Fertility / IVFProduct Catalogue2013-2014

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Pictured: Esco Micro Pte. Ltd. is headquartered in Singapore, a modern city state located in Southeast Asia with a population of more than 4 million. From Singapore, Esco manages operations throughout the world.

Esco represents innovation and forward - thinking designs, which are all coupled with the highest standard quality since 1978. The Esco Group of Companies is a global life sciences tools provider with sales in over 100 countries. The group is active in lab, medical and pharmaceutical equipment. Manufacturing facilities are located in Asia and Europe. R&D is conducted worldwide spanning the US, Europe and Asia. Sales, service and marketing subsidiaries are located in 12 major markets worldwide. Regional distribution centers are located in the US, UK, and Singapore. We operate under ISO 9001 and ISO 14001 certified Quality and Environmental Management Systems. Esco Medical is one of the divisions of the Esco Group of Companies, the other two being the laboratory and pharmaceutical equipment divisions. Esco is now targeting innovative technological solutions for fertility clinics and laboratories. Esco Medical is positioned to become a leading manufacturer and innovator of high-quality equipment such as long-term embryo incubators, time lapse benchtop incubators, ART workstations, anti vibration table, gas analyser and etc. Most products are designed in Denmark and made in the EU. The primary focus of this division is to increase pregnancy success rates.

Welcome to Esco

ART / IVF Quick Facts

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Miri® TL (Time Lapse) Benchtop Incubator

Annotations of the embryo are stored. When an event occurs, the user simply selects the event from the events list. If two events relate to some developmental stage, the period between the milestone events is highlighted with a useful color fill.

Miri® TL main screen showing general incubation parameters

Onboard data logger records allincubation chamber parameters

Built-in standard pH meter (BNC-type) is accessed from the pH meter screen

When a decision is to be made, the user needs only to click a button. A resulting ‘transfer map’ gives the user an easy method to identify embryos that have been selected for either embryo transfer, cryopreservation, or discarding.

3 Components of Miri® TL System

Miri® TL Incubator

Miri® TL Server

Miri® TL ViewerPatient data organization

Embryo annotation

Powerful yet easy to use tools for selection

Secure and reliable storage of time lapse data

Designed in Denmark

Made in the E.U.

6 completely separate culture heat chambers with heated lid

Time lapse monitoring with 5 minutes (adjustable) interval

1 CultureCoin per Miri® TL chamber;1 4 embryos per CultureCoin = 84 embryos total

CO2 and O2 regulation system

HEPA + VOC filtration

Key FeaturesTime Lapse Monitoring of Embryo Development

The most user friendly time lapse benchtop incubation system on the market,

with the best sample protection and the industry’s lowest total cost of ownership.

Miri® TL Viewer screenshots

Miri® TL incubator viewers screenshots

EN 61010-1:2010

Silent Embryo Hypothesis

Parents are vigilant when it comes to their children’s safety. Similarly, Miri® TL gives

importance to monitoring the embryo during its development.

The Miri® TL enables time-lapse image monitoring of the growing embryos and thus

gives the embryologist a valuable tool in ensuring the most viable embryos are selected.

Temperature fluctuations

Gas concentration fluctuations

Non-optimal pH

Volatile Organic Compounds (VOCs)

Common Stressors:

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*Includes Miri® TL Incubator, Miri® TL Server, Miri® TL Viewer and 1pc HEPA + VOC filter, and 2pcs In-line Filter

Miri® TL Technical Specifications

Total Dish Capacity 6x CultureCoin dishes, 14 embryos per dish, total of 84 embryos

Temperature Control Range 25 - 40ºC

CO2 Control Range 1.9 - 10%

O2 Control Range 20 - 5%

Input Gases and Pressure Pure CO2 and pure N2, 0.6 bar (8.7psi)

Overall Dimension 950 mm x 600 mm x 370 mm (37.4” x 23.6” x 14.6”)

Ordering Information*

MRI-TLA-8 Miri® Time Lapse Incubator System, 230 V

MRI-TLA-9 Miri® Time Lapse Incubator System, 115 V

Accessories

MRA-1007 HEPA + VOC filter (to be replaced every 3 months)

MRI-CCA CultureCoin for Time Lapse of 14 embryos

Miri® Time Lapse CultureCoin

The Miri® Time Lapse CultureCoin is

a specially designed culture dish that

enables the Esco Miri® Time Lapse

incubator to take photos of incubating

embryos.

Miri® Time Lapse CultureCoin

The Miri® TL has an advanced temperature

regulation system. There are 6 completely

independent chambers (with heated lid) to

avoid crossover of heat.

Gas mixing

UV sterilization

Incubationchambers

CO2

O2 from atmosphere

N2

Recirculation

HEPA+VOCfiltration

Miri® Time Lapse

incubator for IVF

AdvancedTemperatureRegulation

AdvancedCO2 + O2

Regulation

High QualityRecirculatedAirstream

ART / IVF Quick Facts

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Miri® Multi-room Incubator

A ground-breaking design for IVF

The Miri® is a certified EU Class IIa Medical Device and it is also the only incubator that has been certified to the 3rd edition of the IEC/EN 60601

standard. It is thus no wonder that the remarkable characteristics of the Miri® make it an entirely exceptional incubator for in vitro fertilization applications.

Miri® Multi-room Incubator Technical Specifications

Total Dish Capacity

Falcon, Nunc, or Vitrolife brands 24x IVF 4-well

24 x 60 mm Petri Dishes (0.9” x 2.4”)48 x 35 mm Petri Dishes (1.9” x 1.4”)

Temperature Control Range 25 - 40ºC

CO2 Control Range 1.9 - 10%

O2 Control Range 20 - 5%

Input Gases and Pressure Pure CO2 and Pure N2, 0.6 bar (8.7 psi)

Dimension and Weight 700 mm x 580 mm x 150 mm (27.6” x 22.8” x 5.9”), 35 kg (77.2 lbs)

Shipping Dimension and Weight 840 mm x 735 mm x 300 mm (33.1” x 28.9” x 11.8”), 40 kg (88.2 lbs)

Ordering Information*

MRI-6A10-8F Miri® Incubator, 230 V, for Falcon Dishes

MRI-6A10-9F Miri® Incubator, 115 V, for Falcon Dishes

MRI-6A10-8N Miri® Incubator, 230 V, for Nunc Dishes

MRI-6A10-9N Miri® Incubator, 115 V, for Nunc Dishes

MRI-6A10-8V Miri® Incubator, 230 V, for Vitrolife Dishes

MRI-6A10-9V Miri® Incubator, 115 V, for Vitrolife Dishes

Accessories

MRA-1007 HEPA + VOC filter (to be replaced every 3 months)

MRI-1014 Stacking frame for 2x Miri® units

*Includes Data Logger Software, 1pc HEPA + VOC Filter, 2pcs In-Line Filters

Designed in Denmark

Made in the E.U. 6 completely separate heating chambers

Advanced temperature regulation + heated lid

CO2 and O2 regulation

HEPA + VOC filtration

UV-C Filtration airstream

Data logging

Easy validation

Built-in pH meter (BNC)

Audible and visual alarms

Stackable with accessory stacking frame

Key Features

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Miri® Accessories

HEPA + VOC Filter

Order Code: MRA-1007

Ensures that clean and VOC-free air is supplied to the

incubation chambers. Advisable to be replaced every 3 months.

Special Lid for pH Probe

Order Code: MRA-1016

Allows pH reading while keeping gas contained.

Disinfectant Spray

Order Code: DIS-500

Safely and effectively disinfect incubators and other general

surfaces.

In-line Filters

Order Code: MRA-1001

Filters gas input. Order code is for 2 pcs external filters

and 2 pcs internal filters (not shown in the image).

Micro pH Probe

Order Code: MRI-MPH

Capable of taking pH probe measurement with

microdrop volumes of media. Buffers not included.

Stacking Frame for 2x Miri® Unit

Order Code: MRA-1014

Space-saving efficiency is provided by the sturdy solid

metal frame designed to stack 2 Miri® incubator units.

Note: With some types of pH probes, pH measurement can drift.

Ensure that a suitable probe or procedure is used (pH probe not

included).

CelCulture® CO2 Incubators

Laminar Flow Cabinet

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Key Features

ULPA filtration system

90°C moist heat decontamination cycle, validated by HPA-UK

Cost effective

Key Features

ISO Class 3 workzone

Airflow monitoring

Energy saving

Cradle for Beautiful Cells

CelCulture® CO2 incubators are widely used in scientific research to grow and maintain cell cultures. Typical

fields of application include tissue engineering, in vitro fertilization, neuroscience, cancer research, stem cell

research, regenerative medicine, and other mammalian cell research.

Sleek, reliable and intuitive, Esco CelCulture® CO2 Incubators provide well-rounded sample protection.

Product Protection at your Fingertips

Airstream® Vertical Laminar Flow Clean Benches offer proven protection for your samples and

processes where operator protection is required. Vertical laminar flow offers certain tangible

advantages over horizontal flow clean benches (which may be the convention to some parts of the

world), such as lower energy consumption (40% of conventional system) levels through the use of

exclusive motorized impeller technology and less airflow turbulence (especially when large objects

are used on the workzones). In fact, the negative pressure filter mounting system employed on these

models is widely recognized to be superior to that of conventional horizontal flow clean benches.

SUPPRESSED O2 MODEL

MODELS DESCRIPTION

CCL-170T-8-Cu CelCulture® Incubator, 170L, IR Sensor, CO2 Control, O2 Control ULPA, Moist Heat Decon, 230VAC 50/60HZ

CCL-170T-9-Cu CelCulture® Incubator, 170L, IR Sensor, CO2 Control, O2 Control ULPA, Moist Heat Decon,115VAC 50/60HZ

CCL-240T-8-Cu CelCulture® Incubator, 240L, IR Sensor, CO2 Control, O2 Control ULPA, Moist Heat Decon, 230VAC 50/60HZ

CCL-240T-9-Cu CelCulture® Incubator, 240L, IR Sensor, CO2 Control, O2 Control ULPA, Moist Heat Decon,115VAC 50/60HZ

Model AVC-2D_ AVC-3D_ AVC-4D_ AVC-5D_ AVC-6D_

Nominal Size 0.6 m (2”) 0.9 m (3”) 1.2 m (4”) 1.5 m (5”) 1.8 m (6”)

ExternalDimensions(W x D xH)

730 x 770 x 1250 mm28.7” x 30.3” x 49.2”

1035 x 770 x 1250 mm40.7” x 30.3” x 49.2”

1340 x 770 x 1250 mm52.8” x 30.3” x 49.2”

1645 x 770 x 1250 mm64.8” x 30.3” x 49.2”

1950 x 770 x 1250 mm76.8” x 30.3” x 49.2”

730 x 770 x 1961 mm28.7” x 30.3” x 77.2”

1035 x 770 x 1961 mm40.7” x 30.3” x 77.2”

1340 x 770 x 1961 mm52.8” x 30.3” x 77.2”

1645 x 770 x 1961 mm64.8” x 30.3” x 77.2”

1950 x 770 1961 mm76.8” x 30.3” x 77.2”

Internal Work AreaDimensions (W x D xH)

660 x 700 x 695 mm26.0” x 27.6” x 27.4”

965 x 712 x 695 mm38.0” x 28.0” x 27.4”

1270 x 712 x 695 mm50.0” x 28.0” x 27.4”

1580 x 712 x 695 mm62.2” x 28.0” x 27.4”

1884 x 712 x 695 mm74.2” x 28.0” x 27.4”

Internal Work Area Space 0.39 m2 (4.2 sq.ft.) 0.59 m2 (6.3 sq.ft.) 0.79 m2 (8.5 sq.ft.) 0.98 m2 (10.5 sq.ft.) 1.18 m2 (12.7 sq.ft.)

Without BaseStand

With OptionalBase Stand711mm (28”)

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Fertilisafe™ Multi-Zone ART Workstation

Key Features

Multiple heating zone work surface

Surveillance system with data logging

Laminar airflow with ULPA filtration

Low noise and vibration

Provision for microscope integration

Humidification system Variable configuration

Designed in Denmark

The most advanced workstation in its class

It is designed for use in applications that require a high level of control over

environmental conditions. Applications can range from animal embryo culture

in research to human embryo manipulation done in fertility laboratories.

FertilisafeTM

Technical SpecificationsMAW-4D_ MAW-6D_ MAW-4D_DUAL

Work Area Dimensions(Width x Depth x Height)

1260 x 500 x 710 mm(49.6” x 19.7” x 28”)

1870 x 500 x 710 mm(73.6” x 19.7” x 28”)

External Dimensionwithout Support Stand (Width x Depth x Height)

1340 x 640 x 1300 mm(52.8” x 25.2” x 51.2”)

1950 x 640 x 1300 mm(76.8” x 25.2” x 51.2”)

External Dimensionwith “B” type Support Stand (Width x Depth x Height)

1340 x 640 x 2160 mm(52.8” x 25.2” x 85”)

1950 x 640 x 2160 mm(76.8” x 25.2” x 85”)

Laminar Airflow Velocity Average of 0.21 m/s or 41 fpm (+/- 20%)

Filter EfficiencyMinimum: 999.9991% at 0.3 µm / 99.9984% at 0.12 µm / 99.9982% at MPPS

Typical: 999.9998% at 0.3 µm / 99.998% at 0.12 µm / 99.9987% at MPPS

Noise Level (as per IEST) ≤ 47 dBa ≤ 48 dBa

Pre-filter Disposable and non-washable polyester fibers with 85% arrestance / EU3 rated

Heating SystemSmart power injection

electrical heating, 9+1 zonesSmart power injection

electrical heating 2 x (9+1) zones

Temperature Accuracy ± 0.2ºC

Temperature Uniformity ± 0.2ºC

Included Advance Features

Integrated Humidification System HS-1Surveillance System with Data Logger

AIO PCHeated Glass Stage

Transmitted Light Source SC-1 (with bulb)5x PT1000 Validation Ports

Dual Integrated Humidification System HS-1Surveillance System with Data Logger

AIO PC2x Heated Glass Stage

2x Transmitted Light Source SC-1 (with bulb)10x PT1000 Validation Ports

Included Accessories1x Water Bottle fo HS-1, including tubing

1x Sample Carry Tray1x Humidified Glass Plastic Cover

2x Water Bottle fo HS-1, including tubing2x Sample Carry Tray

2x Humidified Glass Plastic Cover

Microscope Provision Included for 1 microscope Included for 2 microscopes

MicroscopeRequired,

Not included (see Ordering Information)

Support StandRequired,

Not included (see Ordering Information)

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FertilisafeTM ComponentsMulti-Zone heating system

The 10 zones each have their own heating mechanisms

and temperature sensors. This allows excellent uniformity.

Accuracy: ± 0.2ºC

Uniformity: ± 0.2ºC

*Provision for integration of stereomicroscope

HS-1 Humidification system

SC-1 Light Source

Warmed glass stage

Surveillance system with touchscreen monitor (AIO PC)

The surveillance system gives the user the ability to see the temperature

of all the zones in real time.

Microscope provisional features*

Most common stereomicroscopes can be integrated in the FertilisafeTM. This

includes Nikon, Olympus, Carl Zeiss, Leica models. Lighted bases cannot be

integrated; the Esco SC-1 light source is designed for use with the workstation

and thus will outperform lighted bases, which are not specified for this application.

Important: The ‘microscope base’ part number must be

provided to Esco to ensure proper fitting.

B

A

C

D

C1

C2

System guide

MAW-#D# “Code D system” includes:

MAW-#F# “Code F system” includes:

A

A

B

C

C

C1

C1

C2

C2

D

D

6 completely separate heating chambers

Advanced temperature regulation + heated lid

CO2 and O2 regulation

The surveillance system is also a data logger and stores parameter

data and alarm events. The touchscreen monitor is a fully functional

Windows PC. It has WiFi and a USB port.

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Ordering Information

CODE DESCRIPTION

MAW-4D9 Multi-Zone ART Workstation 4 ft (1.2 m), 110 V, 50 / 60 Hz

MAW-4D8 Multi-Zone ART Workstation 4 ft (1.2 m), 220 V, 50 / 60 Hz

MAW-4D9- SINGLE / DUAL / MP Multi-Zone ART Workstation 6 ft (1.8 m), 110 V, 50 / 60 Hz

MAW-4D8- SINGLE / DUAL / MP Multi-Zone ART Workstation 6 ft (1.8 m), 220 V, 50 / 60 Hz

MICROSCOPE PROVISION CODE DESCRIPTION 6 ft MAIN BODY SUFFIX (explanation)

NIKONCPSNULL Nikon C-PS

SINGLE - Single Stereomicroscope Provision

DUAL - Dual Stereomicroscope Provision

MP - Stereomicroscope + Inverted microscope / micromanipulator

NIKONCPS160 Nikon C-PS 160

OLYMPUSSZ(X)ST Olympus SZX-ST

OLYMPUSSZ(TWO)ST Olympus SZ2-ST

ZEISSTANDN Zeiss Stand N

ESCOSCOPE Esco Stereomicroscope MS-1

SUPPORT STAND DESCRIPTION

SMC - 4A0 4 ft MAW Support Stand with castor wheels, overall height 711 mm (28”)

SMC - 6A0 6ft MAW Support Stand with castor wheels, overall height 711 mm (28”)

SML - 4A0 4 ft MAW Support Stand with leveling feet, overall height 711 mm (28”)

SML - 6A0 6 ft MAW Support Stand with leveling feet, overall height 711 mm (28”)

SMC - 4B0 4 ft MAW Support Stand with castor wheels, overall height 860 mm (33.9”)

SMC - 6B0 6 ft MAW Support Stand with castor wheels, overall height 860 mm (33.9”)

SML - 4B0 4 ft MAW Support Stand with leveling feet, overall height 860 mm (33.9”)

SML - 6B0 6 ft MAW Support Stand with leveling feet, overall height 860 mm (33.9”)

4 ft SINGLE Configuration ORDER CODE: MAW-4D8 (230 V), MAW-4D9 (115 V)

6 ft DUAL Configuration ORDER CODE: MAW-6D8-DUAL (230 V), MAW-6D9-DUAL (115 V)

4 ft width configuration with provision for single stereomicroscope

6 ft width configuration with provision for two stereomicroscope

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Connected to a PC, the logging software will document

parameters and optionally send e-mail alarms if set up.Designed in Denmark

Made in the E.U.

Constantly validate up to 6 x CO2 / O2 incubators

Controllable flow rate

Monitor up to 6 x PT1000 sensors

6 ports for sequential gas samples

Gas feedback returns sampled gas to incubator or exhaust

Key Features

Parameter data logging

Audible and visual alarms

Adjustable alarm thresholds

As a validation unit, Miri® GA can provide:

Desktop CO2/O2 & Temperature Validation Unit

The Miri® GA contains high precision quality components. These components are chosen to ensure a high durability and performance of the equipment.

Note: AVT-1 is designed to be easy to use and almost maintenance free

Technical Specifications AVT-1

Overall Dimensions (W x D x H)1200 x 800 x 800 mm

(47.2” x 31.5” x 31.5”)

Weight 70 kg (154 lbs)

MaterialMaterial

Powder painted mild steel,Stainless steel and glass

Float Dimension540 mm x 340 mm(21.26” x 13.39”)

Designed in Denmark

Made in the E.U.

Isolate Microscope from External Vibrations

Inverted miroscopes with micromanipulators are used for Intracytoplasmic Sperm Injection (ICSI) and must be completely isolated from external vibrations. The AVT-1 is specially made for purposes of providing effective passive-type damping of vibrations.

Anti Vibration Table

Miri® GA (Gas Analyser)

*Includes data logging software, 1 pc PT1000 cable, 1 pc gas connection tube, and 1 pc gas feedback tube

Miri® GA Technical Specifications

Input ports 6x PT1000 ports for temperature monitoring

Output ports 1x gas feedback port

Shipping Dimension and Weight 440 mm x 430 mm x 240 mm (17.3” x 16.9” x 9.4”), 15 Kg (33.1 lbs)

Ordering information*

MRI-GA Miri® GA CO2 / O2 & Temperature Validation Unit, 115V / 230V

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“

“Hand in hand in achieving high fertility success rates.

Asia (Headquarters)Esco Micro Pte Ltd 21 Changi South Street 1, SingaporeTel +65 6542 0833 • Fax +65 6542 6920csis-medical@escoglobal.comwww.medical.escoglobal.com

EuropeEsco GB LtdUnit 20, Parkers Close, Downton Industrial EstateDownton, Wiltshire SP5 3RBTel: +44 (0) 1725 514 555 • Fax: +44 (0) 1725 514 551mark.darton@escoglobal.com • www.escogb.com

North AmericaEsco Technologies, Inc.2940 Turnpike Drive, Units 15-16 Hatboro, PA, USATel: 215 441 9661 • Fax: 215 441 9660nick.wang@escoglobal.comwww.us.escoglobal.com

Esco Global Offices: Manama, Bahrain | Beijing, China | Chengdu, China | Guangzhou, China | Shanghai, China | Bangalore, India | Delhi, India | Mumbai, India

Jakarta, Indonesia | Osaka, Japan | Kuala Lumpur, Malaysia | Melaka, Malaysia | Manila, Philippines | Singapore | Seoul, South Korea | Salisbury, UK | Philadelphia, PA, USA | Hanoi, Vietnam

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Index of order codes of notable Esco Medical Products

CODE DESCRIPTION PAGE

MRI-TLA-8 Miri® Time Lapse incubator system, 230 V Page 3-4

MRI-TLA-9 Miri® Time Lapse incubator system, 115 V Page 3-4

MRI-6A10-8N Miri® Multi-Room benchtop incubator, 230 V, with plates for Nunc dishes Page 5-6

MRI-6A10-9N Miri® Multi-Room benchtop incubator, 115 V, with plates for Nunc dishes Page 5-6

MRI-6A10-8F Miri® Multi-Room benchtop incubator, 230 V, with plates for Falcon dishes Page 5-6

MRI-6A10-9F Miri® Multi-Room benchtop incubator, 115 V, with plates for Falcon dishes Page 5-6

MRA-1014 Stacking frame for 2x MRI-6A10 Page 6

MRA-1007 HEPA + VOC filter for MRI-TLA or MRI-6A10 Page 6

MRA-1001 In-line filter set (2x internal, 2x external) for MRI-TLA or MRI-6A10 Page 6

MRA-1016 Special lid for pH probe Page 6

MRI-MPH Micro-pH probe (BNC connector) Page 6

DIS-500 Disinfectant spray (500 mL spray bottle) Page 6

MAW-4D8 Fertilisafe™ Multi-Zone Workstation, 230 V, 4 ft, complete system Page 8-10

MAW-4D9 Fertilisafe™ Multi-Zone Workstation, 115 V, 4 ft, complete system Page 8-10

MAW-6D8 Fertilisafe™ Multi-Zone Workstation, 230 V, 6 ft, single microscope, complete system Page 8-10

MAW-6D9 Fertilisafe™ Multi-Zone Workstation, 115 V, 6 ft, single microscope, complete system Page 8-10

MAW-4F8 Fertilisafe™ Multi-Zone Workstation, 230 V, 4 ft, with no surveillance system and monitor Page 8-10

MAW-4F9 Fertilisafe™ Multi-Zone Workstation, 115 V, 4 ft, with no surveillance system and monitor Page 8-10

MAW-6F8 Fertilisafe™ Multi-Zone Workstation, 230 V, 6 ft, with no surveillance system and monitor Page 8-10

MAW-6D9 Fertilisafe™ Multi-Zone Workstation, 115 V, 6 ft, with no surveillance system and monitor Page 8-10

AVT-1 Antivibration table for inverted microscope setup (ICSI) Page 11

MRI-GA Miri® GA CO2 / O2 & Temperature validation unit, 115 V / 230 V Page 11