examen i - weebly
TRANSCRIPT
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Examen I
MEDIA : 72.14 PASS RATE: 60.6%
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Examen I
SIGUE:
PARA:
EMPIEZA:
MEDIA : 72.14 PASS RATE: 60.6%
ESTIMADO PROFESOR:
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Examen I
SIGUE:
PARA:
EMPIEZA:
MEDIA : 72.14 PASS RATE: 60.6%
QUERIDÍSIMO YO:
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LAS DOS CONFORMACIONES DE HEMOGLOBÍNA
TENSE Baja afinidad por O2
RELAXED Alta afinidad por O2
http://en.wikibooks.org/wiki/Structural_Biochemistry/Hemoglobin#mediaviewer/File:Hemoglobin_t-r_state_ani.gif
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TRANSICIÓN DE ESTADOS DE HEMOGLOBINA Y AFINIDAD POR O2
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HEMOGLOBÍNA TAMBIÉN TRANSPORTA DOS PRODUCTOS DE RESPIRACIÓN CELULAR
BAJA SOLUBILIDAD
CARBONIC ANHYDRASE ABUNDANTE EN ERITROCÍTOS
[H+]
CO2
TEJIDOS PERIFERALES
O2
[H+]
CO2
TEJIDOSTT PS ERIFERALESPP
O2
[H+]
CO2
CAPILARES PULMONARES
O2
[H+]
CO2
CAPILARESCC PS ULMONARES
O2
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EFECTO BOHR EFECTO DEL pH EN LA INTERACCIÓN Hb-O2
TEJIDOS PERIFERALES
CAPILARES PULMONARES
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CARBAMINOHEMOGLOBÍNA GRUPO CARBAMATO SE ENLAZA A TERMINAL AMINO CADENAS
[H+]
CO2
TEJIDOS PERIFERALES
O2
[H+]
CO2
TEJIDOSJTT PS ERIFERALESPP
O2
[H+]
CO2
CAPILARES PULMONARES
O2
[H+]
CO2
CAPILARESCC PS ULMONARES
O2
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PARES DE IONES ESTABILIZAN LA ESTRUCTURA DE DEOXYHEMOGLOBINA EN EL ESTADO T
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BPG TAMBIÉN REGULA INTERACCIÓN Hb-O2 OTRA MODULACIÓN ALLOSTÉRICA HETEROTRÓPICA
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BPG TAMBIÉN REGULA INTERACCIÓN Hb-O2 OTRA MODULACIÓN ALLOSTÉRICA HETEROTRÓPICA
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BPG TAMBIÉN REGULA INTERACCIÓN Hb-O2 OTRA MODULACIÓN ALLOSTÉRICA HETEROTRÓPICA
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Función\de\Proteínas.dos
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http://localtvkdvr.files.wordpress.com/2014/07/s008343013.jpg
Función\de\Proteínas.dosOBJETIVOS DE APRENDIZAJE:
1. Entender y apreciar la importancia de las interacciones complementaria entre proteinas y ligando a través del estudio, análisis y aplicaciones del los anticuerpos (inmunoglobulinas)
2. Entender la forma y función de los anticuerpos, su especificidad por el sustrato (antígeno).
3. Apreciar la diversidad de anticuerpos y sus funciones fisiológicas. 4. Investigar el gran potencial del uso clínico de los anticuerpos
monoclonales a través del estudio y análisis del uso de Zmapp. 5. Analizar la diversidad de procedimientos analíticos y clínicos que se
aprovechan de la especificidad de la interacción entre anticuerpos y antígenos.
6. Analizar las interacciones de proteínas modulas por la energía química a través del estudio de la actina, miosina y los motores moleculares.
(Sección 5.3 – Estudio Independiente)
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http://www.utsandiego.com/news/2014/aug/07/zmapp_drug_graphic/
COMO ATACA EL VIRUS DEL ÉBOLA (EBOV)
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http://en.wikipedia.org/wiki/Ebola_virus_disease#mediaviewer/File:Symptoms_of_ebola.png
SÍNTOMAS DEL ÉBOLA (EBOV)
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CICLOS Y TRANSMISIÓN
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http://en.wikipedia.org/wiki/Ebola_virus_disease#mediaviewer/File:Diseased_Ebola_2014.png http://www.zerohedge.com/sites/default/files/images/user5/imageroot/2014/03/ebola%20outbreaks.jpg
BROTE ACTUAL DEL ÉBOLA (EBOV) EN AFRICA 1,500 MUERTES (PUEDE LLEGAR A 20,000)
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Publicado: 29 de agosto del 2014
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http://upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Antibody.svg/500px-Antibody.svg.png
PROTEÍNAS DE RECONOCIMIENTO SON ALTAMENTE ESPECÍFICAS EN HUMANOS = 108 DIFERENTES TIPOS DE ANTICUERPOS
DETERMINANTE ANTIGÉNICO EPITOPE
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Kd=CONSTANTE DE DISOCIACIÓN CONCENTRACIÓN MOLAR DEL LIGANDO DONDE LA MITAD DE LOS SITIOS DE INTERACCIÓN ESTAN OCUPADOS.
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ENLACE ANTICUERPO–ANTÍGENO FUERTE Y ESPECÍFICO
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CÉLULAS ESPECIALIZADAS EN RESPUESTAS INMUNOLÓGICAS
DISCRIMINACIÓN SELF VS. NON-SELF
humor = fluido (latín)
HUMORAL CELULAR
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http://thumbs.dreamstime.com/z/humoral-immunity-lymphocyte-antibody-antigen-vector-diagram-38703007.jpg
CÉLULAS ESPECIALIZADAS EN RESPUESTAS INMUNOLÓGICAS
DISCRIMINACIÓN SELF VS. NON-SELF
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CÉLULAS BLANCAS DE LA SANGRE
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http://www.utsandiego.com/news/2014/aug/07/zmapp_drug_graphic/
COMO ATACA EL VIRUS DEL ÉBOLA (EBOV)
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http://www.utsandiego.com/news/2014/aug/07/zmapp_drug_graphic/
PRODUCCIÓN DE ANTICUERPOS MONOCLONALES
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http://www.nature.com/nchembio/journal/v4/n6/images/nchembio0608-326-F1.jpg
PRODUCCIÓN DE ANTICUERPOS MONOCLONALES
Mieloma
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PRODUCCIÓN DE ANTICUERPOS MONOCLONALES
https://www.youtube.com/watch?v=sOTdqLDMvcg
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http://www.utsandiego.com/news/2014/aug/07/zmapp_drug_graphic/
PRODUCCIÓN DEL COCTEL DE ANTICUERPOS MONOCLONALES ZMAPP PARA TRATAR EL VIRUS DEL ÉBOLA (EBOV)
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FORMA Y FUNCIÓN DE INMUNOGLOBULINA G (IgG)
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FORMA Y FUNCIÓN DE INMUNOGLOBULINA G (IgG)
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FORMA Y FUNCIÓN DE INMUNOGLOBULINA G (IgG)
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DIVERSIDAD DE INMUNOGLOBULINAS
PENTÁMERO DE IgM
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MECANISMO DE “MUERTE POR MACRÓFAGO”
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MECANISMO DE ZMAPP
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The drug — a cocktail of three purified immune proteins, or monoclonal antibodies, that target the Ebola virus — has been given to seven people: two US and three African health-care workers, a British nurse and a Spanish priest. The priest and a Liberian health-care worker who got the drug have since died. There is no way to tell whether ZMapp has been effective in the patients who survived, because they received the drug at different times during the course of their disease and received various levels of medical care.
In the study, designed and conducted in part by Mapp Pharmaceutical scientists, 18 monkeys were given three doses of the drug starting three, four or five days after they were infected with Ebola. All animals that received the drug lived, no matter when their treatment started; three monkeys that were not treated died.
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ELISA (ENZYME-LINKED IMMUNOSORBENT ASSAY)
http://en.wikipedia.org/wiki/File:ELISA_diagram.png
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UTILIDAD EXPERIMENTAL DE ANTICUERPOS
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WESTERN BLOT
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INMUNOFLUORESENCIA
http://ibidi.com/fileadmin/applications/immunofluorescence/IF_fun.jpg http://www.virology.ws/wp-content/uploads/2010/09/immunostaining-300x144.jpg
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http://en.wikipedia.org/wiki/File:Monoclonal_antibodies.svg
COMBATIENDO EL CÁNCER CON ANTICUERPOS MONOCLONALES
http://sciencebuz.com/2011/08/26/armed-antibodies-pack-a-deadly-punch-against-cancer-cells-26-aug-2011/
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But other researchers say that the findings should be interpreted with caution, because monkeys with Ebola are not a perfect analogue for humans with the disease. “I don’t think the data support that this drug is effective, even in the animal model, in individuals with advanced Ebola disease,” says infectious-disease physician Charles Chiu at the University of California, San Francisco.
Knowing when to give the drug may help guide its use in future outbreaks. But for now, Mapp says that no more ZMapp is available and will not be for months.
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http://ww1.prweb.com/prfiles/2009/09/08/140163/XVIVOHarvardKinesinMidView.jpg
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http://www.uic.edu/classes/bios/bios100/summer2006/kinesin.jpg
MOTORES MOLECULARES : KINESINA
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MOTORES MOLECULARES : MIOSÍNA
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MIOSÍNA : LA CABEZA Y LA COLA
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S1 : EL MOTOR DE MIOSÍNA
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FILAMENTOS GRUESOS DE MIOSÍNA
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FILAMENTOS DELGADOS DE ACTÍNA
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ACTÍNA GLOBULAR (G-ACTÍNA)
http://en.wikipedia.org/wiki/File:Actin-ATP_Dominguez.svg
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FILAMENTOS DELGADOS DE F-ACTÍNA
http://en.wikipedia.org/wiki/File:MEF_microfilaments.jpg
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EL MOTOR DE ACTÍNA Y MIOSÍNA
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LA FIBRA MUSCULAR
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SARCOMERO : LA UNIDAD CONTRÁCTIL FILAMENTOS GRUESOS
MIOSÍNA FILAMENTOS DELGADOS
ACTÍNA
αα-ACTININA DESMINA
VIMENTINA
PARAMIOSÍNA PROTEÍNA-C PROTEÍNA-A
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CONTRACCIÓN MUSCULAR
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CONTRACCIÓN MUSCULAR
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REGULACIÓN DE CONTRACCIÓN MUSCULAR POR TROPOMIOSÍNA Y TROPONÍNA
REGULACIÓN POR CA2+