Experience of a NYC hospital with non-occupational post-exposure prophylaxis

(nPEP)Antonio Urbina1, Georgina Osorio1, Daniel Egan2, Paul

Galatowitsch3, Benjamen Riggan1; Zachariah Hennessey1; Victoria Sharp

Center for Comprehensive Care, St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA1; St. Luke’s-Roosevelt Hospital Center, Columbia University

College of Physicians and Surgeons, New York, NY, USA2;

Health Clear Strategies, New York, NY, USA3

Oral Abstract TUPDC0305

XIX International AIDS Conference

Washington, DC, USA

July 24, 2012

• SLR has provided nPEP in its 2 EDs and 3 outpatient HIV clinics (CCC)

• Retrospective chart review of adult patients who received nPEP from 12/2009 to 2/2012

• Demographics of patients who undertook nPEP and completed follow-up were compared

Patient presents to SLRH ED or CCC within 72 hours of

exposure to potentially HIV-infected fluid.

Baseline HIV rapid antibody testing performed with

surveillance labs. In ED, patient provided 4-day supply of nPEP with follow-up appointment to

CCC outpatient HIV clinic

Patient presents for follow-up. Provided prescription (insured)

or supply of nPEP (grant funded) to complete 28 days of treatment 2-, 4-, and 12-week

follow-up.

Background/Methods

Results Table 1. Baseline characteristics of patients

• 116/138 (84%) of patients referred to CCC completed 4-week f/u

• No significant differences seen for patients who completed nPEP

• One patient sero-converted after initiating nPEP 32 hours post exposure

Characteristic All Patients (N=216)

Patients linked to care & completed 28-day nPEP (N=116)

Mean Age – yr (range) 29.5 (18-62) 30 (18-62) Male - no. (%) 180 (83%) 92 (84%)Race/ethnicity - no. (%)

Non-Hispanic white 99 (46%) 49 (42%)Risk of HIV exposure – no. (%) men who have sex with men 139 (64%) 74 (68%)Hours from HIV exposure to presentation – hours (range)

25 (1-74) 26 (1-74)

Conclusions

• nPEP is a chemo-prophylaxis intervention that can prevent HIV acquisition and transmission and provides additional opportunities for synergistic biological and behavioral interventions.

• A multi-disciplinary approach is necessary to coordinate care, follow-up, and supportive counseling leading to successful linkage to care and completion of 28-day nPEP.

Funding: This work was supported by grants from the New York City Department of Health and Mental Hygiene and the New York State Department of Health AIDS Institute.