featured product of selleck---ino-1001(purity>99%)
DESCRIPTION
Technical Data:M.Wt: 136.15Formula: C7H8N2OSolubility: DMSOPurity: >99%Storage: at -20℃ 2 yearsCAS No.: 3544-24-9Biological Activity of INO-1001:INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties[1,2]. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. [3,4,5]References on INO-1001:[1] Brock WA et al. Cancer Lett. 2004 Mar 18;205(2):155-60[2] Kathryn A. Mason et al. Investigational New Drugs.2008 February;26(1)[3] Besson VC et al.Brain Res. 2005 Apr 18;1041(2):149-56[4] Tóth O et al. Life Sci. 2006 Jun 20;79(4):317-23 [5] Szabó G et al. Shock. 2004 May;21(5):426-32TRANSCRIPT
Product Information
INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties.[1,2]
INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. [3,4,5]
Biological Activity
[1] Brock WA et al. Cancer Lett. 2004 Mar 18;205(2):155-60
[2] Kathryn A. Mason et al. Investigational New Drugs.2008 February;26(1)
[3] Besson VC et al.Brain Res. 2005 Apr 18;1041(2):149-56
[4] Tóth O et al. Life Sci. 2006 Jun 20;79(4):317-23
[5] Szabó G et al. Shock. 2004 May;21(5):426-32
References
S1132 INO-1001
Technical Data:M.Wt:Formula:Solubility:Purity:Storage:CAS No.:
136.15C7H8N2O DMSO99%at -20℃ 2 years3544-24-9
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