excipients guide

PartnershipTowards Success

& GrowthFor over twenty years, we have built partnerships withour customers and with foreign manufacturers whoseproducts we promote and distribute.

From inception, Signet aligned it’s key focus to reflecta global perspective. Our goal was for Indian scientists andformulators to have access to raw materials and excipientsavailable elsewhere in the world. With this in mind, we tiedup with several major producers in USA, France, Germany,Japan and other countries. All are global leaders in theirrespective fields and today Signet proudly occupies a stellarposition as India’s largest excipients distributing company.The following fundamentals have contributedto our success and steady growth.

Customer Service: Close customer contact backed bywell-trained and experienced team dedicated to everyaspect pertinent to sales and personal service. Needs oftiming, pricing, specifications and delivery are metin the best possible manner.

Logistics Support: A management system that assures the right products in the right place at the right time. Careful strategic analysis of lead times, stock levels andpertinent costs that builds maximum efficiency intothe supply chain.

Technical Support: A team of qualified pharmaceuticalpersonnel collaborating at all levels, whether it isintroducing a new product, sampling, assistance informulating or more complex issues involving our principals;Signet goes with you.

Regulatory Support: Pharma industry operates in aregulatory environment. Whether it is for domestic marketsor export areas, documents governing use, safety, etc. area part of the process. GMP, DMF, TSE/BSE, GMO, OVIare just a few of them. Signet is committed to provide allthat is available and required.

We enjoy our legacy and reputation and continually lookforward to deliver better and higher standards of service.

Index ApplicationGuide

FMCBioPolymer

RoquetteFreres

Innophos Domo CP Kelco Rio TintoMinerals(Luzenac)

Tereos Hanns G. Werner

Dead SeaPericlase

Scora

Shin-EtsuChemical Co.

Aqualon(A division ofHercules Inc.)

BASFAktiengesellschaft

Asahi KaseiChemicalsCoporation

FerroIndustriasQuimicas

KronosInternational

Health & BeautySolutions(Amcol)

SpecialtyMinerals

CytecIndustries

Stepan Co. GumBase Co. StearinerieDubois

Lonza MusashinoChemicalLaboratory

Glossary

Contents

1 4 9 17

41 43 45 47

57 61 63

77 79 81

65

25 29 33 39

49 51 53 55

67 69 71 73

1

FMC BioPolymer Avicel PH - Microcrystalline Cellulose (MCC) 9Avicel RC / CL - Microcrystalline Cellulose & Sodium CMC (Hydrocolloid) Avicel CE - Microcrystalline Cellulose & Guar GumAc-Di-Sol - Croscarmellose Sodium LustreClear LC 103 - Aqueous Film Coating System Aquacoat - Aqueous Dispersion for modified releaseProtanal - AlginateProtacid - Alginic AcidMarine Colloids - Carrageenan

Novamatrix Protosan UP - Ultrapure Chitosan Salt 15Pronova UP / SL - Ultrapure / Sterile Sodium AlginateSodium Hyaluronate

Roquette Freres Pearlitol C - Mannitol Crystalline 17Pearlitol SD / DC - Mannitol, Directly CompressibleKleptose - BetacyclodextrinKleptose HPB - Hydroxy Propyl BetacyclodextrinGlycolys - Sodium Starch GlycolateNeosorb - SorbitolXylisorb - XylitolMaltisorb - MaltitolGlucidex - MaltodextrinLycoat - Peas Starch based aqueous film coating systemReadiLYCOAT - Ready-to-use, Aqueous film coating systemLycatab - Modified StarchLycatab Mineral CC - Compound of Calcium Carbonate & Maize StarchG-D-L - Glucono Delta LactoneLycadex PF - Injectable Dextrose MonohydrateLycasin - Maltitol Solution Polysorb - Aqueous Solution of D-Sorbitol & Sorbitan Hi-Sweet - High Fructose Corn Syrup (HFCS)Starlac - Directly compressible Starch & Lactose compound Starch - Maize (Corn) / Potato / WheatNutriose - Soluble FibreRoferose - Dextrose Monohydrate Tackidex - Dextrin Solulys AST - Corn-steep powder

Shin-Etsu Chemical Co. Pharmacoat - HPMC, Low viscosity 25Metolose SH - HPMC, High viscosityMetolose SM - Methyl CelluloseL-HPC - Low Substituted Hydroxy Propyl CelluloseHPMCP - HPMC PhthalateAqoat - HPMC Acetate Succinate

Aqualon (A division of Hercules, Inc.) Ethyl Cellulose Pharm 29Klucel - Hydroxy Propyl Cellulose Natrosol - Hydroxy Ethyl Cellulose Blanose – Sodium Carboxymethylcellulose (Na CMC)

BASF Aktiengesellschaft Kollidon - Povidone (PVPK 12PF, 17PF, 25, 30, 90F) 33Kollidon SR - Matrix Sustained Release Excipient Kollidon VA 64 - Copolyvidone (Vinyl Acetate Copolymer) Kollidon CL - Crosspovidone (Crosslinked PVP)Kollicoat - Aqueous Coating Systems for modified release Cremophor - Non-ionic surfactantsLutrol - PEG (Macrogol) / Poloxamer Solutol HS 15 - Macrogol-15-HydroxystearateLudipress - Advanced Excipient for direct compression Sicovit - Iron Oxide Soluphor P - 2-Pyrrolidone PVP Iodine - Povidone Iodine

Company Products Page

Index

2

Asahi Kasei Chemicals Corporation Celphere - Microcrystalline Cellulose Spheres 39Ceolus KG - Highly Compactible MCCPCS PC 10 - Partly Pregelatinised StarchTrehalose - Non-reducing Di-Saccharide

Innophos Di-Tab - Dicalcium Phosphate Dihydrate, Granular 41A-Tab - Dicalcium Phosphate Anhydrous, GranularTri-Tab - Tricalcium Phosphate Anhydrous, Granular Calipharm - Calcium Phosphate, Powder

Domo Lactochem - Lactose Monohydrate 43Lactopress - DC Lactose

CP Kelco Xantural - Xanthan Gum 45

Rio Tinto Minerals (Luzenac) Talc Luzenac Pharma 47

Ferro Industrias Quimicas Synpro Stearates - Magnesium Stearate / Calcium Stearate / Zinc Stearate 49

Kronos International Kronos 1171 Titanium Dioxide - Anatase & Superwhite Grade 51

Health & Beauty Solutions (Amcol) Magnabrite - Magnesium Aluminium Silicate 53

Specialty Minerals Sturcal L - Heavy, Precipitated Calcium Carbonate 55Calopake - Extra Light, Precipitated Calcium Carbonate

Tereos Compressuc - DC Sucrose 57Icing Sugar - Milled Sucrose

Hanns G. Werner Pharm-a-spheres - Sugar Spheres (Non-Pareil Seeds) 61

Dead Sea Periclase Magnesium Oxide 63Magnesium CarbonateMagnesium Hydroxide

Scora Scoralite - Calcium Carbonate 65Magnesium CarbonateMagnesium Oxide

Cytec Industries Docusate Sodium (DSS) 67

Stepan Co. Stepanol - Sodium Lauryl Sulfate 69

GumBase Co. Medicated Chewing Gum Base / DC Chewing Gum Base 71

Stearinerie Dubois DUB Microlub - Stearic Acid 73DUB SE - Sucrose EstersDUB MCT - Medium Chain TriglyceridesDUB GMS - Glyceryl StearateDUB DBS - Dibutyl SebacateDUB DBHG - Glyceryl DibehenateDUB PP - Hemi-synthetic Glycerides

Lonza D-L Malic Acid 77

Musashino Chemical Laboratory D-L Lactic Acid 79

Company Products Page

4

Fillers and General Binders Alveosucre Agglomerated Sucrose 5599A-Tab Dicalcium Phosphate Anhydrous, Granular 4422Avicel PH Microcrystalline Cellulose (MCC) 1100Calipharm Calcium Phosphate Powder 4422Calopake Extra Light, Precipitated Calcium Carbonate 5566Caster Sugar / Crystal Sugar Screened Sucrose 6600Ceolus KG Highly Compactible MCC 4400Compressuc Directly Compressible Sucrose 5588Dextrose GC Directly Compressible Glucose Monohydrate 2233Di-Tab Dicalcium Phosphate Dihydrate, Granular 4422Glucidex Maltodextrin 2244Icing Sugar Milled Sucrose 5588Lactochem Lactose Monohydrate 4444Lactopress DC Lactose 4444Ludipress Advanced Excipient for direct compression 3377Lycatab Modified Starch 2211Magnesium Salts Magnesium Oxide / Magnesium Carbonate / Magnesium Hydroxide 6644Maltisorb Maltitol 2200Neosorb Sorbitol 1199PCS PC-10 Partly Pregelatinised Starch 4400Pearlitol Mannitol 1188Roferose Dextrose Monohydrate 2233Scoralite Calcium Carbonate of high purity 6666Starch Maize (Corn) / Potato / Wheat based 2211Starlac Directly compressible Starch & Lactose compound 2222Sturcal L Heavy, Precipitated Calcium Carbonate 5566Tackidex Dextrin 2244Trehalose Non-reducing Di-Saccharide 4400Tri-tab Tricalcium Phosphate Anhydrous, Granular 4422Xylisorb Xylitol 2200

Granulating Binders Klucel Hydroxy Propyl Cellulose 3311Kollidon Povidone (PVPK 25, 30, 90F) 3344Kollidon VA 64 Copolyvidone (Vinyl Acetate Copolymer) 3344Lycatab Modified Starch 2211Lycatab DSH Partially Hydrolyzed Maize Starch 2211Metolose SH Hydroxypropyl Methyl Cellulose (HPMC - High Viscosity) 2277Metolose SM Methyl Cellulose 2277Pharmacoat Hydroxypropyl Methyl Cellulose (HPMC - Low viscosity) 2266Starch Maize (Corn) / Potato / Wheat based 2211

Binders cum Disintegrating agents L-HPC Low Substituted Hydroxypropyl Cellulose 2288Lycatab C Partially Pregelatinised Maize Starch 2211PCS PC-10 Partly Pregelatinised Starch 4400

Glidants Talc Luzenac Pharma Talc 4488

Category Product Page

Application Guide

Selection Guide to Excipients - 2.qxd 09-Nov-07 4:43 PM Page 11

5

Disintegrants Ac-Di-Sol Croscarmellose Sodium 1111Glycolys Sodium Starch Glycolate 2222Kollidon CL Crosspovidone (Crosslinked PVP) 3355L-HPC Low Substituted Hydroxypropyl Cellulose 2288Protacid Alginic Acid 1133

Coating agents (Functional & Non - Functional) Aqoat Hydroxy Propyl Methyl Cellulose Acetate Succinate (HPMCAS) 2288Aquacoat CPD 30 Aqueous dispersion of Cellulose Acetate Phthalate 1122Aquacoat ECD 30 Aqueous dispersion of Ethyl Cellulose 1122Ethyl Cellulose Ethyl Cellulose Pharm 3300HPMC P Hydroxy Propyl Methyl Cellulose Phthalate 2266Klucel Hydroxypropyl Cellulose 3311Kollicoat IR Polyvinyl Alcohol-PEG Graft Copolymer 3355Kollicoat MAE Methacrylic Acid Copolymer 3366Kollicoat SR 30D Aqueous Dispersion of PVA and PVP 3366Kollidon SR Matrix Sustained Release Excipient 3355LustreClear LC 103 MCC & Carrageenan based Aqueous Film Coating System 1122Lycoat Peas Starch Based Aqueous Film Coating System 2200Maltisorb Maltitol 2200Metolose SH Hydroxypropyl Methyl Cellulose (HPMC - High Viscosity) 2277Metolose SR Hydroxypropyl Methyl Cellulose (HPMC - Sustained Release grade) 2277Natrosol 250 Pharm Hydroxy Ethyl Cellulose (HEC) 3300Pharmacoat Hydroxypropyl Methyl Cellulose (HPMC - Low viscosity) 2266Protanal Alginate 1133Protanal Ester Propylene Glycol Alginate 1133ReadiLYCOAT Ready-to-use, Aqueous film coating system 2200Xylisorb Xylitol 2200

Colourants Kronos 1171 Titanium Dioxide Anatase & Superwhite Grade 5522Sicovit Iron Oxide 3388

Chewable and Orodispersible aids Avicel CE15 Microcrystalline Cellulose and Guar Gum 1111Ceolus KG Highly Compactible MCC 4400D-L Malic Acid Malic Acid 7788Kollidon CL Crosspovidone (Crosslinked PVP) 3355Ludipress Lactose Monohydrate and povidone (PVPK) compound 3377Lycatab Mineral CC Compound of Calcium Carbonate & Maize Starch 2211Lycoat Peas Starch Based Aqueous Film Coating System 2200Maltisorb Maltitol 2200Neosorb Sorbitol 1199Pearlitol Mannitol 1188Starlac Directly compressible Starch & Lactose compound 2222Xylisorb Xylitol 2200

Fermentation aids Solulys AST Corn-steep powder 1199Soluten 50 Cellulose free, high vegetable protein 1199


Application Guide


6

Lubricating agents DUB DBHG Glyceryl Dibehenate 7755DUB MCT Medium Chain Triglycerides 7755DUB Microlub Stearic Acid 7744DUB SE Sucrose Esters 7744Stepanol Sodium Lauryl Sulfate 7700Synpro Stearates Magnesium Stearate / Calcium Stearate / Zinc Stearate 5500Talc Luzenac Pharma Talc 4488

Chewing gum baseMedGumBase / CPG Medicated Chewing Gum Base / DC Chewing Gum Base 7722

Dental Impression Materials Protanal Potassium Alginate / Triethanolamine Alginate 1133

Mineral supplements A-Tab Dicalcium Phospate Anhydrous, Granular 4422Calipharm Calcium Phospate Powder 4422Calopake Extra Light, Precipitated Calcium Carbonate 5566Di-Tab Dicalcium Phospate Dihydrate, Granular 4422Lycatab Mineral CC Compound of Calcium Carbonate & Maize Starch 2211Magnesium Salts Magnesium Oxide / Magnesium Carbonate / Magnesium Hydroxide 6644Scoralite Calcium Carbonate 6666Sturcal L Heavy, Precipitated Calcium Carbonate 5566Tri-tab Tricalcium Phospate Anhydrous, Granular 4422

Nutritional supplementsNutriose Soluble Fibre 2222DUB MCT Medium Chain Triglycerides 7755

Parenteral & Opthalmic aids Cremophor ELP Polyoxyl - 35 - Castor Oil (Extra pure grade) 3388Crysmeb Low MS Methyl Betacyclodextrin 2233Dextrose Anhydrous PF Injectable Glucose Anhydrous 2233D-L Lactic Acid Synthetic Grade Lactic Acid 8800DUB MCT Medium Chain Triglycerides 7755Kleptose HPB Hydroxypropyl Betacyclodextrin 2233Kollidon Polyvinyl Pyrrolidone (PVPK - 12PF, 17PF) 3344Lutrol E Polyethylene Glycol (PEG) / Macrogol 3377Lutrol F Poloxamer 3377Lycadex PF Injectable Dextrose Monohydrate 2233Metolose SH Hydroxypropyl Methyl Cellulose (HPMC - High Viscosity) 2277Natrosol 250 Pharm Hydroxy Ethyl Cellulose 3300Neosorb PF Sorbitol Pyrogen Free Grade 1199Pearlitol PF Mannitol Pyrogen Free Grade 1188Soluphor P 2 - Pyrrolidone 3366Solutol HS-15 Macrogol - 15 - Hydroxystearate 3388Xylisorb PF Xylitol Pyrogen Free Grade 2200


Application Guide


7

Encapsulating agents Aquacoat ECD 30 Aqueous dispersion of Ethyl Cellulose 1122Crysmeb Low MS Methyl Betacyclodextrin 2233Ethyl Cellulose Ethyl Cellulose Pharm 3300Kleptose Betacyclodextrin 2233Kleptose HPB Hydroxy Propyl Betacyclodextrin 2233Protanal Alginate 1133

Plasticizing agents Cremophor Hydrogenated Castor Oil 3388DUB DBS Dibutyl Sebacate 7755DUB MCT Medium Chain Triglycerides 7755Lutrol E Polyethylene Glycol (PEG) / Macrogol 3377Polysorb 85/70/00 Aqueous Solution of D-Sorbitol & Sorbitan 1199Protanal Ester Propylene Glycol Alginate 1133

Solubilizing aids Cremophor Hydrogenated Castor Oil 3388Crysmeb Low MS Methyl Betacyclodextrin 2233Docusate Sodium (DSS) Dioctyl Ester of Sodium Sulfosuccinate 6688DUB Microlub Stearic Acid 7744DUB SE Sucrose Esters 7744Kleptose Betacyclodextrin 2233Kleptose HPB Hydroxypropyl Betacyclodextrin 2233Lutrol F Poloxamer 3377Soluphor P 2 - Pyrrolidone 3366Solutol HS-15 Macrogol - 15 - Hydroxystearate 3388

Spherical Seed CoreCelphere Microcrystalline Cellulose Spheres 6600Pharm-a-spheres Sugar Spheres (Non-Pareil Seeds) 6622

Emulsifying agentsCremophor A Macrogol - Cetostaryl Ether 3388Docusate Sodium (DSS) Dioctyl Ester of Sodium Sulfosuccinate 6688DUB GMS Glyceryl Stearate 7755DUB Microlub Stearic Acid 7744DUB SE Sucrose Esters 7744Lutrol F Poloxamer 3377Magnabrite Magnesium Aluminum Silicate 5544Stepanol Sodium Lauryl Sulfate 7700Synpro Stearate Sodium Stearate 5500

Suspending agents Avicel RC/CL Microcrystalline Cellulose and Sodium CMC (Hydrocolloid) 1111Blanose Sodium Carboxymethylcellulose (Na CMC) 3322Magnabrite Magnesium Aluminum Silicate 5544Marine Colloids Carrageenan 1144Metolose SH Hydroxypropyl Methyl Cellulose (HPMC - High Viscosity) 2277Metolose SM Methyl Cellulose 2277Natrosol 250 Pharm Hydroxy Ethyl Cellulose (HEC) 3300Protanal Alginate 1133Xantural Xanthan Gum 4466


Application Guide


8

Stabilizing agentsD-L Malic Acid Malic Acid 7788Protanal Ester Propylene Glycol Alginate 1133Kollidon CL Crosspovidone (Crosslinked PVP) 3355

Sweetening agents Alveosucre Agglomerated Sucrose 5599Caster Sugar / Crystal Sugar Screened Sucrose 6600Compressuc Directly Compressible Sucrose 5588Flolys Dextrose syrup with extensive hydrolysis 2233Hi-Sweet High Fructose Corn Syrup (HFCS) 2211Icing Sugar Milled Sucrose 5588Lycasin Maltitol Syrup 2200Maltisorb Maltitol 2200Neosorb Sorbitol 1199Pearlitol Mannitol 1188Roclys Dextrose Syrup without extensive hydrolysis 2233Sucrose Solution Liquid sucrose 5599Xylisorb Xylitol 2200

Taste Masking agents Aquacoat ECD 30 Aqueous dispersion of Ethyl Cellulose 1122Crysmeb Low MS Methyl Betacyclodextrin 2233Ethyl Cellulose Ethyl Cellulose Pharm 3300Kleptose Betacyclodextrin 2233Kleptose HPB Hydroxypropyl Betacyclodextrin 2233Kollicoat IR Polyvinyl Alcohol-PEG Graft Copolymer 3355Kollicoat MAE Methacrylic Acid Copolymer 3366Trehalose Non-reducing Di-Saccharide 4400

Thickening agents Blanose Sodium Carboxymethylcellulose (Na CMC) 3322DUB GMS Glyceryl Stearate 7755Klucel Hydroxy Propyl Cellulose 3311Kollidon Povidone (PVPK 25, 30, 90F) 3344Lutrol F Poloxamer 3377Magnabrite Magnesium Aluminum Silicate 5544Marine Colloids Carrageenan 1144Metolose SH Hydroxypropyl Methyl Cellulose (HPMC - High Viscosity) 2277Metolose SM Methyl Cellulose 2277Natrosol 250 Pharm Hydroxy Ethyl Cellulose 3300Protanal Alginate 1133Tackidex Dextrin 2244Xantural Xanthan Gum 4466

Suppository basesDUB PP Hemi-synthetic Glycerides 7766Synpro Stearate Sodium Stearate 5500

DisinfectantsPVP Iodine Povidone Iodine 3366


Application Guide


Microcrystalline Cellulose,Alginate, Carrageenan,Cellulose Gel and CoatingSystems. For more than half acentury, manufacturers aroundthe world have turned to FMCBIOPOLYMER for theuncompromising performanceand quality of these distinctiveproducts. The very name FMCBioPolymer reflects the naturaland renewable raw materialsfrom which their products arederived and the polymerchains within the products thatcreate strong and stableapplications in thepharmaceutical industry.

Apart from a very focussedcustomer service network,FMC BioPolymer offerspartnerships to companies indeveloping new technologies,applications and othertechnical support. It has ISOcertified manufacturingfacilities in Europe, NorthAmerica and Asia. Theircommitment to product qualityand functionality exists at everylevel - from raw materialsourcing to manufacturing,process control, storage andshipping.

It is one global producer that isdifferent from all others.

FMC BioPolymer


10

AVICEL® PHMicrocrystalline Cellulose USP/NF, EP, JP

Avicel PH is purified, partially depolymerized alpha cellulose derived from purified speciality grades ofwood pulp. The unique properties of Avicel PH makes it an indispensable formulation tool. It is theexcipient of choice for direct compression formulations, lending superior compactibility, drug carryingcapacity and rapid disintegration. These properties also benefit dry granulation processes such as rollercompaction or slugging. When used in wet granulation processes, Avicel reduces the risk ofovergranulation, avoids screen blockage and promotes uniform, rapid drying. Avicel PH is an excellentextrusion-spheronization binder. The inclusion of Avicel PH in capsule formulations improves flow,facilitates plug formation and aids capsule disintegration.

Grade Description Application

Avicel PH -101 Standard grade withmedium particle size

For conventional applications, especially in wetgranulation and roller compaction

Avicel PH -102 Standard grade with largeparticle size

For improved flow in direct compression, the dryphase of wet granulation and dry granulation

Avicel PH -103 Low moisture content withfine particle size

Well suited to moisture-sensitive drugs

Avicel PH -105 Extra fine particle size For use in direct compression of coarse or hard-to-compress materials

Avicel PH -112 Very low moisture contentwith large particle size

For increased flow in direct compression withmoisture-sensitive ingredients

Avicel PH -113 Very low moisture contentwith fine particle size

Helps extend shelf life and improve final productstability especially with moisture-sensitive drugs

Avicel PH -200 Largest particle size For best flow rate in direct compression and drygranulation maintaining high levels of compressibilityand minimizing problems of weight-variation andcontent uniformity

Avicel PH - 200 LM Largest particle size withvery low moisture content

For best flow rate in direct compression withmoisture-sensitive ingredients

Avicel PH -301 High bulk density with fineparticle size

Reduces powder stratification, helps mixing of fineactives and facilitates making smaller tablets

Avicel PH -302 High bulk density withlarge particle size

Avoids powder segregation, achieves good flowrates and can be used for high dose formulations toproduce thin tablets


11

AVICEL® RC/CLMicrocrystalline Cellulose and Carboxymethylcellulose Sodium USP/NF, BP, JPE

Avicel RC/CL are water dispersible, spray-dried blends of microcrystalline cellulose and sodiumcarboxymethylcellulose used in preparation of pharmaceutical suspensions and emulsions. Usage of theseproducts eliminate lengthy hydration time and provides long shelf-life stability. They act as viscosityregulators and modifiers thus preventing caking or sedimentation in suspensions.

AVICEL® CEMicrocrystalline Cellulose and Guar Gum

Avicel CE 15 is a speciality proprietary combination product specially engineered to improve theorganoleptic properties of chewable tablets.

AC-DI-SOL®

Croscarmellose Sodium USP/NF, EP, JP

Ac-Di-Sol is a crosslinked sodium CMC that facilitates rapid disintegration and drug dissolution in tablets,capsules and other solid dosage forms. It performs dual functionality of water wicking and rapid swellingresulting in it's superior disintegration characteristics.


Avicel RC-591 Spray dried, requiring lowshear for dispersion

Provides a structured dispersion vehicle, acts as aprotective colloid and facilitates dispersion

Avicel RC-581 Bulk dried, requiring highshear for dispersion

Conventional suspending agent and dispersion aid

Avicel CL-611 Spray dried, requiring lowshear for dispersion

Excellent for reconstitutable / dry suspensions


Avicel CE-15 Co-processed MCC andGuar Gum

Improved mouth feel, less grittiness, chalkiness,softer tablets with reduced friability and in generalsuperior sensory characteristics in chewable tablets


Ac-Di-Sol SD-711 Cross linked Sodium CMCor Modified Cellulose Gum

Highly effective in wet granulation & directcompression products, independent of tablethardness with low use level and excellent stability.Best known super disintegrant that is effective intraand extra-granularly


12

LUSTRECLEAR™

Microcrystalline Cellulose and Carrageenan based Coating System

LustreClear LC-103 is a new product line based on proprietary FMC technology - aesthetic coatings withexciting sensory properties that enhance the patient’s experience and create unique product designopportunities.

AQUACOAT® ECDAqueous dispersion of Ethyl Cellulose USP/NF, EP, JP

Aquacoat Ethyl Cellulose is a 30% solid polymer aqueous dispersion of submicron Ethyl Cellulose spheresfor pharmaceutical film coating.

AQUACOAT® CPDAqueous dispersion of Cellulose Acetate Phthalate USP/NF, EP, JP

Aquacoat Cellulose Acetate Phthalate is a 30% solid polymer aqueous dispersion for enteric coatedformulations.


LustreClear LC-103 An aqueous clear film coatingfor tablets and other soliddosage forms

All-in-one solvent free, clear conventional coatingproviding formulators with flexibility and resultingin elegant, easy to swallow and taste maskedfinished forms


Aquacoat ECD-30 A water based pseudo-latexsystem allowing solvent freecoating. Also allows a widechoice of plasticizer

Sustained released beads for capsules / tablets,moisture barrier / sealant and taste masking forpowders, granules, tablets and capsules


Aquacoat CPD-30 A water based pseudo-latexsystem allowing solvent freeenteric coating

Enteric coating of tablets and capsules. Providesan elegant appearance for even embossedtablets and facilitates formation of stable films with6 - 10% coating level by weight. Can also becoated onto beads for hard gelatin capsules


13

PROTANAL® & PROTACID™

Alginates and Alginic acid USP/NF, EP, JP

Alginates are natural hydrocolloids of vegetable origin that occur as a structural component in marinebrown algae, where they give strength and flexibility to the plant. FMC Protanal alginates and Protacidalginic acids offer unique gel-forming, film-forming, thickening and stabilizing properties.

Grade Description Viscosity (mPas) (1%) Application

Protacid F 120 NM Acid – Anti-Reflux Tablets

Protanal LFR 5/60 Na Salt 300 - 700 (10%) Anti-Reflux Suspensions

Protanal LFMg 5/60 Mg Salt 1000 - 1800 (7.5%)

Protanal LF 240 D Na Salt 70 - 200 Sustained Release

Protanal LF 120 M Na Salt 70 - 150


Protanal LF 10/60 D Na Salt 20 - 70 Wound Healing

Protanal LF 10/60 LS Na Salt 20 - 70

Protanal LF 10/60 Na Salt 20 - 70

Protanal Ester SD-LB Propylene Glycol 700 - 1800 (2%) Stabilizer, Binder, Plasticizer &Emulsifier

Protanal HF 12 RBS Na Salt 600 - 1000 Dental Impression Materials

Protanal LF 200 DL Na Salt 200 - 400


Protanal LF 200 S Na Salt 200 - 400

Protanal KF 200 RBS K Salt 200 - 400

Protanal KF 200 K Salt 200 - 400

Protanal KF 200 S K Salt 200 - 400

Protanal TA 250 Triethanolamine 200 - 400


14

MARINE COLLOIDS™ CARRAGEENANCarrageenan USP/NF

Marine Colloids Carrageenan is a naturally-occurring family of polysaccharides extracted from redseaweeds. FMC develops blends for specific gelling, thickening and stabilizing properties desired forpharmaceutical applications.


CGN Type Viscosity Gel Type

Gelcarin GP-379 Iota High Thixotropic Elastic, mediumstrength

Creams, SuspensionsPolyol and Protein reactivePromotes freeze thaw

Gelcarin GP-812 Kappa Low Brittle, strong Stronger gels than GP 911Syneresis higher than GP 911

Gelcarin GP-911 Kappa Low Brittle, firm Encapsulation / Delivery systemsPolyol and Protein reactive

Viscarin GP-109 Lambda Medium Non-gelling Creams, LotionsPolyol and Protein reactive

Viscarin GP-209 Lambda High Non-gelling Creams, LotionsPolyol and Protein reactive

SeaSpen PF Iota Medium Thixotropic Elastic, weak Suspensions / ReconstitutablesTopical lotions / creams


15

A business unit of FMC BioPolymer

NovaMatrix is a newly created business unit of FMC BioPolymer. Their current products are special ultrapure grades of sodium alginates, chitosan salts & bases and sodium hyaluronates that satisfy functionaland regulatory specifications. These are well-characterized and documented biopolymers and biomaterialsfor use in the development of novel drug delivery therapies, in the formation of biostructures for tissueengineering, wound healing, implants and advanced biotechnology applications. They also have provenproperties suitable for parenteral administration of challenging drugs and implants.

PRONOVA™ UPUltra pure Sodium Alginates

Pronova alginate is a linear copolymer with homopolymeric blocks of (1�4)-linked beta-D-Mannuronate(M) and its C-5 epimer alpha-L-guluronate (G) residues, respectively, covalently linked together in differentsequences or blocks. Endotoxin (EU/g) is <_ 100.

PRONOVA™ SLSterile Sodium Alginates

Sterilizing alginate solutions may often be an obstacle in pharmaceutical and biomedical applicationsrequiring sterility of the applied material. In particular, this relates to problems with polymer degradationduring autoclaving or irradiation procedures. To meet customer demands, NovaMatrix offers PRONOVA SLalginate as a sterilized and lyophilized product. Endotoxin (EU/g) is <_ 100.

Grade Viscosity (mPas)

Pronova UP LVM 20 - 200

Pronova UP MVM > 200

Pronova UP LVG 20 - 200

Pronova UP MVG > 200

Pronova UP Test Kit Contains gram quantities of the above four UP products

Grade Viscosity (mPas)

Pronova SLM20 20 - 100

Pronova SLM100 > 100

Pronova SLG20 20 - 100

Pronova SLG100 > 100


16

PROTASAN™ UPUltra pure Chitosan salts

PROTASAN ultrapure (UP) chitosan salts and bases is a linear polysaccharide composed of beta-(1�4)-linked D-glucosamine (D) and 2-acetamido-2-deoxy-D-glucosamine. The products are characterized byspecified parameters reflecting the key properties and purity profile of the material. With it's positivelycharged amino groups, chitosan differs from most polysaccharides that are neutral or negatively charged.Thus, chitosan becomes water soluble in acidic solutions.

SODIUM HYALURONATEUltra pure Sodium Hyaluronate USP, JP, JCIC

Sodium Hyaluronate Pharma Grade is a highly purified and well-characterized sodium hyaluronatedeveloped for use in biomedical and pharmaceutical applications. It is manufactured at the NovaMatrix /FMC BioPolymer strategic partner Kibun’s state-of-the-art production facility in Japan. The fermentation ofultra pure sodium hyaluronate is made from non-animal origin material.

Grade Description

Protasan UP CL 113 Chitosan Chloride Salt

Protasan UP CL 213 Chitosan Chloride Salt

Protasan UP G 113 Chitosan Glutamate Salt

Protasan UP G 213 Chitosan Glutamate Salt

Protasan UP Test Kit Contains gram quantities of the above four UP products

Grade Mol. Weight (kDa)

Pharma grade 80 620 - 1150

Pharma grade 150 1400 - 1800

A business unit of FMC BioPolymer


ROQUETTE was founded in1933 and ranks amongst theworld's leading producers ofstarch derivatives and polyolsfor the pharma, food &cosmetic industry. It has ahuge range of excipients andvery specialized products thatact as humectants, molecularencapsulation solutions,injectables, sweeteners,binders, diluents.... etc.

Globally it has 13 productionfacilities manufacturing over600 products and asophisticated Research Centreat Lestrem, France where closeto 350 scientists work, who areavailable to provide technicalassistance to customers.Committed to strong customerservice, Roquette have a worldwide network of subsidiariesand agents.

Roquette Freres


18

PEARLITOL®

Mannitol USP/NF, EP, JP

Mannitol is a polyol manufactured by a process based upon starch. It is remarkably stable and alsosoluble in different solvents. It occurs as a slightly sweet white crystalline powder, that gives a coolingsensation in the mouth. It is non-cariogenic, has low hygroscopicity and thus forms an ideal excipient fordry formulations.


Pearlitol PF (Mannitol PFG) Pyrogen free Diuretic-osmotic for injectable solutions

Pearlitol 25 C (Mannitol 25) Extra fine particle size Diluent, excipient for unstable actives &flash release, freeze drying carrier andsweetener with cooling effectPearlitol 50 C (Mannitol 35) Medium particle size

Pearlitol 160 C (Mannitol 60) Coarse particle size

Spray Dried Mannitol


Pearlitol 100 SD Fine particle size Excellent diluent-binders for directcompression applications (fast dissolving,chewable, oral dispersible, effervescenttablets)Pearlitol 200 SD Medium particle size

Agglomerated Mannitol


Pearlitol 300 DC Fine particle size Excellent diluent-binder for directcompression applications and in additioncan be used as neutral carriers onto whichactive substances are poured or sprayed

Pearlitol 400 DC Medium particle size

Pearlitol 500 DC Coarse particle size

Crystalline Mannitol


19

NEOSORB®

Sorbitol USP/NF, EP, JP

POLYSORB®

Liquid Sorbitol, partially dehydrated EP


Polysorb 85/70/00(Anidrisorb 85/70)

Aqueous solution of D-Sorbitol and Sorbitans

A superior plasticizing agent in the manufactureof soft gelatin capsules

SOLULYS®

Corn-steep powder


Neosorb P 100 T Extra fine particle size Excellent excipient for direct compression ofsuckable and chewable tablets, diluent for sachet& sweetener for pharma chewing gumsNeosorb P 60 W Fine particle size

Neosorb P 20/60 Medium particle size

Neosorb P 30/60 Coarse particle size

Neosorb PFG Pyrogen free Parenteral nutrition; used in combination withamino acids

Neosorb 70/70 B Sorbitol solution - Non crystallizing

Humectant and bulk sweetener for syrups,suspensions, oral ampoules, pastilles andlozenges


Solulys AST Spray dried corn-steeppowder

For seed culture as well as in main fermentation

Soluten 50 Cellulose free, high vegetableprotein

For main fermentation media

GLUCONO-DELTA-LACTONE USP/NF


G-D-L G Crystalline white powder,slightly sweet beforedeveloping an acid taste.Mean Diameter (µm) - G: 790; T: 330

pH acidity regulator, source of gluconate ionsand increases the efficacy of preservatives

G-D-L T

* Also available as Sodium Gluconate Salt


20

MALTISORB® & LYCASIN®

Maltitol USP/NF, EP

XYLISORB®

Xylitol USP/NF, EP, JP


Maltisorb P 90 Fine particle size Diluent for tablets and sachets, excipient forcoating with high sweetening power & goodsolubility. Used for chewable, suckable andeffervescent tablets

Maltisorb P 200 Coarse particle size

Maltisorb 75/75 72% - 76% dry maltitol syrup Liquid sweetener for syrups, suspensions,lozenges, oral ampoules, pastilles and pharmachewing gumsLycasin 80/55 50% - 55% dry maltitol syrup

Lycasin HBC Special grade maltitol syrup Hard boiled candies


Xylisorb 90 Fine particle size Diluent for sachets, chewable & suckable tablets.Sugar free coating (non-cariogenic) withsweetening power identical to that of Sucrose.Xylisorb 300 Medium particle size

Xylisorb 700 / PFG Pyrogen free, coarse particle size Parenteral nutrition; used in combination withamino acids

LYCOAT®

Aqueous Film Coating System

Lycoat is Roquette's innovation in conventional film coating. A new alternative for the formulator; it ispatent protected and has exciting benefits like reduced coating time, instant dispersion at roomtemperature with no foam formation etc. Another important application of Lycoat is to manufactureOrodispersible strips.


Lycoat RS Modified peas starch basedaqueous film coating system

Cold water soluble, easy-to-prepare systemensuring fast coating process giving a smooth,glossy & uniform colour tablet coat

ReadiLYCOATTM Ready to use film coating system Used for aesthetic and functional benefits intablets with improved organoleptic properties,ease of solubilisation and process efficiency

Lycoat NG 73 Modified peas starch basedaqueous film

Used in the manufacture of orally disintegratingfilms (mouth wafers)


21

STARCHGMO Free Starch USP/NF, EP, JP


Maize Starch 5 % (Dried) Extracted from maize.Microbiologically compliant

Dried maize starch is a low moisturegrade for moisture sensitive drugs

Maize Starch B Extracted from maize, wheat orpotato origin. Microbiologicallycompliant

Diluent and disintegrant for tablets andcapsules

Extra White Maize Starch

Corn Starch 400 L

Wheat Starch TB

Potato Starch B

Modified Starches


Lycatab® PGS Fully pregelatinised maize starch Excellent binder for wet granulation

Lycatab® C Partially pregelatinised maizestarch

Versatile excipient optimised as a filler forhard gelatin capsules. Also used as abinder cum disintegrant for directcompression with self-lubricating propertyand as a binder for wet granulation

Lycatab® DSH Partially hydrolyzed maize starch Low viscosity, natural binder for wetgranulation. Ready to use, easilydispersible, quickly soluble and nomaturation time. It can also be directlyincorporated in dry blends

Lycatab® Mineral CC Compound of precipitatedcalcium carbonate granulatedwith maize starch

Direct compression of chewable calciumtablets with improved mouth-feel

Native Starches

HI-SWEET®

High Fructose Corn Syrup (HFCS)


Hi-Sweet 55 Contains minimum 55% fructose(DS basis)

Used as a bulk sweetner and viscosifierin medicated syrups and suspensions.Provides high sweetness and clearmouth feel compared to sucrose andinvert sugar

Hi-Sweet 42 Contains minimum 42% fructose(DS basis)


22

GLYCOLYS®

Sodium Starch Glycolate USP/NF, EP, JP


Glycolys Standard grade - Type A Conventional disintegrant for soliddosage forms. Used in both WG and DCprocesses

Glycolys LV Low viscosity grade - Type A Designed to resist high sheer in WGprocess

Glycolys Low pH Acid stable grade - Type B Designed to resist acidic pH informulations

STARLACTM

Spray-dried compound of Maize Starch & Lactose Monohydrate USP/NF, EP


Starlac Designed for direct compressionwith superior flowability andexceptional disintegrationproperties with superior storagestability

Direct compression filler fororo-dispersible tablets, low-dosageformulations, capsule filling and cores forcoating


Nutriose FB Wheat fibre For enteral nutrition and low calorieformulations. Has properties like high fibrecontent (85%), well tolerated digestion,low calorific value, non-cariogenic andlow glycaemic & insulinaemic index

Nutriose FM Maize fibre

NUTRIOSE®

Soluble Fibre

Nutriose products are dextrins developed by Roquette's research centre as innovation soluble fibres withvaluable technological advantages. Their chemical stability as well as their controlled powder propertiesmake them flexible ingredients for a variety of pharmaceutical and nutraceutical applications.


23

KLEPTOSE®

Betacyclodextrin USP/NF, EP, JPE & derivatives

Betacyclodextrins and its hydroxy-propyl derivatives (HPBCD) are cyclic oligosaccharides obtained fromstarch by enzymatic cyclisation using enzymes called cycloglycosyl transferases. Its non-polar cavityallows the formation of complexes with actives in the solvent or dry phase. Used as encapsulating agentsand solubility enhancers for tablets, capsules, sachets, syrups, solutions and oral suspensions.

GLUCOSEDextrose USP/NF, EP, JP


Lycadex® PF Pyrogen free dextrosemonohydrate

Osmotic agent in injectable & dialysissolutions, parenteral nutrition and treatment ofhypoglycaemia

Dextrose AnhydrousPF

Pyrogen free dextrose anhydrous

Dextrose GC Agglomerated dextrosemonohydrate

Direct compression diluent with excellentcompressability & flowability for tablets,sachets and capsule formulation

Roferose® Dextrose Monohydrate Diluent for tablets, capsules and sachets

Roclys® Dextrose syrups withoutextensive hydrolysis

Inhibiting sucrose crystallization, texturizerand bulk sweetener in syrups, lozenges,pastilles and pharmaceutical chewing gums

Flolys® Dextrose syrups with moreextensive hydrolysis


Kleptose STD Standard grade Inclusion in solvent phase

Kleptose DC Granular grade Direct compression

Kleptose 10 Micronised grade Suitable for aerosols

Kleptose 7PC Low water content grade Inclusion in dry phase

Kleptose HPB Hydroxy Propyl BetacyclodextrinMedium Molar Substitution

Increases water solubility of poorly solubledrugs and also suitable for parenteral use

Crysmeb® Methyl BetacyclodextrinLow Molecular Substitution

Similar to Kleptose HPB. In addition it isintrinsically crystallisable and has lowhaemolytic power


24

GLUCIDEX®

Maltodextrin and Dried glucose syrup USP/NF, EP

TACKIDEX®

Dextrin USP/NF, EP


Tackidex B 147 White dextrin from maize starch Tablet & capsule filler, binder for tabletgranulation, sugar coating ingredient,thickening agent for suspensions


Glucidex 2 D Maltodextrin with dextrosemaximum 3

Soluble in water and offer high standard oforganic, mineral and bacteriological purity

Used as diluent for tablets, capsules,sachets; spray-drying carrier andcarbohydrate source in infant and enteralfoods

Glucidex 6 D Maltodextrin with dextroseequivalent of 5 to 8





Glucidex 21 D Dried glucose syrup with dextroseequivalent of 20 to 23



Note : Also available in IT grades which provides free flowing properties and better solubilization due to its particular physicalstructure.


Founded in Japan in 1926,SHIN-ETSU has grown to be aleader in many fields with amajor presence in the arena ofexcipients required by thepharmaceutical industry. It isthe world's largest MC &HPMC producer and ranksamongst the top five chemicalcompanies, globally.

Their products are pioneeringinnovations in use sincedecades with additionsconstantly being developedand introduced at regularintervals. Specialities includefilm coating materials, binders,water soluble cellulose ethersand derivatives, sustainedrelease agents, enteric coatingmaterials and several othersmaking them indispensible inthe development of newgeneration formulations.

Shin-Etsu Chemical Co.


26

PHARMACOAT®

Hydroxypropyl Methylcellulose USP/NF, EP, JP

Pharmacoat is low viscosity Hydroxypropyl Methylcellulose initially developed as an under-coat for sugarcoating. It is very versatile, gives an excellent finish and suitable for many applications in the design of filmcoated tablet formulations. It is also effective as a binder since it does not interact with drugs, has superiorstability, non-ionic character and available in various viscosity grades.


Viscosity (cps) USP Substitution Type

Pharmacoat 603 3 2910 Wet granulation binder

Pharmacoat 603W 3 2910 White grade of 603

Pharmacoat 606 6 2910 Regular film coating

Pharmacoat 606W 6 2910 White grade of 606

Pharmacoat 606G 6 2910 Granular grade of 606 (dispersesquickly)

Pharmacoat 615 15 2910 Film coating, greater film strength

Pharmacoat 645W 4.5 2910 White grade, short processing

Pharmacoat 904 4 2208 Sugar coating binder

HPMCPHydroxypropyl Methylcellulose Phthalate USP/NF, EP, JP

HPMCP is a phthalic half ester of HPMC. It is a solvent based enteric coating agent to protect drugs fromdegradation from gastric acid and to prevent them from causing side effects in the stomach.


Dissolving pH* Viscosity (cst)

HPMCP HP-55 >_5.5 40 Regular grade

HPMCP HP-55S 170 Greater film strength

HPMCP HP-50 >_5.0 55 Soluble at lower pH

* Mcllvaine's buffer (citric acid-Na2HPO4)


27

METOLOSE®

Hydroxypropyl Methylcellulose (HPMC) / Methylcellulose (MC) USP/NF, EP, JP

Metolose is a non-ionic water soluble cellulose ether derived from pulp. It is available in a wide viscosityrange from 4 cps to 100000 cps. It provides a variety of functions such as water retention, thickening,protective colloid, surface activity, sustained release etc. Shin-Etsu also manufactures special HPMCgrades used as sustained release agents for matrix systems.


Viscosity (cps) USP Substitution Type

Metolose 60SH-50 50 2910 HPMC polymer used forsustained release, thickener,suspending agent and binder fortablets and granules. Also usedfor opthalmics

Metolose 60SH-4000 4000 2910

Metolose 60SH-10000 10000 2910

Metolose 65SH-50 50 2906

Metolose 65SH-4000 4000 2906

Metolose 90SH-100 100 2208

Metolose 90SH-4000 4000 2208

Metolose 90SH-15000 15000 2208

Metolose 90SH-100000 100000 2208

Metolose 90 SH-100SR 100 2208 Special HPMC grades used ashydrophilic matrix agentsallowing more controllable andreproducible drug release, thusproviding consistency in the finalproduct

Metolose 90SH-4000SR 4000 2208

Metolose 90SH-100000SR 100000 2208

Metolose SM-4 4 - MC polymer used for granulecoating

Metolose SM-15 15 - MC polymer used as granulatingagent, emulsifying agent,thickener, bulk laxative, etc.Metolose SM-400 400 -

Metolose SM-4000 4000 -


28

L-HPCLow substituted Hydroxypropyl Cellulose USP/NF, EP, JP

L-HPC is a low substituted Hydroxypropyl ether of cellulose. It is insoluble in water and solvents but swellsin water. It causes changes in the binding and disintegrating characteristics as a result of subtle changesin physical properties. Thus, it is widely used as dual-functional excipient (disintegrant/binder) for tablets,granules or other pharmaceutical solid dosage forms.


Mean particle size * (µm) Particle type

L-HPC LH-11 50 Highly fibrous Direct Compression (anti-capping)

L-HPC LH-21 40 Moderately fibrous Regular grade (dry mixing, wetgranulation)

L-HPC LH-22 40 Moderately fibrous Lower hydroxypropoxy content(sometimes better disintegration)

L-HPC LH-31 20 Micronized Micronized grade (pelletextrusion, layering)

L-HPC LH-32 20 Lower hydroxypropoxy content

L-HPC LH-B1 50 Non fibrous High bulk density grade used indirect compression or fluid bedgranulation process especiallyfor high load formulations

SHIN-ETSU AQOAT® (HPMCAS)Hydroxypropyl Methylcellulose Acetate Succinate USP/NF, JP

Aqoat is a new enteric coating material for application in aqueous, solvent and dry coating system. Canalso be used in the design of sustained release dosage form in combination with gastric solublepreparation.


Dissolving pH* Acetyl(%) / Succinoyl(%)

Aqoat AS-LF ≥ 5.5 8 / 15 Micronized grades for aqueousand dry coating

Aqoat AS-MF ≥ 6.0 9 / 11

Aqoat AS-HF ≥ 6.5 12 / 6

Aqoat AS-LG ≥ 5.5 8 / 15 Granular grades for solvent-based coating

Aqoat AS-MG ≥ 6.0 9 / 11

Aqoat AS-HG ≥ 6.5 12 / 6

* Mcllvaine's buffer (citric acid-Na2HPO4)

* Laser diffraction method


AQUALON has been deliveringpharmaceutical performancesince the 1950s, through thelegacy of Hercules Inc. andHenkel GmbH. Aqualon wasoriginally founded in 1987 as ajoint venture between the water-soluble polymer groups ofthese two companies. Aqualonhas it's headquarters,corporate research centre andpharmaceutical laboratory inWilmington, Delaware, USAand production facilities inFrance, Netherlands and USA.

Currently, their product mixincludes a series of celluloseethers that meet requirementsfor use as excipients inpharmaceutical formulations.All products comply withpharmacopoeial standards laiddown by individual regulatorybodies. Aqualon products arewell known for their exceptionaland consistent quality.

Aqualon – (A division of Hercules, Inc.)


30

AQUALON® ETHYL CELLULOSE PHARMEthyl Cellulose USP/NF, EP, JP

Ethyl cellulose is a non-ionic ethyl ether of cellulose containing not less than 44% and not more than 51%of ethoxy groups, calculated on dried basis. They are soluble in a wide range of organic solvents. Whenwater-soluble binders cannot be used, ethyl cellulose is often the polymer of choice. They are classifiedinto a range of polymer viscosities for different applications.

Grade Viscosity range (cps)* Application

EC N 7 Pharm 5.6 to 8 Micro encapsulation - Stabilize against activeinteractions, hydrolysis and oxidation

Tablet coating - Impart sustained release to film coatings

Tablet binder - Plastic flow, suitable for directcompression, injection molding and melt extrusion

Flavor masking - Improved taste through suppression ofstrong flavors

EC N 10 Pharm 8 to 11





EC T 10 Pharm 8 to 11 Directly compressible, micronized grade with highethoxyl content and low viscosity for optimizedcompactibility and good powder flow

NATROSOL® 250 PHARMHydroxy Ethyl Cellulose USP/NF, EP

Natrosol HEC is a non-ionic water-soluble cellulose ether, formed by reaction of cellulose with ethyleneoxide. It is used as a modified release tablet matrix, a film former and a thickener, stabilizer & suspendingagent for oral and topical applications when a non-ionic material is desired. Natrosol is easily dispersed incold or hot water to give solutions of varying viscosities and desired properties, yet it is insoluble inorganic solvents.


Natrosol HHX Pharm 3500 - 5500 (at 1%) Modified release - provides effective diffusion limitingmatrix systems

Tablet coating - Imparts flexibility to films while providinga good barrier to water and oxygen transmission

Solution thickening, stabilizing and suspending agent -Controls rheology and provides pseudoplasticity

Natrosol HX Pharm 1500 - 2500 (at 1%)

Natrosol M Pharm 4500 - 6500 (at 2%)

Natrosol G Pharm 250 - 400 (at 2%)

Natrosol L Pharm 75 - 150 (at 5%)

* Concentration in water, weight %. Viscosities determined at 250 C, using a Brookfield LVF viscometer.

* Determined using 5% ethyl cellulose in 80 parts toulene, 20 parts ethanol by weight.


31

KLUCEL®

Hydroxy Propyl Cellulose USP/NF, EP, JP

Klucel is a non-ionic cellulose ether with a versatile combination of properties. It is soluble in many polarorganic solvents and in water below 380 C, but is insoluble in water above 450 C. It's solutions are highlysurface-active, with low surface and interfacial tensions. In films and coatings, Klucel is heat-sealable andit is extremely flexible without plasticizers.

Grade Viscosity range(cps)* Application

Klucel EF Pharm 300 - 600 (10%) Tablet binding for immediate release - Yieldsunmatched tablet hardness and friability in wetgranulation and direct compression or drygranulation

Modified release - Provides effective diffusionlimiting matrix systems

Tablet coating - Imparts good flexibility andadhesion to films while providing a good barrier towater and oxygen transmission

Klucel EXF Pharm (extra fine) 300 - 600 (10%)

Klucel LF Pharm 75 - 150 (5%)

Klucel JF Pharm 150 - 400 (5%)

Klucel JXF Pharm (extra fine) 150 - 400 (5%)

Klucel GF Pharm 150 - 400 (2%)

Klucel GXF Pharm (extra fine) 150 - 400 (2%)

Klucel MF Pharm 4000 - 6500 (2%)

Klucel MXF Pharm (extra fine) 4000 - 6500 (2%)

Klucel HF Pharm 1500 - 3000 (1%)

Klucel HXF Pharm (extra Fine) 1500 - 3000 (1%)



32

BLANOSE® CELLULOSE GUMSodium Carboxymethylcellulose USP/NF, EP, JP

Blanose cellulose gum is the sodium salt of carboxymethylcellulose (CMC), purified to meetpharmaceutical standards. They are soluble in water but insoluble in organic solvents. Generally are usedas thickeners, binders, stabilizers, suspending agents and rheology modifiers. Lower substitution typesprovide thixotropy and higher substitution types are used where smooth solutions are required.


Blanose 7H4F-PH 2500 - 4500 (1%) Tablet coatings - Film former

Mucoadhesives - Absorbency

Syrups & suspensions - Thickener, suspendingagent

Sustained release - Thickener, diffusion barrier

Bulk laxatives - Physiologically inert, high waterbinding capacity

Ointments, creams and lotions - Stabilizer,thickener, film-former

Blanose 7HOF-PH 1000 - 2800 (1%)

Blanose 7H3SF-PH 1000 - 2800 (1%)

Blanose 7HF-PH 1500 - 2500 (1%)

Blanose 7M31F-PH 1500 - 3100 (2%)

Blanose 7M8SF-PH 200 - 800 (2%)

Blanose 7MF-PH 400 - 600 (2%)

Blanose 7M1F-PH 50 - 100 (2%)

Blanose 7LF-PH 25 - 50 (2%)

Blanose 9H4F-PH 2500 - 4500 (1%)

Blanose 9M31F-PH 1500 - 3100 (2%)

Blanose 9M8F-PH 400 - 800 (2%)

Blanose 12M8P 200 - 800 (2%)

Blanose 12M31P 1500 - 3100 (2%)


DS-Type Substitution range Sodium content, %

7 0,65 to 0,90 ** 7,0 - 8,9

9 0,80 to 0,95 9,2 - 9,3

12 (for USP grades) 1,15 to 1,45 10,4 - 12,0

12 (for EP grades) 1,12 to 1,21 10,2 - 10,8

** in 7S and 7O types, the upper limit of substitution is 0,95.


BASF is the world's leadingchemical company. As atransnational company, itmaintains businessrelationships with customers inmore than 170 countries andoperates production facilities in39 countries.

BASF's association in Indiastarted way back in 1943. It'spharmaceutical involvementincludes dozens of actives,excipients and vitamins.Excipients viz. Kollidon, Lutrol,Cremophor etc are familiarnames even to students ofpharmaceutical sciences. Overthe years, several specialityproducts have been developedand today offer versatilechoices to the modern dayformulator. They maintain aclose partnership with theindustry.

BASF Aktiengesellschaft


34

KOLLIDON®

Polyvinylpyrrolidone (PVPK) USP/NF, EF, JP

The soluble grades of Kollidon are obtained by free-radical polymerization of vinylpyrrolidone in water orisopropanol according to the cGMP regulations, yielding the chain structure of polyvinylpyrrolidone[1,141]. Because of its solubility in water and many organic solvents, it's high binding power and ability toform complexes, soluble PVP occupies a special position among the synthetic colloids. Kollidon isavailable in a wide range depending on their K-value and molecular weight.


K-value Molecular weight

Kollidon 12 PF 10.2 - 13.8 Low Pyrogen free grades for use as solubilzer,crystallization inhibitor, suspensionstabilizer and lyophilization agent ininjections and ophthalmic preparationsKollidon 17 PF 15.3 - 18.0 Low

Kollidon 25 22.5 - 26.7 Medium Versatile and widely used as binders intablets, capsules & granules, stabilizers inoral suspensions, film formers, dispersantsfor pigments, thickeners and bioavailabilityimprovers

Kollidon 30 27.0 - 32.1 Medium

Kollidon 90 F 81.0 - 96.3 High A highly effective binder, stabilizer for oraland topical suspensions, thickener,hydrophilizer and pore former in medicaldevices

KOLLIDON® VA 64Copolyvidone USP/NF, EP, JPE


K-value Characteristics

Kollidon VA 64 25.2 - 30.8 Copolymer ofVinylpyrrolidone-Vinylacetate inratio of 6 : 4 bymass

Dry binder, Wet Binder, Film forming agentin coatings and topical sprays

Kollidon VA 64 Fine Fine particle size grade for increased tablethardness resulting in less friability andbetter mechanical stability


35

KOLLIDON® SRPolyvinyl Acetate and Povidone based excipient

KOLLIDON® CLCrosslinked Polyvinylpyrrolidone (Crosspovidone) USP/NF, EP, JPE


Kollidon CL Standard grade Used as a super disintegrant in tablets for improving releaseof active substances. Fine grade is ideal for small tablets(less content uniformity problems). Superfine grade is for fastdispersible tablets (with superior mouth feel). Micronizedgrade is used as a stabilizer for suspensions

Kollidon CL-F Fine particle sizegrade

Kollidon CL-SF Superfine particlesize grade

Kollidon CL-M Micronized grade


K-value Characteristics

Kollidon SR 60.0 - 65.0 Mixture of 80% Polyvinylacetate and 20%Povidone K 30

pH independent matrix former fordirect compression of sustainedrelease tablets, pellets andgranules

KOLLICOAT® IRGraft copolymers


Kollicoat IR Polyvinyl alcohol -polyethylene glycolgraft copolymer,very soluble in water

Instant release coatings and quick dissolving formulations.Also used as a pore former in sustained release formulationsand as a binder. It has enormous flexibility, low viscosity andrapid rate of dissolution besides not having to use a plasticizer

Kollicoat IR White Graft copolymer of75% polyvinylalcohol units and 25% polyethyleneglycol units withother additions forman instant releasewhite coating system

To produce white tablets or with a colour premix for colouredtablets. Used also for taste masking, appearance enhancingand protection of light sensitive actives

Kollicoat IR Protect Coprocessedproduct of KollicoatIR and PVA to form ahomogenous powder

Provides excellent moisture protection and taste masking inaddition to advantages of Kollicoat IR


36

KOLLICOAT®

Methacrylic acid / Ethyl acrylate copolymers USP/NF, EP, JPE

Kollicoat grades are state of the art aqueous coating agents characterized by excellent film formingproperties, a reliable adjustment of release rates, easy and cost saving coating processes.


Kollicoat MAE 30DP Aqueous, milky white, lowviscosity, fast to use dispersionwith solid content of 30%

For white, coloured, & colourless enteric filmcoatings of pellets, crystals, soft gelatincapsules and other solid dosage forms. Alsoused as a moisture barrier, taste odourmasking and a barrier between incompatibleactives

Kollicoat MAE 100P White, redispersible powderpreferred when subject toextreme climatic conditions intransport or storage

Kollicoat EMM 30D Aqueous dispersion of acopolymer derived from ethylacrylate / methyl methacrylatewith solid content of 30%

Sustained release, pH independentmembrane coatings and matrix. Forms veryflexible films without plasticizer and allowsstable and reproducible drug release profiles.Also used for taste masking and moisturebarrier applications

Kollicoat SR 30D Aqueous dispersion of 27%polyvinyl acetate, 2.5% povidone& 0.3% sodium lauryl sulfate withsolid content of 30%

pH-independent sustained releaseformulations (coating or matrix), tastemasking and protective coatings

POVIDONE-IODINEPVP-Iodine USP/NF, EP, JP


PVP-Iodine 30/06 Standard grade Used as a disinfectant in topical formulationssuch as ointments, solutions, creams, ovulaand others. It is applied in gargle solutions,surgical scrubs and soaps

PVP-Iodine 30/06 M10 Micronised grade

SOLUPHOR® P2-Pyrrolidone, Distilled


Soluphor P Allows more rapid absorption ofactive substances on topicalapplication of drugs

Solvent for veterinary injections. Alsodescribed for transdermal systems and fortransmucosal application


37

LUTROL®

Plasticizers & Solubilizers


Lutrol E 300 Molecular weight : 285 - 315Viscosity : 5.4 - 6.4 cps

Solvents for parenteral, topical, ophthalmic,oral, and rectal preparations. Widely used asan ointment base

Lutrol E 400 Molecular weight : 380 - 420Viscosity : 6.8 - 8.0 cps

Poloxamer USP/NF, EP


Lutrol F 68 Poloxamer 188 (Block polymer of81% PEG and 19% PPG)

Used as emulsifier, solubilizer, suspensionstabilizer, thickener in liquids, orals, topicals,parenterals and for enhancing bioavailabilityin solid preparations

Micronized grades avoids segregation ofpowder blends, gives a homogenous mixtureof actives and excipients, which results incontent uniformity concerns with tablets

Lutrol M 68 New, micronized grade of F 68with mean particle size of 50 µm

Lutrol F 127 Poloxamer 407 (Block polymer of73% PEG and 27% PPG)

Lutrol M 127 New, micronized grade of F 127with mean particle size of 50 µm

LUDIPRESS®

Advanced excipient for direct compression


Ludipress Granules of LactoseMonohydrate, Povidone 30 andCrosspovidone

For production of fast disintegrating tabletsby direct compression process

Ludipress LCE Compound of LactoseMonohydrate and Povidone 30

Direct compression of lozenges, sublingual,chewable and effervescent tablets. Alsosuitable for controlled release formulations

Polyethylene Glycol / Macrogol USP/NF, EP


38

SOLUTOL® HS 15Macrogol-15-Hydroxystearate EP


Solutol HS 15 Well-tolerated, efficient solubilizerin aqueous systems forinjectables

For manufacturing aqueous parenteralpreparations with vitamins and other lipophilicactive pharmaceutical ingredients

SICOVIT®

Iron Oxide USP/NF, EP

CREMOPHOR®

Non-ionic surfactants USP/NF, EP


Cremophor RH 40 Polyoxyl-40 Hydrogenated Castor Oil

To solubilize vitamins, water-insoluble activesubstances and other hydrophobicsubstances in oral and topical liquid & semi-liquid dosage formsCremophor EL Polyoxyl-35 Castor Oil

(Standard Grade)

Cremophor ELP Polyoxyl-35 Castor Oil (Extra Pure Grade)

Used as a solubilizer in parenteral dosageform especially for sensitive drugs

Cremophor A 6 Macrogol-6 cetostearyl ether Non-ionic emulsifiers for production ofointments and creams based on oil-in-wateremulsions / water-in-oil emulsionsCremophor A 25 Macrogol-25 cetostearyl ether


Sicovit Red 30 E 172 Red colour pigment Stable colouring pigments approved for usein the pharma industry

Sicovit Yellow10 E 172 Yellow colour pigment

Sicovit Black E 172 Black colour pigment

Sicovit Brown E 172 Brown colour pigment


ASAHI KASEI CHEMICALSCORPORATION, a membercompany of Asahi KaseiGroup, was founded in 1931and employs 4500 people. Byyear 2000, it had fourproduction facilities in Japanand a consolidated net salesturnover of approx. 10 billionUS Dollars.

Their product line includessome very specializedexcipients viz. Celphere (MCCSpheres), starch derivativesamongst others.

Asahi Kasei ChemicalsCorporation


CELPHERE®

Microcrystalline Cellulose Spheres USP/NF, EP, JPE

CEOLUS® KGMicrocrystalline Cellulose USP/NF, EP, JP

Grade Particle size (µm) Description Application

Ceolus KG-802 50 Dry binder with adistinctive rod-formparticle configurationthat providesincomparablecompactibility

Particularly effective intableting large dose drugs,low compressible drugs,pressure sensitive drugs,coated granules and oraldispersible tablets

Ceolus KG-1000 50

PCS® PC-10Partly Pregelatinized Starch USP/NF, EP, JP

Grade Particle size (µm) Description Application

PCS PC-10 70 It is inert, pH-independent and hasgood flowability. Itachieves disintegratingproperties by swellingdue to absorption ofwater

A stabilizer for moisture-sensitive drugs, dissolutionenhancer, carrier forhygroscopic ingredientsand a granulation aid

Grade Particle size range (µm) Description Application

Celphere SCP-100 75 - 212 High mechanicalstrength, low reactivity,high sphericity, fine &uniform particle size andoptimum waterabsorption

Used as spherical seedcore for drug layering & filmcoating and in themanufacture of granuleswith sustained-release,taste-masked and otherspecial properties

Celphere CP-102 106 - 212




Celphere CP 708 710 - 850

40

TREHALOSENon-reducing Di-Saccharide

Grade Form Description Application

Trehalose P Powder Low reactive, non-hygroscopic, heat &pH stable, with taste &smell masking effect

A compactible sugar-typefiller & a taste maskingagent for solid & liquiddosages

Trehalose G Granular


INNOPHOS is the world’sleading manufacturer of high-quality calcium phosphates forthe pharmaceutical and foodindustry. Since 1930 they havebeen manufacturing calciumphosphates in their ChicagoHeights, USA plant whichoperates to the higheststandards, most with ISO 9002and GMP accreditation. Theirclient base includes some ofthe world's leadingpharmaceutical companiesand is testament to the value ofit's consistent ability to supplythe highest quality products.

Innophos subscribes to theprinciples of sustainabledevelopment. To establishtheir position as the marketleaders in calcium phosphates;they continue to add to theirproduct line and have maderepeated improvements in theirproducts and their plant'smanufacturing capability.

Innophos


Calcium Phosphates find wide applications in direct compression and wet granulation tableting. It hasmany positive characteristics as an excipient, including good compressibility, wide compatibility, stabilityand white colour. They are used as compressible filler, flow agents and as a source of calcium andphosphorous.


Di-Tab® Di-calcium phosphate dihydrate Direct compression granulation, ordered mixing,flow agent, blend densifier, tablet punchpolishing agent, time release agent and carrier ofactives. Low lead filler and source of calcium &phosphorous

A-Tab® Di-calcium phosphate anhydrous Same as Di-Tab with added benefit in stabilitydue to no water of hydration. Higher calcium &phosphorous content

Tri-Tab® Tri-calcium phosphate anhydrous Direct compression granulation, glidant due tohigh surface area and carrier of actives. Highcalcium content nutritional products

Tri-Tab® WG Tri-calcium phosphate anhydrous For wet granulation, higher density with similarbenefits as Tri-Tab

TCP DCTM Tri-calcium phosphate Excellent for direct compression

Powder grades USP/NF, EP, JP


Calipharm® D Di-calcium phosphate dihydrate Filler in wet granulation, vitamin premixes andnutritional drinks

Calipharm® A Di-calcium phosphate anhydrous Filler in wet granulation, chewable multivitaminsand nutritional drinks

Calipharm® T Tri-calcium phosphate anhydrous In antacid and other formulations for neutralizingproperties. Nutritional drinks and calcium /phosphorous fortifications

Granular grades USP/NF, EP, JP

42

CALCIUM PHOSPHATE


DOMO, a subsidiary of TheRoyal Friesland Foods, Hollandis a leading globalmanufacturer of high qualitypharmaceutical lactose. With30 years experience and acommitment to supply thehighest quality products;DOMO offers a broad range ofconventinal as well as directlycompressible lactose for avariety of pharmaceuticalapplications.

DOMO's distinctive productrange of anhydrous, spray-dried and monohydrate lactoseare manufactured in their FDAinspected state-of-the-artfacilities in The Netherlandswhich meet the standards setby ISO 9001 and HACCP.Their excipients are tailored tomeet strict requirements forapplications such as tablets,capsules and sachets.

Domo


44

LACTOCHEM®

Lactose Monohydrate USP/NF, EP, JP


Lactochem Powder Milled Lactose Widely used as fillers in wet granulationprocesses. Also used for capsule filling andpowder mixturesLactochem Coarse Powder

Lactochem Regular Powder

Lactochem Fine Powder

Lactochem Extra Fine Powder

Lactochem Super Fine Powder

Lactochem Microfine

Lactochem Crystals Sieved lactose Prevents segregation in capsule basedformulations, DC formulations and sachets

Lactochem Coarse Crystals

Lactochem Fine Crystals

Lactochem Extra Fine Crystals


Lactopress Spray Dried 250 Spray Dried, DC Lactose Ideal for DC tabletting with excellent flow,high compressibility and enables goodcontent uniformityLactopress Spray Dried

Lactopress Anhydrous 250 Anhydrous, DC Lactose Improves stability of moisture-sensitiveactives as well as their dissolution due to it'shigh intrinsic solubilityLactopress Anhydrous Fine

Powder

Lactopress Anhydrous

Lactochem is a white, crystalline, alpha monohydrate lactose powder. The water of crystallization is tightlybound and shows no chemical activity while bound. Mositure absorption is extremely low, even at highrelative humidity. Lactochem is available in milled and sieved forms.

LACTOPRESS®

Directly Compressible Lactose USP/NF, EP, JP

Lactopress is a white free-flowing DC lactose powder and is available in two forms; spray-dried andanhydrous lactose. Both forms have good flowability and excellent compactibility characteristics makingthese products ideal for direct compression tabletting.


More than 30 years ago,CP KELCO pioneered thecommercialization of xanthangum and developed KELZAN®

xanthan gum. Today, CP Kelcois the world leader in xanthanand other biopolymersproduced by leading-edgefermentation technology. Theirproducts, combined with anunsurpassed depth oftechnical expertise, bringunique functionality to a broadrange of products andapplications.

With manufacturing facilitieslocated in two continents,extensive processingtechnology, and research anddevelopment resources, CP Kelco have the ability tofind the right solution for yourspecific product or processingneeds.

CP Kelco


46

XANTURAL®

Xanthan Gum USP/NF, EP, JP

Xanthan Gum is an exocellular heteropolysaccharide produced by fermentation. It has a unique polymericstructure where chains tends to associate forming a complex network gel-like structure. When shear isapplied, these hydrogen bonds are disrupted and a flowable liquid is produced. The process reverseswhen shear is removed. Hence, Xanthan Gum solutions exhibit extremely high viscosity at rest and verylow viscosity when force is applied. Xantural grades give a clear, transparent gel.


Xantural 180 Standard grade Normal grade for suspensions

Xantural 75 Fine particle size grade Used for dry mix powder suspensions, hydrophilic /controlled release tablets

Xantural 11K Agglomerated grade Used when good physical dispersion methods are notavailable and agitation is minimal


RIO TINTO MINERALS(LUZENAC) Group is a marketfocused Talc producer. Asworld leaders in this field, theyare committed to setting thestandards for the talc industryin areas such as innovation,technical assistance, productquality, health safety and theenvironment.

Every year, Rio Tinto Minerals(Luzenac) Group producesand sells in excess of 1.4million tonnes of talc from over30 mines and processingplants in Europe, North andCentral America and AsiaPacific. With the widest talcproduct range andunsurpassed applicationsexpertise, they are the only talcproducer that can meet allend-use requirementsworldwide.

Rio Tinto Minerals


48

TALC LUZENAC® PHARMATalc USP/NF, EP, JP

Talc is a purified and hydrated magnesium silicate. It is a natural material of mineral origin and sterilizedfor use in the pharmaceutical industry as a lubricant and diluent in solid dosage forms, dusting powder intopical preparations and also used to clarify liquids. The speciality of Luzenac talc is it’s fine particle size,extra white colour, grittiness free and it is also bacteria controlled.


Talc Luzenac Pharma Standard grade Flow regulator (glidant), reducesfluctuations in tablet weight, enhancestablet homogeneity & quality and increasesproductivity

Talc Luzenac Pharma M Micronised grade Anti-tack agent for tablet coating,eliminates stickiness during drying,prevents agglomerations in the coater,reduces coating time and producesflawless coated products

Tal Luzenac Pharma UM Ultramicronised grade Lubricant for easier tablet pressing,reduces friction, prevents binding duringcompression & ejection and guaranteessmooth, crack-free results


FERRO - INDUSTRIASQUIMICAS isa leading producer ofperformance materials sold toa broad range of applications.Ferro materials enhance theperformance of products in avariety of end markets,including consumerelectronics,telecommunications,pharmaceuticals, building andrenovation, appliances,transportation, householdfurnishings, and industrialproducts.

Ferro pharmaceutical andcosmetic products includeSynpro Stearates used in avariety of applications.

Ferro Industrias Quimicas


50

SYNPRO® STEARATESStearates USP/NF, EP

Synpro Stearates are special grade vegetable origin stearates. They are made from the salt obtained froma vegetable fatty acid conforming to USP/NF, EP and BP standards with Kosher certification. Widely usedas lubricants and mold release agents; they are available in a very fine particle size white powder formwhich ensures consistent performance. Additionally, they are free from TSE/BSE, GMO, OVI, Gluten,Radiation, Additives and Glycol Ethers.

Grade Application

Synpro Magnesium Stearate VG Added as a lubricant to granules in tablet-making

Synpro Zinc Stearate VG Lubricant in tablet-making and protective application in thetreatment of skin inflammation

Synpro Calcium Stearate VG Added as a lubricant to granules in tablets and capsules

Synpro Sodium Stearate VG Emulsifying and stiffening agent in topicals. An ingredient ofGlycerin Suppositories


The KRONOS Group is one ofthe leading manufacturers ofTitanium Dioxide withproduction facilities located invarious European countries,Canada and the USA. AllKronos plants use modern,environment-friendlyprocesses.

Kronos have more than 80years of experience in thisindustry. Besides being aworld renowned supplier ofTitanium Dioxide pigments forindustrial applications, Kronosalso produce a high puritygrade for pharmaceuticals,cosmetics and foodstuffshaving USP, BP and EUapproval certification.

Kronos International


52

KRONOS® 1171Titanium Dioxide USP/NF, EP, JP

Titanium Dioxide has a very high refractive index and consequently unique light scattering propertieswhich are exploited in it's use as a white pigment and opacifier.


Kronos 1171 TiO2 E 171 Anatase grade, super white, fineparticle size and bacteriacontrolled

Used as a white pigment and opacifier infilm-coating mixes for tablets, gelatincapsules and dermatological preparations


HEALTH AND BEAUTYSOLUTIONS (AMCOL) is amanufacturer of specialityminerals, providing productsand technologies for a widerange of pharmaceutical,industrial and consumer-related markets worldwide.

Established in 1927, it operatesin more than 12 countries withover 1,200 employees.

Health & Beauty Solutions’smectite clays comply with thethree United StatesPharmacopeias-NationalFormulary (USP/NF) categoriesviz., Bentonite, PurifiedBentonite and MagnesiumAluminium Silicate.

Health & Beauty Solutions


54

MAGNABRITE®

Magnesium Aluminium Silicate USP/NF, BP

Magnabrite product line is a blend of highly refined, naturally occurring, complex colloidal white smectiteclays. They are unique thixotropic additives for emulsion stabilizing, suspending, binding, gelling, bodyingand disintegrating.


Magnabrite HV High viscosity grade Exhibits excellent emulsification and thickeningabilities in suspensions. Delivers high viscosity atlow solids

Magnabrite K Acid stable grade Used to reduce thickening and flocculation in acidicpH levels of pharmaceutical acid suspensions

Magnabrite S Standard grade Used when medium viscosity, high brightness andease of dispersion in pharmaceutical suspensionsare desired

Magnabrite F Micro fine particle size grade Used as an inert low-bulk disintegrant, excellent forlarge tablets where the actives are the major weightand bulk of the tablet

Magnabrite HS High stability grade Hydrates readily in warm or cold water producinghigh electrolyte stability


Minerals Technologies producemineral-based and syntheticmineral products for healthcareand other industries. They havetwo subsidiaries - SPECIALTYMINERALS INC. and MINTEQINTERNATIONAL.

Specialty Minerals are theworld's largest producer ofCalcium Carbonate.

Specialty Minerals


56

STURCAL® & CALOPAKE®

Precipitated Calcium Carbonate USP/NF, EP, JP

Precipitated Calcium Carbonate is manufactured via a series of controlled chemical reactions. Generally,quicklime (CaO) is mixed with water to form a slurry and carbon dioxide is added. This produces a veryfine precipitated CaCo3 which is then dried and packaged. Different grades are available depending onparticle size, shape, distribution, colour and purity.


Sturcal L Heavy grade Used mainly in antacid tablets and dentifrice because of it'sspecific flow and polishing properties. Therapeutically usedas a calcium supplement

Calopake Extra light grade Purified with ultra low lead used for food fortification, calciumsupplements and other pharmaceutical and nutraceuticalapplications


TEREOS, a part of the Beghin-Say group was created in 2003when two French marketleaders got together. Tereos istoday the world's secondlargest producer of sugar withplants in Europe, Africa andAmerica. With 9000employees and 26 plants;Tereos processes 10 milliontons of beet and 10 million tonsof sugar cane annually.

For the pharmaceuticalindustry, Tereos offers a widerange of dry crystal sugars,liquid sugars and sugarspecialities. Consistentlypursuing it’s efforts to bring thebest quality; Tereos hasdeveloped a perfect controlover production and marketingof sucrose-based excipients.

Tereos


58

Sucrose is an essential excipient for pharmaceutical products and a good way to give them a sweet taste.It is the reference sweetening flavour and also facilitates oral ingestion. Tereos produces a wide range ofproducts in different forms and different particle sizes that enables many pharmaceutical uses for dry orliquid galenics.

Spray Dried Sucrose USP/NF, EP, JP

SUCROSESugar USP/NF, EP, JP


Compressuc MS Directly compressiblesucrose with maltodextrins /inverted sugar

A new generation of anhydrous DC Sucrose; ithas remarkable free flowing, mixing andcompressive properties thus making it anefficient excipient for chewables, efferrvescentand orodispersible tabletsCompressuc PS Directly compressible pure

sucrose


Icing Sugar Milled Sucrose (100% pure) Very fine powder and easily compressible; itdissolves quickly in water than regular sugar.Used for granulation, coating and in sachetsIcing Sugar with Starch Milled Sucrose with corn

starch added as anti-cakingagent

Icing Sugar with Silica Milled sucrose with colloidalsilica added as fluidizingagent

Milled Sucrose USP/NF, EP, JP


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Alveosucre Obtained by wet granulationof pure icing sugar followedby subsequent drying

Used for sachets and dry syrups. Highlyabsorbent, allows for structured mixtures withhomogenetic distribution of actives whileavoiding separation of ingredients. Instantcold dissolution

Alveosucre with Dextrine Obtained by wet granulationof pure icing sugar withdehydrated glucose syrupadditives

For DC applications, allows very highdensities. Instant cold dissolution

Pearl Sugar 30 Obtained by successivescreenings of sugaragglomerates

For applications requiring a dry excipient as afixing medium. The irregular surface of theagglomerates and it's narrow particle sizedistribution allows highly homogenous andstructured mixes

Agglomerated Sucrose USP/NF, EP, JP


Sucrose Solution Limpid, clear, viscous sugarsyrup

For syrups and coatings

Liquid Sucrose


60

Grade Particle size Application

Caster Sugar 250 200 – 300 µm / 70 – 50 mesh Extremely pure crystalline powder with fine,low coefficient particle size facilitatingdissolution and ensuring a homogenousmixture. Used for granulation, dry syrup andcoating

Caster Sugar N°1 400 300 – 500 µm / 50 – 35 mesh A highly pure fine-grain crystalline powder.Facilitates preparation of syrups due to higherdissolution rate than crystal sugar. Used forgranulation, dry syrup and coating

Crystal Sugar N°1 600 500 – 700 µm / 32 – 25 mesh A highly pure crystalline powderrecommended for applications requiring highquality clear solutions or coatings. Used forsyrups, dry syrups and coatingCrystal Sugar N°1 700 500 – 800 µm / 35 – 22 mesh

Crystal Sugar N°1 800 700 – 1000 µm / 25 – 18 mesh Coarse grain and very high level of purity ofthis crystalline powder makes it easy to pour,transfer and stock in bulk. Used for syrups,dry syrups and coating

Crystal Sugar N°1 1350 1100 – 1600 µm / 17 – 12 mesh Large sized without fine particles preventsagglomeration. Appreciated for its technicalqualitites, especially for slow meltingoperations. Used for syrups, dry syrups andcoating

Crystal Sugar N°1 2000 1750 – 2250 µm / 11 – 9 mesh

Screened Sucrose USP/NF, EP, JP


The HANNS G. WERNERGMBH + Co. KG founded in1952 and located in Germanyis a manufacturer ofexceptionally high qualityneutral pellets (sugar spheres)and globuli sacchari (sugarglobules).

Their brand PHARM-A-SPHERESis known globally for superiorquality sugar spheresconfirming to USP/NF & EPmonograph.

Werner’s specialmanufacturing processenables ideal spherical shape,smooth-nonporous-solventresistant surface and highmechanical stability to theirsugar spheres.

Hanns G. Werner


62

Pharm-a-spheres are inert / neutral pellets composed of sucrose and maize starch. They offer an excellentquality, a narrow particle size range, high sphericity allowing a precise calculation of drug quantity to besprayed, perfect flow characteristics and high mechanical stability thus ensuring very low friability. Pharm-a-spheres are a modern drug excipient with multiple applications and are well-suited for solving problemslike insufficient flow characteristics, interaction of ingredients and retardation of drug action.

Werner’s range of pharm-a-spheres covers the whole spectrum of diameters from 100 µm to 2000 µm.

PHARM-A-SPHERES®

Sugar Spheres (Non-pareil seeds) USP/NF, EP

Mesh Size (ASTM) Diameter in mm (µm) Application

120 – 140 0,106 – 0,125 Used as drug-free cores for controlled or sustainedrelease technologies

100 – 120 0,125 – 0,150

80 – 100 0,150 – 0,180

70 – 80 0,180 – 0,212

60 – 70 0,212 – 0,250

50 – 60 0,250 – 0,300

45 – 50 0,300 – 0,355

45 – 60 0,250 – 0,355

40 – 60 0,250 – 0,425

40 – 50 0,300 – 0,425

40 – 45 0,355 – 0,425

35 – 55 0,355 – 0,500

35 – 50 0,300 – 0,500

35 – 45 0,400 – 0,450

35 – 40 0,425 – 0,500

30 – 35 0,500 – 0,600

25 – 30 0,600 – 0,710

20 – 25 0,710 – 0,850

18 – 20 0,850 – 1,000

16 – 20 0,850 – 1,180

16 – 18 1,000 – 1,180

14 – 16 1,180 – 1,400

12 – 16 1,400 – 1,700

12 – 14 1,400 – 1,700

10 – 12 1,700 – 2,000

* Special sizes and mixtures are also possible.


DEAD SEA PERICLASE, adivision of ICL IndustrialProducts is the world’s leadingproducer of Magnesiaproducts of exceptionally highpurity. They operate from twoplants (Israel & France) usingdifferent processes, bothengineered to produce thehighest quality andcomplimentary range ofMagnesia products.

The waters of the Dead Seaare the most concentratednaturally occuring solutions ofdissolved salts in the world.These are the brines whichserve as raw material for DSP’splant.

DSP's Magnesium Oxide,Magnesium Carbonate andMagnesium Hydroxide arecharacterised by extremely lowlevels of all metals; specificallylow levels of lead. They areavailable in a wide range ofpharmaceutical grades to beused in antacid preparations,mineral supplements and for avariety of other applications.

Dead Sea Periclase


64


Magnesium Hydroxide HD5 Lowest bulk density grade Spray dried, directly compressible powdersfor use in the manufacture of antacidpreparations and mineral supplements.Different bulk densities offer a choice ofcompounding possibilities for tablet andpowder dosage system

Magnesium Hydroxide HD7 Low bulk density grade

Magnesium Hydroxide HD9 Medium bulk density grade

Magnesium Hydroxide HD12 High bulk density grade

MAGNESIUM OXIDE USP/NF, EP, BP


Magnesium Oxide HA Heavy grade - Sieved For use in the manufacture of antacidpreparations, mineral supplements, as a foodadditive for colour retention, pH modifier andin the production of pharmaceutical grademagnesium derivatives

Magnesium Oxide HA4 Heavy grade - Micronised

Magnesium Oxide HA5 Heavy grade - Micronised

Magnesium Oxide DC Granular; Directlycompressible grade

PHRA 50 Active pharmaceuticalingredient

MAGNESIUM CARBONATE USP/NF, EP, BP


Magnesium Carbonate BMC Light grade For use in the manufacture of antacidpreparations and mineral supplements.

In food, used as an anti-caking, free flowingagent, colour retainer, dessicant or pH modifier

Magnesium CarbonateHeavy

Heavy grade

MAGNESIUM HYDROXIDE USP/NF, EP, BP


Established in 1931, SCORAlocated in Caffiers, France is aspecialist in calcium andmagnesium derivatives. Theirdeep insight in the chemistry ofcalcium and magnesium,specialised dedicatedequipments and uniqueproduction process enablesScora manufacture specialityproducts of the highest puritywith exceptional propertiesparticularly valued in thepharmaceutical andnutraceutical industry.

Scora’s products comply toUSP/NF, EP, JP and areproduced according to GMPrules.

Scora


66

Scoralite is a very pure, highly free flowing synthetic calcium carbonate manufactured by using a uniquesynthesis process. Production of Scralite is carried out according to GMP rules and is supplied under aC-O-S from the European pharmacopeia.

SCORALITE®

Calcium Carbonate USP/NF, EP, JP, BP

MAGNESIUM OXIDE USP/NF, EP, BP


Scoralite Heavy grade Used in the manufacture of antacidpreparations, osteoporosis treatment,tablets and production ofpharmaceutical calcium derivatives. Alsoused for mineral supplements, foodadditives and production of high puritycompounds

Scoralite LL Heavy grade with Low Lead


Light Magnesium Oxide Light grade, free flowing powder Used as a pH modifier, viscosityregulator and as a mineral supplement.Also used in the manufacture of antacids

* Scora can also provide tailor-made grades of Magnesium Oxide

MAGNESIUM CARBONATE USP/NF, EP, BP


Magnesium Carbonate BMC Basic Magnesium Carbonate Used in the manufacture of antacidpreparations & tablets and theproduction of magnesium derivatives.Also used as an anti-caking & freeflowing agent and as a mineralsupplement


CYTEC is the world’s leadingsupplier of Docusate Sodium(Dioctyl Ester of SodiumSulfosuccinate - DSS), aversatile and highly effectiveanionic surfactant. Cytecmanufactures pharmaceuticalgrade DSS products to thehighest quality standardsunder cGMP, ensuringexceptional quality andperformance for use as eitheractive ingredients or excipients /formulating aids. They complywith USP & EP and arecompatible with a broad rangeof active drugs. They meetworldwide recognisedstandards of quality, strength,purity and potency.

Cytec Industries


68

Docusate Sodium (DSS) is one of the most versatile and effective anionic surfactants (surface activeagents). It is an excellent solubilizing, wetting, dispersing, and emulsifying agent beneficial for use in oraldosage forms.

DOCUSATE SODIUM USP, EPDioctyl Ester of Sodium Sulfosuccinate

Grade Appearance Application

DSS 100 % Rolls of waxlikeplastic sheets

Aids the granulation process, improves tabletdisintegration and dissolution, facilitates tablet coating,emulsifies gels & liquid suspensions.

Also used as an active ingredient for laxatives and stoolsofteners, prenatal and geriatric vitamin preparations andear wax removal compounds.

DSS Granular 85 %with Sodium Benzoate

White crystallinepowder

DSS 50 % inPolyethylene glycol

White to yellow,clear viscous liquid


STEPAN founded in 1932 is aglobal manufacturer of anionicsurfactants, germicidalquaternary compounds andother speciality products thatinclude flavours, emulsifiersand solubilizers. Withheadquaters in Illinois, USA ithas twelve manufacturinglocations worldwide and over1500 employees.

Stepan’s SLS (Sodium LaurylSulfate) is very popular in thepharmaceutical industry, iscompliant with mostpharmacopeias and has allregulatory approvals.

Stepan Co.


70

Stepanol WA-100 is sodium lauryl sulfate produced from the sulfation of fatty alcohol via Stepan's SO3

process. The product of this process is then spray dried to produce a high active powder ofexceptional quality.

STEPANOL®

Sodium Lauryl Sulfate USP/NF, EP, JP, BP


Stepanol WA-100 Sodium Lauryl Sulfate Tablet and capsule lubricant, wetting agent, anionicsurfactant, emulsifying agent, skin penetrant and skincleanser in topical applications


GUMBASE CO. founded in1967 is a world leader in themanufacture of compressedpowder gum base, chewinggum base and bubble gumbase for the pharmaceutical,nutraceutical and confectionaryindustry. With headquarters inItaly it has sales in over 130countries and delivers a rangeof more than 200 different gumbase formulations supplied infive different shapesaccording to customer'srequests on productpecularities.

At GumBase Co. quality is amatter of constant dedicationand improvements. It hasachieved BRC (British RetailConsortium) certification whichis a global standard that goesbeyond other quality standardslike HACCP and ISO

GumBase Co.


72

The chewing gum base is an inert, insoluble preparation designed to deliver flavours, minerals, vitamins,sweetners, functional and pharmaceutical active principles. It is not designed or intended to be swallowedbut is removed and disposed adequately after consumption. In the pharma industry, it is now consideredas a new, alternative drug delivery system.

Unique formulations have been designed with gum base for smoking reduction, weight management,heart-burn relief, dry mouth relief, stress reduction, memory & concentration improvement, pain relief,breath freshening, dental health, etc.

GUM BASENon-nutritive masticatory substance

Grade Description Advantages

MedGumBase® Specific gum basedeveloped for medicatedchewing gums

Absorption through oral mucosa, good distribution ofactive principles, easy & pleasant administration,consumer controlled dosage and kinetics controlled activeprinciple release.

Product can be taken anywhere at any time as it does notrequire liquids for swallowing and is ready-for-use inemergencies.

CPG® Directly compressiblechewing gum basepowder enabling a coldand dry process whichprotects delicatefunctional ingredients /actives.

* Available in flavours as well as without flavours. Conventional chewing gum base and Bubble gum base can also be provided.


Founded in 1820 in France,STEARINERIE DUBOISdevelops, manufactures andsells a wide range of fatty acidesters specialities for thepharmaceutical, food andcosmetic industry. Theirproducts coming fromoleochemistry haveoutstanding properties and areused as lubricants, solubilizers,compressing agents,suppositories bases etc.

With it’s plant located inScoury, France; StearinerieDubois is committed toproducing high qualityproducts and has obtained theinternational ISO 9001 : 2000certification. Their specialitiescomply to globalpharmacopeias viz. USP/NF &EP, are exclusively ofvegetable and/or syntheticorigin and are widely used fortablets and granules, hard andsoft capsules, solutions,creams and lotions, coating,suppositories etc.

Stearinerie Dubois


74

Stearic acid is a mixture of stearic acid (C18H36O2) and palmitic acid (C16H32O2). The content of stearic acidis not less than 40%. The content of palmitic acid is not less than 40% and the sum of the two is not lessthan 90%. Hard, white or faintly yellowish, somewhat glossy and crystalline solid or white / yellowish whitepowder; it’s odor and taste are slight, suggesting tallow.

DUB MICROLUBTM

Stearic Acid USP/NF, EP

Sucrose esters are natural surfactant materials obtained by the esterification of one or more of the hydroxylgroups of the sucrose molecule with vegetable fatty acids. These compounds are non-ionic and haveexcellent emulsifying, wetting and dispersing properties. By modifying the esterfication degree of thesucrose, it is possible to obtain a range of different emulsifiers with HLB from 3 to 16. Sucrose esters aretasteless, odorless and non-toxic additives. They are non-irritative and mild to the skin.

DUB SETM

Sucrose Esters USP/NF, EP


DUB Microlub 70 Stearic Acid 70% - Micronised powder Used as tablet lubricant. Micronisedgrades imparts a smooth surface tothe film coated tablets. Also used asemulsifying and solubilizing agent intopical formulations.

DUB Microlub 50 Stearic Acid 50% - Micronised powder

DUB PO 70 Stearic Acid 70% - Fine powder

DUB PO 50 Stearic Acid 50% - Fine powder

DUB 70 P Stearic Acid 70% - Pellets

DUB 50 P Stearic Acid 50% - Pellets


DUB SE 3S Sucrose tristearate Used as tablet and / or capsulelubricant, solubilizing agent, foamingenhancer and as an emulsifier tostabilise oil-into water emulsions

DUB SE 5S Sucrose distearate

DUB SE 11S Sucrose stearate

DUB SE 15P Sucrose palmitate

DUB SE 16P Sucrose palmitate

* Also available is Stearic Acid 95% in flakes form


75

Medium chain triglycerides are a class of fatty acids. Their chemical composition is of a shorter length thanthe long-chain fatty acids present in most other fats and oils, which accounts for their name. They are alsodifferent from other fats in that they have a slightly lower calorie content and they are more rapidly absorbedand burned as energy, resembling carbohydrate more than fat. The unique metabolic and functionalproperties of MCT, a consequence of their chemical structure make them versatile ingredients in numerouspharmaceutical applications.

DUB MCTTM

Medium Chain Triglycerides USP/NF, EP


DUB MCT 5545 Oily liquid Used as plasticizer, tablet lubricant and assolutions & suspension base for parenterals. Alsoused for dietetic preparations (energy with lowcalorie)

DUB MCT 7030

DUB MCT 6535

DUB GMSGlyceryl Stearate EP


DUB GMS Liquid Mild emulsifier, used as a co-emulsifier. Also usedas a thickener for hard and soft capsules

DUB GMS SE Pellets

DUB DBSDibutyl Sebacate


DUB DBS Fatty liquid Used as plasticizer for tablets and granules

DUB DBHGGlyceryl Dibehenate EP


DUB DBHG Fine, micronised powder Used as lubricant for tablets. Also can be used aslipidic matrix for sustained release


76

DUB PP are hard fat suppository bases and are a mixture of triglycerides, diglycerides andmonodiglycerides which may be obtained either by esterification of natural fatty acids with glycerol or byinteresterification of natural fats. Each type of hard fat is characterised by it's melting point, itssaponification value and its hydroxyl value. These suppository bases, DUB PP are made from vegetablefatty acids. They are presented in pellets form allowing an easier use and are non-toxic & neutral in activeprinciples. Moreover, they do not contain any oxidizing nor stabilizing agent.

DUB PPHemi-synthetic Glycerides USP/NF, EP

Grade Saponification Value Melting Point (C°) Hydroxyl Value Application

DUB PP C 3 230 - 240 33 - 35 20 - 30 MultipurposeSuppository Bases

DUB PP CDL 1 225 - 245 33,5 - 35,5 ≤ 15

DUB PP D 1 234 - 247 34 - 36 ≤ 10

DUB PP E 1 235 - 245 35 - 36,5 ≤ 10

DUB PP E 3 235 - 245 35 - 36,5 20 - 30

DUB PP F 1 235 - 245 36 - 37,5 ≤ 10

DUB PP H 1 230 - 240 38 - 40 ≤ 10

DUB PP M 1 223 - 233 42 - 44 ≤ 10

DUB PP KC 3 225 - 240 33,5 - 35,5 20 - 30 SpecificSuppository Bases

DUB PP KCD 1 235 - 245 33,5 - 35,5 ≤ 15

DUB PP KD 3 225 - 240 34 - 36 20 - 30

DUB PP KE 3 215 - 236 35,5 - 37,5 20 - 30

DUB PP KF 1 235 - 250 36 - 38 ≤ 15


Lonza SpA ( Polynt SpA), adivision of the Swiss-basedAlusuisse-Lonza groupmanufactures a broad range ofadditives, polymers andspeciality chemicals for thepharmaceutical and foodindustry. With over 5300employees and sales worthCHF 1.7 billion; it has severalplants in Europe, UK and USA.

Lonza manufactures MalicAcid by hydration of MaleicAnhydride at high temperatureand pressure in their verymodern plant in Bargamo, Italywith world class accredition.

Lonza


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Malic Acid is widely found in nature and is the predominant organic acid in many fruits and berries. Itplays an essential role in carbohydrate metabolism and therefore used in the production of basic energyfor cellular processes. In the pharmaceutical industy, malic acid is used by blending it with essences andflavours. It's acid taste builds up slowly at the begining but persists for a very long period. The final effectis to give an enhanced sensation of a stronger taste.

MALIC ACIDD-L Malic Acid USP/NF, EP


Malic acid granular Has the ability to enhance theeffect of the aromas used tomask the undesirable tastesand smells of medicinals

Used in throat lozenges, cough syrups,effervescent powders and tablets

Malic acid fine granular

Malic acid special fine granular

Malic acid powder


MUSASHINO CHEMICALLABORATORY LTD., areleading manufacturers ofLactic Acid, D-L-alanine andPyruvic Acid. Established in1949, they have fulfilled theirmission with over a half centuryof accumulated research,development and productiontechnology, usingenvironmentally friendlyfacilities to produce high-quality products that seek finebalance between the needs ofthe human race and theenvironment.

Musashino's products are ofexcellent quality and are usedfor manufacturingpharmaceuticals, foods &brewing, cosmetics and otherindustrial products. Theirproducts are used in a varietyof applications all over theworld.

Musashino ChemicalLaboratory


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Lactic acid is prepared synthetically by reaction between acetaldehyde and carbon monoxide at hightemperature and pressure or by the hydrolysis of hexoses with sodium hydroxide.


D-L Lactic Acid Synthetic gradePurity 88.0% - 92.0%

In injections in the form of lactates, as anacidifying agent / acidulant and in topicalformulations as a softener

LACTIC ACID USP/NF, EP, JP


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Ac-Di-Sol Croscarmellose Sodium (Crosslinked Sodium CMC) FMC BIOPOLYMER 1111Alveosucre Agglomerated Sucrose TEREOS 5599Aqoat Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS) SHIN-ETSU 2288Aquacoat Aqueous Dispersion for modified release FMC BIOPOLYMER 1122A-Tab Dicalcium Phosphate Anhydrous, Granular (DCPDA) INNOPHOS 4422Avicel CE Microcrystalline Cellulose and Guar Gum FMC BIOPOLYMER 1111Avicel PH Microcrystalline Cellulose (MCC) FMC BIOPOLYMER 1100Avicel RC/CL Microcrystalline Cellulose and Sodium CMC (Hydrocolloid) FMC BIOPOLYMER 1111Blanose Sodium Carboxymethylcellulose (Na CMC) AQUALON - HERCULES 3322Calipharm Calcium Phosphate INNOPHOS 4422Calopake Precipitated Calcium Carbonate (Extra Light) SPECIALTY MINERALS 5566Caster Sugar / Crystal Sugar Screened Sucrose TEREOS 6600Celphere Microcrystalline Cellulose Spheres ASAHI-KASEI 4400Ceolus KG Microcrystalline Cellulose (Ultracompactible) ASAHI-KASEI 4400Compressuc Directly Compressible Sucrose TEREOS 5588Cremophor Non-ionic surfactant BASF 3388Crysmeb Low MS Methyl Betacyclodextrin ROQUETTE 2233Dextrose Anhydrous PF Injectable Glucose Anhydrous ROQUETTE 2233Dextrose GC Directly Compressible Glucose Monohydrate ROQUETTE 2233Di-Tab Dicalcium Phosphate Dihydrate, Granular (DCPD) INNOPHOS 4422Docusate Sodium (DSS) Dioctyl Ester of Sodium Sulfosuccinate CYTEC 6688DUB DBHG Glyceryl Dibehenate STEARINERIE DUBOIS 7755DUB DBS Dibutyl Sebacate STEARINERIE DUBOIS 7755DUB GMS Glyceryl Stearate STEARINERIE DUBOIS 7755DUB MCT Medium Chain Triglycerides STEARINERIE DUBOIS 7755DUB Microlub Stearic Acid STEARINERIE DUBOIS 7744DUB PP Hemi-synthetic Glycerides STEARINERIE DUBOIS 7766DUB SE Sucrose Esters STEARINERIE DUBOIS 7744Ethyl Cellulose Ethyl Cellulose AQUALON - HERCULES 3300Flolys Dextrose Syrup ROQUETTE 2233G-D-L Glucono Delta Lactone ROQUETTE 1199Glucidex Maltodextrin ROQUETTE 2244Glycolys Sodium Starch Glycolate ROQUETTE 2222Hi-Sweet High Fructose Corn Syrup (HFCS) ROQUETTE 2211HPMCP Hydroxypropylmethylcellulose Phthalate SHIN-ETSU 2266Icing Sugar Milled Sucrose TEREOS 5588Kleptose Betacyclodextrin ROQUETTE 2233Kleptose HPB Hydroxy Propyl Betacyclodextrin ROQUETTE 2233Klucel Hydroxy Propyl Cellulose AQUALON - HERCULES 3311Kollicoat IR PVA and PEG graft co-polymer for instant release BASF 3355Kollicoat MAE / EMM Methacrylic Acid Copolymer / Ethyl Acrylate BASF 3366Kollicoat SR 30 D Aqueous dispersion of PVA and PVP BASF 3366Kollidon Povidone (PVPK, 12PF, 17PF, 25, 30, 90F) BASF 3344Kollidon CL Crosspovidone (Crosslinked PVP) BASF 3355Kollidon SR Matrix Sustained Release Excipient BASF 3355Kollidon VA 64 Copolyvidone Vinylacetate Copolymer BASF 3344Kronos 1171 Titanium Dioxide Anatase & Superwhite Grade KRONOS 5522Lactic Acid D-L Lactic Acid MUSASHINO 8800Lactochem Lactose Monohydrate DOMO 4444Lactopress Anhydrous 250 DC Lactose DOMO 4444Lactopress Spray Dried 250 DC Lactose DOMO 4444L-HPC Low-Substituted Hydroxypropyl Cellulose SHIN-ETSU 2288Ludipress Advanced Excipient for direct compression BASF 3377LustreClear LC 103 MCC & Carrageenan based Aqueous Film Coating System FMC BIOPOLYMER 1122

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PDF-Selection Guide to Excipients - 2.qxd 17-Nov-07 3:49 PM Page 88

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Lutrol E Polyethylene Glycol (PEG) / Macrogol BASF 3377Lutrol F Poloxamer BASF 3377Lycadex PF Injectable Dextrose Monohydrate ROQUETTE 2233Lycasin Maltitol Solution ROQUETTE 2200Lycatab Modified Starch ROQUETTE 2211Lycatab Mineral CC Compound of Calcium Carbonate and Maize Starch ROQUETTE 2211Lycoat Peas Starch based Aqueous Film Coating System ROQUETTE 2200Magnabrite Magnesium Aluminium Silicate HBS (AMCOL) 5544Magnesium Carbonate High Purity Magnesium Carbonate DEAD SEA / SCORA 6644Magnesium Hydroxide Spray Dried, DC Magnesium Hydroxide DEAD SEA 6644Magnesium Oxide High Purity Magnesium Oxide DEAD SEA / SCORA 6644Malic Acid D-L Malic Acid LONZA 7788Maltisorb Maltitol ROQUETTE 2200Marine Colloids Carrageenan FMC BIOPOLYMER 1144MedGumBase / CPG Medicated Chewing Gum Base / DC Chewing Gum Base GUMBASE CO. 7722Metolose SH Hydroxypropyl Methylcellulose (HPMC - High viscosity) SHIN-ETSU 2277Metolose SM Methyl Cellulose (MC) SHIN-ETSU 2277Metolose SR Hydroxypropyl Methylcellulose (HPMC - Sustained Release grades) SHIN-ETSU 2277Natrosol 250 Pharm Hydroxy Ethyl Cellulose AQUALON - HERCULES 3300Neosorb Sorbitol ROQUETTE 1199Nutriose Soluble Fibre ROQUETTE 2222PCS PC-10 Partly Pregelatinised Starch ASAHI-KASEI 4400Pearl Sugar Sucrose grains TEREOS 5599Pearlitol Mannitol / DC Manitol ROQUETTE 1188Pharmacoat Hydroxypropyl Methylcellulose (HPMC - Low viscosity) SHIN-ETSU 2266Pharm-a-spheres Sugar Spheres (Non-Pareil Seeds) WERNER 6622Polysorb 85/70/00 Aqueous Solution of D-Sorbitol & Sorbitan ROQUETTE 1199Pronova UP / SL Ultrapure / Sterile Sodium Alginate NOVAMATRIX 1155Protacid Alginic Acid FMC BIOPOLYMER 1133Protanal Alginate FMC BIOPOLYMER 1133Protasan UP Ultrapure Chitosan Salt NOVAMATRIX 1166PVP Iodine Povidone-Iodine BASF 3366ReadiLYCOAT Ready-to-use, Aqueous film coating system ROQUETTE 2200Roclys Dextrose Syrup ROQUETTE 2233Roferose Dextrose Monohydrate ROQUETTE 2233Scoralite Calcium Carbonate of high purity SCORA 6666Sicovit Iron Oxide BASF 3388Sodium Hyaluronate Pharma Grade Sodium Hyaluronate NOVAMATRIX 1166Solulys AST Corn-Steep powder ROQUETTE 1199Soluphor 2-Pyrrolidone BASF 3366Soluten 50 Cellulose free, high vegetable protein ROQUETTE 1199Solutol HS 15 Macrogol-15-Hydroxystearate BASF 3388Starch Maize (Corn) / Potato / Wheat ROQUETTE 2211Starlac Directly compressible Starch & Lactose compound ROQUETTE 2222Stepanol Sodium Lauryl Sulfate STEPAN 7700Sturcal L Precipitated Calcium Carbonate (Heavy) SPECIALTY MINERALS 5566Sucrose Solution Liquid Sucrose TEREOS 5599Synpro Stearates Synpro Stearates - Mg Stearate / Ca Stearate / Zn Sterate / Na Stearate FERRO 5500Tackidex Dextrin ROQUETTE 2244Talc Luzenac Pharma Talc RIO TINTO (LUZENAC) 4488Trehalose Non-reducing Di-Saccharide ASAHI-KASEI 4400Tri-Tab Tricalcium Phosphate Anhydrous, Granular (TCP) INNOPHOS 4422Xantural Xanthan Gum CP KELCO 4466Xylisorb Xylitol ROQUETTE 2200

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Corporate Office:B-305, Neelam CentreHind Cycle RoadWorli, Mumbai 400 030 India

Phone: +91 22 24937725Fax: +91 22 24937726Email: [email protected]

Warehouse:L-9, Shree Rajlaxmi Commercial ComplexKalher, Bhiwandi 421 302

Phone: +91 2522 277366Fax: + 91 2522 277366Email: [email protected]

Signet Chemical Corporation Pvt. Ltd.

www.signetchem.com


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