evolution and impact of subclonal mutations in chronic lymphocytic leukemia dan a. landau, scott l....
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![Page 1: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/1.jpg)
Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson, Michael S. Lawrence, Carrie Sougnez, Chip Stewart, Andrey Sivachenko, Lili Wang, Youzhong Wan, Wandi Zhang, Sachet A. Shukla, Alexander Vartanov, Stacey M. Fernandes,
Gordon Saksena, Kristian Cibulskis, Bethany Tesar, Stacey Gabriel, Nir Hacohen, Matthew Meyerson, Eric S. Lander, Donna Neuberg, Jennifer R. Brown, Gad Getz, Catherine J. Wu
Cell Volume 152, Issue 4, Pages 714-726 (February 2013)
DOI: 10.1016/j.cell.2013.01.019
Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 2: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/2.jpg)
Figure 1
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 3: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/3.jpg)
Figure 2
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 4: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/4.jpg)
Figure 3
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 5: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/5.jpg)
Figure 4
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 6: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/6.jpg)
Figure 5
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 7: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/7.jpg)
Figure 6
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 8: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/8.jpg)
Figure 7
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 9: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/9.jpg)
Figure S1
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 10: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/10.jpg)
Figure S2
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 11: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/11.jpg)
Figure S3
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 12: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/12.jpg)
Figure S4
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 13: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/13.jpg)
Figure S5
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 14: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/14.jpg)
Figure S6
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions
![Page 15: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,](https://reader035.vdocuments.net/reader035/viewer/2022062304/56649f395503460f94c564da/html5/thumbnails/15.jpg)
Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions