fabrication of zwitterionic and ph-responsive polyacetal ... · 1 fabrication of zwitterionic and...
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Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for
anticancer drug delivery
Yaqiang Wang,‡a,b Da Huang,‡c Xing Wang,*a,b,d Hong Shen,a Fei Yanga,b and Decheng Wu*a,b
a Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of
Sciences, Beijing 100190, China. E-mail: [email protected]; [email protected]; Tel: +86 10
82611492
b University of Chinese Academy of Sciences, Beijing 100049, China
c College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, China.
d State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433,
China.
Electronic Supplementary Material (ESI) for Biomaterials Science.This journal is © The Royal Society of Chemistry 2019
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Fig. S1 1H NMR spectrum of acetal monomer (AEEEM).
Fig. S2 13C NMR spectra of G1-G3 polyacetal dendrimers.
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Fig. S3 1H NMR spectra of Gn’-DMAEA.
Fig. S4 Resistance protein absorption behavior of G3’-SB.
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Fig. S5 Comparison of the 1H NMR spectra recorded in situ for degradation of G3’-SB at pH=5.0.
Fig. S6 Comparison of the DLS profiles recorded in situ for degradation of G3’-SB at pH=5.0.
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Fig. S7 Size of G3’-SB@DOX measured by DLS.
Fig. S8 Flow cytometer analysis of G3’-SB@DOX nanoparticles incubated with HeLa cells under
(A) pH=4.0, (B) pH=6.0 and (C) pH=8.0 buffer solutions.
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Fig. S9 In vitro cytotoxicity of G3’-SB against MC3T3-E1 cells.