Fibroepithelioma of PinkusFibroepithelioma of Pinkus(Basal cell carcinoma, fibroepithelioma of Pinkus type)(Basal cell carcinoma, fibroepithelioma of Pinkus type)

Deba P Sarma, MDDeba P Sarma, MD

OmahaOmaha

M 79, backM 79, back

CommentComment

First described by Hermann Pinkus in 1953.First described by Hermann Pinkus in 1953.

It is a rare variation of basal cell carcinoma with very indolentIt is a rare variation of basal cell carcinoma with very indolent

clinical course.clinical course.

Unlike other histologic types of basal cell carcinoma, the tumor Unlike other histologic types of basal cell carcinoma, the tumor occurs commonly on the sun-protected skin of trunk, especially occurs commonly on the sun-protected skin of trunk, especially back.back.

Presents as a slowly enlarging, fleshy, raised or pedunculated Presents as a slowly enlarging, fleshy, raised or pedunculated papilloma or achrochordon with a broad base on the trunk or the papilloma or achrochordon with a broad base on the trunk or the extremities.extremities.

Age: Older adults, M=FAge: Older adults, M=F

Histology: Fibroepithelioma of Pinkus shows long, thin, branching Histology: Fibroepithelioma of Pinkus shows long, thin, branching and anastomosing strands of basal cell carcinoma within in a and anastomosing strands of basal cell carcinoma within in a fibrovascular stroma. Many strands show a connection with the fibrovascular stroma. Many strands show a connection with the epidermis. The basaloid strands show two types of cells: a lighter epidermis. The basaloid strands show two types of cells: a lighter staining cell comprising the bulk of the strand and peripheral, small staining cell comprising the bulk of the strand and peripheral, small darker cells showing palisading pattern. darker cells showing palisading pattern.

Unusual examples of fibroepithelioma of PinkusUnusual examples of fibroepithelioma of Pinkus

Pan Z, Huynh N, Sarma DP. Pan Z, Huynh N, Sarma DP. (2008). (2008). FibroepitheliomaFibroepithelioma of of PinkusPinkus in a 9-year-old boy: a case report. Cases Journal 1:21. in a 9-year-old boy: a case report. Cases Journal 1:21. PMID: PMID: 18588684 [PubMed – indexed for MEDLINE] 18588684 [PubMed – indexed for MEDLINE]

Repertinger SK, Stevens T, Markin N, Klepacz H, Sarma DP.Repertinger SK, Stevens T, Markin N, Klepacz H, Sarma DP.(2008). (2008). FibroepitheliomaFibroepithelioma of of PinkusPinkus with with pleomorphicpleomorphic epithelial giant cells. Dermatology Online J 14(12):13. [ epithelial giant cells. Dermatology Online J 14(12):13. [PubmedPubmed- indexed for MEDLINE].- indexed for MEDLINE].