extensions of mendelian analysis - find people
TRANSCRIPT
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Extensions of Mendelian Analysis
• Modifications of Mendelian Ratios• Single Gene modifications• Two gene pair modifications: modified
9:3:3:1 ratios• Modification of Expression• Quantitative Genetics
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Single Gene modifications
• Incomplete dominance (partial dominance) • Multiple alleles • Lethal alleles
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Incomplete dominance (partial dominance)
• Expression of a heterozygous phenotype that is distinct from and usually intermediate to either homozygous phenotype
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Incomplete dominance
• Tay Sachs and Sickle Cell Anemia
• Heterozygous are intermediate at
• the biochemical level.
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Multiple Alleles &Co-Dominance
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Two gene pair modifications: modified 9:3:3:1 ratios
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Recessive Epistasis
• H allele affected
• Recessive epistasis
• Show O phenotype
• Genotype variable
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Modification of Expression• Temperature effects• Pleiotropic effects • Penetrance and
Expressivity
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Pleiotropic effects
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Penetrance & Expressivity
No expression
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Polygenic inheritance
• 2 or more genes• Show continuous
variation vsdiscontinuous
• Additive component• Distinct phenotypic
classes• Quantitative traits:
size, weight, height,IQ
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Quantitative Genetics