently, the cellular factors (and the external stimuli) that are responsible for different types of cancer constitute a vast research field. New findings are essential for designing new specific approaches related to an efficient prevention and treatment of the disease. The discovery of novel factors associated to cancer development and progression is growing exponentially at the present time. A similar observation is valid for the number of external stimuli and supposedly simple physiologic responses, which could show unsuitable intensity or being extended for inappropriate periods of time. We hope and wish that the most recent discoveries that are going to be discussed in this meeting, which are typically achieved due to collaborative and multi-disciplinary endeavours, will shed new light on our understanding of this significant health and social problem. We expect that all attendees may experience two wonderful and fruitful days in the City of Light. Paris welcomes you all!

Mario D. GalignianaProfessorUniversity of Buenos AiresArgentina

Welcome Message

WORKSHOP on

Dr. Kazuko TatsumuraDirector, Gaia Holistic Health USA

INTRODUCTION: Onnetsu means comfortable heat. Onnetsu Thermotherapy invented by Dr. Kazuko Tatsumura emits from a special patented ceramic; 1) Heat 2) Precise 8-10μ of vibration of Far Infrared SunRay and 3) Vibration of Terahertz.

Dr. Tatsumura is the first in the world to incorporate Terahertz minerals to medical use from active volcanos stones from Japan. Worldwide patent pending.

METHODS: When Onnetsuki is slid over the skin, healthy areas are comfortable, but IF deep tissue is unhealthy or cold, degenerated, patient feels this spot to be ‘hot’. When this ‘hot spot’ is effectively treated with Onnetsu Thermotherapy (Far-Infrared & Terahertz vibrations, and Heat), the hot sensation subsides and the Disease Conditions improve through vibrating water molecules of our deep tissue. Therefore, the Onnetsu Thermotherapy is both a diagnostic and therapeutic.

Dr Kazuko’s Onnetsu Thermotherapy is based on four historical and scientific facts.

1. Traditional Japanese Concept of the significance of Body Temperature. Hippocrates also has left quotes on Heat.

2. NASA’s finding regarding Far-Infrared vibration from Sun light precise 8-10μ. Also, added is the specific Terahertz vibration of earth minerals from volcanos stones from the depth of our planet earth.

3. Immunology by Dr. Toru Abo, balancing autonomic nervous system to improve condition of white cells; Raising Immunity.

4. Promoting four flows of Energy throughout our body by using acupuncture meridian technique.

RESULT: Some countries (Peru, Cuba & Mexico) are practicing it in the hospitals and clinics. Clinical trials have shown improvements on many diseases: such as asthma, brain, ear & eye problems, cancers, diabetes, rheumatoid arthritis, tuberculosis and various pain conditions. Clinical studies from Cuba and Peru will be presented.

CONCLUSION: Onnetsu Thermotherapy is a new, easy & noninvasive treatment modality to treat difficult chronic medical conditions. Therapy uses Universal Vibrations, Heat, Light, Autonomic Nervous System

Balance and Acupuncture Meridian System.

Dr. Kazuko has taught Onnetsu Thermotherapy to MDs and health practitioners over past decades throughout the world.

“Effects of Far-Infrared & Terahertz Onnetsu Thermotherapy on Various Cancers, Rheumatoid Arthritis and other diseases”

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Oncology | Pancreatic Cancer | Breast Cancer | Oral and Oropharyngeal Cancer | Eye Cancer | Uterine Cancer | Lung Cancer | Skin Cancer | Kidney Cancer | Bladder Cancer | Prostate Cancer | Colorectal Cancer | Anal Cancer | Cervical Cancer | Bone Cancer | Liver Cancer | Stomach Cancer | Blood Cancer | Brain Cancer | Gastrointestinal Cancer | Ovarian & Testicular Cancer | Cancer research and Cancer vaccines | Cancer Genetics | Treatment of cancer

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MONDAY, MARCH 30, 2020Concurrent Educational Sessions

GROUP PHOTO

LUNCH BREAK

COFFEE BREAK

COFFEE BREAK

ONCOLOGy

EyE CANCER

PANCREATIC CANCER

UTERINE CANCER

BREAST CANCER

LUNG CANCER

ORAL AND OROPHARyNGEAL CANCER

SKIN CANCER

• Risk factors• Screening• Signs & Symptoms• Diagnosis & staging• Specialities

• Dermoid cysts• Rhabdomyosarcoma• Retinoblastoma• Intraocular tumors• Choroid tumor• Iris tumor

• Adenosquamous carcinomas• Squamous cell carcinomas• Giant cell carcinomas• Insulinomas (Insulin)• Glucagonomas (Glucagon)• Gastrinomas (Gastrin)• Somatostatinomas (Somatostatin)• VIPomas (Vasoactive Intestinal

Peptide)

• Pelvic pain• Vaginal bleeding• Mass in the vagina• Metabolic syndrome• Type-2 diabetes

• Inverted nipple• Nipple discharge• Discomfort• Lumps• Fibroadenoma

• Smoking• secondhand smoke• Radon• Asbestos• Family history of lung cancer

• Mouth Ulcer• Tobacco use• Alcohol• Human papillomavirus (HPV)• Poor oral hygiene• Marijuana use• Poor diet/nutrition

• Expose to ultraviolet radiation• Tanning beds• Fluoruorcil• Kaposi’s sarcoma• Sebaceous carcinomas

KIDNEy CANCER BLADDER CANCER PROSTATE CANCER COLORECTAL CANCER

• Renal cell cancer• Transitional cell cancer• Wilms tumor• WAGR syndrome• Renal tubule & renal pelvis

• Blood in urine• Transurethral resection• Urinary diversion• Cystitis• Benzidine• 2-Naphthylamine

• Benign prostate hyperplasia• Gonorrhea• Prostate-specific Antigen

(PSA)• 5α-reductase inhibitors• Bisphosphonates

• Inflammatory bowel disease• Crohn’s disease• Ulcerative colitis• Colonoscopy• Sigmoidoscopy• Aspirin

ANAL CANCER CERVICAL CANCER BONE CANCER LIVER CANCER

• Rectal bleeding• Sexual activity• Immunosuppression• Cloacogenic carcinoma• Apoptosis• Anal intraepithelial neoplasia

(AIN)

• Sexual intercourse• Birth control pills• Henrietta Lacks (HeLa)• Multiple pregnancies• Oral contraceptives

• Fatigue• Wieght loss• Osteochondroma• Osteoblastoma• Enchondroma• Ewing’s sarcoma

• Mucinous cystic neoplasm• aflatoxin• Hepatocellular carcinoma (HCC)• Cholangiocarcinoma• Ablation therapy• Liver transplantation


GROUP PHOTO

LUNCH BREAK

COFFEE BREAK

STOMACH CANCER

OVARIAN & TESTICULAR CANCER

BLOOD CANCER

CANCER RESEARCH AND CANCER VACCINES

BRAIN CANCER

CANCER GENETICS

GASTROINTESTINAL CANCER

TREATMENT OF CANCER

• Helicobacter pyroli• Mesenchymal tumors• Constipation• Blood vomiting• Dysphagia• Tropical sprue

• Fertility medication• Menopause• Sex cor stromal tumors• Germ cell tumors• Undescended testis• Crytochidism

• Ionizing radiation• Down syndrome• Acute lymphoblastic leukemia• Acute myeloid leukemia• Chronic lymphoblastic leukemia• Chronic myeloid leukemia

• Antigem vaccines• Whole cel vaccines• Dendritic cell vaccines• DNA vaccines• Anti idiotype vaccines

• Change in mental capacity• Hallucination• Brain strokes• Hemorrhages• Vasculitis

• Human Genome Project• Whole genome sequencing• Operomics• Oncogenomics• Point mutations• Cancer genome sequencing

• Hoarseness of voice• Barrette’s esophagus• Esophageal cancer belt• Caustic substances• Barium solution• Tube prosthesis

• Surgery• Bone marrow transplantation• Radiation treatment• Chemotherapy• Immunotherapy• Hormone therapy• Precision medicine• Stem cell treatment


TUESDAY, MARCH 31, 2020Concurrent Educational Sessions

Title: Effects of Far-Infrared & Terahertz Onnetsu Thermotherapy

on Various Cancers, Rheumatoid Arthritis and other diseases

Kazuko Tatsumura | Director, Gaia Holistic Health USA and Japan

Abstract: Onnetsu means comfortable heat. Onnetsu Thermotherapy invented by Dr. Kazuko Tatsumura emits from a special

patented ceramic; 1) Heat 2) Precise 8-10µ of vibration of Far Infrared SunRay and 3) Vibration of Terahertz. Dr. Tatsumura is the

first in the world to incorporate Terahertz minerals to medical use from active volcanos stones from Japan. Worldwide patent

pending.

METHODS: When Onnetsuki is slid over the skin, healthy areas are comfortable, but IF deep tissue is unhealthy or cold,

degenerated, patient feels this spot to be ‘hot’. When this ‘hot spot’ is effectively treated with Onnetsu Thermotherapy (Far-

Infrared & Terahertz vibrations, and Heat), the hot sensation subsides and the Disease Conditions improve through vibrating

water molecules of our deep tissue. Therefore, the Onnetsu Thermotherapy is both a diagnostic and therapeutic. Dr Kazuko’s

Onnetsu Thermotherapy is based on four historical and scientific facts. 1. Traditional Japanese Concept of the significance of Body

Temperature. Hippocrates also has left quotes on Heat. 2. NASA's finding regarding Far-Infrared vibration from Sun light precise 8-

10µ. Also, added is the specific Terahertz vibration of earth minerals from volcanos stones from the depth of our planet earth. 3.

Immunology by Dr. Toru Abo, balancing autonomic nervous system to improve condition of white cells; Raising Immunity. 4.

Promoting four flows of Energy throughout our body by using acupuncture meridian technique.

RESULT: Some countries (Peru, Cuba & Mexico) are practicing it in the hospitals and clinics. Clinical trials have shown

improvements on many diseases: such as asthma, brain, ear & eye problems, cancers, diabetes, rheumatoid arthritis, tuberculosis

and various pain conditions. Clinical studies from Cuba and Peru will be presented.

CONCLUSION: Onnetsu Thermotherapy is a new, easy & noninvasive treatment modality to treat difficult chronic medical

conditions. Therapy uses Universal Vibrations, Heat, Light, Autonomic Nervous System Balance and Acupuncture Meridian System.

Dr. Kazuko has taught Onnetsu Thermotherapy to MDs and health practitioners over past decades throughout the world.

Title: Bio-Physical tendencies with applied methods of mind/body/soul

techniques sound frequencies and including the art of intuition

Marilyn Parkin | International College of Medical Intuition, Inc., USA

Abstract: This study was conducted to determine the effects of sound vibration on individuals with depression. The

study also examined changes to the blood cells as observed through live blood analysis when the intervention of

vibratory frequencies ranged from 64Hz to 600Hz. Variables consisted of a time frame of one hour of control group

(n=17) listening to music from the position of a chair in a contained room, and experimental group (n=27) positioned

on a sound vibrational treatment table. The random study was conducted on 7 males and 37 females with a minimal

six-month diagnosis of depression. Measurement was accomplished through evaluation of live blood analysis level of

aggregation and Profile of Mood States questionnaire for depression. A drop of blood from a finger puncture was

obtained and examined through Darkfield microscopy for specific quality and level of visible clumping. Post blood

analysis determined less clumping and healthier activity of the cells after intervention in the experimental group. The

live blood analysis of the control group remained unchanged. Profile of Mood States for Depression indicated there

was no significant difference between the experimental and control groups. Results indicated an increase in mood

state from the use of music and blood aggregation was reduced only with the sound vibrational treatment table

Title: HSF1-dependent regulatory mechanism of Hsp90-binding

immunophilins on hTERT subcellular localization and biological action

Mario D. Galigniana | Instituto de Biología y Medicina Experimental (IBYME), Argentina

Abstract: Cancer cells achieve proliferative immortality by up-regulating telomerase. hTERT is the telomerase catalytic subunit

responsible for the reverse-transcriptase activity. hTERT forms oligomeric complexes with a template functional RNA, the

chaperone Hsp90,the co-chaperone p23, and other accessory proteins. Recently, our laboratory demonstrated that a significant

pool of the Hsp90binding immunophilin FKBP51 is located in mitochondria. FKBP51 shows antiapoptotic action, is overexpressed

in cancer cells, and undergoes nuclear-mitochondrial trafficking upon the onset of stress. In this study it is demonstrated that

FKBP51 nuclear accumulation depends on the activation of the transcription factor HSF1. In the nucleus, FKBP51 and also its highly

homologous partner FKBP52 bind to the hTERT•Hsp90 nuclear heterocomplex in a peptidylprolyl-isomerase (PPIase)independent

manner. Both immunophilins enhance telomerase enzymatic activity in a PPIasedependent fashion. The basal nuclear localization

of hTERT is favored by FKBP52 due to two reasons: a) its involvement in the Hsp90•FKBP52•dynein-dependent mechanism for

hTERT cytoplasmic transport towards the nucleus, and b) by anchoring hTERT to the nucleoskeleton matrix. The disruption of the

hTERT heterocomplex with the Hsp90 inhibitor radicicol or due to the overexpression of the Hsp90-binding TPR peptide,

delocalizes hTERT from nucleus to cytoplasm, demonstrating a cardinal role of the chaperone in this process. On the other hand,

the Hsp90-free hTERT becomes unstable and is targeted to proteasome degradation, unless hTERT is translocated to

mitochondria, where it seems to complement the overall antiapoptotic action of FKBP51. Oxidative stimuli (H2O2, arsenite, BSO,

tert-butyl-hydroperoxide, etc.) also disengage hTERT from nuclear structures favoring its nuclear export. Importantly, oxidative

stress increases hTERT expression. Because several stimuli such as high ionic strength, high glucose, heat-shock, etc. also show

similar effect, it was hypothesized that the HSF1 activation is involved. This was confirmed due to the lack of hTERT induction in

HSF1-KO cells compared to wild-type cells, and by the high basal expression of hTERT due to the mere overexpression of HSF1,

even in the absence of stimuli. It is concluded that: a) the nuclear translocation of FKBP51 from mitochondria depends on the

activation of HSF, b) the expression level of hTERT also depends on HSF1 activation, and c) the subcellular localization and stability

of hTERT is commanded by Hsp90

Title: Novel preclinical models for drug validation studies in

cancer and osteoarthritis fields

Mingxing Wei | Scientist, Cellvax, France

Abstract: Cellvax, founded in 2001, is a French SME which provides complete preclinical innovating drug validation

studies both in vitro and in vivo allowing to accelerate the drug development process for unmet needs related to severe

human diseases, mainly in Cancer and Osteoarthritis (OA) fields. Cellvax, founded in 2001, is a French preclinical CRO

which provides complete innovating drug validation studies both in vitro and in vivo allowing to accelerate the drug

development process for unmet needs related to severe human diseases, mainly in Cancer and Osteoarthritis (OA)

fields. Through a strategic partnership with two Chinese CROs, Cellvax can provide large animal studies such as in

monkeys, Beagle dogs and pigs, and for clinical trials, product registrations in China. Since 2019, Cellvax made a

strong commitment in GLP implementation. Cellvax has a strong will to work and collaborate with biotech companies,

public and pharmaceutical laboratories in order to speed up the development of innovative compounds. By offering its

know-how and its capacity of innovation, Cellvax is willing to collaborate with biotech companies, public laboratories

and pharmaceutical societies. Also, academic groups or small biotechs interested in working with Cellvax towards EU

grant funding applications. Cellvax was created by a motivated and complementary team consisting of scientists and

experts in these fields. By offering its know-how and its capacity of innovation, Cellvax is willing to collaborate with

public and private laboratories. Cellvax’s expertise is based on its know-how in the field of molecule biology, cellular

biology, and original in vitro and in vivo models. These services can be offered to all laboratories involving in anti-

cancer and anti-OA drug development process. These proposed services adapt to the validation and development of

drug candidates and fully validated such as sub-cutaneous and orthotopic tumors models in animals; in vitro and in vivo

angiogenesis models; an original “Nodule” system, in vivo imaging, bio-distribution, pharmacokinetics, toxicity,

spontaneous and induced animal models for OA, etc. Cellvax is always ready to obey market evolution and to satisfy its

customers’ specific needs all over the world. Cellvax is strongly willing to develop and enhance its national and

international collaboration with public laboratories, biotechnological companies and pharmaceutical companies.

Title: Efficacy and Safety of Oncoxin-Viusid, a Nutritional Supplement, in Twenty

Patients with Stage IIB-III of Cutaneous Melanoma. An open-label proof of concept

study

Olaine R. Gray Lovio | Manuel Fajardo University Hospital, Cuba

Abstract: Surgery is the treatment of choice of melanoma, but in advanced stages, it is often necessary to combine

this with other therapeutic options. Oncoxin-Viusid has demonstrated antitumor and immunomodulating effects in

various type of cancers, in addition to boosting the antiproliferative effect of standard chemotherapy agents in

experimental studies. Our study was aimed to identify the efficacy and safety of the Oncoxin-Viusid as an adjuvant

treatment for patients with stage IIB-IIIA cutaneous melanomas.

METHODS: From September 2014 to April 2018, a proof of concept, open label nonrandomized and uncontrolled

study was conducted at the Manuel Fajardo University Hospital (Havana, Cuba), including 20 patients with

histologically-confirmed diagnosis of stage IIB-III of primary cutaneous melanoma. All patients received surgical

treatment with or without chemotherapy in combination with Oncoxin-Viusid 25 ml twice a day for 1 year. Overall

and Progression Free Survival and 95 % confidence interval was estimated after one year of inclusion and quality of life

was measured at inclusion and after a year using QLQ-C-30 EORTC questionnaire.

RESULTS: Most of the patients were women with a median age of 59 years, cutaneous phototypes II-III, occupations

without photoexposure, without personal or family background of cutaneous cancer. 40 % of patients presented with

superficial spreading melanoma, epithelioid presentation being histologically predominant. Adverse reactions were,

for the most part, mild and short-lived. There were two deaths among 3 patients that progressed. Two patients were

early withdrawal to follow-up. Overall survival estimated was 90 % [95 CI: 0.65; 0.97]

CONCLUSION: Nutritional supplement Oncoxin-Viusid showed safety; meanwhile patients kept a stable quality of life

at the end of study and a high overall survival rate

Title: Practical use of amino acids in oncology: replacement therapy as a structural components

of proteins and / or for correction of metabolism in quantities comparative with metabolism in

quantities comparative with their endogenous concentrations?

L. Nefyodov | Yanka Kupala Grodno State University, Belarus

Abstract: Changes in amino acid pool of oncology patients specifically characterize development of cancer and largely induced by

metabolic competition between the tumor and the tumor carrier. The aim of our research is the formulation of methodology

creation for practical application of the regulatory action of endogenous concentrations of separate amino acids or their

pathogenetically justified compositions. Our clinical studies of biological fluids and tumors with cancer depending on the location

and stage of the process showed significant changes in concentrations of amino acids which regulate processes of antitumor

response, oncogenesis, immunogenesis and apoptosis.

Methods: Our methodology is based on studies of concentrations of free amino acids, their derivatives, precursors and

metabolites, as well as biochemical marker parameters in healthy donors and patients with oncology and construction of an

empirical mathematical model consisting of pathogenic markers of oncology and amino acid profiles, specialized development of

new formulations of the compositions of infusion solutions of amino acids.

Results: The amino acids pool as a dynamical system-generated supply of them from outside, but also due to endogenous

synthesis, transport, degradation and excretion and allows the identification of “key points” in intermediate metabolic equilibrium

shift that may reflect ratios at the individual levels of endogenous amino acids and related species compounds to achieve

“metabolic comfort”.

Conclusion: On the basis of the our data we suggest that the differences discovered in certain amino acids concentrations in fluids

and tissues are criteria in early diagnostics as in estimation of the efficacy of specific cancer treatment. The creation methodology

of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical

application of their regulatory effects in oncology was discussed.

Title: 2D to 3D Conformal Radiation Therapy for Breast Cancer

Vinay Sharma | University of Witwatersrand, Johannesburg, South Africa

Abstract: Conformal radiation therapy for breast cancer is being used as a standard radiation therapy technique in most centres in

the world.

Aim: The aim of the study was to document the doses to lung and heart (organs at risk) in addition to breast tumour volumes to

correlate with treatment related toxicities.

Methods: A total of 183 patients of cancer of breast underwent CT scans and planning procedure after decision at the

multidisciplinary management meeting during 2016-19. Both right and left breast were almost equally affected (Right – 98 patients

(54%) and left -85 patients (46%)). All patients had MUGA scans before RT planning. Sixty-six patients (37%) had conservative

breast surgery and 117 had mastectomies. One hundred eleven patients (61%) received 50Gy in 25 fractions and 70(39%) patients

had 40.05Gy in 15 fractions. The Radiation therapy was delivered using 6Mv photos with different fields. The patients with

conservative surgery received a boost to the tumour bed following tangential field. The patients with locally advanced disease and

nodal involvement received radiation to chest wall as well lymph drainage areas. Fifty-one percent (93 patients) had radiation to

chest wall and lymph drainage areas; 38 patients (21%) had tangential field and tumour bed boost. The lung constraints used were

V20 =≤30Gy, V8= 35-40% and mean lung dose = <15Gy.

Results: One hundred and Sixty - eight patients (92%) achieved the lung constraints. The heart constraints used were V25Gy =

<10% and mean heart dose = <26Gy. The heart constraints both V25 as well as mean heart dose could be achieved in all except 1

patient.

Conclusion: Conformal radiation was able to achieve the aim of study and constraint were maintained in over 90 percent patients.

There is no toxicity reported up till now on follow up

Title: Targeting angiogenesis by blocking ATM-SerRS-VEGFA pathway for

UV-induced skin photodamage and melanoma growth

Yadong Song | Nankai University, China

Abstract: Retinoic acid (RA) has been widely used to protect skin from photo damage and skin carcinomas

caused by solar ultraviolet (UV) irradiation, yet the mechanism remains elusive. Here, we report that all-

trans retinoic acid (tRA) can directly induce the expression of a newly identified potent anti-angiogenic

factor, seryl tRNA synthetase (SerRS), whose angiostatic role can, however, be inhibited by UV-activated

ataxia telangiectasia mutated (ATM) kinase. In both a human epidermal cell line, HaCaT, and a mouse

melanoma B16F10 cell line, we found that tRA could activate SerRS transcription through binding with the

SerRS promoter. However, UV irradiation induced activation of ATM-phosphorylated SerRS, leading to the

inactivation of SerRS as a transcriptional repressor of vascular endothelial growth factor A (VEGFA), which

dampened the effect of tRA. When combined with ATM inhibitor KU-55933, tRA showed a greatly enhanced

efficiency in inhibiting VEGFA expression and a much better protection of mouse skin from photo damage.

Also, we found the combination greatly inhibited tumor angiogenesis and growth in mouse melanoma

xenograft in vivo. Taken together, tRA combined with an ATM inhibitor can greatly enhance the anti-

angiogenic activity of SerRS under UV irradiation and could be a better strategy in protecting skin from

angiogenesis-associated skin damage and melanoma caused by UV radiation

Title: A retrospective study of malignant melanoma from a

tertiary care centre in Saudi Arabia from 2004 to 2016

K. Anwar | Alfaisal University, Riyadh, Saudi Arabia

Abstract: Malignant melanoma is a well-known and commonly lethal tumour yet there exists scarce published

information available from Saudi Arabia.

Materials and methods: This study examined the demographic, clinical, and histopathological profile of melanoma in

a sample of Saudi patients over a period of 13 years. Medical records of 98 patients from 2004 to 2016 were retrieved

from the Department of Pathology and Laboratory Medicine at King Faisal Specialist Hospital (KFSH), Riyadh, Saudi

Arabia.

Results: Forty two males and fifty six females (median age of 58 years) were analysed. Most cases were diagnosed in

patients aged 50 years or above. The most common sites of occurrence were the extremities, especially the feet,

followed by the head and neck, and then mucosal regions. Most mucosal melanomas were located in the mouth. The

most common histopathological form was nodular melanoma (38 cases) followed by acral lentiginous melanoma (27

cases). Most of the cases were diagnosed in late diagnostic stages III and IV (59 cases) and most had higher Clark’s

level and stage V Breslow thickness. The cases with preceding history of xeroderma pigmentosum and dysplastic nevi

tended to be diagnosed earlier. The most common mode of treatment was surgical resection. Patients on palliative

treatment were older. Only 27/40 patients were confirmed to be alive and the rest were lost to follow-up.

Conclusion: Our data contrast with previously published studies from other parts of the world. Further work is needed

to confirm our findings of female preponderance, common histological subtypes of nodular and acral melanomas, and

the high involvement of oral mucosa in our Saudi patients

Title: Viruses germinations by especial quanta Solar rays cause influenza, HIV etc.

and oncologic diseases through Oncogenesis processes of an organism

M. Ponizovskiy | Kiev regional p/n Hospital, Ukraine

Abstract: Solar thermonuclear synthesis causes by especial quanta of Solar rays, which promote to generate viruses as

well as other living creatures. Just viruses are initial generated into living organisms. Because viruses have no cellular

respiratory mechanism especially electron respiratory chain, they use it from living organisms. Thus there are arised

different viruses causing different diseases as influenza viruses, HIV viruses, oncoviruses [v-oncogen] etc. Thus

oncogenesis is exerted causing cellular genome transmutation that form cancer cells. Besides viral initial prokaryotic

cells have haploid genomes which exert anabolic endergonic biosynthetic processes but need catabolic exergonic both

anaerobic processes of oxidative phosphorilation and aerobic processes of respiratory oxidation, i.e. human cell’s

electron transport chain. Furthermore each cell can function due to balance anabolic endergonic processes & catabolic

anaerobic exergonic processes & catabolic aerobic exergonic processes which stimulate also driving mechanism cellular

cycle. Therefore it should be considered the coupled viral prokaryotic and human eukaryotic genomic mechanism in

cancer cells’ cellular cycle. All viruses use human electron transport chain for its cellular oxidative processes to build

new cells via proliferative processes of viruses’ cells. However these consumptions energy are different by different

viruses because different viruses obtain Basic Internal Energy [molecular bonds energy] in different levels of an

organism. For example, influenza viruses obtain Basic Internal Energy [molecular bonds energy] from type cells being

light separated by an organism, but v-oncogenes intrude in deep level Basic Internal Energy [molecular bonds energy]

of cellular genome, maybe on levels either Oligopotent stem cells or even Multipotent stem cells using also

mitochondrial oxidative processes of an organism’s cells that give cancer cell possibility firm binding in genome and to

develop itself in autonomic mode from some regulatory functions of an organism causing obstacles for treatment with

moderate dosage cytotoxic drugs, compelling treatment with great dosage cytotoxic drugs. Just the viral oncogenes,

which intrude in Oligopotent stem cells, replace Oligopotent stem cells into Cancer stem cells causing following

sequence of cencerous genetic link Basic stem cells → Totipotent stem cells → Pluripotent stem cells → Multipotent

stem cells → Cancer stem cells → Cancer cells. Cancer cells obtain energy through this link from Basic Internal energy.

It is meant that several v-oncogenes genome bind affected human cells’ genome with covalent bonds causing couple

cancer cells‘ genomes which contain mixed genome containing from 49 till 56 chromosomes exhibiting aneuploidy,

versus 46 chromosomes in normal eukaryotic cells. As concerning to HeLa independent from an organism cancer cells,

HeLa cells absorb whole mitochondrial oxidative system in their bodies creating metabolisms similar as bacteria

https://en.wikipedia.org/wiki/Totipotency

https://en.wikipedia.org/wiki/Pluripotency



Title: Lazy lateral technique: an innovative approach for upper

outer quadrant breast cancer near the anterior axillary fold

M. Abdelhamid | Zagazig University, Egypt

University, Zagazig, Egypt

Abstract: Surgical treatment of breast cancer was challenged over years. Breast conservation is as oncologically safe

as mastectomy and gives better cosmetic and psychological outcomes.

Aim: The aim of our study was to evaluate the oncological and esthetic outcomes of the lazy lateral technique as a

new approach for tumor located at the upper outer quadrant near anterior axillary fold.

Patients and methods: Between October 2012 and September 2014, 18 patients with early breast cancer at the upper

outer quadrant and near the anterior axillary fold were surgically treated with the lazy lateral technique.

Results: the age of our patients ranged from 36 to 58 years (median: 47 years). Most of the patients in this study were

diagnosed as having infiltrating ductal carcinoma (14 patients, 77.7%). The size of the tumor ranged from 0.9 to 3.8

cm. No involved margin on frozen section. Seroma was the most common postoperative complication and developed

in two (11.1%) patients. The cosmetic outcome was excellent in 12 (66.6%) patients, good in five (27.7%) patients, and

satisfactory in one (5.5%) patient. No local recurrence or systemic metastasis was noticed in our patients during a

median follow-up period of 38 months (range:

27–49 months).

Conclusion: The lazy lateral technique is a novel approach for surgical treatment of upper outer quadrant breast

cancer near the anterior axillary fold. It is an oncologically safe procedure and promotes satisfactory esthetic

outcomes

Title: Application of a statistical modelling to handle breast cancer

patients with no recurrence

Freshteh Osmani | Birjand University of Medical Sciences, Iran

Abstract: Recurrent event data arise frequently in longitudinal medical studies. In many situations, there are a large

portionof patients without any recurrences, manifesting the “zero-inflated” nature of the data.Also, there often exists

a terminal event which may be correlated with the recurrentevents. The goal of this study is to extend the applications

of joint frailty modelto identify the prognostic factors associated with curing in patients with breast cancer.

Methods: As a prospective study, medical records of women who had been attended to cancer research center,

Shahid Beheshti University of medical sciences from January 1998 to February 2016 were reviewed.Finally after an

initial review of medical records, 711 patients were included in the study and analyzed .A checklist that included items

drawn from demographic background of patientswas provided in the study. Two joint frailty models for zero-inflated

recurrent events, combining a logistic model for “structural zero” status (Yes/No) and a joint frailty proportional

hazards model forrecurrent and terminal event times were performed to identify factors associated with BCS.

Results: The mean age of patients was 38.2 years. The numbers of subjects with 1,2, 3, 4 recurrent events were 392, 207, 97, and 15, respectively.The median follow-up time was 6.87 years. There were 137(19.2%) deaths from cancer during the follow-up. Among the574 patients who were censored, 418 had no tumor recurrence. That is, there may exist a large portion of “cured” subjects. We can see that the radiation (OR=6.02, CI=(3.87,8.61)) and tumor size interaction with radiation(OR=1.065,CI=(1.002-1.26))were significant in the cure model (p <0.05) that it meanspatients with smaller tumor sizes were more likely to be cured by radiation therapy.

Title: Anthocyanin Acts As Scavenger For Heavy Metal ions , Attack Cancer cell, and

Interacts With Uric Acid and Urea To Expel it Through Urine System

Jaleel Kareem Ahmed | University of Babylon, Iraq

Abstract: Anthocyanin is found mainly in red beet juice, cherry , red rose • It is red color pigment with high solubility

in water . • The power of exchangeable proton in its juice from red beet nearly 6.4 while in red rose juice more acidic

.i.e. pP < 6.4 . • The radius of exchangeable proton = 1.5 x 10-15 meter thus it is called trans membrane proton. • This

proton is called exchangeable proton due to its ability to exchange with metal ions and precipitated as metal

anthocyanate • This is similar to the behavior of cation exchanger in demineralization processes of water (hetero

reaction ) while with the anthocyanin juice is homogenou reaction. • Addition of heavy metal salt like metal nitrate (

water soluble) result in sudden precipitation of metal anthocyanate and the color of the solution disappear slowly and

the pP of the solution become more acidic due to the formation of nitric acid in which the pP reaches nearly four . •

No precipitations shown with sodium and potassium ions while with magnesium and calcium ions need high

concentration of them . • Anthocyanin can be used to purify water from poisonous metals ions . • Anthocyanin color

in acidic solution is shine red while changed to reddish green color in basic solution and deep red color in neutral

solutions so it is suitable indicator in acid-base reaction more suitable than classically used phenophthalene indicator

which is water insoluble. • Irrigation of red rose plant with acidic solution like hydrochloric acid result in changing the

color of the rose from deep red to shine red , also that happen when red rose plant left in acidic atmosphere . this is a

good test for detection of acidic rain in industrial area. • A case study is carried out on the urine of a man of (40) years

old. Two samples urine were taken from the urine system of that man, one after drinking concentrated red beet juice

(mechanically extracted) and the second one without drinking juice. The results show that: a- Anthocyanin formed

hydrogen bonding with uric acid and urea which enhancing detoxification of both of them from blood. b- Anthocyanin

lowers the acidity of urine which is good for lessening human tension. c- Anthocyanin reduces viscosity of urine even

less than that of pure water which enhance the flow of urine through urine system. d- Reducing conductivity of urine

i.e. captures proton of uric acid. e- Changing color of urine from yellow to pink as shown in figure above.

Title: AWARENESS ABOUT CANCER

Salam Azad | President, Soheli Mirza Cancer Foundation, Dhaka, Bangladesh

Abstract: Bangladesh, at 160 million people, is the ninth most populous country in the world. There are almost two million cancer patients in my country, with about two lakh patients newly diagnosed with cancer each year. As an overview, lung cancer and mouth-coronary cancer rank as the top two prevalent cancers in males. Other types of cancers are esophagus cancer and stomach cancer. In women, CA Ovary and breast cancer are most prevalent.

This is my pleasure that organizer invite me as a keynote speaker. After Yokohama ,Japan October 2017 and Tangier of Morocco May 2018 by IASIC, Tokyo, Japan May 2019- this my 4th participation .

All of speakers in this house try to tell about treatment protocol of different kind of cancer, like chemo therapy, Radio therapy, Immunotherapy etc. But I try to discuses on awareness only. Awareness is the only prevention. Slogan of our organization AWARENESS FIRST. We, ‘Soheli Mirza Cancer Foundation’ aware the people of Bangladesh about cancer by work shops, Cancer awareness camp, seminar, symposium and others way / ways.

My wife, Soheli Mirza took treatment almost one and half year in the All India Institute of Medical Science ( AIIMS ), New Delhi.. I am thankful, But sorry, not grate full to cancer specialist of AIIMS. They can try, but they cannot do any positive outcome for treatment of my wife. How can they do? Because there is no medicine for fully cure of cancer all over the globe.

What is the cause of cancer ? Genetic, food habit, smoking etc ? No body knows actual cause of Cancer. If know, medicine for cure of Cancer invented and thousand of man-women-children can able to survive. Suspected some of cause, like smoking. If the cause of lunch cancer is smoking. Why not stop cultivation of tobacco?

Awareness better than treatment. If person aware about cancer her / his malignancy detected early or earliest. Early detection means extended her / his life.

Before operation or started treatment protocol it is mandatory that finding the stage of malignancy. If stage cross two please don’t go to operation or don’t give the patients any kind of treatment protocol.

Because some times Chemotherapy is more harmful, than Cancer. Chemotherapy kill immunity, kill WBC etc

Title: Muco-epidermoid carcinoma of lung:A case report

SMA Islam | National institute of cancer research and hospital, Dhaka, Bangladesh

Abstract: Mucoepidermoid carcinoma (MEC) is a rare lung cancer constitute 0.1-0.2% of all lung cancer.MECs most often arise from the salivary glands most commonly from parotid and submandibular. Pulmonary MECs are proximal bronchial origin with symptoms related to bronchial obstruction such as cough,hemoptysis,wheezing and post obstructive pneumonia. Histologically, collection of mucus-secreting, squamous, and intermediate cell types are common. The prognosis of localized low-grade disease is excellent. Reported 5- and 10-year survival rates are very good. Locally advanced high-grade disease has less favorable prognosis and most of the patients subsequently succumb to the disease.We are reporting a case of locally advanced MEC of left lung at the age of 13 years on 2003 and subsequently receive local and systemic therapy with recurrent flare during course of treatment and ultimately presented with metastatic disease with deteriorating clinical condition during 2019. We share our knowledge about the disease in our clinical setting with review of cases presented worldwide

Title: Human Papillomavirus Infection in genital Women in four

regions of Senegal

El Hadji Seydou Mbaye | Aristide Le Dantec Hospital, Dakar, Senegal

Abstract: Cervical cancer is the most frequent cancer among women in Senegal. However, there are few data

concerning the HPV types inducing neoplasia and cervical cancers and their prevalence, in the general

population of Senegal

AIMS: The aim of this study is to determine the prevalence of HPV infection in Senegalese women aged from

18 years and older.

MATERIALS AND METHODS: A study was performed on 498 cervix samples collected from healthy women

aged 18 and older in Dakar. 438 other samples were collected from three other regions, Thiès, Saint Louis

and Louga. The samples were screened for 21 HPV genotypes using an HPV type-specific E7 PCR bead-based

multiplex genotyping assay (TS-MPG) which is a laboratory-developed method for the detection of HPV.

RESULTS: The prevalence for pHR/HR-HPV in the region of Dakar was 20.68%. HPV 52 (3.21%) was the most

prevalent HPV type, followed by HPV 16 (3.01%) and HPV 31 (3.01%). In the regions of Thiès, Louga and Saint

Louis, the prevalence for pHR/HR-HPV was 29.19%, 23.15% and 20%, respectively

CONCLUSION: The study revealed the specificity of the HR-HPV prevalence in Dakar and other regions of

Senegal. The patterns differs from the one observed in the other regions of the world and rise the issue of

the development of vaccination program in the country. Such a program should take into account the real

HPV prevalence for an effective protection of HPV-associated diseases


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