FINAL MEETING PROGRAM

Ion Channels in the Cardiovascular SystemO 12-15 September 1992 O.

Westfields International Conference Center, Chantilly, VA

Sponsored by National Heart, Lung, and Blood Institute, NIH and American Association for the Advancement of Science

Take part in an intensive conference that will synthesize therecent explosion of information on the function and dysfunc-tion of ion channels in the cardiovascular system.

The conference will bring together leaders from three groups:basic scientists researching molecular aspects ofcardiovascu-lar channel structure and function, academic clinicians con-cerned with disease processes resulting from channel dys-function, and pharmaceutical scientists involved in the designand testing of channel active drugs.

Discussion will focus on such issues as subunit function,modulation and control, mutagenesis and amino acid replace-ment studies, de- and repolarizing sodium and potassium

channels, and channel involvement in disease processes (e.g.,arrhythmias and sudden death). Participants will explore theways in which this information could be used in the develop-ment of new pharmaceuticals to treat ion channel mediateddiseases.

Westfields, a state-of-the-art conference center, will provide anatmosphere conducive to a high level of interaction among theparticipants and make you feel like a guest at one ofVirginia'smagnificient colonial estates. Yet, it's just minutes fromWashington's Dulles International Airport.

Space is limited, so use the registration form on page 273today!

Program Committee: Arthur M. Brown (co-chair), William A. Catterall (co-chair), Gregory J. Kaczorowski, Arnold M. Katz,Thomas W. Smith, Peter M. Spooner, Harold C. Strauss, August Watanabe, Robin Yeaton Woo

Saturday, 12 SeptemberNoon - 3:00pm Registration

3:00pm - 3:05pm WelcomePeter M. Spooner, National Heart, Lung and BloodInstitute Robin Yeaton Woo, American Associationfor the Advancement of Science

3:05pm - 3:30pm Opening RemarksArnold M. Katz, Univ. of Connecticut Health Ctr.Ion channels and cardiology: Need for bridges across awidening boundary

3:30pm - 5:30pm Ion Channels and Cardiac Disease:Dimensions of the ProblemClinical Tutorial

A. John Camm, St. George's Hosp. Med. Sch.Current pharmacologic and nonpharmacologicapproaches to SCD

5:30pm - 6:00pm Break

6:00pm - 8:00pm Ion Channels and Cardiac Disease:Fundamentals of the Problem-Basic Science Tutorial

William A. Catterall, Univ. of WashingtonIntroduction to molecular analysis of ion channelstructure

Arthur M. Brown, Baylor Colt. ofMed.Introduction to biophysical analysis of ion channelfunction

8:00pm Dinner

Harold C. Strauss, Duke Univ. Med. Ctr.Conformational-dependent drug binding to cardiacpotassium channels

Robert J. Meyerburg, Univ. ofMiami Sch. ofMed.Epidemiology of sudden cardiac death (SCD)Peter J. Schwartz, Univ. ofPaviaAutonomic markers of SCD

Douglas P. Zipes, Indiana Univ. Sch. ofMed.Autonomic mechanisms underlying arrythmogenesisand SCD

Sunday, 13 September7:00am - 9:00am Breakfast

9:00am - 12:30pm Ion Channels and Cardiovascular FunctionChair: Harold C. Strauss, Duke Univ. Med. Ctr.

Harry A. Fozzard, Univ. of ChicagoSodium channels and cardiac excitabilityEduardo Marban, Johns Hopkins Univ.Sodium and calcium channels in the heart

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Michael C. Sanguinetti, Merck Research LabsDelayed rectifier K+ channels of cardiac muscle

Joseph R. Hume, Univ. ofNevada Sch. ofMed.Chloride channels

David C. Spray, Albert Einstein Colt. ofMed.Cardiovascular gap junctions: Gating properties,function, and dysfunction

Discussion

12:30pm - 2:00pm Lunch and Poster Session

2:00pm - 5:00pm Channel Modulation and Autonomic ControlChair: Arthur M. Brown, Baylor ColL. ofMed.

Wayne R. Giles, Univ. of Calgary Sch. ofMed.Alpha- 1 adrenoceptor effects in single cells andsarcolemmal membranes from rabbit atrial andventrical myocytes

Bruce Bean, Harvard Univ.Beta-adrenergic modulation of cardiac calcium channels

Martin Morad, Univ. of PennsylvaniaRegulation of cardiac sodium channels by cAMPreceptors

Arthur M. Brown, Baylor Colt. of Med.Pore of a K+ channel and its regulation by G proteins

Discussion

6:00pm - 8:00pm Cocktails and Dinner

8:00pm - 10:00pm Poster Session

Monday, 14 September7:00am - 9:00am

Kurt Beam, Colorado State Univ.Structural basis of calcium channel function inskeletal muscle

Franz Hofmann, Tech. Univ. ofMunichRegulation of the L-type calcium channel by itssubunits

Discussion

6:00pm - 8:00pm Cocktails and Dinner

8:00pm - 10:00pm Poster Session

Tuesday, 15 September7:00am - 9:00am

9:00am - Noon

Noon - 2:00pmBreakfast

Breakfast

Molecular PharmacologyChair: William A. Catterall, Univ. of Washington

Harold C. Strauss, Duke Univ. Med. Ctr.Conformation-dependent drug binding to cardiacpotassium channels

Thomas Colatsky, Wyeth-Ayerst ResearchBlock of myocardial potassium channels by anti-arrythmic drugs: Dependence on channel gating

Robert S. Kass, Univ. ofRochester Med. Ctr.Dihydropyridines and the molecular properties ofheart calcium channels

Jorg Striessnig, Inst. for Biochemical PharmacologyCalcium antagonist binding domains of L-typecalcium channels

Discussion

Lunch

9:00am - 12:30pm Structure-Function of Ion Channels I

Chair: Arthur M. Brown, Baylor Colt. ofMed.

Rod MacKinnon, Harvard Med. Sch.Molecular physiology of potassium channels

Richard Aldrich, Stanford Univ.Mechanisms of voltage-dependent channel gatingPeter Hess, Harvard Med. Sch.Mechanisms of potassium channel gating probed bysite-directed mutagenesis

Michael M. Tamkun, Vanderbilt Med. Sch.Molecular physiology of cardiac potassium andsodium channels

Discussion

12:30pm - 2:00pm Lunch and Poster Session

2:00pm - 5:00pm Structure-Function of Ion Channels 11Chair: William A. Catterall, Univ. of Washington

William A. Catterall, Univ. of WashingtonStructure and modulation of sodium channels

Walter Stiihmer, Max Planck Inst.Extracellular potassium modulates a transientpotassium current in rat atrial cells

2:00pm - 4:30pm Drug DiscoveryChairs: August Watanabe, Eli Lilly & Co.; Gregory J.Kaczorowski, Merck Research Labs

Gregory J. Kaczorowski, Merck Research LabsStrategies to discover novel ion channel modulators

Benedict R. Lucchesi, Univ. ofMichigan Med. Sch.Potassium channels, repolarization, andantifibrillatory drugs

S. David Kimball, Bristol-Meyers SquibbThe design of new calcium antagonistsWilliam C. Lumma, Jr., Merck Research LabsInhibitors of cardiac delayed rectifying potassiumcurrents as potential novel anti-arrythmic agents

Discussion

4:30pm - 5:00pm Concluding ObservationsArnold M. Katz, Univ. of Connecticut Health Ctr.Ion channels: Building the bridge

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Ion Channels in the Cardiovascular System

DOI: 10.1126/science.257.5067.271 (5067), 271-273.257Science 

ARTICLE TOOLS http://science.sciencemag.org/content/257/5067/271.citation

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is a registered trademark of AAAS.ScienceScience, 1200 New York Avenue NW, Washington, DC 20005. The title (print ISSN 0036-8075; online ISSN 1095-9203) is published by the American Association for the Advancement ofScience

1992 by the American Association for the Advancement of Science

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