FAKTOR VIRULENSI

Aggregatibacter actinomycetem-comitansPorphyromonas gingivalisTannerella forsythia

Treponema denticola

Fusobacterium nucleatum

Prevotella intermedia

Campylobacter rectus

PerlekatanAdhesin, OPM 100,Adhesin, koagregasiSurface layerProtein Lrra (koagregasi)Surface layer, koaggregasi-Surface layer, Flagellum

InvasiPenetrasi ke epitel gingiva, fimbriae,OPM 100Hemaglutinin,fimbriae, Penetrasi ke epitel gingiva, HagASurface layer, LRR-Surface layerFimbriaeSurface layer

Merusak jaringan hostLPS, cdt, OMP-1, GroEL (Hsp 60),Kolagenase, Gingipain, LPS, HagB, GroEL (Hsp60),Dpp, Protein sistein.LPS, enzim tripsin like proteases,lipoprotein, glikosidaseEnzim proteolysis (prolyl-fenilalanin), LPSDNase ( deoxyribonuclease), LPSLPS dan enzim proteaseGroEL (Hsp60)

Pertahanan diriLeukotoksin, inhibitor kemotaksis, cdt,

Fc-binding ptotein, resisten terhadap antibiotik, surface protein, GroEL (Hsp 60),Asam suksinat, Kapsul,Membran protein luar,, hemoglobin-binding domain,GroEL (Hsp 60), ---Kapsul GroEL (Hsp60)

Menghambat perbaikan jaringanInhibitor proliferasi fibroblas dan pembentukan tulang---Asam butirat, asam propionat dan ion amonium--