Patient / Problemheart failure, ejection fraction 40%, elderlyInterventionirbesartan or avaproComparison, if anynone, placebo, standard careOutcomeprimary: reduce need for hospitalization; secondary: reduce mortality

http://www.hsl.unc.edu/services/tutorials/ebm/studies2.htm

Diagnosishow to select and interpret diagnostic testsTherapyhow to select treatments to offer patients that do more good than harm and that are worth the efforts and costs of using themPrognosishow to estimate the patient's likely clinical course over time and anticipate likely complications of diseaseHarm/Etiologyhow to identify causes for disease (including iatrogenic forms)

*

http://www.hsl.unc.edu/services/tutorials/ebm/studies2.htm

Type of Question:Suggested best type of study:Diagnosisprospective, blind comparison to a gold standardTherapyRCT > cohort > case control > case seriesPrognosiscohort study > case control > case seriesHarm/EtiologyRCT > cohort > case control > case seriesPreventionRCT > cohort study > case control > case seriesClinical Examprospective, blind comparison to gold standardClinical Exameconomic analysis

*