Department of Veterinary Pharmacology and Toxicology

History

Dr. P. R. More Dr. A. P. Somkuwar Dr. S. B. Shendre Professor & Head Associate Professor Assistant Professor2006-2012 2006-2008 2008 - Feb. 2015

Facilities available: Small animal laboratory facility

Faculty

1. Name of faculty member: Dr. B. C. GhumareDesignation:Assistant Professor Qualification:M. V. Sc (Veterinary Pharmacology & Toxicology)Email ; bcghumare@gmail.comPhone : NilMobile : 094984681, 7709511741

Research area of Interest: Medicinal plants of Western Maharashtra

Publications:

1. Research paper :08

1. “Efficacy of picroriza kurrooa benth in experimentally induced Hepato-toxicity in cross bred calves” published in Veterinary world Vol-3, Jan.-2010. 2. “Advances in Laboratory animal experiments”

3.” Registration with CPCSEA, Role & selection of CPCSEA Nominee.” 4.”Emergence of antibiotic resistance”. Article No.2,3 & 4 Published in Compendium of winter school on,”Application of Advanced technologies in Veterinary Science.” Organized by KNPVC, Shirwal between 30th Nov. to 20th Dec. 2009. 5.” Effect of Hygrophila schuli on the growth and development of testes in Wistar rats”. Published in Aryavaidyan Vol.XXIV.,No.3, April-2011Pages-139-144. 6.”Qualitative test for Diagonosis of poisons in Livestock” Published in training compendium of,” Recent advances in animals & avian diseases & disease Diagnostic Technique”, held between 10th -17th Oct.2011 at KNPVC, Shirwal. 7.” Acaricidal effect of herbal spray formulation of Tobacco Extract& Eucalyptus oil combination in HF cross bred Cattle”, published in Animal Science Journal issue Jan.2012 page No.31. 8.” Protective effect of Carica Papaya L. seed extract on Gentamicin induced”, published in International Journal of Pharma and Biosciences2012July,3(3)508-5015.

2. Popular Articles :553. Books (Marathi) :14. Radio Talks :125. TV Shows : Nil6.Delivered lectures toFarmers training : 257.Participated in exhibition as a animal judging committee member: 038.Delivered lectures to farmers training: 259. Conference attended : 0510. Training/ workshops attended: 05 trainings and 03 workshops11.Working as Member on IAEC of various institutes.12. Publication of Extension leaflets : 05

No.OfstudentGuided(MV. Sc):02

Contact Information

 Office: Department of Veterinary Pharmacology & ToxicologyKNP College of Veterinary Science,

Shirwal, Dist- Satara. 412 801                                                            Phone: ---                                                           Mobile: 7709511741, 9421984681

2. Name of faculty member: Dr. Sonal A. DubeyDesignation: Assistant Professor Qualification: M. V. Sc (Veterinary Pharmacology & Toxicology) and qualified ICAR –

ASRBNET in the year 2011.

Email : drsonal0409@yahoo.co.in Mobile : 8888820838

Research area of Interest: Indigenous medicinal plants in animal healthcare

Achievements

1. Smt. Vasantha Ranganathan Memorial award (Young scientist) for best paper presentation in

XIV Annual Conference of Indian Association of Women Veterinarians (IAWV) and National

Seminar on Recent advances in Veterinary and animalsciences and role of women veterinarian in

2015.

2. Jawaharlal Nehru Krishi Vishwa Vidyalaya Gold Medal in M.V.Sc. & A.H in 2012.

3. A.M Shrivastava Gold Medal in M.V.Sc & A.H by J.V.C Alumni Association, Jabalpur in

2010.

4. Jawaharlal Nehru Krishi Vishwa Vidyalaya Gold Medal in B.V.Sc. & A.H in 2009.

5. Dr. Chelva Ayengar Gold Medal in Anatomy, Dr. M.Y Magrulkar Gold Medal in Pathology,

Bacteriology & Parasitology, Dr. M.L Mehta Gold Medal in Medicine and Dr. V.N Shukla

Gold Medal in Microbiology by J.V.C Alumni Association, Jabalpur in 2008.

Publications:

1. Research paper :03

1. Effect of WithaniaSomnifera on Egg Cholesterol & Production traits in Birds in Journal of veterinary pharmacology & Toxicology in year 2010. 2. Efficiency of Indigenous Herbs withania somnifera and Emblica officinalis on egg Yolk Cholesterol in Birds in Journal of veterinary pharmacology & Toxicology in year

2014. 3. Effect of Emblicaofficinalis on Egg Cholesterol & Production performance traits in Birds in Journal of veterinary pharmacology & Toxicology in year 2014.

2. Popular Articles : 08

1. Satark Rahein Swan ke Palak in Navbharat, Nagpur. 2. Pashuo par antibiotic davaon ka vipirit parinam in National Sandesh, Nagpur. 3. Rabies ke vahak sirf swan hi nahi in National Sandesh, Nagpur. 4. Saugad sabit hogi desh ke liye Nanotechnology in National Sandesh, Nagpur. 5. Pashuo ke saath hi insano ke liye bhi khatarnak hain Brucellosis in Vidharbh ki Baat, Nagpur. 6. Pashuo dwara insano mein phail sakti hain T.B in Yugdharma, Nagpur. 7. Umar batatein hai pashuo ke data in National Sandesh, Nagpur. 8. Bhed bakariyo ke liye pranghatak hai PPR in National Sandesh, Nagpur.

3. Radio Talks : 04

1. Gau Pashume Tika Karan in Gyanvani Station, Nagpur 2. Rabies Sambandhi Batein in Gyanvani Station, Nagpur 3. Swan Sambandhi Samasya in Gyanvani Station, Nagpur 4. Swan Sambandhi Samasya in Gyanvani Station, Nagpur

Contact Information

 Office: Department of Veterinary Pharmacology & Toxicology, KNP College of Veterinary Science,

Shirwal, Dist- Satara. 412 801                                                    Mobile: 8888820838

1. COURSES OFFERED A. FOR B. V. Sc. & A.H. DEGREE

Course No. &

Course title

Credit Hrs

Syllabus (please provide the teaching schedule)

VPT-311

General and Systemic Pharmacology

2+1=3THEORY SCHEDULE (New syllabus) Course No. VPT-311 Course Title: General and Systemic Pharmacology, Semester: Vth

Sr.no

Name of Topic

01 Historical development, branches and scope of pharmacology02 Pharmacological terms and definitions 03 Sources and nature of drugs 04 Principle of drug action (drug action effect sequence)05 Pharmacokinetics- definitions and scope06 Route of administration , absorption, distribution, 07 metabolism and excretion of drugs08 Biotransformation of drugs 09 Pharmacodynamics, concept of drug and re receptor,

types of receptor dose response relationship10 Terms related to drug activity (agonist & antagonist)11 Factors modifying drug effect and dose12 Drug assay and drug screening 13 Drug interaction, ADR (adverse drug reaction)14 Designing and development of drug, bio-prospecting of drug15 Interaction to biopharmaceuticals and gene therapy16 Drug acting on digestive system- stomachic, antacids, antiulcer, prokinetics,

carminatives Antizymotics, Emetics, antiemetic, purgatives, antidiarrhoeal, Cholaretics and choleragogues.

17 Rumen pharmacology 18 Drugs acting on Cardiovascular System- cardiac glycosides – source,

uses, toxicity, and digitalization19 Antiarrhythmic drugs – quinidine, Procainamide , calcium channel blockers20 Vasodilator and antihypertensive drugs 21 Coagulants and anticoagulants – local and systemic & hematinics 22 Drugs acting on respiratory systems- expectorants, Antitussive,

respiratory stimulant , bronchodilators and mucolytics23 Drugs acting on uro-genital system- diuretics and its classification, & mechanism

of action.24 Urinary alkalizers, urinary acidifiers.25 Fluid therapy, ecbolics and tocolytics 26 Pharmacotherapeutics of hormones 27 Estrogen, progesterone, FSH, LH and testosterone etc.28 Pharmacotherapeutics of vitamins 29 Drugs acting on skin and mucus membrane, emollients, demulcents and

counter irritants 30 Bioenhancers

VPT-321Veterinary Neuropharmacology

2+1=3

31 Immunostimulant and immunosuppressant 32 New drugs and drug formulations

PRACTICAL SCHEDULE (New syllabus) Course No. VPT-311 Course Title: General & Systemic Pharmacology

Sr.No.

Name of Topic

01 Introduction of Pharmacy, pharmacy appliances 02 Principles of compounding and dispensing.03 Metrology – systems of weights and measures and weighing of drugs 04 Pharmacy calculations 05 Pharmaceutical processes.06 Pharmaceutical dosage forms 07 Prescription writing. 08 Pharmaceutical incompatibilities 09 Drug standards and drug regulations 10 Custody of poisons 11 Compounding and dispensing of powders and mixtures 12 Compounding and dispensing of ointments, liniments and lotions 13 Compounding and dispensing of liquors and tinctures 14 Compounding and dispensing of emulsions and electuaries.15 Drug reading.

THEORY SCHEDULE (New syllabus) Course No. VPT-321 Course Title: Veterinary Neuropharmacology Semester: VIth

Sr.No. Name of Topic01 Introduction to Autonomic Nervous System- functions, autonomic

relationship and central integration 02 Neurohumoral transmission03 Adrenoreceptors – agonist and antagonist 04 Adrenergic neuron blockers 05 cholinoreceptors – agonist and antagonist06 Ganglionic stimulants and Ganglionic blockers07 Autocoids I – histamine and antihistamine agents.08 Autocoids II – 5 Hydroxytryptamine and its antagonists 09 Autocoids III – prostaglandins angiotensins and bradykinins 10 Drugs acting on Central nervous system- introduction & classification 11 Neurotransmitter pharmacology12 General anesthesia – history, theories and its classification13 Inhalant anesthesia I– Ether, Halothane, nitrous oxide.14 Inhalant anesthesia II- Enflurane, isoflurane, methoxyflurane,

cyclopropane.15 Intravenous anesthesia – Barbiturates and its classification.16 Barbiturates- pharmacological actions and uses.17 Dissociative anesthetics – Ketamine hydrochloride, Phencyclidine

hydrochloride etc.

18 Hypnotics and sedatives19 Tranquilizers and psychotropic drugs – classifications & mechanism20 Anticonvulsants – phenobarbitone sodium, phenytion sodium and

primidone. 21 Analgesics – Opioid analgesics, morphine & derivatives.22 Nonnarcotics analgesics – salicylates, paraminophenol derivatives,

pyrazolon derivatives and others.23 Non steroidal anti-inflammatory drugs (NSAID), COX-I, COX-II

inhibitors. 24 Analeptics. 25 CNS stimulants. 26 Central muscle relaxants. 27 Drugs acting on Somatic nervous system.28 Local anesthetics.29 Peripheral muscle relaxants 30 New drugs and drug formulations.

PRACTICAL SCHEDULE (New syllabus) Course No. VPT-321 Course Title: Veterinary Neuropharmacology

Sr.No. Name of Topic

01 Introductions to the instruments used for Experimental pharmacological experiments.

02 Demonstration of adrenergic activity on isolated heart.03 Demonstration of cholinergic drugs on isolated intestine.04 Demonstration of anti-cholinergic drugs on. isolated intestine05 Demonstration of adrenergic/ cholinergic activity on rabbit eye.06 .Demonstration of adrenergic/ anti-adrenergic activity on dog blood

pressureDemonstration of cholinergic/ anti-cholinergic activity on dog blood pressure

07 Demonstration of CNS depressants activity in laboratory animals.08 Demonstration of CNS stimulant activity in laboratory animals.09 Demonstration of analgesia in laboratory animals.10 Demonstration of anticonvulsant activity in laboratory animals.11 Demonstration of muscle relaxant activity in laboratory animals.12 Demonstration of local anesthetics effect.13 Alternate use of animals a model of demonstration.14 Drug reading.

VPT-411

Chemotherapy

2+0=2THEORY SCHEDULE (NEW SYLLABUS)Course No. VPT-411 Course Title: Chemotherapy Semester: VII

Sr. No. Name of Topic01 Distribution of Lecture schedule, Brief orientation of the course,

Definitions of Antibiotic, antibacterial agents, MIC, MBC, etc.02 Classification of antibiotics, Mechanism of action of antibiotics and

antibacterial.

VPT-421Toxicology

2+0=2

03 General principles of Chemotherapy, factors affecting action of antibiotics.04 Resistance to antibiotics and methods to overcome it , Antibiotics

combinations.05 Penicillin, penicillin-G, procaine penicillin.06 Semi synthetic penicillin, Beta lactum inhibitors, combinations of penicillin07 Cephalosporin and its classifications.08 Tetracycline and its classification 09 Amino glycoside and its classification.10 Lincosamides and macrolide antibiotics.11 Quinolones and classification.12 Chloramphenicol miscellaneous antibiotics.13 Miscellaneous antibiotics.14 Sulfonamides and potentiated sulfonamides.15 Antiseptic and disinfectants.16 Antiseptic and disinfectants and Nitro furans.17 Antifungal agents.18 Antifungal agents.19 Anticancer drugs.20 Antiviral drugs. 21 Antihelmentics: Introduction, classification, ideal Antihelmentics and

resistance. 22 Mechanism of action of Antihelmentics and antinematodal drugs.23 Antinematodal drugs: Imidathiazoles, tetrahydropyrimidines.24 Antinematodal drugs: Avermectins and other miscellaneous drugs.25 Anticestodal and antitrematodal drugs. 26 Antiprotozoan drugs: for trypanosomiasis, theileriosis, Babesiosis.27 Antiprotozoan drugs: amoebiosis, giardiasis, trichomoniasis.28 Anticoccidial drugs.29 Antimalarial drugs and antitubuler drugs.30 Insulin and hypoglycemic drugs.31 Corticosteroids and anabolic drugs.32 Oxytocics and tocolytics and galatogogues.33 Indigenous herbal drugs.

LECTURE SCHEDULE (NEW SYLLABUS)Course No. VPT-421 Course Title: Toxicology Semester: VII

Sr.No. Name of Topic

01 Introduction to Toxicology, Scope and Definitions.02 Sources of poisoning and Classification of poisons.03 Toxicokinetics of poisons in general, mode of actions of poisons. 04 Types of poisoning, special toxicity tests.05 General principles of diagnosis and treatment of poisonings.06 Factors modifying toxic responses.07 Study of Lead poisoning.08 Study of Mercury poisoning09 Study of Copper poisoning10 Study of Arsenic poisoning11 Study of Fluorine poisoning

12 Study of Selenium poisoning and selenium accumulating plants.13 Study of Nitrate and Nitrite Poisoning. 14 Study of Salt toxicity.15 Study of Cyanide toxicity. 16 Study of different plant poisonings- Abrus, Nerium, Castor, 17 Study of different plant poisonings- Lantana, Datura, Ipomoea 18 Study of different plant poisonings- Calotropis, Nuxvomica 19 Study of plants causing special toxic effects.20 Oxalate containing plants and their toxic effect Photosensitization. 21 Study of different mycotoxins- ergot, aflatoxins etc.22 Study of different bacterial toxins- Botulinum, Tetanus etc.23 Agrochemical toxicity-Organophosphates24 Agrochemical toxicity-Organochlorines25 Agrochemical toxicity- Carbamates and Pyrethroids.26 Rodenticide toxicity.27 Toxicity of Herbicides.28 Study of different venoms and their toxic effects- snake, scorpion, toads,

wasp etc.29 Environmental toxicity- air pollution, water pollution etc.30 Radiation Hazards.31 Study of different drug toxicities.32 Toxicity of feed additives and food preservatives.

A. FOR M. V. SC DEGREE.

Course No. &Course title

Credit Hrs.

Syllabus (please provide the teaching schedule)

VPT-601General Pharmacology

2+0=2

Theory Schedule

VPT- 602Autonomic and Autocoid Pharmacology

2+1=3

Theory Schedule

Practical Schedule: VPT- 602, Autonomic and Autocoid Pharmacology

VPT-603CNS Pharmacology

2+1=3 Theory Schedule

Practical Schedule: VPT- 603, CNS Pharmacology

VPT-604Digestive and Respiratory Pharmacology

2+0=2Theory Schedule

VPT-605Cardiovascular and Renal Pharmacology

2+0=2

Theory Schedule

VPT-606Endocrine and Reproductive Pharmacology

2+0=2Theory Schedule

VPT-607Chemotherapy

2+1=3Theory Schedule

Practical Schedule: VPT- 607, Chemotherapy

\

VPT-608Toxicology of Xenobiotics

2+1=3Theory Schedule

Practical Schedule: VPT- 608, Toxicology of xenobiotics

VPT-609Toxicology of Plants and Toxins

2+0=2Theory Schedule

VPT-610Pharmacological Techniques

1+1=2Theory Schedule

Practical Schedule: VPT- 610, Pharmacological techniques

VPT-611Techniques in Toxicology

1+1=2Theory Schedule

VPT-612Ethnopharmacology

2+0=2

Theory Schedule

VPT-691Master seminar

VPT-699Master Research

0+1=1

20

Research Conducted by Department of Veterinary Pharmacology & Toxicology, from commencement of the PG program and schemes.

M.V.Sc. Thesis Sr. No.

Title of the thesis Name of the student

Name of the Guide/Advisor

Year of submission

Silent conclusions

1.

2.

3.

Studies on effect of seed extract of Carica papaya Linn. On Gentamicin induced nephrotoxicity in Wistar rats

Studies on effect of Pedalium murex Linn. On Cisplatin induced nephrotoxicity in Wistar rats

Studies on effect Of Zingiber Officinale Rosc on Gentamicin induced nephrotoxicity in Wistar rats

Nale Lalita Prabhakar

Tambade Santosh Arun

Shejal Mahesh Ambadas

Dr. P. R. More

Dr. S. B. Shendre

Dr. B.C.Ghumare

2011

2012

2014

Both preventive and curative doses of Carica papaya Linn seed extract had nephroprotective effect in Wistar rats

Both preventive and curative doses of Pedalium murex Linn. fruit extract had nephroprotective effect in Wistar rats

Preventive dose of alcoholic Zingiber Officinale Roscrhizome extract provided more pronounced protective effect than curative dose of rhizome extract.

4.

5.

Study of some plant extract against Gram positive and Gram negative Bacteria

Anti-diabetic effect of methanol extract of Cassia Auriculata on experimental Diabetes in Wistar rats

Nimbore Shubhangi Shahaji

Patil Vishal Bharat

Dr. S. B. Shendre

Dr. B.C.Ghumare

2014

2014

Based on In-vitro and In-vivo assay findings aqueous and ethanolic leaves extract of Murraya koenigii and Hibiscus rosa sinensis Linn showed antibacterial effect against E. coli and Staph. aureus.

Methanolic extract of C. auriculata bark showed significant hypoglycemic effect with improvement against Alloxan induced diabetes.