experiment number: 20209 - 04 p09: non-neoplastic ......experiment number: 20209 - 04 p09:...
TRANSCRIPT
-
F1_Rev.1_M3NTP Study Number: C20209
Lock Date: 08/31/2011
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 3.0.2.2_002
PWG Approval Date: NONE
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Acute 2MineralizationNecrosis 2
Gallbladder + + + + + + + A M + + + + + + M + M + + + + + M +
Intestine Large, Cecum + + + + + + + A + + + + + + + + + + + + + + + + +Lymphoid Tissue, Necrosis 3
Intestine Large, Colon + + + + + + + A + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + A + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + A + + + A + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + A + + + A + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + A + + + + + + + + + + + + + + + M +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Basophilic Focus XClear Cell Focus X X X XDepletion Glycogen 2Eosinophilic Focus X X XEosinophilic Focus, MultipleFatty Change 2 2 2 2 2 2 3 1Hematopoietic Cell Proliferation 1 1 1 3 1Hemorrhage 2
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 2
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Inflammation, Chronic 2 1 1 1 1 1 1 1Mineralization 1Mixed Cell FocusNecrosis, Focal 2Tension LipidosisBile Duct, CystKupffer Cell, Pigmentation 1
Mesentery + + + + + + +Hemorrhage 2Inflammation, ChronicArtery, Thrombosis 2Fat, Necrosis 2 2 2 2
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 2 1 1 3Cyst 2Hypertrophy, FocalInflammation, Chronic 1 1 2 1 1 1 1Inflammation, Chronic Active 2 2
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 2 2Cyst 2Infiltration Cellular, Mononuclear Cell 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Inflammation, Granulomatous 2
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +ErosionFibrosis
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 3
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Inflammation 1 1 1 2 2Mineralization 1Necrosis 2Ulcer 2 1 2Epithelium, Hyperplasia 3 3 2 3 2 2 1 1 3 2
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +InflammationInflammation, AcuteMineralizationUlcer
Tooth +Inflammation, Acute 2Inflammation, Chronic ActiveNecrosis
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 1 1 1 1Mineralization 2Artery, Inflammation, Chronic Active
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Accessory Adrenal Cortical Nodule 2Degeneration, Fatty 1
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 4
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Hypertrophy, Focal 2 1 1 2 1 1Hypertrophy, Diffuse 1Vacuolization CytoplasmicCapsule, Hyperplasia 2 2 1 2 2 2 2 1 1 1 2 1 1 2 1 1 2 1 1
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 1 1 1 1 2 1 4 1 1 1 1 1
Parathyroid Gland + + + + + + + + + + M + + + + M + + + + + + + + +Cyst 2
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Pars Distalis, Angiectasis 3Pars Distalis, Cyst 2
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Mineralization 1Follicle, Degeneration 1 2 1 1 1 2 1 1 1 2Follicle, Hypertrophy 1 1 1 1 1 1 1 1 1
GENERAL BODY SYSTEM
Tissue NOS +
GENITAL SYSTEM
Coagulating GlandCyst
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 5
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +Granuloma SpermInflammation, GranulomatousInflammation, Chronic 1 1 1 1 1 1 1 1 1Inflammation, Chronic ActiveNecrosisArtery, Inflammation 2
PenisConcretionInflammation, Acute
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 4 2 2 2 2Inflammation, Acute 2 2Inflammation, Chronic 2 2 1 2 1 2 1 2Inflammation, Chronic Active
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Acute 4 3 2Inflammation, Chronic 2 1 1 1 1 1 1 1 1 1 1 1Epithelium, Hyperplasia 2 1 1
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Acute 2Inflammation, Chronic 1
Testes + + + + + + + + + + + + + + + + + + + + + + + + +Giant Cell 1 1Germinal Epithelium, Atrophy 2 1 1 1 2 1
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 6
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Myeloid Cell, Hyperplasia 2
Lymph NodeHyperplasia, LymphoidPigmentation
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +AtrophyHemorrhage 2Hyperplasia, Plasma Cell 2Infiltration Cellular, Polymorphonuclear 2Necrosis, Lymphoid 2Pigmentation 2 1 2 2 1 1 1 1 1 1 1 1 1 1 3 2 1 1 2 2 1
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +CongestionEctasia 3Hematopoietic Cell Proliferation 2Hemorrhage 2 4Hyperplasia, LymphoidInfiltration Cellular, Polymorphonuclear 2Pigmentation 1
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 3Hematopoietic Cell Proliferation 1 2 2 2 2 2 2 3Pigmentation 2 2 2 1 1
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 7
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Lymphoid Follicle, AtrophyLymphoid Follicle, Hyperplasia 2 1 1 3
Thymus + + + + + + + + + + M + + + + + + M + + + I + + IAtrophy 1 1 3 1 3 3 4 1 1 1 3 4 2 4Cyst 2 2 2 2 2 2Hyperplasia, Lymphoid 1
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M + M M M M M M M M M
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Hyperkeratosis 4Inflammation, Acute 2Inflammation, Chronic 1 3Inflammation, Chronic ActiveUlcerEpidermis, HyperplasiaLip, Inflammation, Acute 1Subcutaneous Tissue, Inflammation, ChronicSubcutaneous Tissue, Necrosis 2
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + I +Fibro-Osseous Lesion 1Tail, Developmental Malformation XVertebra, Callus 1 4
Skeletal Muscle + +
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 8
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Fibrosis 3 4Hemorrhage 4 3Inflammation, Chronic 2 3Regeneration 2
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +Hemorrhage 1 1Meninges, Inflammation, Chronic
Peripheral Nerve + +Degeneration 3 3Hemorrhage 2
Spinal Cord +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +CongestionHemorrhage 2 2 2 2Infiltration Cellular, Histiocyte 2 2 2 3Inflammation, Acute 1 1Inflammation, Chronic 2MineralizationThrombosis 2Alveolar Epithelium, Hyperplasia
Nose + + + + + + + + + + + + + + + + + + + + + + + + +Foreign Body
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 9
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
FungusInflammation, Acute 1 3 1MineralizationGlands, Fibrosis
Trachea + + + + + + + + + + M + + + + M + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 4Anterior Chamber, Edema 2Anterior Chamber, Infiltration Cellular,
Polymorphonuclear2
Anterior Chamber, Necrosis 2Cornea, FibrosisCornea, Inflammation 2Cornea, Inflammation, AcuteCornea, Inflammation, Chronic ActiveCornea, Necrosis 2Cornea, Epithelium, HyperplasiaNerve, Degeneration 2Nerve, Inflammation, Acute 1
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +AtrophyFibrosisHemorrhage 2HyperplasiaHyperplasia, FocalInflammation, Acute 2
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 10
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Inflammation, Chronic 1Necrosis 4
Zymbal's Gland +
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Congestion 3InfarctInfarct, Multiple 3Infiltration Cellular, Mononuclear Cell 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1Inflammation, Acute 2Metaplasia, OsseousMineralization 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1Nephropathy 2 2 2 1 1 1 1 1 1 1 4 1 1 1 2 1 2 4 1 1Artery, Perirenal Tissue, Inflammation 2Interstitium, InflammationInterstitium, Inflammation, Chronic 1Papilla, Inflammation, Acute 1Papilla, Necrosis 1 2Pelvis, Inflammation, AcutePelvis, Inflammation, Chronic 2Renal Tubule, CystRenal Tubule, Cyst, MultipleRenal Tubule, Degeneration 2Renal Tubule, Dilatation 1 1 2 1 1 1 1 1Renal Tubule, PigmentationTransitional Epithelium, Hyperplasia 1
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 11
-
DAY ON TEST
B6C3F1 MICE MALE
0684
0729
0729
0731
0729
0729
0730
0639
0298
0730
0569
0600
0592
0680
0730
0494
0598
0606
0730
0584
0626
0730
0730
0003
0731
0 MG/KGANIMAL ID
00001
00002
00003
00004
00005
00006
00007
00008
00009
00010
00011
00012
00013
00014
00015
00016
00017
00018
00019
00020
00021
00022
00023
00024
00025
males(cont...)
Hemorrhage 2Inflammation, Acute 2Necrosis
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 12
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Acute 1 2.0Mineralization 1 1 1.0Necrosis 1 2.0
Gallbladder + + + + + + + A + + + + + + A + + + + + + + + + + 43
Intestine Large, Cecum + + + + + + + A + + A + + + A + + + + + + + + + + 46Lymphoid Tissue, Necrosis 1 3.0
Intestine Large, Colon + + + + + + + + + + + + + + A + + + + + + + + + + 48
Intestine Large, Rectum + + + + + + + + + + + + + + A + + + + + + + + + + 48
Intestine Small, Duodenum + + + + + + + A + + + + + + A + + + + + + + + + + 46
Intestine Small, Ileum + + + + + + + A + + A + + + A + + + + + + + + + + 45
Intestine Small, Jejunum + + + + + + + I + + + + + + A + + + + + + + + + + 46
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Basophilic Focus X X X X X 6Clear Cell Focus X X X X X X 10Depletion Glycogen 1 2.0Eosinophilic Focus X X X X X X X X X X X 14Eosinophilic Focus, Multiple X 1Fatty Change 2 2 2 2 2 2 2 4 2 17 2.1Hematopoietic Cell Proliferation 1 1 1 1 1 10 1.2Hemorrhage 2 2 3 2.0
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 13
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Inflammation, Chronic 1 1 2 1 2 13 1.2Mineralization 1 1.0Mixed Cell Focus X X 2Necrosis, Focal 4 2 3.0Tension Lipidosis 1 1 1.0Bile Duct, Cyst X 1Kupffer Cell, Pigmentation 1 1 1 1 5 1.0
Mesentery + + + + + 12Hemorrhage 1 2.0Inflammation, Chronic 2 1 2.0Artery, Thrombosis 1 2.0Fat, Necrosis 2 2 2 2 8 2.0
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 1 1 2 1 2 1 10 1.5Cyst 1 2.0Hypertrophy, Focal 2 1 2.0Inflammation, Chronic 1 1 1 1 1 12 1.1Inflammation, Chronic Active 2 2.0
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 2 2.0Cyst 1 2.0Infiltration Cellular, Mononuclear Cell 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 31 1.0Inflammation, Granulomatous 1 2.0
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Erosion 3 2 2 3 4 2.5Fibrosis 2 1 2 1.5
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 14
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Inflammation 1 2 1 1 3 1 2 1 3 2 2 2 2 18 1.7Mineralization 1 1.0Necrosis 1 2.0Ulcer 2 4 2 4 2 2 9 2.3Epithelium, Hyperplasia 2 2 2 1 2 3 2 1 2 2 2 2 1 4 2 3 26 2.1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation 1 1 1.0Inflammation, Acute 1 1 1.0Mineralization 1 3 3 1 4 2.0Ulcer 2 1 2.0
Tooth + 2Inflammation, Acute 1 2.0Inflammation, Chronic Active 3 1 3.0Necrosis 2 1 2.0
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Cardiomyopathy 1 1 1 1 8 1.0Mineralization 1 2.0Artery, Inflammation, Chronic Active 2 1 2.0
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Accessory Adrenal Cortical Nodule 1 2 1.5Degeneration, Fatty 1 1.0
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 15
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Hypertrophy, Focal 2 2 1 1 10 1.4Hypertrophy, Diffuse 1 1.0Vacuolization Cytoplasmic 1 1 1.0Capsule, Hyperplasia 2 2 1 1 2 2 2 2 1 1 2 2 2 2 1 1 2 3 2 2 4 2 1 42 1.7
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 1 1 2 1 2 1 1 2 1 1 2 2 1 1 1 1 1 1 32 1.3
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48Cyst 2 2 3 2.0
Pituitary Gland + + + + + + + + + + I + I + + + + + + + + + I + + 47Pars Distalis, Angiectasis 1 3.0Pars Distalis, Cyst 2 2 2.0
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Mineralization 1 1.0Follicle, Degeneration 4 3 1 1 2 1 2 1 2 2 1 21 1.6Follicle, Hypertrophy 1 1 1 1 2 1 1 1 1 2 2 1 1 2 1 1 25 1.2
GENERAL BODY SYSTEM
Tissue NOS + 2
GENITAL SYSTEM
Coagulating Gland + 1Cyst 4 1 4.0
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 16
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50Granuloma Sperm 3 1 3.0Inflammation, Granulomatous 2 1 2.0Inflammation, Chronic 1 1 1 1 1 2 1 1 1 2 1 1 21 1.1Inflammation, Chronic Active 3 1 3.0Necrosis 2 1 2.0Artery, Inflammation 1 2.0
Penis + 1Concretion 4 1 4.0Inflammation, Acute 2 1 2.0
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 2 2 2 2 9 2.2Inflammation, Acute 2 2.0Inflammation, Chronic 2 2 1 1 2 2 1 2 2 2 2 2 2 1 1 1 24 1.6Inflammation, Chronic Active 2 1 2.0
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Acute 3 4 3.0Inflammation, Chronic 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 27 1.1Epithelium, Hyperplasia 3 1.3
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Acute 4 2 3.0Inflammation, Chronic 1 1 3 1.0
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50Giant Cell 2 1.0Germinal Epithelium, Atrophy 1 2 2 2 1 11 1.5
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 17
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Myeloid Cell, Hyperplasia 1 2 1.5
Lymph Node + + + + + 5Hyperplasia, Lymphoid 2 1 2.0Pigmentation 2 3 2 2.5
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 2 1 2.0Hemorrhage 1 2 1.5Hyperplasia, Plasma Cell 1 2.0Infiltration Cellular, Polymorphonuclear 1 2.0Necrosis, Lymphoid 1 2.0Pigmentation 1 1 2 1 2 1 2 1 2 1 2 1 2 1 2 3 1 2 1 2 1 1 2 2 45 1.5
Lymph Node, Mesenteric + + + + + + + + + M + + + + + + + + + + + + + + + 49Congestion 4 1 4.0Ectasia 1 3.0Hematopoietic Cell Proliferation 1 2.0Hemorrhage 2 3 2.7Hyperplasia, Lymphoid 3 1 3.0Infiltration Cellular, Polymorphonuclear 1 2.0Pigmentation 1 1.0
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 1 3.0Hematopoietic Cell Proliferation 2 3 2 1 3 3 14 2.1Pigmentation 1 1 2 2 1 2 3 3 13 1.8
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 18
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Lymphoid Follicle, Atrophy 2 1 2.0Lymphoid Follicle, Hyperplasia 1 1 4 2 2 2 1 11 1.8
Thymus + + + + + M + M + + + + M + A I I + + + + + + + + 40Atrophy 1 1 2 1 4 4 2 2 2 1 4 1 26 2.2Cyst 2 2 2 2 2 2 2 2 14 2.0Hyperplasia, Lymphoid 1 1.0
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M + M M M M M M M M M M M M M M M M 2
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperkeratosis 1 4.0Inflammation, Acute 1 2 1.5Inflammation, Chronic 2 2.0Inflammation, Chronic Active 1 1 1.0Ulcer 4 4 2 4.0Epidermis, Hyperplasia 2 1 2.0Lip, Inflammation, Acute 1 2 1.0Subcutaneous Tissue, Inflammation, Chronic 1 1 1.0Subcutaneous Tissue, Necrosis 1 2.0
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 49Fibro-Osseous Lesion 1 2 1.0Tail, Developmental Malformation 1Vertebra, Callus 2 2.5
Skeletal Muscle 2
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 19
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Fibrosis 2 3.5Hemorrhage 2 3.5Inflammation, Chronic 2 2.5Regeneration 1 2.0
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemorrhage 1 1 1 1 6 1.0Meninges, Inflammation, Chronic 1 1 1.0
Peripheral Nerve 2Degeneration 2 3.0Hemorrhage 1 2.0
Spinal Cord 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Congestion X 1Hemorrhage 2 2 2 2 1 2 10 1.9Infiltration Cellular, Histiocyte 2 4 4 3 8 2.8Inflammation, Acute 2 1.0Inflammation, Chronic 1 2.0Mineralization 1 1 1.0Thrombosis 1 3 3 2.0Alveolar Epithelium, Hyperplasia 1 4 2 2.5
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50Foreign Body X 1 2 1 4 1.3
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 20
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Fungus X 1Inflammation, Acute 1 1 2 1 3 1 9 1.6Mineralization 1 1 2 1.0Glands, Fibrosis 2 1 2.0
Trachea + + + + + + + + + + + + + + + + + + + + + + + M + 47
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + A + + + + + + + + + + 49Atrophy 1 4.0Anterior Chamber, Edema 1 2.0Anterior Chamber, Infiltration Cellular,
Polymorphonuclear 1 2.0
Anterior Chamber, Necrosis 1 2.0Cornea, Fibrosis 2 1 2.0Cornea, Inflammation 1 2.0Cornea, Inflammation, Acute 2 1 2.0Cornea, Inflammation, Chronic Active 1 1 1.0Cornea, Necrosis 1 2.0Cornea, Epithelium, Hyperplasia 1 1 1.0Nerve, Degeneration 1 2.0Nerve, Inflammation, Acute 1 1.0
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 4 1 4.0Fibrosis 4 1 4.0Hemorrhage 1 2.0Hyperplasia 2 1 2.0Hyperplasia, Focal 1 1 1.0Inflammation, Acute 1 2.0
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 21
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Inflammation, Chronic 1 1.0Necrosis 1 4.0
Zymbal's Gland 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Congestion 1 3.0Infarct 1 3 2 2.0Infarct, Multiple 1 3.0Infiltration Cellular, Mononuclear Cell 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 2 35 1.1Inflammation, Acute 1 2.0Metaplasia, Osseous 1 1 2 1.0Mineralization 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 36 1.1Nephropathy 1 1 1 3 1 1 1 4 1 1 2 2 1 2 1 1 1 1 38 1.5Artery, Perirenal Tissue, Inflammation 1 2.0Interstitium, Inflammation 3 1 3.0Interstitium, Inflammation, Chronic 4 2 2.5Papilla, Inflammation, Acute 1 1.0Papilla, Necrosis 1 1 4 1.3Pelvis, Inflammation, Acute 2 1 2.0Pelvis, Inflammation, Chronic 1 2.0Renal Tubule, Cyst X 1Renal Tubule, Cyst, Multiple X 1Renal Tubule, Degeneration 3 2 3 2.3Renal Tubule, Dilatation 1 1 1 1 1 1 14 1.1Renal Tubule, Pigmentation 4 1 4.0Transitional Epithelium, Hyperplasia 1 1.0
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 22
-
DAY ON TEST
B6C3F1 MICE MALE
0729
0729
0730
0731
0521
0729
0730
0660
0721
0731
0600
0730
0568
0730
0491
0598
0731
0731
0729
0729
0589
0730
0731
0730
0729
0 MG/KGANIMAL ID
00026
00027
00028
00029
00030
00031
00032
00033
00034
00035
00036
00037
00038
00039
00040
00041
00042
00043
00044
00045
00046
00047
00048
00049
00050 * TOTALS
Hemorrhage 2 2 2.0Inflammation, Acute 1 2 1.5Necrosis 1 1 1.0
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 23
-
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0729
0556
0620
0729
0730
0626
0730
0618
0731
0730
0730
0730
0708
0731
0603
0731
0591
0596
0731
0731
0692
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic 1Muscularis, Degeneration 1
Gallbladder + + + + M + A + + M + + + + + + + + + + A A + + +
Intestine Large, Cecum + + + + + + A + + + + A + + + + + + + + A A + + +
Intestine Large, Colon + + + + + + A + + + + + + + + + + + + + A A + + +
Intestine Large, Rectum + + + + + + A + + + + + + + + + + + + + A A + + +Serosa, Fibrosis
Intestine Small, Duodenum + + + + + + A + + + + A + + + + + + + + A A + + +
Intestine Small, Ileum + + + + + + A + M + + A + + + M + + + + A A + + +
Intestine Small, Jejunum + + + + + + A + + + + A + + + + + + + + A A + I +Peyer's Patch, Hyperplasia
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Basophilic Focus XBasophilic Focus, MultipleClear Cell Focus X X XClear Cell Focus, Multiple X XCongestionDepletion GlycogenEosinophilic Focus X X X X XEosinophilic Focus, Multiple X X X X X X X
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 24
-
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0729
0556
0620
0729
0730
0626
0730
0618
0731
0730
0730
0730
0708
0731
0603
0731
0591
0596
0731
0731
0692
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Fatty Change 2 1 1 1 1 2 2 1 1 1 1 1 2 2 1Hematopoietic Cell Proliferation 1 1 1 1 1Hemorrhage 1Inflammation, Chronic 2 1 1 1 1 1 1 1 1Mixed Cell Focus X XMixed Cell Focus, MultipleNecrosis, Focal 1Centrilobular, Hepatocyte, Hypertrophy 2 1 1 1 1 2 1 1 1 1 1 2 2 1 2 2Hepatocyte, Mitotic AlterationKupffer Cell, Pigmentation 1 1 1 1 1 1 1 1 1 1
MesenteryFat, Necrosis
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 1 1 2 1 2 1 1Cyst 2 2 2Inflammation, Granulomatous, Focal 3Inflammation, AcuteInflammation, Chronic 1 1 1 1 1 1 1 1 2 1 1Mineralization 3NecrosisArtery, Inflammation, Chronic ActiveArtery, Mineralization 1Artery, Necrosis
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Mononuclear Cell 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1Inflammation, Acute 2Mineralization 1 2 1
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 25
-
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0729
0556
0620
0729
0730
0626
0730
0618
0731
0730
0730
0730
0708
0731
0603
0731
0591
0596
0731
0731
0692
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Necrosis 1Vacuolization Cytoplasmic, Macrovesicular 2
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Cyst XErosion 3 2 3 1Inflammation 1 1 2 2 2 2 1 1 2 2 1 2 1Ulcer 2 3 2 1 2 2Epithelium, Hyperplasia 1 1 3 2 3 1 2 1 3 3 3 2 4
Stomach, Glandular + + + + + + + + + + + A + + + + + + + + + + + + +Fibrosis 1InflammationInflammation, Acute 1Mineralization 1Glands, Ectasia, Focal
ToothMalformation
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + M +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 1 1 1 1Inflammation, AcuteThrombosis
ENDOCRINE SYSTEM
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 26
-
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0729
0556
0620
0729
0730
0626
0730
0618
0731
0730
0730
0730
0708
0731
0603
0731
0591
0596
0731
0731
0692
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Accessory Adrenal Cortical NoduleHypertrophy, Focal 1 1 1Capsule, Hyperplasia 1 2 2 2 2 1 2 2 1 2 2 1 2 1 2 1 2 2
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 2
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 2 2 1 1 1 2 1 2 2 1 1 1 2
Parathyroid Gland + + + + + + + + + + + M + + + + + + M + M + + + +Cyst 2
Pituitary Gland + + + + I + + + + + + + M + + + + + + + I + + M +Pars Distalis, CystPars Distalis, Hyperplasia, Focal 2
Thyroid Gland + + + + + + + + + + + + + + + + + + + + A + + + +HypertrophyFollicle, Degeneration 2 2 3 1Follicle, Degeneration, Focal 2Follicle, Hypertrophy 1 1 2 1 2 1 1 1 2 2 1 2 1 1 2 2 1 2
GENERAL BODY SYSTEM
Tissue NOSAbdominal, FibrosisFat, Necrosis
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 27
-
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0729
0556
0620
0729
0730
0626
0730
0618
0731
0730
0730
0730
0708
0731
0603
0731
0591
0596
0731
0731
0692
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic 2 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 2
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 2 2 2 2 2 2 2EctasiaFibrosisInflammation, Chronic 1 1 1 2 2 1 2 2 2 1 2 2 1Inflammation, Chronic Active 1
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +FibrosisInflammation, Acute 1Inflammation, Chronic 1 1 1 1 1 2 2 1 1 2 1 1 2 1 1 2 2 1 1Inflammation, Chronic ActiveNecrosis 2
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +DilatationHemorrhageInflammation, AcuteInflammation, Chronic 1 1 1 1 1
Testes + + + + + + + + + + + + + + + + + + + + + + + + +Abnormal Residual Body 1Germinal Epithelium, Atrophy 1 1 1 1 2
HEMATOPOIETIC SYSTEM
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 28
-
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0729
0556
0620
0729
0730
0626
0730
0618
0731
0730
0730
0730
0708
0731
0603
0731
0591
0596
0731
0731
0692
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node +Iliac, Hyperplasia, Lymphoid
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +Hemorrhage 2 3Hyperplasia, Lymphoid 1Infiltration Cellular, Polymorphonuclear 3Pigmentation 1 1 2 1 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 2 2 1 1 2
Lymph Node, Mesenteric + + + + + + + + + + + + M + + + + + + + + + + + +EctasiaHemorrhage 2 3 2Hyperplasia, Lymphoid 2Infiltration Cellular, Polymorphonuclear 2Necrosis, Lymphoid 2
Spleen + + + + + + + + + + + + + + + + + + + + A + + + +Hematopoietic Cell Proliferation 2 2 3 1 1 3Pigmentation 2 1 1 1 2 2 1Capsule, Fibrosis, Focal 2Capsule, Inflammation, Granulomatous, Focal 2Lymphoid Follicle, Atrophy 2Lymphoid Follicle, Hyperplasia 1 3 2
Thymus + + + + + + + + + + + M I I + + + + + + + A I I MAtrophy 2 2 1 1 4 2 1 4 1 2 2 3 3 1 4Cyst 2 2 2 2 2 2 2Hyperplasia, Lymphoid 1
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 29
-
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0729
0556
0620
0729
0730
0626
0730
0618
0731
0730
0730
0730
0708
0731
0603
0731
0591
0596
0731
0731
0692
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Necrosis, Lymphoid 2 2 3
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M + M
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Fibrosis 2Hyperkeratosis 2 4Inflammation, AcuteInflammation, Chronic 1 1Inflammation, Chronic Active 3Ulcer 4Epidermis, Hyperplasia 2Lip, Inflammation, AcuteSubcutaneous Tissue, Angiectasis, Focal 2
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +Fibro-Osseous Lesion 1Tail, Callus 1 1Tail, Developmental Malformation X X X
Skeletal Muscle +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +Hemorrhage 1Infiltration Cellular, Mononuclear Cell 1
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 30
-
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0729
0556
0620
0729
0730
0626
0730
0618
0731
0730
0730
0730
0708
0731
0603
0731
0591
0596
0731
0731
0692
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Metaplasia, OsseousMeninges, Inflammation, AcuteMeninges, Thrombosis
Peripheral Nerve +Degeneration 1
Spinal Cord +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Hemorrhage 2 2 2 2 2Infiltration Cellular, Histiocyte 1 1 2 1Inflammation, AcuteMineralization 1 1Alveolar Epithelium, Hyperplasia 3 4 2
Nose + + + + + + + + + + + + + + + + + + + + + + + M +Foreign Body 1 1 X 1Inflammation, Acute 2 1 1 2 2Mineralization
Pleura
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +Hemorrhage 2
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + A + + + + + + + + + A + + +
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 31
-
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0729
0556
0620
0729
0730
0626
0730
0618
0731
0730
0730
0730
0708
0731
0603
0731
0591
0596
0731
0731
0692
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Cornea, Inflammation, Chronic Active 2
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 4
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Casts ProteinHydronephrosisHyperplasia, LymphoidInfarct 2Infiltration Cellular, Mononuclear Cell 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1Inflammation, AcuteMetaplasia, Osseous 1 2Mineralization 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1Nephropathy 1 2 1 1 1 1 1 1 4 4 2 4 2 2 2 1 3 1 1 1 2 2 1Interstitium, Inflammation, ChronicPapilla, Inflammation, AcutePapilla, Necrosis 4 4Papilla, Renal Tubule, NecrosisRenal Tubule, Cyst X XRenal Tubule, Dilatation 1 1 2 1Renal Tubule, Hyperplasia
Urethra + + +Angiectasis 4Inflammation, Acute 1Necrosis 1Bulbourethral Gland, Cyst 4Bulbourethral Gland, Inflammation 2
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 32
-
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0729
0556
0620
0729
0730
0626
0730
0618
0731
0730
0730
0730
0708
0731
0603
0731
0591
0596
0731
0731
0692
3 MG/KGANIMAL ID
00051
00052
00053
00054
00055
00056
00057
00058
00059
00060
00061
00062
00063
00064
00065
00066
00067
00068
00069
00070
00071
00072
00073
00074
00075
males(cont...)
Bulbourethral Gland, Necrosis 3
Urinary Bladder + + + + + + + + + + + A + + + + + + + + + + + + +FibrosisHemorrhageInflammation, AcuteInflammation, Chronic ActiveNecrosis 2 1
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 33
-
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0564
0730
0730
0557
0684
0729
0731
0689
0698
0730
0730
0428
0729
0540
0730
0731
0731
0729
0730
0731
0614
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Chronic 1 1.0Muscularis, Degeneration 1 2 1.0
Gallbladder + + + + + + + + + + + + + + A + A + + + + + + A + 42
Intestine Large, Cecum + + + + + + + + + + + + + + A + A + + + + + + A + 43
Intestine Large, Colon + + + + + + + + + + + + + + A + A + + + + + + A + 44
Intestine Large, Rectum + + + + + + + + + + + + + + + + A + + + + + + + + 46Serosa, Fibrosis 2 1 2.0
Intestine Small, Duodenum + + + + + + + + + + + + + + I + A + + + + + + A + 43
Intestine Small, Ileum + + + + + + + + + + + + + + + + A M + + + + + A + 41
Intestine Small, Jejunum + + + + + + + + + + + + + + A + A + + + + + + A + 42Peyer's Patch, Hyperplasia 2 1 2.0
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Basophilic Focus X 2Basophilic Focus, Multiple X 1Clear Cell Focus X X X 6Clear Cell Focus, Multiple X X X X X 7Congestion 1 1 1.0Depletion Glycogen 2 1 2.0Eosinophilic Focus X X X X X X X 12Eosinophilic Focus, Multiple X X X 10
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 34
-
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0564
0730
0730
0557
0684
0729
0731
0689
0698
0730
0730
0428
0729
0540
0730
0731
0731
0729
0730
0731
0614
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Fatty Change 1 2 1 1 2 1 2 1 1 1 25 1.3Hematopoietic Cell Proliferation 5 1.0Hemorrhage 1 1.0Inflammation, Chronic 1 1 2 1 1 2 2 1 1 1 19 1.2Mixed Cell Focus X X 4Mixed Cell Focus, Multiple X 1Necrosis, Focal 1 2 1.0Centrilobular, Hepatocyte, Hypertrophy 2 1 3 2 1 1 1 2 1 2 1 1 28 1.4Hepatocyte, Mitotic Alteration 1 1 1.0Kupffer Cell, Pigmentation 2 3 2 1 1 15 1.3
Mesentery + + + 3Fat, Necrosis 2 2 3 3 2.3
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 1 2 2 1 2 1 1 14 1.4Cyst 2 4 2.0Inflammation, Granulomatous, Focal 1 3.0Inflammation, Acute 2 1 2.0Inflammation, Chronic 1 1 1 1 1 1 17 1.1Mineralization 1 2 2.0Necrosis 2 2 2 2.0Artery, Inflammation, Chronic Active 2 1 2.0Artery, Mineralization 1 1.0Artery, Necrosis 2 1 2.0
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50Infiltration Cellular, Mononuclear Cell 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 38 1.1Inflammation, Acute 1 2.0Mineralization 1 1 5 1.2
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 35
-
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0564
0730
0730
0557
0684
0729
0731
0689
0698
0730
0730
0428
0729
0540
0730
0731
0731
0729
0730
0731
0614
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Necrosis 1 1.0Vacuolization Cytoplasmic, Macrovesicular 1 2.0
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 1Erosion 2 5 2.2Inflammation 2 2 1 2 2 18 1.6Ulcer 2 1 8 1.9Epithelium, Hyperplasia 1 1 2 4 2 3 19 2.2
Stomach, Glandular + + + + + + + + + + + + + + + + A + + + + + + + + 48Fibrosis 1 1.0Inflammation 1 1 1.0Inflammation, Acute 1 1.0Mineralization 2 2 2 1 5 1.6Glands, Ectasia, Focal 1 1 1.0
Tooth + 1Malformation 4 1 4.0
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 49
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Cardiomyopathy 1 1 1 1 1 2 10 1.1Inflammation, Acute 2 1 2.0Thrombosis 4 1 4.0
ENDOCRINE SYSTEM
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 36
-
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0564
0730
0730
0557
0684
0729
0731
0689
0698
0730
0730
0428
0729
0540
0730
0731
0731
0729
0730
0731
0614
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Accessory Adrenal Cortical Nodule 2 2 2 2.0Hypertrophy, Focal 1 1 2 2 1 1 1 10 1.2Capsule, Hyperplasia 2 2 2 2 2 2 2 1 1 2 2 1 2 2 2 2 2 2 1 2 2 2 2 41 1.8
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 2.0
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 3 1 2 1 1 4 2 1 3 1 2 25 1.6
Parathyroid Gland M + + + + M + + + + + M + + + + + M + + + + + + + 43Cyst 1 2.0
Pituitary Gland + + + + + + + + + + M + + + + + + + + + + + + I M 43Pars Distalis, Cyst 2 2 2 2.0Pars Distalis, Hyperplasia, Focal 1 2.0
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Hypertrophy 1 1 1.0Follicle, Degeneration 1 3 1 2 1 2 1 2 1 2 2 1 1 1 1 19 1.6Follicle, Degeneration, Focal 1 2.0Follicle, Hypertrophy 2 2 2 1 2 1 1 1 3 1 1 1 1 1 1 1 1 35 1.4
GENERAL BODY SYSTEM
Tissue NOS + 1Abdominal, Fibrosis 2 1 2.0Fat, Necrosis 2 1 2.0
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 37
-
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0564
0730
0730
0557
0684
0729
0731
0689
0698
0730
0730
0428
0729
0540
0730
0731
0731
0729
0730
0731
0614
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Chronic 1 1 1 1 1 1 1 1 2 1 28 1.2
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 2 2 2 2 2 2 2 2 2 16 2.0Ectasia 3 1 3.0Fibrosis 3 1 3.0Inflammation, Chronic 2 1 2 1 2 1 3 2 2 1 1 2 2 2 2 28 1.6Inflammation, Chronic Active 1 1.0
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrosis 2 1 2.0Inflammation, Acute 4 2 2.5Inflammation, Chronic 1 1 1 2 1 1 1 1 1 2 2 1 1 1 33 1.3Inflammation, Chronic Active 4 1 4.0Necrosis 1 2.0
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50Dilatation 4 1 4.0Hemorrhage 2 1 2.0Inflammation, Acute 2 1 2.0Inflammation, Chronic 1 1 7 1.0
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50Abnormal Residual Body 1 1.0Germinal Epithelium, Atrophy 2 2 1 8 1.4
HEMATOPOIETIC SYSTEM
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 38
-
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0564
0730
0730
0557
0684
0729
0731
0689
0698
0730
0730
0428
0729
0540
0730
0731
0731
0729
0730
0731
0614
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node + + + 4Iliac, Hyperplasia, Lymphoid 4 1 4.0
Lymph Node, Mandibular I + + + + + + + + + + + + + + + + + + + + + + + + 49Hemorrhage 3 3 2.7Hyperplasia, Lymphoid 1 1.0Infiltration Cellular, Polymorphonuclear 1 3.0Pigmentation 2 1 1 1 2 1 1 2 1 1 2 3 1 1 1 1 2 1 1 2 1 3 1 2 48 1.4
Lymph Node, Mesenteric M + + + + + + + + + + + + + + + + + + M + + + + + 47Ectasia 3 1 3.0Hemorrhage 2 1 1 4 7 2.1Hyperplasia, Lymphoid 1 2.0Infiltration Cellular, Polymorphonuclear 1 2.0Necrosis, Lymphoid 1 2.0
Spleen + + + + + + + + + + + + + + A + A + + + + + + + + 47Hematopoietic Cell Proliferation 3 3 2 2 10 2.2Pigmentation 1 2 2 1 1 12 1.4Capsule, Fibrosis, Focal 1 2.0Capsule, Inflammation, Granulomatous, Focal 1 2.0Lymphoid Follicle, Atrophy 3 2 2.5Lymphoid Follicle, Hyperplasia 1 1 1 1 7 1.4
Thymus + + + + + + + + + + + + + + + + + I + + M + + + + 41Atrophy 1 4 4 3 1 4 3 4 4 4 1 2 4 28 2.6Cyst 2 2 2 2 2 12 2.0Hyperplasia, Lymphoid 1 2 1.0
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 39
-
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0564
0730
0730
0557
0684
0729
0731
0689
0698
0730
0730
0428
0729
0540
0730
0731
0731
0729
0730
0731
0614
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Necrosis, Lymphoid 3 1 3 6 2.3
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M + M M M M M M M M M M M M M M M M 2
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrosis 1 2.0Hyperkeratosis 2 3 2.7Inflammation, Acute 2 1 2.0Inflammation, Chronic 2 3 1.3Inflammation, Chronic Active 1 3.0Ulcer 1 4.0Epidermis, Hyperplasia 1 2.0Lip, Inflammation, Acute 1 1 1.0Subcutaneous Tissue, Angiectasis, Focal 1 2.0
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibro-Osseous Lesion 1 1.0Tail, Callus 2 1.0Tail, Developmental Malformation 3
Skeletal Muscle + 2
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemorrhage 1 2 1.0Infiltration Cellular, Mononuclear Cell 1 2 1.0
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 40
-
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0564
0730
0730
0557
0684
0729
0731
0689
0698
0730
0730
0428
0729
0540
0730
0731
0731
0729
0730
0731
0614
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Metaplasia, Osseous 1 1 1.0Meninges, Inflammation, Acute 2 1 2.0Meninges, Thrombosis 2 1 2.0
Peripheral Nerve 1Degeneration 1 1.0
Spinal Cord 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemorrhage 2 6 2.0Infiltration Cellular, Histiocyte 3 3 1 3 3 1 1 11 1.8Inflammation, Acute 1 1 1.0Mineralization 2 1.0Alveolar Epithelium, Hyperplasia 3 3 4 6 3.2
Nose + + + + + + + + + + + + + + + + A + + + + + + + + 48Foreign Body 2 X 2 7 1.4Inflammation, Acute 1 1 3 2 1 1 2 12 1.6Mineralization 1 1 2 1.0
Pleura + 1
Trachea + + + + + + + + + + + M + + + + + + + + + + + M + 48Hemorrhage 1 2.0
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + A + + + + + + + + 47
Experiment Number: 20209 - 04 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2014Test Type: CHRONIC Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 08:48:43Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 02/25/08 / 02/25/08Species/Strain: MICE/B6C3F1 Lab: SRI
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 41
-
DAY ON TEST
B6C3F1 MICE MALE
0731
0730
0730
0564
0730
0730
0557
0684
0729
0731
0689
0698
0730
0730
0428
0729
0540
0730
0731
0731
0729
0730
0731
0614
0730
3 MG/KGANIMAL ID
00076
00077
00078
00079
00080
00081
00082
00083
00084
00085
00086
00087
00088
00089
00090
00091
00092
00093
00094
00095
00096
00097
00098
00099
00100 * TOTALS
Cornea, Inflammation, Chronic Active 1 2.0
Harderian Gland + + + + + + + + + + + + + + + + + M + + + + + + + 49Hyperplasia 4 2 4.0
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Casts Protein 2 1 2.0Hydronephrosis 2 1 2.0Hyperplasia, Lymphoid 2 1 2.0Infarct 1 2.0Infiltration Cellular, Mononuclear Cell 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 41 1.0Inflammation, Acute 3 1 3.0Metaplasia, Osseous 2 1.5Mineralization 1 2 1 2 1 1 1 1 2 1 1 1 1 1 1 32 1.2Nephropathy 1 1 1 3 1 2 2 1 1 4 4 1 1 1 2 1 2 2 1 1 1 1 45 1.7Interstitium, Inflammation, Chronic 2 1 2.0Papilla, Inflammation, Acute 2 1 2 1.5Papilla, Necrosis 1 2 1 4 6 2.7Papilla, Renal Tubule, Necrosis 2 1 2.0Renal Tubule, Cyst 2Renal Tubule, Dilatation 1