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RESPON METABOLISME

PADA STARVASI DAN STRES

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PUSAT PENGATURAN ASUPAN

MAKAN

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METABOLIC PROFILE OF ORGANS

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THE LIVER ASTHE LIVER AS

CENTRAL PLAYER CENTRAL PLAYER 

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PATHWAY APA??

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FLOW SUBSTRAT

DURING FASTING AND

STARVATION STATE

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PATHWAY APA?

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SIKLUS APA?

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PATHWAY OF AMINO ACID

METABOLISM IN THE

LIVER

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POSTABSORPTIVE STATE -> AFTER A MEAL

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Blood-glucose level dropsafter several hours afterthe meal

- > decrease in insulinsecretion

-> rise in glucagon

secretion Low blood-glucose level

 -> stimulates glucagonsecretion of α-cells of thepancreas

EARLY FASTING STATE

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FIRST PRIORITY

-> provide sufcient glucose to brain and other tissues that aredependent on it

SECOND PRIORITY  

-> preserve protein

-> shit rom utilization o glucose to utilization o atty acids + ketonebodies

-> mobilization o TAG in adipose tissues + gluconeogenesis by liver

-> muscle shit rom glucose to atty acids as uel

AFTER 3 DAYS OF STARVATION 

-> liver orms large amounts o ketone bodies

-> brain and heart start to use ketone bodies as uel

AFTER SEVERAL WEEKS OF STARVATION 

-> ketone bodies major uel o brain

AFTER DEPLETION OF TAG STORES

-> proteins degradation accelerates

PROLONGED STARVATION

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