figure s1
DESCRIPTION
non. -. Tg/STg. +. Dox. 200. DTg. +. Dox. 180. 160. 140. 120. Relative CD4 MFI (%). 100. 80. 60. 40. 20. 0. Thymus. pLN. non. -. Tg/STg. +. Dox. DTg. +. Dox. 20. p. =0.002. p. =0.001. p. =0.004. T cells. 15. p. =0.0005. +. 10. % of CD4. 5. 0. hi. hi. - PowerPoint PPT PresentationTRANSCRIPT
Figure S1
0
20
40
60
80
100
120
Thymus pLN
Re
lati
ve C
D4
MF
I (%
)
nonTg/STg + Dox
DTg + Dox
02468
10121416
CD69hi CD25hi CD44hiCD62Llo
% o
f C
D4
T c
ells
non-Tg/STg + Dox
DTg + Dox
p=0.05p=0.03
0
5
10
15
20
25
30
35
Total CD4 TcR CD8TcR B220
Ce
ll n
um
be
rs (
X10
6 )
nonTg/STg + Dox
DTg + Dox
p=0.06
p=0.01
0.00.51.01.5
Total CD4 SP CD8 SP DP
68
10121416182022
Ce
ll n
um
be
rs (
X10
7 )
non-Tg/STg + Dox
DTg + Doxp=0.1
p=0.04
p=0.02
p=0.08
Thymus
pLN
0
20
40
60
80
100
120
Thymus pLN
Re
lati
ve C
D4
MF
I (%
)
nonTg/STg + Dox
DTg + Dox
0
20
40
60
80
100
120
Thymus pLN
Re
lati
ve C
D4
MF
I (%
)
nonTg/STg + Dox
DTg + Dox
02468
10121416
CD69hi CD25hi CD44hiCD62Llo
% o
f C
D4
T c
ells
non-Tg/STg + Dox
DTg + Dox
p=0.05p=0.03
02468
10121416
CD69hi CD25hi CD44hiCD62Llo
% o
f C
D4
T c
ells
non-Tg/STg + Dox
DTg + Dox
p=0.05p=0.03
0
5
10
15
20
25
30
35
Total CD4 TcR CD8TcR B220
Ce
ll n
um
be
rs (
X10
6 )
nonTg/STg + Dox
DTg + Dox
p=0.06
p=0.01
0
5
10
15
20
25
30
35
Total CD4 TcR CD8TcR B220
Ce
ll n
um
be
rs (
X10
6 )
nonTg/STg + Dox
DTg + Dox
p=0.06
p=0.01
0.00.51.01.5
Total CD4 SP CD8 SP DP
68
10121416182022
Ce
ll n
um
be
rs (
X10
7 )
non-Tg/STg + Dox
DTg + Doxp=0.1
p=0.04
p=0.02
p=0.08
0.00.51.01.5
Total CD4 SP CD8 SP DP
68
10121416182022
Ce
ll n
um
be
rs (
X10
7 )
non-Tg/STg + Dox
DTg + Doxp=0.1
p=0.04
p=0.02
p=0.08
Thymus
pLN
F176042 Females
F176043 Females
Nef: - + - + - + + - - +
66KDa
F176043 F176042Nef: - + - + - + + - - +
66KDa
F176043 F176042
A B
C D
E F
G H
I
Rahim et al.
020406080
100120140160180200
Thymus pLN
Rel
ativ
e C
D4
MF
I (%
) non-Tg/STg + Dox
DTg + Dox
0
5
10
15
20
CD69hi CD25hi CD44hi CD45RBlo
% o
f C
D4+
T c
ells
non-Tg/STg + DoxDTg + Dox
p=0.001
p=0.0005
p=0.004p=0.002
Thymus
pLN
020406080
100120140160180200
Thymus pLN
Rel
ativ
e C
D4
MF
I (%
) non-Tg/STg + Dox
DTg + Dox
020406080
100120140160180200
Thymus pLN
Rel
ativ
e C
D4
MF
I (%
) non-Tg/STg + Dox
DTg + Dox
00.51.01.5
Total CD4 SP CD8 SP DP
468
101214161820
7 )
non-Tg/STg + DoxDTg + Dox
p=0.006
p=0.02
p=0.2p=0.1
00.51.01.5
Total CD4 SP CD8 SP DP
468
101214161820
Cel
l nu
mb
ers
(X10
7
non-Tg/STg + DoxDTg + Dox
p=0.006
p=0.02
p=0.2p=0.1
02468
10121416182022
Total CD4 CD8 B220
non-Tg/STg + Dox
DTg + Dox
p=0.009
02468
10121416182022
Total CD4 CD8 B220
Cel
l nu
mb
ers
(X10
6) non-Tg/STg + Dox
DTg + Dox
p=0.009
0
5
10
15
20
CD69hi CD25hi CD44hi CD45RBlo
% o
f C
D4+
T c
ells
non-Tg/STg + DoxDTg + Dox
p=0.001
p=0.0005
p=0.004p=0.002
0
5
10
15
20
CD69hi CD25hi CD44hi CD45RBlo
% o
f C
D4+
T c
ells
non-Tg/STg + DoxDTg + Dox
p=0.001
p=0.0005
p=0.004p=0.002
Thymus
pLN
100 101 102 103 104
CD8 FITC100 101 102 103 104
CD8 FITC
- Dox + Dox
CD8
CD4
6.3±2
2.2±1.8
Thymus (Female F148571)
88±5.5 6±2.2
2.3±1
87.2±4.3
Figure S2
05
101520253035
CD69hi
CD44hi
CD45RBlo
CD62Llo
CD8+ T cells (F148571 Male)
% o
f c
ells
- Dox
+ Dox
p<0.01
05
101520253035
CD69hi
CD44hi
CD45RBlo
CD62Llo
CD8+ T cells (F176042 Female)
% o
f c
ells
- Dox
+ Dox
p<0.02
05
101520253035
CD69hi
CD44hi
CD45RBlo
CD62Llo
CD8+ T cells (F148571 Male)
% o
f c
ells
- Dox
+ Dox
p<0.01
05
101520253035
CD69hi
CD44hi
CD45RBlo
CD62Llo
CD8+ T cells (F148571 Male)
% o
f c
ells
- Dox
+ Dox
p<0.01
05
101520253035
CD69hi
CD44hi
CD45RBlo
CD62Llo
CD8+ T cells (F176042 Female)
% o
f c
ells
- Dox
+ Dox
p<0.02
05
101520253035
CD69hi
CD44hi
CD45RBlo
CD62Llo
CD8+ T cells (F176042 Female)
% o
f c
ells
- Dox
+ Dox
p<0.02
Figure S3
Rahim et al.