“

Meet New Faculty: Drs. de Alba and Kersten

spots in the visual field. Althoughtreatment can delay or even preventdeterioration of the sight, uveitisoften leads to cataracts, retinalscarring, macular edema, orglaucoma. For some lucky patients,prompt short-term treatment calmsthe inflammation and symptoms donot return. Many, however, mustlearn to live with a chronic condition

that has no easy answers.

Uveitis Team a Regional ResourceOphthalmologists as far north as Oregon

and as far south as San Luis Obisporely on UCSF vision scientists todiagnose and treat the disorder. With

numerous possible causes, complicationsaffecting almost every part of the eye, and a lack of benign therapeutics, uveitis

requires excellence and teamwork. More

It was the most beautifulsurgery,” says George Marian,

a 51-year old patient fromPhoenix who recently underwentan artificial corneal transplant byspecialist Bennie Jeng, MD,co-director of the UCSF Cornea

Fall Annual Report 2009Koret Vision Institute + Beckman Vision Center + Department of Ophthalmology + Francis I. Proctor Foundation

Continued on page 7

new sign at the entrance to UCSF’s Francis I. ProctorFoundation for Research in Ophthalmology reads Join Today. UveitisSupport Group. And join they do. A first meeting in April connectedmore than 60 UCSF patients and family members. This uveitis supportgroup – one of only a handful in the world – was organized byNisha Acharya, MD, head of the Uveitis Service at the ProctorFoundation, and Allison Loh, a visiting fellow.

Uveitis accounts for around 10 percent of the blindness in the UnitedStates and affects all age groups. Symptoms of this inflammation of theuvea (the layer of the eye just beneath the white sclera, plus the iris)can include redness, sensitivity to light, blurred vision, pain, or dark

TMMS Annual Report:Marilyn Pratt Reports to Readers

Service. “Every day when I wakeup and look around, I am happy.”

“When the nurse took off thebandage, it was such a shock –so emotional.” Not only couldthe patient see the people

A P E E K I N S I D E :

A

University of California, San Francisco + That Man May See

Envision the FutureReversing Blindness withan Artificial Cornea

Continued on page 7

29Dr. Erik Ullian – New Innovator Award

9Recent Gifts Fund Vision Research

Meet Our New Residents

Focal Point

Dear Friends,

Our theme in this issue is makingconnections. Innovative research and our vibrant community atUCSF thrive on collaboration andconnections – among researchersapproaching common problems fromdifferent perspectives; among ourclinical and research staff; amongtrainees, students, and faculty; andamong our donors.

We are pleased to feature the ProctorFoundation’s new networkingeffort, a supportive group of patientsbeing treated for a variety ofcomplex inflammatory eye diseases.

UCSF’s Ophthalmology facultyremains on the cutting edge of new technology, and we featureDr. Bennie Jeng’s pioneering artificialcornea surgery that brought sight toa man who shares his experiencewith us.

We extend a warm welcome to newfaculty members, Dr. Alejandra deAlba Campomanes in pediatricophthalmology and strabismus andDr. Robert Kersten in ophthalmicplastic and reconstructive surgery.Also, we welcome five new energeticand talented residents to our program.

Thank you for your generousconnections to us. With your help, wewill discover better ways to reduce theburden of blindness and continue oursearch for cures that transform lives.

Sincerely,

Stephen D. McLeod, MDTheresa M. and Wayne M. Caygill, MD, Endowed Chair Professor and Chairman

3thank you

10

Ophthalmology Insight

Community of Support for UveitisUCSF provides a critical resource for uveitis patients.

2 Fall 2009

UCSF Ophthalmology Welcomes New Faculty

That Man May See is a 501(c)3 public

charity. Its mission is to raise funds for the

dedicated faculty of UCSF Ophthalmology

to make possible breakthroughs in vision

research, state-of-the-art patient care, and

educational opportunities for residents

and fellows.

To make a gift of cash or securities,

go to www.ucsfeye.net/tmms/shtml

or contact Danielle Pickett at 415.476.4016

or pickettd@vision.ucsf.edu.

Checks are payable to That Man May See.

That Man May See

10 Koret Way, Box 0352

San Francisco, CA 94143-0352

tmms@vision.ucsf.edu

VISIONS is a publication of the

Department of Ophthalmology

at UCSF and is produced by

That Man May See.

Editorial Board

Hilary E. Beggs, PhD

Robert B. Bhisitkul, MD, PhD

Jacque L. Duncan, MD

Todd P. Margolis, MD, PhD

Copy

Becky Jennings

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Managing Editor

Becky Jennings

Editorial Assistant

Danielle Pickett

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Photography

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Chris Anderson

Printing

Sungold Litho

Bruce Mayfield

For a free subscription to

VISIONS Newsletter, please

call 415.476.4016.

To receive or cancel further fundraising

communications from the Department of

Ophthalmology or That Man May See,

please contact:

Records Manager

Department of Ophthalmology, UCSF

Box 0248

San Francisco, CA 94143-0248

Dr. Alejandra de Alba CampomanesPediatric Ophthalmology

Dr. Robert C. KerstenOphthalmic Plastic, Reconstructive, and Orbital Surgery

Alejandra de Alba Campomanes,MD, an energetic young doctor, views her appointment asAssistant Professor of PediatricOphthalmology and Strabismusas an opportunity to improvepatients’ lives, train residents,and bring more young doctorsinto pediatric ophthalmology.

“Dr. de Alba is one of the most promising pediatricophthalmologists of hergeneration and has anencyclopedic knowledge of thefield,” says Department ChairStephen McLeod, MD. “Shebrings one of the most creativeminds to the problems ofchildhood blindness.” She joinsTina Rutar, MD, JonathanHorton, MD, PhD, and JoanO’Brien, MD, at UCSF’s newVisual Center for the Child andwill also serve at San FranciscoGeneral Hospital (SFGH).

Serving a Diverse PopulationWith a background in publichealth, Dr. de Alba is well suitedto her new role as Director ofPediatric Ophthalmology andStrabismus at SFGH. “The needfor services is enormous – thecity has a big and very diversepediatric population.” Becausestrabismus – a disorder of theeye muscles that results in aninability to align both eyes –generally shows up in childhood,Dr. de Alba guides residentsthrough its mysteries duringtheir pediatric rotation. As clinic director, she also wants tomake Pediatric Ophthalmology

and Strabismus even moreresponsive to patient needs.

Commitment to StrabismusDr. de Alba's interest in strabismusbegan at home. Her mother is a strabismus specialist at theUniversidad Nacional Autónomain Mexico City, where UCSF’s Dr. de Alba was namedvaledictorian and graduatedfirst in her class. During Dr. deAlba’s UCSF residency, she becameas intrigued by strabismusresearch as she was by treatment.She credits Creig Hoyt, MD,and Dr. Horton for their“outstanding mentorship.”

Research and AspirationsDr. de Alba also plans research onthe retinopathy of prematurity, a disease in which prematureinfants’ developing retinas are compromised by abnormalblood vessel growth. She gainedexpertise on this disease duringher fellowship at the University ofPennsylvania Children’s Hospitalof Philadelphia. Additionalprojects will aim to improveaccess and delivery of vision care for minority populations. •

Robert C. Kersten, MD, FACS, anophthalmic plastic surgeon withan international reputation andmore than 20 years of practice tohis credit, has been appointedProfessor of Ophthalmic Plasticand Reconstructive Surgery. Dr.Kersten is recognized as one ofthe “Best Doctors in America”based on national surveys, hasbeen chosen “Teacher of theYear” three times, and was aHeed Fellow at the University of Iowa. The American Academyof Ophthalmology awarded himits prestigious Senior HonorAward, and he served as editorof that Academy’s textbook on ophthalmic plastic surgery,the world’s best-sellingoculoplastics textbook.

During a two-year academichiatus, Dr. Kersten practiced at a cosmetic services firm inDenver and pursued anotherpassion – performing vision-saving surgeries in developingcountries. Life was good, but hemissed being at the heart of anacademic community – theexcitement and stimulation ofcolleagues, residents, and

fellows. “Teaching is a majorreason I am returning to theuniversity,” says Dr. Kersten. “I like to use my cases to trainup-and-coming specialists.”

Expanding UCSF OculoplasticsUCSF’s Timothy McCulley, MD,Director of Oculoplastic,Reconstructive, and OrbitalSurgery, is one of Dr. Kersten’sformer fellows, and the two areforming an expanded plasticsand reconstructive surgery servicewithin the OphthalmologyDepartment. Dr. Kersten’sexperience with private cosmeticpractice reaffirmed his interestin providing a wide range ofeyelid and facial cosmetictreatments including facialrejuvenation procedures such as Botox injections, injectablefillers, facial peels, laserresurfacing, and cosmetic eyelidand facial surgery. Both he andDr. McCulley perform surgeriesthat range from cosmetic workto removal of orbital tumorsand reconstruction of congenitalabnormalities.

“Dr. Kersten’s stellar reputationfor oculoplastic surgery andclinical research, along with hisexperience in mentoring youngdoctors, increases our ability toprovide world-class treatmentand training in this area,” saysDepartment Chair StephenMcLeod, MD. “We are lucky to get him.” •

She brings one of the mostcreative minds to the problems of

childhood blindness.”

– Dr. Stephen McLeod

Teaching is a major reason I am returning

to the university.”

– Dr. Robert C. Kersten

3Fall 2009

A N N U A L R E P O R T

Dear Friends of That Man May See,

Stephen D. McLeod, MDProfessor and Chair, Department of Ophthalmology

Todd Margolis, MD, PhDProfessor and Director, Francis I. Proctor Foundation for Research in Ophthalmology

Clinical/Research Faculty Richard Abbott, MDCornea and External Disease

Nisha Acharya, MD, MSUveitis (Director)

Jorge Alvarado, MDGlaucoma

Robert Bhisitkul, MD, PhDVitreoretinal Surgery

Michele Bloomer, MDComprehensive Ophthalmology and Pathology

Matilda Chan, MD, PhDCornea and External Disease

Cynthia Chiu, MDComprehensive Ophthalmology (Director)

Brooks Crawford, MDPathology (Director)

Alejandra de Alba Campomanes, MD, MPHPediatric Ophthalmology

Eugene de Juan, Jr., MDVitreoretinal Surgery

Jacque Duncan, MDMedical Retina, Electrophysiology, and Imaging

Allan Flach, MDComprehensive Ophthalmology

Jonathan Horton, MD, PhDNeuro-ophthalmology (Director) and Pediatric Ophthalmology

William Hoyt, MDNeuro-ophthalmology

David Hwang, MDCornea and External Disease (Co-Director), and Refractive Surgery (Director)

Bennie Jeng, MD Cornea and External Disease (Co-Director)

Jeremy Keenan, MDCornea and External Disease

Robert Kersten, MDOculoplastic, Reconstructive and Orbital Surgery

Thomas Lietman, MDCornea and External Disease

Shan Lin, MDGlaucoma

Timothy McCulley, MDOculoplastic, Reconstructive and Orbital Surgery(Director), and Neuro-ophthalmology

Stephen McLeod, MDCornea, External Disease, and Refractive Surgery

Ayman Naseri, MD Cataract, Cornea and External Disease

Joan O’Brien, MDOcular Oncology (Director)

Tina Rutar, MDPediatric Ophthalmology

Daniel Schwartz, MDVitreoretinal Surgery (Director)

Stuart Seiff, MDOculoplastic, Reconstructive and Orbital Surgery

Robert Stamper, MDGlaucoma (Director)

Jay Stewart, MDVitreoretinal Surgery

Ira Wong, MDUveitis

Research Science FacultyDavid Copenhagen, PhD (Vice Chair)Hilary Beggs, PhDDouglas Gould, PhDJeanette Hyer, PhDJennifer LaVail, PhDMatthew LaVail, PhDJulie Schnapf, PhDDavid Sretavan, MD, PhDErik Ullian, PhD

Faculty Emeriti and RecallStuart Seiff, MD

Faculty EmeritiChandler Dawson, MDCreig Hoyt, MDAlexander Irvine, MDJames O’Donnell, MDJohn Stanley, MDJohn Whitcher, MD, MPH

UCSF Vision Sciences Faculty

This annual report for That Man May See for fiscal year 2008-2009 comes to you with gratitude from our Board of Directors.Your connection with us is truly important. I especially want to thank you for generously funding leading-edge vision researchat the University of California, San Francisco (UCSF). Your gifts provide hope for so many who suffer from the most complexconditions of the eye.

This was a year of cautious spending and careful management of resources. Both the board and staff of That Man May See leverage your investments to attract even more funding to make a greater difference. Our gifts are a part of theover $50 million at work in the laboratories at UCSF Department of Ophthalmology and the Francis I. Proctor Foundation forResearch in Ophthalmology. We are grateful that every one of our laboratories is productive, working toward breakthroughsin the treatment of age-related macular degeneration (AMD), glaucoma, infectious and inflammatory diseases of the eye,childhood blindness and vision loss, and the epidemics of eye disease in the developing world.

We hope you will enjoy reading about our progress again this year. Your continued commitment and willingness to introduceothers to our mission help us succeed in preserving and restoring vision for so many who depend on us. Thank you for makingthis work possible.

Sincerely,

Marilyn PrattChair, Board of DirectorsThat Man May See, Inc.

As a patient, I’m privileged to have a group of physicians of this quality helping me. As a philanthropist, I’m glad to help an organization of the quality of That Man May See.”

– Michael Braude, patient at UCSF Proctor Foundation and Department of Ophthalmology

In Gratitude for DISTINGUISHED LONGEVITY CONTRIBUTORSThe following exceptional donors have madecumulative gifts of $1,000,000 or moreArnold & Mabel Beckman Foundation*Theresa M. and Wayne M. Caygill, MDPaul L. and Lois M. Fahrney TrustsFoundation Fighting Blindness*Mrs. Pearl T. KimuraKoret Foundation*Mrs. Jeannik M. LittlefieldThe Thomas J. Long FoundationDr. Thomas and Mrs. Yvonne MazzoccoBernard A. Newcomb Fund at Silicon ValleyCommunity Foundation

Helen Pritchard Estate

Research to Prevent Blindness*Shirley Reich EstateMr. and Mrs. Walter Rosenberg Robert Henry Sanborn Estate*Mr. and Mrs. Marshall Steel, Jr.Wayne and Gladys Valley Foundation

20/20 LEGACYVisionary individuals who have chosen to includethe UCSF Department of Ophthalmology, Francis I.Proctor Foundation, and That Man May See, Inc., intheir estate plansLillian AlbertsenMrs. Helen E. AmmenElaine G. Bauer

4 Fall 2009

Thank Thank you for generous support received betweenJuly 1, 2008 and June 30, 2009.

Distinguished Contributors ($1,000,000+)Wayne and Gladys Valley Foundation

Honored Patrons ($250,000+)Alcon USA*The Thomas J. Long FoundationJohn & Lisa Pritzker Family FundEstate of Jon Shastid*

Visionaries ($100,000+)American Health Assistance Foundation* Jeanne CopelandHellman Family FoundationMrs. Jeannik M. LittlefieldMarch of Dimes Birth Defects Foundation*Don and Judy McCubbinResearch to Prevent Blindness*Aline Sinai and the David and Elva Sinai Foundation, Inc.Estate of Jane Steel*

Entrepreneurs ($50,000+)Allergan Pharmaceuticals*Barbara and Gerson BakarThe Larry L. Hillblom Foundation*Hope for VisionLucy and Fritz JewettKarl Kirchgessner Foundation*The Bernard A. Newcomb Foundation at SiliconValley Community Foundation

OptiMedica CorporationSandler Foundation

Investors ($25,000+)AnonymousAlcon Laboratories, Inc.Thomas and Johanna BaruchDaniel and Jeanne BenatarDr. and Mrs. Eugene de Juan, Jr.Frannie and Mort FleishhackerThe Glaucoma Foundation*Stephen and Paula SmithThe Jewish Guild for the BlindJoan and David Traitel

Director’s Council ($10,000+)AnonymousThe Bellini FoundationDr. David and Victoria ChangClausen Family FoundationJerry and Geraldine ColeSuzanne and Bruce CrockerJanet and Bill DinsmoreFight for Sight*Dr. and Mrs. Sylvan D. GrossThomas B. Inglis, Jr.Pearl T. KimuraThe Joan Leidy Foundation, Inc.Alastair Mactaggart*The Mattson Family Conservation FoundationBNY MellonIvan, Maris, and Harry MeyersonMike and Susan MokelkeThe Mooring Family Foundation of Silicon Valley Community FoundationNancy and Tim MüllerPayne Family FoundationJaMel and Tom Perkins Family FoundationFund of the Chicago Community TrustMarilyn and David PrattRobert and Karen RishwainFamily FoundationVenetta and John RohalEdwin M. ShonfeldThe Schreck FamilyWalter H. & Phyllis J. Shorenstein FoundationSue and Laurence SpittersJohn P. StockMichel and Masako Vacheron

Luminaries ($5,000+)American Society of Cataract and Refractive Surgery*V. Nicholas Batra, MD, and Rani BatraJohn Bosetti, MD, and Nancy Jameson, MD

H. Michael BraudeSylvia and Buck BreiholzSelina and Johnson ChaJames W. and Shirley C. CrawfordJohn de Benedetti and Nina SrejovicRobert J. Drabkin and Davina and Ronald DrabkinLorie and Ron HirsonKathlyn McPherson MasneriMorris Family FundEstate of Patsy P. Nascimento*Francis S. North FoundationJoan PlattSkaer Family FoundationBob and Naomi StamperDiane B. Wilsey

Dream Makers ($2,500+)Mary and Phil AndersonJoan and Peter AvenaliBecky and Jeff BleichFilomena BuckJune M. Carros*Mr. and Mrs. Norman E. CimaEdward and Margaret CollinsMr. and Mrs. Donald W. DavisSandra and Conrad DonnerEnersen FoundationGunilla and Tom FollettKomes FoundationDr. and Mrs. Shiu Y. KwokDr. and Mrs. Stacy R. Mettier, Jr.James and Janet MitchellRichard and Candace OlsenEleanor and Catherine ParacEstate of Nina Pera*Chuck RobelToni and Arthur RockKathleen L. RydarDr. and Mrs. David Tai-Man ShenMr. and Mrs. Dexter C. TightBetty E. ToalJacqueline and Robert YoungThe Zaffaroni Foundation

Innovators ($1,000+)Anonymous (4)Dr. and Mrs. Pierre R. AlfredAllergan PharmaceuticalsAmy's KitchenRobert R. Anderson, MDRichard J. AnnesserJorge Arroyo, MD, MPHPaula and Joel BlankMr. and Mrs. Robert BlochMark H. BoxerC.M. Capital FoundationJohn E. and Helen K. Cahill FundDr. and Mrs. Arnett CarrabyTheresa M. CaygillShi-Hwa William Chang, MDDiana K. Conrad, MDNancy and James CoristonDr. and Mrs. J. Brooks CrawfordChandler and Paula DawsonHal Dawson and Mary McVeySue and John DiekmanJohn and Marilyn DougeryMichael V. Drake, MDShustek Dubinsky Family Philanthropic FundDr. and Mrs. James F. EggertElaine A. EklundMichael F. and Netta F. FedorGloria and Saul FeldmanEmily Huggins FineAllan and Teri FlachJames and Jessica FlemingAndrew C. Fong, MDMary Ellen and Michael E. Fox Family FoundationGap FoundationMr. and Mrs. Milo S. GatesMaxwell and Frankie GillettePaul and Béatrice GomoryLorrie and Richard GreeneGrimm Family Fund at Silicon Valley Community Foundation

Christine HarrisCarole and Rod HartlessJonathan and Lidia HortonHuntington FarmsPaige M. HutsonDrs. Janet Lee Hwang and David G. HwangDrs. Alex and Chauncy IrvineMargo and Leonard KarstadtMr. and Mrs. Nicholas I. KemsleyTerence G. Klingele, MDScott E. Lee, MDDoris S. LeeMeta and Dan LightfootLocal Independent CharitiesLydia A. LukianMr. and Mrs. Angus L. MacLean, Jr.Gerry L. MarshallJohn D. McCann, MD, PhDDrs. David and Susan McCartneyStephen D. McLeod, MD, and Marion FaymonvilleFaye Mellos and Michael HollandMorgan Stanley FoundationAnthony and Lary Lynn Muller Fundof the Community Foundation for MontereyCounty

Ayman Naseri, MD, and Alejandra de Alba Campomanes, MD, MPHJean A. NiblettOwen and E. Toki OakleyRosanne and Michael OglesRichard and Susan OlnessWalter J. and Patsy R. PartonMr. and Mrs. Jackson PerryBarry and Jan PetersenPauline L. Pizante-HaddadSamuel I. Rapaport, MDVirginia and Leonard RattoWilliam L. Ridgway, MDMr. and Mrs. James W. Ross*John W. and Barbara H. Rosstonat Silicon Valley Community FoundationDr. Massy Safai and Ms. Parvaneh AssefiRobert and Isabel SchuchardtEdward C. Shotwell III 1996 Charitable Annuity Lead TrustMarshall and Mary SmallJohn and Peggy StockW. Scott ThomasLori and Christopher ToomeyThe Tumori FoundationAlexander S. WalkerCecily A. WatermanWCP II, LLCJack and Marilyn WhitcherDrs. Myra and Burton WiseDr. and Mrs. Ira G. WongP. Mason WoodEric Zankman and Pamela Kaufmann

Supporters ($500+)Anonymous (2)Richard L. Abbott, MD, and Cecilia B. AbbottDr. and Mrs. Samuel B. AronsonDr. and Mrs. Edwin E. BoldreyRobert and Daphne BranstenJanet Chen, MDChevron Humankind ProgramOlive F. CookMrs. Daniel G. CookJudge and Mrs. John S. CooperMary Lou and Hartley CravensFrancis S. and Christine M. CurriePeter D'Alena, MDMary Edna Davidson, PhDRosalind Gray Davis and Robert M. DavisDonna and Ken DerrDr. and Mrs. James DowlingThe Gallo Family Fund at Silicon Valley CommunityFoundation

Dr. and Mrs. Francisco A. Garcia*Dr. and Mrs. Plato J. GrivasDean and Debra HirabayashiRon and Dianne HogeAnn and Dunbar HoskinsPaige M. HutsonDrs. Janet Lee Hwang and David G. HwangJ. Michael Jumper, MDDr. Man Kim and Grace Kim

Heinrich and Marianne KonigThomas F. KosticShan C. Lin, MDBill and Barbara LovelessDiane and Dave LudersJames M. Lyon, MDMr. and Mrs. Angus L. MacLean, Jr.Morgan StanleyDr. and Mrs. Raymond S. MullenEllen and Walter NewmanMr. and Mrs. Walter H. ObermeyerRoma and Cyril PeletzGeorge and Karen RathmanFred and Judy RiedelDr. and Mrs. Philip D. Schild and the Dichek FamilyFund

Stuart and Marilou SeiffTheodore and Suzanne SetonVictoria C. SmithSharon D. Solomon, MDMary Ann Milias St. PeterJudith Good StearnsThe Commonwealth FundWashington Mutual Matching Gift ProgramTerry and Madeline WelshJohn Williams IIIPeggy and Lee Zeigler

Patrons ($250+)Dana and Erin AlbertTerry Pink AlexanderMarianne and Dimitri BartonDaniel A. Bassi in honor of Wanda R. HambyMichele M. Bloomer, MDMuriel and Allan BrotskyMargaret CarterRaymond and Marian ChristensenDavid and Margot CooksonDavid and Joyce CopenhagenLisa and Peter CracknellJanet Tashima DeboskeyHarold and Annette Dobbs Family SupportingFoundation of the Jewish CommunityEndowment Fund

Emma O. Dong, MDMichael V. Drake, MDCatherine DunlapMr. and Mrs. George J. FesusJohn T. Flynn, MDMichael E. FoleyWilliam R. Frazer, PhDGreer Lauren Geiger, MDPete and Nancy GrecoMargo and Bill HardingPeter D. and Florence HartHerbst Foundation, Inc.Yoshitsugu Inoue, MDEli Kaczynski, MDLinda and Robert KlettKohl FamilyDr. and Mrs. Arthur KolatchJ. Michael Lahey, MDMatthew LaVail, PhDMr. and Mrs. Daniel LevineDiane and Hubert MarcusPaul and Joan McKnightThomas F. Minas, MDAurelia Morris*Helen and Fraser MuirheadGeorge J. Nakano, MDKristin Nesburn Silver, MD, and Barry SilverRita and Philip NeumarkWalter S. Newman, Jr., MDVelimir and Ming PetrovicMs. Sudha RajagopalanSandra Madison Reinhardt, CPASamuel ShutmanLionel Sorenson, MDScott and Jenny SykesHelen and George TaitEddy and Susan TamuraRobert TomMark VolpicelliDr. Koanglu WangA. Sydney Williams, MDScarlette M. Wilson, MDRandy Wolfe

Mrs. Clyde CarringtonMrs. Sarah Carroll-HirschTheresa M. CaygillRalph CechettiniMr. and Mrs. Ralph A. CoddeJeanne CopelandDr. Joan E. DiblinJanet and Bill DinsmoreDr. and Mrs. James DowlingDavid and Adeline EdwardsDenise B. EvansMrs. Janet GolnerJohn Hall and Rebecca DerringtonArthur HarperMrs. Mildred B. HartMr. and Mrs. William G. Hoffman

Creig S. Hoyt, MDThomas B. InglisMarjorie JacksonMrs. Clarence K. JonesMrs. Elizabeth KennedyPearl T. KimuraMr. and Mrs. Sigmond A. Kriegsman, Jr.David and Mary Jane LaityMr. and Mrs. Harold LillardMr. and Mrs. James P. LivingstonMr. and Mrs. McKay MarlerAngiolina MartiniDr. and Mrs. Stacy R. Mettier, Jr.Ivan and Maris MeyersonPeter and Lela MoulthropBoris D. Nahlovsky, PhD

A N N U A L

ENDOWMENTS

Current Endowed Professorships and ChairsProfessorships and chairs provide sustained support forresearch and clinical faculty.

Jean Kelly Stock Distinguished ProfessorshipEdward and Estelle Alexander Chair for VisionResearch

Thomas W. Boyden Endowed Chair in Ophthalmology

Theresa M. and Wayne M. Caygill, MD, Chair in Ophthalmology*

Deborah Hoyt and Creig S. Hoyt, MD, Chair inPediatric Ophthalmology

William F. Hoyt Chair in OphthalmologyAlexander R. Irvine, MD, Chair inOphthalmology**

Pearl T. and Samuel J. Kimura, MD, Chair

Steven G. Kramer, MD, PhD, Endowed Chair inOphthalmology

Shirley Reich Chair in OphthalmologySteven P. Shearing Chair in OphthalmologyMichal Vilensky Endowed Chair for Research inOphthalmology

Rose B. Williams Chair for Research in Corneal Disease*

Endowed Research FundsResearch funds support innovative research.

Theresa E. Allen Endowed Research Fund inOphthalmology

The Dawn Society Endowment Heleanor Campbell Foerster Ophthalmic PathologyEndowment*

William Randolph Hearst Endowment for PediatricOphthalmology

Generous GiftsAllen W. JonesMax KaufmannTheodore M. KniescheJ. W. KohlGünther O. KossackWilliam C. KuehneJacques M. LittlefieldAlice MartinelliRose B. MatasyDean MawdsleyDonald MiladinovichDonald J. MorrisEleanor NewmanIvan OdomPatsy R. PartonRichard PetersonLore M. Rasmussen

Theodore E. RocheGeorge RoeJacob RosenfeldAriah Schwartz, MDLawrence SmucklerDaniel VolkmannRalph O. WallersteinSeymour Zoger

BEQUESTSRealized bequests benefiting the UCSF Department of OphthalmologyEstate of Patsy P. Nascimento*Estate of Nina Pera*Estate of Jon Shastid*Estate of Mrs. Marshall J. Steel, Jr.*

5Fall 2009

YouFriends ($100+)Anonymous (9)Anthony K. Agadzi, MDGeorge T. AllenAmerican Ophthalmological SocietyJose H. F. AntoninoDr. and Mrs. Joe F. ArterberryTaylor Asbury, MDJoan and John BarkanMichael and Zondra BarricksAnne and David BaudlerAlice S. BiererRoderick Biswell, MD, and Naina BiswellKatherine M. BonniciDean C. BrickPatricia L. BrownBunker & Company, LLPNieca D. Caltrider, MDMichaela CassidyDr. and Mrs. S. Kumar ChandrasekaranLisa Chang and Douglas MasonDrs. Valerie and Devron H. CharCatherine E. ChiltonYun Tim and Opal ChoyFrederick ChristiansenJoan G. CogenFrancisco Contreras, MDBarbara A. CoulterDr. and Mrs. John DawsonDepartment of Ophthalmology Staff, VA MedicalCenter

Janet C. DittoeRosalind and Sanford DorbinKeith and Jacque DuncanMarjorie EbertsSimone C. and Gene Lloyd EdwardsMark H. Elias, MDLouise and Robert ElliottMark Feldberg and Emilyn PageLaurence FinbergBarbara K. Finck, MD, and George A. FinckBunnie and Art FinkelsteinLillian and Robert FisherThomas D. France, MDDoug and Mary Pat FredrickDr. and Mrs. L. Neal FreemanBruce D. Gaynor, MDDouglas Gerstein, MDMarie C. GidréLichen GongCharles and Myrtle GriffinMarilyn GrossColleen P. Halfpenny, MDJohn Hall and Rebecca DerringtonMr. and Mrs. John F. HenshawJohn N. Hetherington, Jr., MDMidge and Sylvan HeumannJeffrey HillA. Joan HolstiusDr. and Mrs. George K. HortonDr. and Mrs. Thomas C. Hoyle IIIPeggy E. HuangBob and Judy HuretIBM CorporationWilliam E. and Corinne J. JensenDolores G. JuskowiczJohn and Leone KingTerry and Bill KrivanEdward H. KruseSapna and Mahesh LalwaniScott and Elizabeth LambertJennifer H. LaVail, PhDMr. and Mrs. Kimun LeeEric and Monica LeensonBarry L. LockenJoseph MaMr. Thomas Maloney and Ms. Trisha SanchezPatricia and Joseph ManciniAndrei M. ManoliuDennis R. MarDr. Eugene and Mrs. Brenda McLaurinT. Neal McNamaraMarilyn and Francis McNameeSharon McVickerAlexis MedinaTodd and Stacey MelcherMills-Peninsula Health Services Professional StaffHerbert P. Moore, Jr.

Dr. Gary MorrowMr. Khalil MounzerYukihiro Nakaizumi, MDTed R. Nehrenberg, MDRichard NormanGary D. Novack, PhDJoseph J. O'BrienSusan Page and Richard MetcalfeMr. and Mrs. Charles Joseph Passarell*Carlos E. Pavesio, MDTerri Pickering, MDJames M. Pickrel and Carolyn WoolleyAlan J. and Lois Kaye PopePaul and Christine PrusinerRosemary and Dick RankinDr. and Mrs. J. Earl RathbunBernard and Florence RechtschaffenAnne ReismanThe Honorable and Mrs. Richard W. RhodesWilliam E. RikerBenson B. Roe, MDBernice RosenthalGail M. Royal, MDGregory J. RykenMojy S.Joel and Sylvia SaldingerKim Scala and Akaya WindwoodIrma ScanlonJulie L. Schnapf, PhDRuth T. SchoenbergAlbert L. SchultzNoha SchulzeDr. and Mrs. Stephen S. SeiffJean and William SelbachBarbara ShaferPak L. ShumTed and Doris SmithNorman and Masa SoskinJohn A. Stanley, MD, and Manel E. de Silva StanleyDr. and Mrs. Stuart StephensDaniel E. StoneCornelia V. C. TaggartStephen C. Tanaka, MDWalter T. Conway Jr. and Meredith M. TennentJohn and Jane ThrelkeldGeorge and Sheila TichyStephanie Turner and Randall FlemingUnited Way California Capital RegionPatricia and Gary VickCarol Sue VieleDonna WagnerTsien Wu J. WangMaxine Wanner, MDJoanne E. WatersA. Alan Weber, MDDorothy Helen WesleySally O. WhiteRichard Whitten, MDNancy Beard WilsonMr. and Mrs. Ian S. WishartSusan Wong, MDEliza WuKathleen Yamaguchi, MD

ContributorsAnonymous (10)Lorita D. AaronsRuth J. AllenGeorge AntoniottiDebbie S. ArnowitzMrs. Roma M. AuerbackPatricia L. Austin, MDMr. and Mrs. Sergio BaldocchiBank of AmericaMr. and Mrs. Larry BankyRobert and Barbara BeckerSusan C. Benes, MDInge S. BerlinerMaria D. Bernal, MDJohn BlackmanSamantha BlasiBernard BlumbergKen BollierThomas F. BoozeJames F. Bowman and Jean B. Hatfield*Mr. and Mrs. John E. BrownMarilyn Brown and Stephen CornellBarbara Bunting

Allyson BurkeJean E. and Ed BurkeDr. and Mrs. John N. CallanderJoseph J. CamposSharon A. CandeloRose CatonAllan ChalmersEllen C. ChamplinMei Ling ChanMei Yun ChengEleanor ChingCynthia S. Chiu, MD, and Annjoe Wong-Foy, PhDLisa ClayAndrew and Suzanne ColvinShirley J. CostelloCarmen CritchlowMartine and Michael CurranMargaret De BonoThe De Goff FamilyDeogracias and Felisa de la RosaMike and Anthea Del BiancoCarol R. Dembe, MDTricia H. DizonWilliam H. DorsettKathleen DysertEdward Glen EisenmanAnn W. EliaserHeather A. EnnisKaren EpsteinAnnette and Paul EuphratMr. and Mrs. Gregory B. Fedran*Mik P. FlynnRobert C. Frates, Jr., DDS, and Patricia A. FratesMyra FreisingerJoseph M. FriedmanJoyce and Jay FriedrichsIda and Robert FujiiSunne M. FungeEdward A. GallagherJames GeeMr. and Mrs. Harold J. GieblerMarianna GiokasGerald A. and Kathryn L. GlendenningJane B. GoldbergKimmy P. GoldkrantzRemedios S. GomezLenore R. Goodman*Doris Livingston GrasshoffMichael GriffinWilliam W. HalprinWanda R. HambyAvalon Art Gallery, Inc.Leah S. HawkinsMaria Z. HertzJorgen HildebrandtMr. and Mrs. Roy E. Hills IIIAlex and Betty HollettCaroline HurdMary A. IjichiDonna and William InmanOdette JacobLana JangDouglas and Ann JohnsonDr. and Mrs. Jerrold KaplanDr. and Mrs. John D. KasterLev and Berta KatsnelsonJoan and Stan Gross and Madeleine KaufmannDonald M. Kay, MD, and Bonnie LevinsonViolet and Soo H. KhooLillian and Eugene KodaniHadassah and Ralph KramerAnatoliy KrasilovskyLillian and Robert KurtzDonna Lee LampertJanet B. LandauerSandra Lane and James WorleyThomas A. LattaCaptain and Mrs. Guy J. LeBreton, USN (Ret.)Phyllis and Harold LevyWalter Lew and Mary M. Wu-LewKermit LipezJacqueline LiuZhiyun LiuWoenchung Jane LohRay and Mary LopezEvelyn LordMark Mackler

Beverly N. MacLellanMargaret E. MalloryIrwin and Sonia MarcusMassucco Family TrustBetty MatarangasElizabeth Ann McDonaldJohn F. MeadowsLucille MeyerBahman MeykadehRoy and Loraine MichaelKathleen Heitz Myers and George E. MyersMr. and Mrs. Minton J. NewellMary NicolaisenPam L. and Robert K. NightingaleJaney B. NormanMercedita T. PacisHelen L. PalmerSally and Bill PalmerJose R. PanamenoAlan R. ParsonsMr. and Mrs. Gerald PelznerDr. and Mrs. Edward C. PersikePG&E CorporationCeleste and Roger PhillipsDanielle PickettSally Bunting PittsWilliam PlaskonJan PorushS. Peter Poullada and Nancy A. SheppardGrace Eaves PrienDoris QuanStephen QuiroloJoyce S. RaicheMaria T. RamirezSandi RandallAnn W. RayburnRachel Naomi Remen, MDMrs. Helen E. RiceH. T. and Marguerite RichterElaine H. RosenfeldMrs. Fred J. RossDagmar E. and Marcel G. RossEmanuel and Miriam RozentalGuillermo and B. Adela RuizWilliam and Wilma RyanStanley SalekPhillip and Carol SansoneJennifer Schlauder LinWerner and Marian SchmidtLouise B. SchooleyDr. and Mrs. Norman F. Schwilk, Jr.Roseann and Edwin ScottLarry and Dona ShaidnagleMick and Meg SheldonVivian B. "Gina" SimsSunny SkysCarol E. SlettvedtStuart A. SnellWalter H. SokelSusan and Glen SolanderMrs. Thomas L. SossDoris and Bill Spitzig and Millie KushmanMerilyn StearnsJulia Steinberg and Grigoriy KoganEnid StevensJay and Emmanuelle StewartHope W. StreeterSharon SzaboPearl TalbotRichard TerdimanYvonne TevisBarbara Ann and Richard G. ThompsonMrs. Diana ToomajianFrances UyesakaJerry VaioLinda Van DijkRobin A. Vora, MDWilliam and Camele WanatKathryn D. WilliamsBryan J. Winn, MDMarilyn WolperCarrie Chan WonJune WongElsie Wright

* Gifts received via the UCSF Foundation or UC Regents

IN MEMORIAMTribute gifts that have been given to commemoratethe passing of special friends listed below.Peter J. AvenaliCarla BalzariniBette BarryFlavian T. BauerFred BertettaMarcia BleekerJohnson S. BogartThomas W. BoydenRobert A. CooksonGeorge P. CostelloMax FineEvelyn S. GoodLiang Hsiao

R E P O R T

Pauline L. Pizante-HaddadFred and Judy RiedelMiss Emily B. RievaulxKathleen L. RydarBranna SisenwienSkaer Family FoundationJohn P. StockDaniel E. StoneMs. Carole StraussMr. and Mrs. Dexter C. TightMrs. George A. WatsonRichard and Joyce WeismannRonald P. WinikerDr. and Mrs. Ira G. Wong

Samuel J. Kimura, MD, Endowment FundThe Martinelli Otstott Endowed Fund for VisionResearch

Robert H. Sanborn Research Fund*David and Elva Sinai Foundation Endowment for theVisual Center for the Child**

Jane and Marshall Steel, Jr., Endowment Fund forVision Research

Dexter C. Tight Macular Degeneration EndowedResearch Fund

Endowed Education FundsEducation funds provide permanent funding for academic lectures.

George and Rosalie Hearst Fellowship inOphthalmology*

Amy S. McNamara Endowed Fund*Francis I. Proctor Lecture Fund*Transamerica Visiting Professorship in Vision Science

General Endowed FundsThese endowments are applied wherever the need is greatest.

Frances W. and Levon K. Garron Endowment

Michael J. Hogan, MD, Endowment FundCharles Taylor Reeve Endowed Fund*Agnes M. Welsh Eye Fund*

* UC Regents endowments. Others are held by the UCSF Foundation.

** In process.

6 Fall 2009

A N N U A L R E P O R T

Board of DirectorsThat Man May See, Inc.

Direct to Via OtherSources of Funds TMMS UCSF Entities* Total %

� Donations and new pledges $1,847,043 $26,000 $1,873,043 37%from Individuals

� Donations and new pledges from $698,889 $1,602,524 $2,301,413 45%Corporations and Foundations

� Bequests and Trusts $170,000 $587,530 $757,530 15%

� Earnings on Deposited Funds $147,172 $147,172 3%

Total Revenue $2,863,105 $2,216,054 $5,079,159 100%

*Board of Regents & UCSF Foundation

Fundraising Review: That Man May See Generated Funds

Application of Funds Actual %

Research, Education, Patient Care, and Community Services:

� Dispersed Funds $2,976,978 59%

� Committed Funds $1,456,203 29%

� Fundraising $398,447 8%

� Management and Administration $247,531 5%

Total Expenses $5,079,159 100%

Past PresidentsWalter S. NewmanStacy R. Mettier, Jr., MDCrowell Beard, MDSamuel J. Kimura, MD

* Executive Committee** Passed away during 2008–2009

directorsboard of

Distinguished Honorary BoardTheresa M. Caygill

Honorary BoardEmily Huggins Fine, ChairJackson BuschBrook H. ByersAnn Jones CarlsonRoger S. CarlsonJ. Hallam DawsonMargaret DuflockReed FreyermuthMaurice Galante, MDWilliam H. GreenLarry HaimovitchArthur O. HarperOssama R. Hassanein, PhDCharles W. HomerH. Dunbar Hoskins, Jr., MDThomas F. KosticWilliam C. Kuehne**Peter H. MattsonNan Tucker McEvoy

Herbert P. Moore, Jr.J. Fraser Muirhead, MDAllen S. MusikantowWalter S. NewmanRosanne B. OglesStanley Powell, Jr.Stephen S. Seiff, MDSteven P. Shearing, MDJohn P. StockJames B. SwinertonR. M. “Terry” ThomasDexter C. “Ted” TightAlejandro A. Zaffaroni, MD

Past ChairsStephen S. SmithPeter H. MattsonAngus L. MacLean, Jr.Dexter C. “Ted” TightRichard J. OlsenBrook H. ByersStacy R. Mettier, Jr., MDJames P. LivingstonWilliam H. Green

Ronald DrabkinFrançoise G. “Frannie”Fleishhacker*Thomas D. Follett*David H. GlotzerJohn E. Hall IIICreig S. Hoyt, MD Paige M. HutsonAngus L. MacLean, Jr.*Gerry L. MarshallFaye A. MellosMaris MeyersonRichard J. Olsen* J. Frederick Riedel, MDAlbert R. Schreck*Isabel P. “Patsy” SchuchardtStephen S. Smith* Robert L. Stamper, MDJohn V. StockDavid T. TraitelJohn P. Whitcher, MD, MPHAndrew YauDirectors EmeritiPearl T. KimuraJames P. LivingstonThomas R. Mazzocco, MDStacy R. Mettier, Jr., MD

Directors and OfficersMarilyn M. Pratt*Chair

Kathleen L. Rydar*President

Paul L. Gomory, Jr.*Vice Chair

Stephen D. McLeod, MD*Chair, UCSF Ophthalmology

W. Scott Thomas*Secretary

Bruce E. Crocker*Treasurer

Richard L. Abbott, MDThomas R. BaruchDaniel Benatar*Thomas J. BirdDavid F. Chang, MDEdward B. CollinsJ. Brooks Crawford, MDJohn F. de BenedettiJanet L. Dinsmore

Fall 2009

than a dozen retinal and glaucoma specialists from the Department of Ophthalmology join forces with the Proctor Foundation faculty, which specializes ininflammatory and infectious eye disease, to help uveitispatients manage their condition and retain vision. AllProctor Foundation clinicians treat uveitis patients, withDr. Acharya, Todd Margolis, MD, and IraWong, MD,taking the lead on most cases.

Deep knowledge of every aspect of ocular medicineallows the team to provide the best possible diagnostictesting, consultation, therapeutic plans, and surgeries.“Uveitis patients tend to have extreme versions ofocular complications,” says Jay Stewart, MD, a UCSFretinal specialist. He manages surgeries for complicationssuch as macular edema, retinal detachment, and evenunusual cataracts that must be removed through theback of the eye.

Expanding a Supportive NetworkDr. Acharya developed the peer support group in responseto the stress levels of uveitis patients. Chronic uveitispatients face declining vision and the threat of blindness.Many become unable to continue their jobs. Treatmentsinclude surgeries, complex medication protocols withsignificant side effects, and innovative therapies that comewith unknown long-term consequences.

“Patients often cry during their appointments,” says Dr. Acharya. “Because uveitis is uncommon, some patientsfeel as if they cannot turn to friends and family foranswers. Most of my patients go through emotional crises.”

Patient Melanie Siemon is grateful for the new group.“It is wonderful to be with so many people who share mycondition,” she says. “Often I feel that I’m the only one.”

At 17, Ms. Siemon experienced moments of blurredvision that quickly resolved themselves. Not understandingthe danger of these episodes, she did not seek treatmentfor nearly three months. Permanent deterioration of hercentral vision had already begun, and she became legallyblind at age 19. Three decades later she remains intreatment, working with her doctors at UCSF to holdonto her remaining peripheral vision.

“There are so many stresses,” Ms. Siemonexplains. “Adjusting to low vision in aworld designed for sight is huge. Youwant to crawl into a hole, but you haveto find ways to regain control of yourlife and take care of yourself.” As alegally blind woman who completedcollege, developed a career, and raised a family, Ms. Siemon has a wealth ofexperience and empathy to share withother patients. She is planning to share a list of tips and strategies that help her enjoy a full life. Ms. Siemon co-facilitates the support group with Pam Chan.

Ms. Chan is the mother of an 11-year-old son who has been in treatment since kindergarten.“One day Jordan [not his real name] woke up screamingwhen we turned his light on,” she recalls. “He wouldput his shirt over his face in the car.” Uveitis was makingher son hypersensitive to light. The pain alerted hisparents to get him to a pediatrician right away. Threedays later, he had his first exam with Dr. Wong.

Ms. Chan understands that families need support beyondwhat their doctors can provide. “At the beginning you’reso scared, and it’s all so overwhelming,” she says. “Wecame to each appointment with a list of questions andthought of new ones as soon as we left.” She is excitedthat long-time patients and family members in the supportgroup can help those just learning about their diagnosis.

For those with vision sufficient for computer use, a newwebsite provides a safe forum for patient blogs and othercommunication that extends beyond the monthlymeetings. Patients who are unable to attend the SanFrancisco meetings will find the site particularlyvaluable. Uveitis patients and their families can join the site by contacting Lizzi Esterberg atelizabeth.esterberg@ucsf.edu or (415) 476-6687.

The Cause Is KeyUCSF Ophthalmology teams determine each patient’scourse of treatment through a battery of sophisticateddiagnostic tests, including some that are carried out bythe Proctor Foundation Clinical Diagnostics lab. When

Community of Support for UveitisContinued from page 1

Artificial CorneaContinued from page 1

Human Corneas TriedOnce the Marians settled in the United States, doctors implanted a human cornea inhis less damaged eye. Initially, this surgery brought Mr. Marian his first sight of his wifeand two children. Over time, however, his eye rejected the new cornea. With a fiercedesire to see, he repeated this surgery “maybe eight or nine times,” he says. Eachimplant eventually returned him to darkness.

The procedure of replacing a damaged or diseased cornea with healthy donatedcorneal tissue has helped hundreds of thousands of people across the world regain theirsight. Corneal specialist David Hwang, MD, established the UCSF Eye Bank morethan 15 years ago to help alleviate the worldwide shortage of corneal tissue. However,healthy stem cells in the front of the eye are critical for permanent integration of a newcornea. Severe damage to the eye, such as from chemical injuries as in Mr. Marian’scase, can destroy these stem cells and limit the success of human corneal transplants.

the inflammation is caused by an autoimmune disease(such as lupus or arthritis) or by an underlyinginfectious disease (such as herpes virus), successfultreatment for that underlyingdisease also can relieve

symptoms in the eye. In half of uveitis cases, however, doctors are unable to pinpoint a culprit. They theorize that these cases may be caused by an accumulation of triggersincluding genetic predispositionto immune-system reactivity,

stress, and the environment.

Newer Drugs Improving OutcomesSystemic steroids have long been the standard for treatinguveitis. Specialists are now reducing dependence onsteroids by turning to newer immuno-modulatorytherapies (IMTs) for patients with “immune-mediated”uveitis. IMTs were originally developed to treatsystemic autoimmune disorders such as rheumatoidarthritis and cancer and to prevent rejection of organtransplants. According to Dr. Acharya, this type of “offlabel” treatment for uveitis is improving clinical optionsand patient outcomes.

“IMTs are improving my patients’ lives and providing a new dimension of care,” says Dr. Acharya. Eleven-year-old Jordan Chan, diagnosed with autoimmunejuvenile arthritis, is being treated with two IMTs. These drugs suppress the damaging immune reaction in his eye without the serious health consequences of ongoing steroid use. IMTs carry their own risks,however. Suppressing the immune system exposes the patient to an increased risk of infection, so closemonitoring is required.

A clinical trial run by Dr. Acharya is testing whetheranother “off-label” drug, LucentisTM, can help reducemacular edema (swelling) in some uveitis patients. Damageto the macula (an area of the retina) can result in centralvision loss. LucentisTM was developed to reduce macularswelling in patients with macular degeneration.

around him, he could read magazines and walk unassisted. His sister had to stop himfrom driving home from the hospital a few days later. “I was told that I needed to healmore first,” he recalls.

A First for the Bay AreaIn Spring 2009, Mr. Marian became the first patient in the Bay Area to undergoimplantation of an artificial cornea (called a keratoprosthesis). He was referred toUCSF’s Dr. Jeng, well known for his expertise with artificial corneas, by the StanfordUniversity Medical Center. Once Dr. Jeng established with reasonable certainty that Mr. Marian’s optic nerve was healthy, he knew an artificial cornea would work – andthat the patient would have an excellent chance to have clear vision.

Journey in Miles and FaithMr. Marian’s medical journey began at a brick factory in Romania in 1976, when acontainer of lime blew up in his eyes. By the time he reached a hospital, the lime hadseverely burned both corneas. Left unable to distinguish images beyond the silhouettesof his hands, he was told there was no hope of regaining sight. He was only 18.

With unflagging faith that help existed, Mr. Marian dreamed of coming to the UnitedStates for advanced treatment. To keep his spirits up, he learned to play guitar, violin,and mandolin. After he married, he and his wife escaped from Romania intoYugoslavia and received permission to immigrate to the United States for medicalhelp. Artificial corneas were in development at that time.

7

Artificial corneas open a new avenue for restoring sight.”

– Dr. Bennie Jeng

Nisha Acharya, MD

Thomas Lietman, MD Daniel Schwartz, MD

Eugene de Juan, MD Shan Lin, MDIra Wong, MD

Jeremy Keenan, MD Jacque Duncan, MD

Jorge Alvarado, MDJay Stewart, MD

Robert Stamper, MD

Tina Rutar, MD

Matilda Chan, MD

Robert Bhisitkul, MDTodd Margolis, MD

8V I S I O N S Fall 2009

Proctor Foundation Diagnoses for Uveitis*

New Avenue for Sight“Artificial corneas open a new avenue for restoring sight to peoplewith the most severe damage to the front of the eye,” explains Dr. Jeng. This device, composed of surgical plastic, sandwiches naturalcorneal tissue from a donor between two plastic pieces. This devicedoes not need to be covered by the surface cells that are usuallyproduced by the stem cells, and therefore, in cases when stemcells are not present, this procedure still works. In fact, not having stem cells is an excellent and common indication for having thisdevice implanted.

Today Mr. Marian is enjoying his life – and his 11children – with 20/40 vision in his repaired eye.

Every day is a remarkable adventure in seeing. In fact, Mr. Marian is looking forward to having an artificial cornea placed in his other eye in the coming months. “With proper care andmonitoring, it is my hope that this could be the last eye surgery he will ever need,” says Dr. Jeng with a smile. •

The stem joins the parts of the keratoprosthesis.

Human corneal tissue prepared for transplant

The back plate secures the humancorneal tissue, and the holes allowfluid in the anterior chamber tonourish this transplanted tissue.

C

B

A

Leveraging Research Worldwide In the United States, uveitis research relies on federalgrants and gifts from philanthropists. Because the disorderis relatively uncommon in developed countries whereprofits could outweigh development costs, there has beenlittle commercial investment in uveitis-specific treatment.

Creative UCSF researchers are improving strategies for understanding and treating the disorder. Dr. Acharyais developing a network of several medical centers onthe West Coast plus a center in India to share patientoutcome data and reach insights more quickly. Thisresearch network is also planning clinical trials to comparethe effectiveness of uveitis treatments. Dr. Margolis leadsa clinical trial to compare the effects of IMTs with localadministration of corticosteroids to the eye via asurgical implant.

Proctor Foundation researchers are broadening uveitisinquiry as well, studying tuberculosis detection in uveitispatients in India, the association between smoking anduveitis here in the United States, and the use oftelemedicine to diagnose conditions in underservedcommunities. Their goal remains constant: to providethe best possible solutions for uveitis patients at UCSFand around the world.

UCSF funding for uveitis research is gratefully received fromthe National Institutes of Health; the Research to PreventBlindness Foundation; Ivan, Maris, and Harry Meyerson; thePeierls Foundation; Selina and Johnson Cha; C.M. CapitalFoundation; and Genentech. •

9% Infectious disease (such as herpes virus or tuberculosis)

39% Underlying noninfectious disease(such as rheumatoid arthritis ormultiple sclerosis)

52% Unknown

Ocular Inflammatory Diseases Retina Glaucoma

UCSF’s Uveitis Team

*The number of cases in each diagnostic category variesgreatly by country and region.

PediatricOphthalmology

A

B

C

The Boston Keratoprosthesis

Iris

Lens

University of California

San Francisco

Department of Ophthalmology

10 Koret Way, Room K-301San Francisco, CA 94143-0730www.ucsfeye.net

ChairStephen D. McLeod, MD

HOW TO REACH US

Comprehensive Eye Center415.353.2800Routine eye care, acute care, eye disease referrals

Eyeglasses & Contact Lenses415.476.3100

Cataract and Cornea Care415.476.3705

Glaucoma Care415.476.3707

Neuro-Ophthalmology415.476.7176

Ocular Oncology Care415.502.3206

Ocular Plastic Surgery415.353.2800

Pediatric Ophthalmology415.353.2800

Proctor Medical Group415.476.1442

Retinal Care415.353.2402

Vision Correction Surgery Center415.476.5698Individualized vision correctionsurgery, including LASIK andPRK

Koret Vision Institute + Beckman Vision CenterA facility of the UCSF Department of Ophthalmology

9 V I S I O N S Fall 2009

Recent Gifts to That Man May SeeThank you for generous contributions and pledges for vision research, teaching, patient care,and community outreach received between July 1, 2009, and October 15, 2009.

Honored Patrons ($250,000+)The Bernard A. Newcomb

Foundation at Silicon ValleyCommunity Foundation

Visionaries ($100,000+)The John and Lisa Pritzker

Family Fund

Investors ($25,000+)Theresa M. CaygillJon R. and Gale Love

Director's Council ($10,000+)Dr. David and Victoria ChangMrs. Jeannik M. Littlefield

Luminaries ($5,000+)H. Michael BraudeDonald and Roslyn Kahn

Philanthropic FundThe Mattson Family

Conservation Foundation

Dream Makers ($2,500+)Harold and Annette Dobbs Family

Supporting Foundation of the Jewish CommunityEndowment Fund

Innovators ($1,000+)AnonymousMary and Phil AndersonMrs. Daniel G. CookHal Dawson and Mary McVeyWilliam and Charlene

Glikbarg FoundationMr. and Mrs. Theodore B. LeeStephen D. McLeod, MD, and

Marion FaymonvilleBee Mullen, MD, and

Ray Mullen, MDJean A. NiblettStuart and Marilou Seiff

Supporters ($500+)Linda FrankFrederica L. LewisTina G. and Peter J. LockeFaye Mellos and Michael HollandJohn A. Stanley, MD, and

Manel E. de Silva Stanley

Patrons ($250+)Vyvien and Peter GearDean and Debra HirabayashiJack and Irene KausLocal Independent Charities

Monterey Bay Chapter, Ikebana International

Susan Page and Richard MetcalfeStuart and Marilou SeiffJames M. Pickrel and

Carolyn WoolleySogetsu San Francisco

Bay Area BranchDr. and Mrs. Lionel SorensonUnited Way of the Bay Area

Friends ($100+)Katherine M. BonniciPatricia L. BrownDavid J. ConleyFrancisco Contreras, MDClifford and Miriam CranerMilton GoldbergJeanne S. GressensChristie HastingsTomoko HayashidaJorgen HildebrandtMarvin and Rhoda LewisBeverly MerrillElsie OgataBernard and Florence

RechtschaffenSandra Madison Reinhardt, CPA

Mary Ann Milias St. PeterSoho Study GroupJoan SuzukiStephen C. Tanaka, MD

ContributorsAnonymous (4)Helen F. AdamsFrances AubertJohn BlackmanIkue BurneyCarmen CritchlowGeorgia CrowderDeogracias and Felisa de la RosaKimiko DixonCharlotte DoiBetty DowdDonna GamelPatricia HarperMaria Z. HertzMitsuru HiranoYoshi HollisGina HookYoko HosakaBetty JetterDouglas and Ann JohnsonRenee KlionskyDennis R. Mar

June MatsuokaDorothy McCowenSumi MetzJane NaitoJune OharaPG&E CorporationPauline PezzoloMaria T. RamirezSusan RobertsonMojy S.Ildiko Sandord, MDDr. and Mrs. David ScheetzLarry and Dona ShaidnagleMr. and Mrs. Spence SutherlandMargaret TaltHelen TashimaKatsuko ThielkeBarbara Ann and Richard G.

ThompsonRobyn TorresAlice TungRosamond VallejoLinda Van DijkLiz VernonYoshiko WilliamsElsie Wright

Congratulations to Erik Ullian, PhD, for hisDirector’s New Innovator Award from theNational Institutes of Health (NIH). This

tremendously competitive award will supportgroundbreaking work that is highly promising, novel,and broadly applicable to a variety of neurodegenerativeconditions and diseases, including glaucoma.

As a neurobiologist, Dr. Ullian is concerned with hownerve cells communicate with each other and how thisprocess will impacttreatment, rangingfrom glaucoma toregeneration ofdamaged nerves.

Glaucoma is a major cause of vision lossworldwide and is expected to become an even more serious health issue as the population ages. The underlying cause of disability in glaucoma is theprogressive loss of retinal ganglion cells (RGCs), whichlink the retina to the brain through the optic nerve. One major cause of RCG cell death is damage to thecell’s axons, which conduct electrical impulses awayfrom the cell body. To better understand how RGCs die in glaucoma, Dr. Ullian’s research team is developingmethods to use human skin-derived stem cells (iPS cells)

to make neurons, including retinal ganglion neurons tostudy mechanisms leading to neuronal dysfunction anddeath.This technology promises to provide a way to usea patient’s own neurons to develop treatments to stop orreverse disease progression. His work has also identifiedanother common cell type in the brain, the astrocyte, as a source of factors that can promote the survival andfunction of human neurons and may lead to new waysto treat diseases.

The NIH Director'sNew InnovatorAward addressestwo importantgoals: stimulatinghighly innovativeresearch andsupportingpromising new

investigators. The award brings $2.3 million over thenext five years to accelerate the work of Dr. Ullian’slaboratory at UCSF.

NIH Director Francis S. Collins, MD, PhD, announcedthe awards saying, “The appeal of the Pioneer, NewInnovator, and now the T-R01 programs, is thatinvestigators are encouraged to challenge the status quowith innovative ideas, while being given the necessaryresources to test them.” •

Dr. Erik Ullian Wins Prestigious Award from NIH

…investigators are encouraged tochallenge the status quo with innovativeideas, while being given the necessary

resources to test them.”

– Francis S. Collins, MD, PhD, NIH Director

Meet Our New ResidentsClass of 2012 Begins Training

Michael C. Chen, MD

Birthplace Fullerton, California

College Jacobs School of Engineering, UC San Diego: BS, Bioengineering

Medical School David Geffen School ofMedicine, UCLA

Internship Scripps Mercy Hospital, San Diego

Interests Surfing, backpacking

Sara J. Haug, MD, PhD

Birthplace Iowa City, Iowa

College St. Olaf College, Northfield,Minnesota: BA, Chemistry and Mathematics;Yale University: MS, Chemical Engineering

PhD Yale University: Biomedical Engineering

Medical School UCSF

Internship St. Mary’s Medical Center, San Francisco

Interests Running with my dogs, skiing, reading

Jonathan B. Greene, MD

Birthplace Santa Monica, California

College Yale University: BA, Psychology

Medical School University of MichiganMedical School

Internship Cedars-Sinai Medical Center, Los Angeles

Interests Music, hiking, travel

Aiyin Chen, MD

Birthplace Taipei, Taiwan

College Cornell University: BA, Biological Sciences

Medical School UCSF

Internship Atlantic Health, Morristown, New Jersey

Interests Snorkeling, traveling, creative writing in Mandarin

Daniel A. Greninger, MD

Birthplace San Leandro, California

College Dartmouth College: BA; EngineeringScience Thayer School of Engineering atDartmouth: Bachelor of Engineering

Medical School Weill Cornell Medical College

Internship Santa Clara Valley Medical Center,San Jose, California

Interests Skiing, hiking, playing the piano

New doctors who entered the UCSF Ophthalmology residency program in Fall 2009 are (left to right) Michael Chen, Sara Haug, Jonathan Greene, Aiyin Chen, and Daniel Greninger.

University of California

San Francisco, CA 94143

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