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Examples of Epigenetic Phenomena
Monozygotic
Genomes are identical
Epigenetic phenomena
heritable alternative states
of gene activity that do not result
from altered nucleotide sequence
lrsquoepigenoma e lrsquoepigenetica
Epigenoma trasformazioni del genoma a livello
cellulare
Epigenetica la trasmissibilitagrave di queste
trasformazioni nelle generazioni successive
Ambiente
ambiente
citoplasma
genomalrsquoambiente cellulare dellrsquoorganismo
lrsquoambiente esterno
Nutrizione ed epigenetica - Profssa Franca Saccucci
AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved
Epigenetic phenomena
heritable alternative states
of gene activity that do not result
from altered nucleotide sequence
lrsquoepigenoma e lrsquoepigenetica
Epigenoma trasformazioni del genoma a livello
cellulare
Epigenetica la trasmissibilitagrave di queste
trasformazioni nelle generazioni successive
Ambiente
ambiente
citoplasma
genomalrsquoambiente cellulare dellrsquoorganismo
lrsquoambiente esterno
Nutrizione ed epigenetica - Profssa Franca Saccucci
AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved
lrsquoepigenoma e lrsquoepigenetica
Epigenoma trasformazioni del genoma a livello
cellulare
Epigenetica la trasmissibilitagrave di queste
trasformazioni nelle generazioni successive
Ambiente
ambiente
citoplasma
genomalrsquoambiente cellulare dellrsquoorganismo
lrsquoambiente esterno
Nutrizione ed epigenetica - Profssa Franca Saccucci
AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved
Ambiente
ambiente
citoplasma
genomalrsquoambiente cellulare dellrsquoorganismo
lrsquoambiente esterno
Nutrizione ed epigenetica - Profssa Franca Saccucci
AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved
Nutrizione ed epigenetica - Profssa Franca Saccucci
AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved
AbstractSend toCold Spring Harb Perspect Biol 2015 Nov 27(11) pii a019422 doi 101101cshperspecta019422Germline and Pluripotent Stem CellsReik W1 Surani MA2Author informationAbstractSUMMARYEpigenetic mechanisms play an essential role in the germline and imprinting cycle Germ cells show extensive epigenetic programming in preparation for the generation of the totipotent state which in turn leads to the establishment of pluripotent cells in blastocysts The latter are the cells from which pluripotent embryonic stem cells are derived and maintained in culture Following blastocyst implantation postimplantation epiblast cells develop which give rise to all somatic cells as well as primordial germ cells the precursors of sperm and eggs Pluripotent stem cells in culture can be induced to undergo differentiation into somatic cells and germ cells in culture Understanding the natural cycles of epigenetic reprogramming that occur in the germline will allow the generation of better and more versatile stem cells for both therapeutic and research purposesCopyright copy 2015 Cold Spring Harbor Laboratory Press all rights reserved