Κωνσταντίνος Γαρδίκης, msc, phd, scientific affairs director · extensive...
TRANSCRIPT
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Έρευνα και ανάπτυξη προϊόντωνΚωνσταντίνος Γαρδίκης, MSc, PhD, Scientific Affairs Director
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AP
IVITA
BR
AN
D
APIVITA is a highly sophisticated natural cosmetics brand,
developing and producing natural, effective and holistic
cosmetics and well being products and services
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INSP
IRA
TION
S
BEE SOCIETY
GREEK FLORA
HIPPOCRATES
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.
OUR DRIVING AXIS
1. Our Brand Identity
2. APIVITA strategic goals on
Raw Materials Development
3. Market research defining
Cosmetics and Health
market status
4. Scientific Collaborations &
Research Programs
5. Cosmetics Legislation
Evolution
6. Innovation
Product Development
Platform … driven by Value
Innovation
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WHAT MAKES OUR PRODUCTS UNIQUE
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36 YEAR RESEARCH &
DEVELOPMENT
EVOLUTION
Certifications
Scientific collaboration with universities and
research institutes for extensive research on
Greek plant actives and applications
7 research programs in collaboration with the
University of Athens accomplished and 10 in progress
In house plant extracts and oils development
and production
60 plants studied / 200 extracts developed since
1979
37 years proven experience in natural products
development
Experience and flexibility leads to more than 100
new product developments every year Extensive
knowledge of natural and organic cosmetics (the first
in the Greek market to produce natural cosmetics,
the first in the Greek pharmacies to produce organic
sunscreens).
Extensive ingredients testing and deep under-
standing
5000 ingredients tested / 1500 ingredients used.
New developments in increasing products natural
ingredients level such as innovative preservation
systems, emulsifying systems, active ingredients.
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The department consists of 14 scientists, chemists, pharmacists, chemical engineers
and cosmetologists who are in charge of the development of natural raw materials,
cosmetic products’ formula and notification & legalization of the products to the
countries of company’s operation
A success story of innovation
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PRODUCT
NATURAL – EFFECTIVE - HOLISTIC
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NA
TUR
AL
APIVITA products have formulas with high percentage of
natural ingredients 85%-100% , environmentally friendly
packaging and they are produced with respect to nature.
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WITH
WITHOUT
NATURAL
Plant extracts
Plant oils
Plant Infusions
Bee Products
Essential oils
*Greek plant, organically cultivated, Hippocrates plants
Parabens
Silicones
Propylene Glycol
Mineral Oil
Ethanolamines
Phthalates, Nitromusks,
Polycyclic Musks
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PLANT EXTRACTS
Organic Plants: 99% of the plants we
use for the in house production of
extracts are from organically certified
cultivations
Greek Plants: Combining the
knowledge of the traditional use and
modern scientific research on the
Greek biodiversity
Hippocrates Plants: Thorough study of
his literature brought to light the exact
plant species which he used for his
therapeutic methods.
Hippocrates
Botanical
Garden on
Kos island
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EFFEC
TIVE
APIVITA’s R&D department has a proven track record of
experience in developing effective cosmetics.
The ingredients used are on the cutting edge of green
cosmetology and fulfills efficacy substantiation
requirements
Ingredients' activity and effectiveness is measured in
house and in collaborations
In vivo clinical studies are conducted on the final
products in close partnership with research institutes and
universities.
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Analytical tests
Physicochemical tests(pH, Specific gravity etc)
UV-Visspectrophotometry
Microbiological tests
Chromatographicanalysis
(HPTLC, HPLC)
Qualitativeanalysis
Quantitative analysis
Total phenolics(Folin- Ciocalteau method)
Total Flavonoids
Radical Scavenging (DPPH)
Total Phenolics
PROOF OF EFFICACYPhytochemistry Lab
http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=PmCYKI8vc35bGM&tbnid=LvcKE7ol8PZvNM:&ved=0CAgQjRw4Lw&url=http://www.sorbtech.com/wordpress/2010/10/getting-resolution-scaling-up-from-tlc-to-column-with-tight-rf-values/&ei=3OPYUsLaJJCjhgeft4CoCw&psig=AFQjCNGmrMOHyVAtoECUEXtuzvl6HGhkig&ust=1390032220664622http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=9z6sz9Tk8rR8oM&tbnid=yRbHd81yICTiNM:&ved=0CAgQjRw4Eg&url=http://ebm.sagepub.com/content/231/8/1287/F1.expansion&ei=m-PYUtP0E8uThQf3roHoAg&psig=AFQjCNHWYVHAgcB3YBkADKieMt5uWlbTuQ&ust=1390032155392294
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Biochemistry assays
Gel Electrophoresis
DNA barcoding
Gene expression
Allergen identification
Genetic fingerprinting
Microbiological testing
Real Time Polymerase Chain Reaction (qPCR)
Elisa Immunosorbent
Assay Protein detection
PROOF OF EFFICACYBiochemistry Lab
http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=vUnCrpeYfJqV5M&tbnid=Dw857RLkiJitnM:&ved=0CAgQjRw4EA&url=http://en.wikipedia.org/wiki/Retinoblastoma_protein&ei=7R_YUuWILMeVhQe2v4Ag&psig=AFQjCNFWNCoPzN8oSiJoLoIFiXcgTdPHbQ&ust=1389982061878539http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=e2PYxJGsnaiuoM&tbnid=VxjeFheRF0-I0M:&ved=0CAgQjRw&url=http://en.wikipedia.org/wiki/Gel_electrophoresis_of_nucleic_acids&ei=4KLfUtmpHYbrywPmwICQAw&psig=AFQjCNH6LbNN5_tAscyuj6kGnSy6pSbvgg&ust=1390474336581486http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=iQtruCUmtehzfM&tbnid=7gHNuJAoUGfi9M:&ved=0CAgQjRw&url=http://www.sigmaaldrich.com/life-science/molecular-biology/automation/automation-products/quantitative-pcr.html&ei=9qLfUrqkCuqEyAOc1oDwCg&psig=AFQjCNH7IMNSxTvMbNmUCbPXSwq36AOlMA&ust=1390474358345348http://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=9vB4SU62wv0D8M&tbnid=UgbnWQqdNWKLoM:&ved=0CAgQjRw47QE&url=http://www.biologyreference.com/Dn-Ep/Electrophoresis.html&ei=Wh_YUu3SLZKjhgfykYDgDQ&psig=AFQjCNEYm9R4AswwjDPyjK3JA9EWs3LDAg&ust=1389981914828401
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Extracellular Molecules
Transcription Regulators
Cell growthand
Proliferation
Apoptosis
Response to Stress
Ageing
Oxidative Stress
Hydration
Inflammation
200 API - Genes
PROOF OF EFFICACYGene Database
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Results
• Skin moisturization is improved by 18% after the
first application and by 21%, after 28 days
• 24 h , Skin moisturization
• TEWL is decreased by 18% after 28 days
• Skin elasticity is improved by 16% after 28 days
Results
• Skin’s density was improved at 87% of the
volunteers after 46 days
• Skin’s tone was improved at 97% of the volunteers
after 46 days
• Skin’s texture was improved at 90% of the
volunteers after 46 days
PROOF OF EFFICACYIn-vivo tests
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HO
LISTIC
HOLISTIC INSPIRED BY HIPPOCRATES
Multifunctional products which offer more than one
action & cover all skin's needs. Maintain skin’s health
and beauty.
Formulas enriched with 100% pure organic essential
oils in order to enhance a feeling of well being
Holistic approach on health and beauty based on
Hippocrates Philosophy
The teaching of Hippocrates on Experience,
Methodology,Discipline and Evidence is a key
inspiration on new product development
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INGREDIENTS
NATURAL – EFFECTIVE - HOLISTIC
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PLANT INFUSIONS
Replacing water with herbs infusions to
enhance effectiveness
Greek Wild rose Infusion
Antioxidantanti-aging
action
Rosemary water
Toning
action
Calendula(marigold) water
Calmingand
soothingaction
action
Chamomile water
Anti-irritantand
soothing
action
MountainTea infusion
INNOVATION
http://en.wikipedia.org/wiki/File:Divlja_ruza_cvijet_270508.jpg
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• Total phenolic content is assessed by Folin-Ciocalteau assay
• The ability of the infusion to scavenge free radicals is measured by DPPH method
EFFECTIVE
PLANT INFUSIONS
Effectiveness of herb infusions is measured by scientific methods
0
0,05
0,1
0,15
0,2
Sideritisscardica
Sideritisraeseri Sideritis
perfoliataSideritis
blend Green tea
Tro
lox
equ
ival
ent
Antioxidant activity
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Sideritis scardica/raeseri/perfoliata
(PATENT USE)
SIDERITIS INFUSION PATENT
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Propolis
(PATENT METHOD)
SOPHISTICATED
SKIN DELIVERY SYSTEMS :
Propolis Encapsulation In
Cyclodextrins
EFFECTIVE BEE PRODUCTS
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A patent of innovative extraction
method and simultaneous
encapsulation in cyclodextrins
8 In Vitro Studies
1. Cell Viability Protection- UV
treatment
2. Cell Viability Protection –
Heavy metal treatment
3. Cell Metabolism Protection –
UV Treatment
4. Cell Metabolism Protection –
Heavy metal treatment
5. Cell antioxidant capability- UV
treatment
6. Cell antioxidant capability –
Heavy metal treatment
7. Collagen synthesis
8. Elastin Synthesis
SOPHISTICATED
SKIN DELIVERY SYSTEMS : Propolis
Encapsulation In Cyclodextrins
EFFECTIVE BEE PRODUCTS
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Benefits of a liposomal formulation
Royal Jelly forms in presence of soy
lecithin (phospholipids) vesicles,
the liposomes
The active ingredients
of Royal Jelly are incorporated
either in the core of the vesicle or
integrated in the phospholipid
bilayer
SOPHISTICATED ‘
SKIN DELIVERY SYSTEMS : Fresh Greek Royal Jelly in
Liposomes
EFFECTIVE BEE PRODUCTS
http://upload.wikimedia.org/wikipedia/commons/8/89/Weiselzellen_68a.jpghttp://www.google.gr/url?sa=i&source=images&cd=&cad=rja&docid=gw7r4GYsXjZR9M&tbnid=3jYdmUSth8QBxM:&ved=0CAgQjRwwAA&url=http://www.lyposphericnutrients.co.uk/reasearchanddevelopment.aspx&ei=WPa6UZazAYSmO6P7gBA&psig=AFQjCNEfMH0r6KwEJeLF5elVO5uBtiYkiw&ust=1371293656059992
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in-vivo Clinical studies
Increase of skin firmness skin in 90% of volunteers
Increase of skin elasticity in 90% of volunteers
Reducing the depth of wrinkles in 85% of volunteers
Growth stimulation of fibroblasts
SOPHISTICATED
SKIN DELIVERY SYSTEMS : Fresh Greek Royal Jelly in Liposomes
EFFECTIVE BEE PRODUCTS
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RESEARCH
PROGRAMS NATURAL – EFFECTIVE - HOLISTIC
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HORIZON 2020 PROGRAMS
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1st round: 16.000 proposals1st stage success: 11%2nd stage success: 16%
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HORIZON 2020: MARISURF
Title: Novel, sustainable marine bio-surfactant / bio-emulsifiers for commercial exploitation
• Call: H2020- Blue Growth--‐3--‐2014• Topic: : Novel marine derived biomolecules and industrial biomaterials• Type of action: Research and Innovation actions
• Target: Isolation and production of new bio-surfactants and bio-emulsifiers by environmental pollution degrading bacteria (green biotechnology and sustainability)
• APIVITA interest: Cosmeceutical formulation / green marketing• Total Budget: 4750000 euro• APIVITA budget: 198000 euro• Reimbursement rate: 100%• Duration: 60 months• Start date: 9/2015
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PARTICIPANTS
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PARTICIPANT NO PARTICIPANT ORGANIZATION NAME COUNTRY
1 (Coordinator) HERIOT WATT UNIVERSITY UK
2 ULSTER UNIVERSITY UK
3 UNIVERSITY OF PATRAS GREECE
4 DEMOCRITUS UNIVERSITY OF THRACE GREECE
5 APIVITA, S.A. GREECE
6 BIO BASE EUROPE PILOT PLANT BELGIUM
7 ECOVER BELGIUM
8 ACONDICIONAMIENTO TARRASSENSE SPAIN
9 NOVA INSTITU Gmbh GERMANY
10 NANOIMMUNOTECH, S.L. SPAIN
11 ETS ITALY
12 MARLOW FOODS UK
13 MACHPIE UK
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HORIZON 2020: TASCMAR
Title: Tools And Strategies to access to original bioactive compounds from Cultivation of MARine invertebrates and
associated symbionts
• Call: H2020- Blue Growth--‐3--‐2014• Topic: Novel marine derived biomolecules and industrial biomaterials• Type of action: Research and Innovation actions
• Target: Isolation and production of new antioxidant molecules or enhanced extracts from invertebrates
• APIVITA interest: New sustainable and effective raw materials derived with innovative green methods of extraction
• Total Budget: 6760000 euro• APIVITA budget: 400000 euro• Reimbursement rate: 100%• Duration: 48 months• Start date: 4/2015 31
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PARTICIPANTS
32
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HORIZON 2020: ALGAE4A-B
Title: Development of Microalgae-based novel high added-value products for the Cosmetic and Aquaculture industry
• Call: H2020-MSCA-RISE-2015
• Topic: MSCA-RISE• Type of action: Marie-Curie actions
• Target: New -omic technologies and new strains for the production of high added value cosmeceuticals
• APIVITA interest: New multifunctional enhanced extracts and isolated enzymes
• Total Budget: 972000 euro• APIVITA budget: 216000 euro• Reimbursement rate: 100%• Duration: 48 months• Start date: 11/2015 33
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PARTICIPANTS
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PARTICIPANT
NO
PARTICIPANT ORGANIZATION NAME COUNTRY
1 (Coordinator) FITOPLANCTON MARINO SPAIN
2 APIVITA GREECE
3 CNRS FRANCE
4 AGRICULTURAL UNIVERSITY OF ATHENS GREECE
5 IFAPA SPAIN
6 CCMAR PORTUGAL
7 LIFESEQUENCING SPAIN
http://www.google.gr/url?sa=i&source=imgres&cd=&cad=rja&uact=8&ved=0CAkQjRwwAGoVChMIrMvo_OK_xwIVS5QsCh2rzAHF&url=http://www.ccmar.ualg.pt/index.php?id=838&ei=uQjaVeyKBcuosgGrmYeoDA&psig=AFQjCNG5AdFqLg87n9aSTEHopyVct7zBpg&ust=1440438841177838https://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRxqFQoTCLah94Piv8cCFYd_GgodQT8DmA&url=https://el.wikipedia.org/wiki/%CE%93%CE%B5%CF%89%CF%80%CE%BF%CE%BD%CE%B9%CE%BA%CF%8C_%CE%A0%CE%B1%CE%BD%CE%B5%CF%80%CE%B9%CF%83%CF%84%CE%AE%CE%BC%CE%B9%CE%BF_%CE%91%CE%B8%CE%B7%CE%BD%CF%8E%CE%BD&ei=uwfaVfbXIof_acH-jMAJ&psig=AFQjCNEZ32k9zqu8Qjen7MhkjhDHkJL0dw&ust=1440438582005476http://www.easyalgae.com/index_ingles.asphttp://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRxqFQoTCPeZk-jiv8cCFYpZGgodurAI7Q&url=http://lourdesdiezfajardo.com/nueva-convocatoria-de-empleo-en-el-ifapa/&ei=jQjaVbefLYqzabrhougO&psig=AFQjCNFj1U36Cl7BNf-JtSDC3FeO6t_LPg&ust=1440438783610768http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRxqFQoTCP7A26rjv8cCFcgEGgod5YwI4w&url=http://mscbioinformatics.uab.cat/base/base3.asp?sitio=msbioinformaticsen&anar=redemp&ei=GQnaVb7QFMiJaOWZopgO&psig=AFQjCNGOKwY8ks8NKHBrlwHNuPGf1SIlaw&ust=1440438932298776http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRxqFQoTCP7A26rjv8cCFcgEGgod5YwI4w&url=http://mscbioinformatics.uab.cat/base/base3.asp?sitio=msbioinformaticsen&anar=redemp&ei=GQnaVb7QFMiJaOWZopgO&psig=AFQjCNGOKwY8ks8NKHBrlwHNuPGf1SIlaw&ust=1440438932298776
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FRAMEWORK 7/GREEK FRAMEWORK PROGRAMS
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Exploitation of microalgae diversity for the development of novel high added-value cosmeceuticals
AlgaeCom
http://www.easyalgae.com/index_ingles.asp
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Agricultural University of
Athens(AUA)
Participant
Participants
Centre National de Recherches
Scientifique (CNRS)
APIVITA S.A.
FITOPLANCTON MARINO
Greece
Country
France
Greece
Spain
Dept. Agric. Biotechn.
Lab.Molec. Biology
Dept.
Marine plant and
biomolecules
Scientific Affairs-R&D
Dr. EmmanouilFlemetakis
Scientist in charge
Dr. WilliamHelbert
Dr. Konstantinos
Gardikis
Dr. Carlos
Unamunzaga
3
4
2
1
Molecular Biology &
Manufacturing
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ALGAECOM-TARGET
Extract(s) with important firming/antiageing properties1
•Setup of biochemistry lab•APIGENES library development•Control/proof of effectiveness•DNA barcoding
2
Contact with a new world of ingredients3
Incorporation in products 2017
Βudget: 1,570,928.00 euro
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Nannochloropsis gaditana extract (1st time in cosmetics) +
Propolis patent
PRO-ALGAE PATENT
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Bee-based natural products as potential cosmeceutical agents with health promoting properties against UV-induced skin
photo-ageing
BeeCosmAge
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APIVITA S.A
Participants
Participants
University of Ioannina (UoI
Democritus University of Thrace
(DuTh)
Greece
Country
Greece
Greece
Depart.Research &
Development
Dept.
Pathologic Anatomy
Molecular Pharmacology
Dr. Konstantinos
Gardikis
Scientist in charge
Dr. Anna Gousia
Dr. Aglaia Pappa
2
1
University of Athens (UoA)
Greece PharmacognosyDr.
Nektarios Aligiannis
Nanchang University (NCU) China
Food Science & Technology
Dr. Liping Luo
3
4
5
Pharmacognosy
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•Proof of the uniqueness of Greek bee products
BeeCosmAge-Target
•New series of innovative extracts
•Contact with Chinese academia & market
Βudget: 500,000.00 euro (Greek side)
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BeeCosmAge-Dissemination
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•European Biotechnology Congress (May 2015, Bucharest)
BeeCosmAge-Dissemination
TOXICITY PROFILING OF PROPOLIS EXTRACTS FROM DIFFERENT GEOGRAPHIC REGIONS OF GREECE AND EVALUATION OF THEIR ANTI-OXIDANT AND ANTI-MUTAGENIC AND ANTI-AGEING PROPERTIES ON HUMAN KERATINOCYTES UNDER UVR EXPOSURE CONDITIONS
Voulgaridou Georgia-Persephoni1,2, Alexis Galanis1, Sofia Eftaxia2, Anna Gousia2, Nektarios Aligiannis3, Kostantinos Gardikis4, Panayiotidis Michalis4 and Pappa Aglaia 1*
1Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis,Greece2Department of Pathology Medical School, University of Ioannina, 45110 Ioannina3Department of Pharmacy, Division of Pharmacognosy & Natural Products Chemistry, University of Athens Athens, 157714APIVITA SA, Industrial Park, Markopoulo Mesogaias 19003, Markopoulo Attiki, Athens 5School of Life Sciences, Heriot Watt University, Edinburgh, Scotland*Correspondance: [email protected]
http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http://srilankanscientist.com/event/european-biotechnology-congress-2015/&ei=EnhbVaD-IMmnsAGIw4GYCw&bvm=bv.93564037,d.bGg&psig=AFQjCNFlxNmfPiltP0v-HpNu-7QmXZIuRg&ust=1432144267702444
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•Polyphenols (June 2015, Malta)
BeeCosmAge-Dissemination
APPLICATION OF GREEN EXTRACTION METHODOLOGIES TO DEVELOP PROPOLIS-BASED
NATURAL EXTRACTS AS POTENTIAL COSMECEUTCAL AGENTS
STAVROPOULOU M.-I. (1), STATHOPOULOU K. (1), KANAKIS H. (1), GARDIKIS K. (2), ALIGIANNIS N. (1)
(1) Department of Parmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of
Athens, Athens 15771,Greece
(2) Apivita SA Industrial Park of Markopoulo Mesogaias,19003 Markopoulo Attiki ,Athens ,Greece
Propolis is a resinous material collected by honeybees and has various biological activities (antibacterial, antiviral etc.)[1]. It contains
phenolics [2], widely recognized as strong antioxidants and suggest that propolis could be applied topically to prevent and treat skin damages [3].
Moreover, safety hazards, high cost of organic solvents and the increased concern for environmental pollution, led to green technologies and
innovative extraction procedures [4-6]. This project aims to develop high-quality cosmeceutical agents, based on Greek propolis involving
environmentally friendly techniques.
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Controlled Release Propolis
(PATENT METHOD)
PROPOLIS PATENT CONTROLLED RELEASE
Cyclodextrin propolis
Aqueous core
Propolis
Polar head
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Physicochemical and biological characterization and improvement of natural muds to produce high added-value
products
PharmaMuds
http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&uact=8&docid=QAHymLYt2wfesM&tbnid=q8buM2Pshk2hVM:&ved=0CAUQjRw&url=http://www.annalotan.com/&ei=_sCVU5WeDcitO8KvgLgD&bvm=bv.68445247,d.bGQ&psig=AFQjCNGK6OTG4apYkScVlcafNx4WTQatzQ&ust=1402409593722540
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APIVITA S.A
Participants
Participants
University of Patras (UPatras)
University of Athens(UoA)
Greece
Country
Greece
Greece
Scientific Affairs-R&D
Dept.
ChemicalEngineering
Medical School/Biological
Chemistry
Dr. Konstantinos
Gardikis
Scientist in charge
Dr. Ioannis Tsamopoulos
Dr. Paraskevi
Moutsatsou
2
1
Technion University (Tech)
IsraelChemical
EngineeringDr.
Avi Nir
Anna Lotan (AL) Israel R&DDr.
Liping Luo
3
4
5
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•Stable raw materials
PhatmaMuds-Target
•New face masks
•Proof of the efficacy of traditionally used materials
Incorporation in products 2018
Βudget: 300,000.00 euro (Greek side)
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Stabilized Messologi Mud
(PATENT FORMULATION/USE)
STABILIZED MUD PATENT
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APIVITA SCIENTIFIC SYNERGIES ECOSYSTEM
74 Universities and Research Institutes 23 countries16 million euro total budget
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Our global presenceSince 1979
Our global presence
USA
Cyprus
Japan
SpainGreece
Romania
Benelux
UK
Croatia
Ukraine
Bulgaria
14 COUNTRIES
Hong
Kong
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APIVITA Experience Store
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APIVITA Experience Store
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Athens International Airport Store
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Athens Shop in Shop
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Athens Pharmacy corner
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INNOVATION
extracton of Greek Propolis for the productonof high valued raw material with ant-oxidant and
photo-protectve and ant-aging actvityactvity. a
method with minimum energy consumpton and zerowaste
in order to increase stability, permeability and bio-availability of actve componentsGreek Royal Jelly encapsulaton in liposomes offersnew and enhanced propertes for an-tageing
SPAIN: APIVITA SPAIN S.A.
APIVITA entered the Spanish market in 2003, initially operating
through a distribution agreement
In November 2009, APIVITA established a wholly owned subsidiary
Products are currently placed in:
1 flagship store in Madrid open since March 2010
87 EI Corte Ingles department stores
870 pharmacies
5 Hotel & SPA
Key highlights
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SPAIN 1 Store 87 El Corte Ingles 870 Pharmacies
http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http://espaergasia.gr/?p=14625&ei=H6k4VbG5BMniarWFgPAL&bvm=bv.91427555,d.bGg&psig=AFQjCNG6vDF6iCAmfM8hfqheXGivLy-K3Q&ust=1429863070057548
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Madrid Flagship Store
http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http://espaergasia.gr/?p=14625&ei=H6k4VbG5BMniarWFgPAL&bvm=bv.91427555,d.bGg&psig=AFQjCNG6vDF6iCAmfM8hfqheXGivLy-K3Q&ust=1429863070057548
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El Corte Ingles, Barcelona
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INNOVATION
extracton of Greek Propolis for the productonof high valued raw material with ant-oxidant and
photo-protectve and ant-aging actvityactvity. a
method with minimum energy consumpton and zerowaste
in order to increase stability, permeability and bio-availability of actve componentsGreek Royal Jelly encapsulaton in liposomes offersnew and enhanced propertes for an-tageing
JAPAN: APIVITA JAPAN
APIVITA entered the market in 2010, initially operated through a distribution
agreement
In November 2013, APIVITA established a wholly owned subsidiary. Currently,
since 2015, in joint venture
Products are currently placed in:
10 stores in key departments stores
Key highlights
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Tokyo Flagship Store Jiyugaoka
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INNOVATION
extracton of Greek Propolis for the productonof high valued raw material with ant-oxidant and
photo-protectve and ant-aging actvityactvity. a
method with minimum energy consumpton and zerowaste
in order to increase stability, permeability and bio-availability of actve componentsGreek Royal Jelly encapsulaton in liposomes offersnew and enhanced propertes for an-tageing
HONG KONG
Apivita is the market for 10 years
Partnership with IMAGINEX, a leading
brand management and distribution
company on the luxury market
segment of the Great China region,
based in Hong Kong
11 shop in shop in key departments
stores
Raised market awareness through key
advertising campaigns
Key highlights
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NEW TOWN PLAZA Shatin
http://www.google.gr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http://espaergasia.gr/?p=14625&ei=H6k4VbG5BMniarWFgPAL&bvm=bv.91427555,d.bGg&psig=AFQjCNG6vDF6iCAmfM8hfqheXGivLy-K3Q&ust=1429863070057548
-
INNOVATION
extracton of Greek Propolis for the productonof high valued raw material with ant-oxidant and
photo-protectve and ant-aging actvityactvity. a
method with minimum energy consumpton and zerowaste
in order to increase stability, permeability and bio-availability of actve componentsGreek Royal Jelly encapsulaton in liposomes offersnew and enhanced propertes for an-tageing
Romania
APIVITA is in the market for 6 years
Partnership with SensiBlu
SensiBlu owns 80% of the pharmacy channel in Romania
Products are currently placed in:
405 pharmacies - 320 full brand
1 flagship store
2 shop in shop
Key highlights
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ROMANIA 405 Pharmacies (53 corners)
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Romania Pharmacy Corner
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ROMANIA New Store Bucharest
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INNOVATION
extracton of Greek Propolis for the productonof high valued raw material with ant-oxidant and
photo-protectve and ant-aging actvityactvity. a
method with minimum energy consumpton and zerowaste
in order to increase stability, permeability and bio-availability of actve componentsGreek Royal Jelly encapsulaton in liposomes offersnew and enhanced propertes for an-tageing
Cyprus
APIVITA is in the market for 20 years
Partnership with Drogopharma
Products are currently placed in:
250 pharmacies
1 experience store open since October 2015
Key highlights
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CYPRUS New Experience Store
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CYPRUS International Airport
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CYPRUS Pharmacy Corner
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INNOVATION
extracton of Greek Propolis for the productonof high valued raw material with ant-oxidant and
photo-protectve and ant-aging actvityactvity. a
method with minimum energy consumpton and zerowaste
in order to increase stability, permeability and bio-availability of actve componentsGreek Royal Jelly encapsulaton in liposomes offersnew and enhanced propertes for an-tageing
Benelux
Present since July 2010
Products are currently placed in:
Belgium (100+ pharmacies)
Luxembourg
The Netherlands ( 1 Apivita store open since November 2015)
Key highlights
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The NETHERLANDS New Amsterdam
Store
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BELGIUM 100 Pharmacies
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INNOVATION
extracton of Greek Propolis for the productonof high valued raw material with ant-oxidant and
photo-protectve and ant-aging actvityactvity. a
method with minimum energy consumpton and zerowaste
in order to increase stability, permeability and bio-availability of actve componentsGreek Royal Jelly encapsulaton in liposomes offersnew and enhanced propertes for an-tageing
Ukraine
APIVITA is in the market for 4 years
Partnership with Olfa
Products are currently placed in:
• 250 pharmacies
• 2 Apivita stores
Key highlights
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UKRAINE 250 Pharmacies
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INNOVATION
extracton of Greek Propolis for the productonof high valued raw material with ant-oxidant and
photo-protectve and ant-aging actvityactvity. a
method with minimum energy consumpton and zerowaste
in order to increase stability, permeability and bio-availability of actve componentsGreek Royal Jelly encapsulaton in liposomes offersnew and enhanced propertes for an-tageing
Bulgaria
APIVITA is in the market for 2 years
Partnership with A&D Pharma
Products are currently placed in:
• 60 pharmacies
• Notos Department Stores
Key highlights
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Six Senses Spa -
Elounda,
Greece
HOTEL & SPA
Six Senses Spa -
Turkey
Me by MELIÁ,
Madrid
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Thank you