PRELIMINARYPROGRAMME

EXCEMED Blended Education2nd interactive course in MS advanced management

Live intervention in Toronto, Canada 12-13 December 2018

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Target audienceThis programme is designed for neurologists working in the field of multiple sclerosis.

ChairsXavier MontalbanDivision of NeurologyUniversity of Toronto, CanadaSt Michael’s HospitalToronto, Ontario, Canada

Multiple Sclerosis Centre of Catalonia (Cemcat)Neurology-Neuroimmunology DepartmentVall d’Hebron University HospitalBarcelona, Spain

Daniel SelchenDivision of NeurologyUniversity of Toronto, CanadaSt Michael’s HospitalToronto, Ontario, Canada

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2nd interactive course in MS advanced management

ONLINEPREPARATORYTUTORIALS

November 2018

LIVEINTERVENTION

12-13 December 2018

ONLINEIN-DEPTHTUTORIALSJanuary 2019

OverviewThe field of multiple sclerosis (MS) is constantly evolving. Immunological pathways, diagnosticcriteria and prognostic markers are updated year by year. In addition, new treatments with innovativemechanisms of action have been recently approved. The design of this course aims to strengthenthe knowledge and competence of neurologists in charge of MS patients according to the mostrecently discoveries in the field. Participants will also benefit from the expertise of internationallyrenowned speakers and will have the opportunity to discuss clinical cases in an interactive setting.Seminal lectures on hot topics in MS will also be delivered via webinar to extend the learningopportunity to participants from other countries.

An EXCEMED Learning JourneyThe EXCEMED blended education approach reinforces concepts from different angles using diverseformats which strengthen the learning experience. A multistep approach is used, encompassingweb- based and live activities. All activities – in-person and online – involves the full interactivityof learners. At three stages throughout the process, you will be asked to give your feedback on thelearning experience through the 3 surveys. The aim of this learner-centered programme is toenhance clinical practice by exploring the ideal outcomes desired by patients, neurologists, andclinicians following MS, with individualized approaches toward attaining these goals. Aftercompleting your Learning Journey with EXCEMED, you will receive a Diploma signed by the Chairsand a final Outcomes and Feedback Report.

Learning objectivesBy attending this programme, you will be able to:• Illustrate immunological abnormalities in MS • Describe how to diagnose and classify MS • Explain the main symptomatic and non symptomatic treatment strategies

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CME ProviderEXCEMED is a non profit foundation dedicated, since the last four decades, to the development of high-quality medical education programmes all over the world.

EXCEMED adheres to the guidelines and standards of the European Accreditation Council forContinuing Medical Education (EACCME®) which states that continuing medical education must bebalanced, independent, objective and scientifically rigorous.

EXCEMED - Excellence in Medical EducationProgramme Manager: Silvia CristofanelliT +39 06 420413 421 - F +39 06 420413 677silvia.cristofanelli@excemed.org

Medical Advisor: Doriana Landidoriana.landi@libero.it

EXCEMED adheres to the principles of the Good CME Practice group (gCMEp).

ONLINE PREPARATORY TUTORIALSNovember 2018

ONLINEPREPARATORYTUTORIALS

November 2018

LIVEINTERVENTION

12-13 December 2018

ONLINEIN-DEPTHTUTORIALSJanuary 2019

Register now and receive the EXCEMED invitation to start your Learning Journey!

VIDEO CONTRIBUTIONThis online preparatory tutorial is a video contribution by Professor M. Comabella on genetic and nongenetic biomarkers in MS and will enable to:• Illustrate the genetic variants and alleles associated with heightened risk of developing MS • Describe the most important soluble biomarkers in MS and their prognostic value• Describe their current use in clinical practice

VIDEO LECTUREThis video lecture by Professor Hemmer will enable to:• Describe the main immunological dysfunction subtending MS• Illustrate the differential role of B and T cells• Define the role of peripheral and compartmentalised inflammation in disease progression

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LIVE INTERVENTION12-13 December 2018

ONLINEPREPARATORYTUTORIALS

November 2018

LIVEINTERVENTION

12-13 December 2018

ONLINEIN-DEPTHTUTORIALSJanuary 2019

The live component of this Learning Journey is a compination of frontal lectures, panel discussions andinteractive clinical cases.

By attending the live intervention you will be able to:• List the key immunological mechanisms subtending MS• Discuss the new criteria for MS diagnosis• Describe the main features of paediatric MS and related disorders• Illustrate how to evaluate treatment efficacy in everyday clinical setting

VenueThis live intervention will take place at the:Pantages Hotel200 Victoria St Toronto, Canada

LanguageThe official language of the live intervention will be English.

Jack AntelMontreal Neurological InstituteMcGill UniversityMontreal, Québec, Canada

Amit Bar-OrDepartment of Neurology and NeurosurgeryClinical Research UnitMontreal Neurological InstituteMcGill UniversityMontreal, Québec, Canada

Multiple Sclerosis DivisionDepartment of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphia, PA, USA

Ralph H.B. BenedictDepartment of Neurology and PsychiatryUniversity at BuffaloBuffalo, NY, USA

Aditya BharathaDepartments of Medical Imaging and SurgeryDivision of NeuroradiologySt. Michael’s HospitalUniversity of TorontoToronto, Ontario, Canada

INVITED FACULTY

Tania BrunoDepartment of Neurology Toronto Rehabilitation InstituteToronto, Ontario, Canada

Anthony FeinsteinDivision of Psychiatry University of TorontoToronto, Ontario, Canada

Jennifer GommermanDepartment of ImmunologyUniversity of TorontoToronto, Ontario, Canada

Marika HoholDepartment of Medicine Division of Neurology St. Michael's Hospital Toronto, Ontario, Canada

Liesly LeeSunnybrook Health Sciences Centre. Department of Medicine Division of Neurology University of TorontoToronto, Ontario, Canada

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Xavier MontalbanDivision of NeurologyUniversity of Toronto, CanadaSt Michael’s HospitalToronto, Ontario, Canada

Multiple Sclerosis Centre of Catalonia (Cemcat)Neurology-Neuroimmunology DepartmentVall d’Hebron University HospitalBarcelona, Spain

Jiwon OhDepartment of Medicine Division of Neurology St. Michael's Hospital Toronto, Ontario, Canada

Alexander PratDepartment of Neuroimmunology University of MontrealMontreal, Québec, Canada

Dalia RotsteinDepartment of Medicine Division of Neurology St. Michael's Hospital Toronto, Ontario, Canada

Gustavo SaposnikDepartment of Medicine Division of NeurologySt. Michael's Hospital Toronto, Ontario, Canada

Wednesday, 12 December 2018

08.20 Registrations

08.45 Welcome and introductionX. Montalban (Canada and Spain), D. Selchen (Canada)

09.00 L1: Epidemiology and risk factors of MSD. Rotstein (Canada)

09.30 L2: Immunopathogenesis of MSA. Prat (Canada)

10.00 L3: Role of B cells in the pathogenesis and treatment of MSJ. Gommerman (Canada)

10.30 Coffee break

11.00 L4: Diagnostic criteria in MSM. Hohol (Canada)

11.30 L5: MRI J. Oh (Canada)

12.00 L6: Cognitive involvement in MS and how to measure itR.H.B. Benedict (USA)

12.30 Lunch

Session I

Session II

Legend: L : Lecture CC : Clinical cases : Wrap up : Site visit

PROGRAMME

Daniel SelchenDivision of NeurologyUniversity of Toronto, CanadaSt Michael’s HospitalToronto, Ontario, Canada

Eluen Ann YehUniversity of Toronto The Hospital for Sick Children (SickKids)Toronto, Ontario, Canada

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13.30 L7: Novel treatment targets J. Antel (Canada)

14.00 L8: Progressive MSX. Montalban (Canada and Spain)

14.30 L9: MS and NMO in childrenE.A. Yeh (Canada)

15.00 CC: Clinical cases on MS and differential diagnoses work upA. Bharatha (Canada), L. Lee ( Canada)

17.00 End of the first day

Session III

Thursday, 13 December 2018

08.30 L10: Update on MS therapyX. Montalban (Canada and Spain)

09.30 L11: Therapeutic InertiaG. Saposnik (Canada)

10.00 L12: Measures of treatment response in clinical trials and in real life settingJ. Oh (Canada)

10.30 Coffee break

11.00 L13: Risks of treatments in clinical trials and in real life settingD. Selchen (Canada)

11.30 L14: Risks of treatment suspension and immune-reconstitution dynamicA. Bar-Or (Canada and USA)

12.00 L15: Comprehensive neurohabilitation approach to MS T. Bruno (Canada)

12.30 L16: Emotional burden and disturbances in MSA. Feinstein (Canada)

13.00 Wrap up of the educational course and closing remarksX. Montalban (Canada and Spain)

13.30 Lunch

14.30 Visit to Neurorehabilitation centerTBD

16.30 Return to the Hotel and end of the live intervention

Session IV

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ONLINE IN-DEPTH TUTORIALJanuary 2019

ONLINEPREPARATORYTUTORIALS

November 2018

LIVEINTERVENTION

12-13 December 2018

ONLINEIN-DEPTHTUTORIALSJanuary 2019

Continue your Learning Journey after the live intervention!

VIDEO LECTUREThe in-depth tutorial will be a video talk by Professor J. Oh concerning spinal cord lesion. This tutorialwill enable to:• Explain why spinal cord lesions are prognostically relevant• Illustrate technical issues that limit the investigation of spinal cord• Comment on what is new in the field and how imaging can help in the differential diagnosis process

SLIDE KITThe final online tutorial will be a slide kit by Professor G. Arrambide focusing on Optica-NMO andanti MOG disease. It will enable to:• Describe specific clinical and radiological features of NMO and NMO spectrum disorder• Define pathogenetic mechanisms subtending NMO and NMO spectrum disorder • Illustrate treatment strategies

Registration

ONLINEPREPARATORYTUTORIALS

November 2018

LIVEINTERVENTION

12-13 December 2018

ONLINEIN-DEPTHTUTORIALSJanuary 2019

Registration for the whole blended programme is free and includes:• Access to the online tutorials• Scientific sessions• Coffee breaks and luncheons• Educational materials• Certificate of attendanceDinners are not included

For registration, accommodation and any logistic inquiry, please contact:Laletravel - Alessandra Levi T +1 416-880 1801 - info@laletravel.com

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All EXCEMED programmes are organized solely to promote the exchange and dissemination of scientific andmedical information. No forms of promotional activities are permitted. There may be presentations discussinginvestigational uses of various products. These views are the responsibility of the named speakers, and do notrepresent an endorsement or recommendation on the part of EXCEMED. This independent programme ismade possible thanks to educational grants received from: Merck KGaA Darmstadt Germany and San RaffaeleHospital Milan.

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EXCEMED - Excellence in Medical Education14, Rue du Rhône - 1204 Geneva, Switzerland

Improving the patient's life through medical educationwww.excemed.org