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Fondazione IconaI T A L I A N C O H O R T N A I V E A N T I R E T R O V I R A L S

ROMEJanuary 29-30, 2016

Auditorium Via Veneto

S C I E N T I F I CP R O G R A M M E

Face-to-FaceHIV and COINFECTIONS2nd INTERCOHORTS MEETING

Scientific Coordinators:

Andrea Antinori

Antonella d’Arminio Monforte

Antonella Castagna

Francesca Ceccherini-Silberstein

Alessandro Cozzi-Lepri

Enrico Girardi

Sergio Lo Caputo

Cristina Mussini

Massimo Puoti

Founded by Professor Mauro Moroni

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I. C O.

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Fondazione IconaI T A L I A N C O H O R T N A I V E A N T I R E T R O V I R A L S

ROMEJanuary 29-30, 2016Auditorium Via Veneto

Face-to-FaceHIV and COINFECTIONS2nd INTERCOHORTS MEETING

Founded by Professor Mauro Moroni

CME Provider and Organizing SecretariatEffetti SrlVia Gallarate, 106 - 20151 Milan, Italy Ref. Barbara BocciardiPhone +39 02 3343281 - Fax +39 02 38002105Mail: barbara.bocciardi@effetti.itwww.effetti.it - www.fondazioneicona.org

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Promoted by the ICONA Foundation Study, the Face-to-Face 2nd Intercohorts Meeting is aclosed-workshop dedicated to ICONA researches which also involve representatives of someof the major European Cohorts enrolling patients with HIV and coinfections (CRNS, France -EuroSIDA, Denmark - GeSIDA, Spain - ICONA, Italy - HepaICONA, Italy - Swiss Cohort, Swit-zerland - Piter, Italy).The aim of the workshop is pursuing new findings, analyses as well as works in progress and al-lows open discussions among European Experts on cutting-edge issues in HIV and coinfections.For this reason, the scientific program of this two-day Meeting has been structured intotwo sections:

Day one, January 29Based on four themes, interactive round tables among cohorts representatives on the followingmain topics:

Long-term outcomes in the treatment of HIV

Future settings of HIV/HCV coinfection

Long-term outcomes in the treatment of HCV

New perspectives in hepatitis B and Delta

Scientific evidence and new research project by ICONA and HepaICONA Cohort in the treatment of HIV and HIV/HCV coinfectionOfficial language of this section is English.

Day two, January 30Based on ICONA Foundation latest data and scientific projects discussion among all researchersfrom ICONA clinical sites only.Official language of this section is Italian.

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ROME January 29-30, 2016 Auditorium Via Veneto

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ADRIANA AMMASSARI IRCCS – INMI Lazzaro Spallanzani, Rome I

MASSIMO ANDREONI University of Tor Vergata, Rome I

GIOACCHINO ANGARANO University Hospital of Bari I

ANDREA ANTINORI IRCCS - INMI Lazzaro Spallanzani, Rome I

JUAN BERENGUER Gregorio Marañón University Hospital, Madrid E

RAFFAELE BRUNO University of Pavia I

STEFANIA CARRARA IRCCS – INMI Lazzaro Spallanzani, Rome I

ANTONELLA CASTAGNA San Raffaele Scientific Institute, Milan I

ROBERTO CAUDA Catholic University, Rome I

FRANCESCA CECCHERINI-SILBERSTEIN University of Tor Vergata, Rome I

ANTONIO CHIRIANNI Domenico Cotugno Hospital, Naples I

ANTONELLA CINGOLANI Catholic University, Rome I

ALESSANDRO COZZI-LEPRI Royal Free & University College Medical School - University College of London UK

ANTONELLA D’ARMINIO MONFORTE San Paolo Hospital, University of Milan I

IURI FANTI Catholic University, Rome I

GIOVANNI DI PERRI University of Turin I

GIOVANNI BATTISTA GAETA Second University of Naples I

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MASSIMO GALLI Luigi Sacco Hospital, University of Milan I

ENRICO GIRARDI IRCCS - INMI Lazzaro Spallanzani, Rome I

GIUSEPPE IPPOLITO IRCCS - INMI Lazzaro Spallanzani, Rome I

HELEN KOVARI University Hospital Zurich CH

ADRIANO LAZZARIN University Vita-Salute San Raffaele, Milan I

MIRIAM LICHTNER Sapienza University of Rome, Polo Pontino, Latina I

SERGIO LO CAPUTO University Hospital of Bari I

GIULIA MARCHETTI San Paolo Hospital, University of Milan I

SIMONE MARCOTULLIO NADIR Onlus Foundation, Rome I

CRISTINA MUSSINI University Hospital of Modena and Reggio Emilia, Modena I

CARLO FEDERICO PERNO University of Tor Vergata, Rome I

LARS PETERS University of Copenhagen DK

MASSIMO PUOTI Niguarda Ca’ Granda Hospital, Milan I

DOMINIQUE SALMON Cochin Hospital, Rene Descartes University, Paris F

ANNALISA SARACINO University Hospital of Bari I

MILENSU SHANYINDE Royal Free & University College Medical School - University College of London UK

GLORIA TALIANI Sapienza University, Rome I

ALESSANDRO TAVELLI San Paolo Hospital, University of Milan I

STEFANO VELLA Istituto Superiore di Sanità, Rome I

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ROME January 29-30, 2016 Auditorium Via Veneto

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10.00-11.15 Registration

11.15-11.30 Introduction: rationale and aims of the 2nd Icona Intercohorts Meeting A. Antinori, A. d’Arminio Monforte, M. Puoti

11.30-11.45 The role of Italian infectious diseases specialists in the International setting A. Chirianni

11.45-13.45 Interactive Round Table among European Cohorts Insights HIV/HCV coinfection: future scenarios, what Cohorts are doing, what we can do together Chairs: A. Antinori, A. d’Arminio Monforte, M. Puoti (Icona Cohort) Participants: Dominique Salmon CRNS France Lars Peters EuroSIDA Denmark Juan Berenguer GeSIDA Spain Helen Kovari Swiss Cohort Switzerland Stefano Vella Piter Italy

13.45-14.30 Lunch

FRIDAYJANUARY 29, 2016

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14.30-15.50 Meet the Experts Chairs: G. Di Perri, G. Taliani

14.30-14.50 Lecture Retention in care: role of cohort studies C. Mussini

14.50-15.10 Lecture Long term outcome in HIV treatment M. Andreoni

15.10-15.30 Lecture Long term outcome in HCV treatment

M. Puoti

15.30-15.50 Lecture New perspectives in hepatitis B and Delta treatment

G.B. Gaeta

15.50-16.10 Discussion

16.10-16.30 Coffee break

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16.30-17.20 SESSION 1 ICONA research in HIV and HIV-HCV coinfection Chairs: G. Ippolito, A. Lazzarin

16.30-16.40 Low-level viremia (LLV) ranging from 50 to 500 copies/mL is associated to an increased risk of AIDS events A. Antinori

16.40-16.50 PrecART proinflammatory milieu, microbial translocation (MT) and risk of disease progression in HIV Infected patients starting their first cART G. Marchetti

16.50-17.00 Risk and determinants of failure of a monoPI/r simplification strategy with LPV/r or DRV/r in clinical practice M. Andreoni

17.00-17.10 HIV-positive subjects treated with EVG/COBI based regimens - preliminary data A. Cozzi-Lepri

17.10-17.20 CD4 explosion after effective HAART in HIV people: the hidden meaning M. Lichtner

17.20-17.40 Discussion

FRIDAYJANUARY 29, 2016

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17.40-18.30 SESSION 2 ICONA research in HIV and HIV-HCV coinfection Chairs: G. Angarano, C.F. Perno

17.40-17.50 Survival in HIV-1 positive and HIV negative individuals with diagnosis of lymphoma A. Cingolani

17.50-18.00 Increased risk of virological failure to the first antiretroviral regimen in HIV-infected migrants compared to natives A. Saracino

18.00-18.10 Correlations of pre-ART HIV-DNA with outcome in 1st-line treated ART patients F. Ceccherini-Silberstein

18.10-18.20 Determinants and impact of late HCV diagnosis among persons with newly diagnosed HIV infection M. Shanyinde

18.20-18.30 Challenges of anti HCV treatment in persons living with HIV in the era of Directly Acting Antivirals (DAA) M. Puoti

18.30-18.50 Discussion

18.50-19.00 Final conclusions A. Antinori, A. d’Arminio Monforte, M. Puoti

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SATURDAYJANUARY 30, 2016

SESSIONE 3Moderatori: R. Bruno, R. Cauda, M. Galli

09.00-09.20 Il valore di ICONA nello scenario internazionale A. Castagna

09.20-10.20 Presentazione del report ICONA ed HepaICONA ICONA S. Lo Caputo

HepaICONA A. Ammassari

10.20-11.20 Questionario ICONA-PRO A. Cingolani, E. Girardi, S. Marcotullio

11.20-11.50 Coffee break

11.50-13.30 Spazio di discussione con i Centri Conducono: S. Carrara, I. Fanti, A. Tavelli

13.30-13.45 Considerazioni conclusive e chiusura dei lavori A. Antinori, A. d’Arminio Monforte, M. Puoti

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January 29-30, 2016

VenueAuditorium Via VenetoVia Veneto, 89 - 00187 Rome Iwww.auditoriumviaveneto.it

Crediti ECM La Commissione Nazionale per la Formazione Continua in Medicina ha assegnato n. 11 creditiformativi al Meeting (N. ECM 150-143229), per Biologi, Farmacisti ospedalieri e territorialie Medici Specialisti in Malattie Infettive, Microbiologia e Virologia, Igiene, Epidemiologia e Sa-nità Pubblica, Allergologia e Immunologia Clinica, Medicina Interna e Gastroenterologia. L’as-segnazione dei crediti formativi è subordinata alla presenza al 100% dei lavori e alla correttacompilazione di almeno il 75% delle domande proposte all’interno del questionario di valuta-zione finale. È inoltre obbligatoria la rilevazione delle presenze e la compilazione del questio-nario di valutazione e di gradimento dell’evento formativo.

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Fondazione IconaI T A L I A N C O H O R T N A I V E A N T I R E T R O V I R A L S

Founded by Professor Mauro Moroni

Board of DirectorsA. d’Arminio Monforte (Vice-President), M. Andreoni, G. Angarano, A. Antinori, F. Castelli, R. Cauda,G. Di Perri, M. Galli, R. Iardino, G. Ippolito, A. Lazzarin, C.F. Perno, F. von Schlösser, P. Viale

Presidential Commitee A. Antinori, A. d’Arminio Monforte, G. Ippolito, A. Lazzarin, C.F. Perno

Scientific SecretaryA. d’Arminio Monforte, A. Antinori, A. Castagna, F. Ceccherini-Silberstein, A. Cozzi-Lepri, E. Girardi,S. Lo Caputo, C. Mussini, M. Puoti

Steering Committee A. Ammassari, M. Andreoni, A. Antinori, C. Balotta, A. Bandera, P. Bonfanti, S. Bonora, M. Borderi,A. Calcagno, L. Calza, M.R. Capobianchi, A. Castagna, F. Ceccherini-Silberstein, A. Cingolani, P. Cinque, A. Cozzi-Lepri, A. d’Arminio Monforte, A. De Luca, A. Di Biagio, N. Gianotti, E. Girardi, A. Gori, G. Guaraldi, G. Lapadula, M. Lichtner, S. Lo Caputo, G. Madeddu, F. Maggiolo, G. Marchetti,S. Marcotullio, L. Monno, C. Mussini, S. Nozza, M. Puoti, E. Quiros Roldan, R. Rossotti, S. Rusconi,M. Santoro, A. Saracino, M. Zaccarelli

Statistical and Monitoring TeamA. Cozzi-Lepri, I. Fanti, L. Galli, P. Lorenzini, A. Rodano, M. Shanyinde, A. Tavelli

Biological Bank INMI F. Carletti, S. Carrara, A. Castrogiovanni, A. Di Caro, F. Petrone, G. Prota, S. Quartui

ICONA FOUNDATIONSTUDY GROUP

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