final slide industrial work practice presentation

8/2/2019 Final Slide Industrial Work Practice Presentation

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QUALITY CONTROL PERFORMANCE FORPHTHALATE ANALYSISBY GAS CHROMATOGRAPHY

MASS SPECTRA

Rania Fardyani08.54.06287

SMK SMAK Bogor


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QUALITY CONTROL PERFORMANCE FOR PHTHALATE ANALYSISBY GAS CHROMATOGRAPHY MASS SPECTRA

InstitutionProfile

Phthalate GasChromatography

MassSpectrometer

ControlChart

AnalyticalMethod

ResultDiscussion

Conclusion


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PT SUCOFINDO (Persero)

Values

The Company Scopes

Laboratories

Instrument Laboratory

INSTITUTION PROFILE



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PHTHALATE



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GAS CHROMATOGRAPHY

1910

History

1930 1941 1952

1955 1959 1973 2007

Mikhail S.Tswett

Schuftan andEucken

Martin andSynge

GasChromatography

PerkinElmer GOW-MAC Hawlett-Packard (HP)

AgilentTechnologies



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GAS CHROMATOGRAPHY

Main DefinitionGas Chromatography is a separating method by using

liquid as stationary phase and gas as mobilepha se . This method can analyze gases, volatilecompounds , or easy to be volatilized .

Sample for GCFactors of Separating Process and Indication of GoodSeparation

The Advantages of GC

The Disadvantages of GC



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GAS CHROMATOGRAPHY

Basic Principal



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GAS CHROMATOGRAPHY

Instrumentation



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GAS CHROMATOGRAPHY

Carrier Gas



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GAS CHROMATOGRAPHY

Sample Injection

Direct Injection



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GAS CHROMATOGRAPHY

Sample Injection

Split Injection



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X

GAS CHROMATOGRAPHY

Sample Injection

Splitless Injection



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GAS CHROMATOGRAPHY

Sample Injection

On Column Injection



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GAS CHROMATOGRAPHY

Oven



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GAS CHROMATOGRAPHY

Oven


Low Temp. High Temp.

Isothermal Temperature Programming


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GAS CHROMATOGRAPHY

Column


Packed Column Capillary Column


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GAS CHROMATOGRAPHY

Detector


An electronic sensor to convert the signal of carrier gasand the components within it into electronic signals.

MASS SPECTROMETER


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MASS SPECTROMETER


sample- -- - --

++ ++ ++++

IonSource

QuadropoleMass Analyzer


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A powerful problem-solving tools and useful in achievingprocess stability and improving capability through thereduction of variability.

HistogramCheck SheetPareto ChartCause and Effect DiagramDefect Concentration DiagramScatter Diagram

Control Chart

CONTROL CHART

Statistical Process Control


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A graphical design of a quality characteristic that has beenmeasured from a sample versus the sample number or time.

CONTROL CHART

Control Chart


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IMPROVE THE PROCESS

CONTROL CHART

The Function of Control Chart

Process

MeasurementSystem

Input Output

Verify andfollow up

Implementcorrective action

Detect assignablecause

Identify root cause of problem


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ANALYTICAL METHOD

A1 A2 A3 A4

(BBP, DBP, DEHP, DIBP, DINP)Vial 2 mL GC/MS


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RESULT | DISCUSSION

Phthalate Standards : 1. Diisobutyl Phthalate 2. Dibutyl Phthalate 3. Benzyl Butyl Phthalate 4. Di (2-ethylhexyl) Phthalate 5. Diisononyl Phthalate

Start Date : January 2, 2012

End Date : January 12, 2012


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RESULT | DISCUSSION

Parameter DIBP DBP BBP DEHP DNIP

Inject 1 0.9999 1.0000 0.9999 1.0000 1.0000

Inject 2 0.9999 0.9999 0.9997 0.9998 1.0000

Inject 3 0.9997 0.9999 1.0000 0.9998 0.9994

Inject 4 0.9998 0.9998 0.9999 0.9994 0.9996

Inject 5 0.9999 0.9987 0.9997 0.9999 1.0000

Inject 6 0.9989 0.9991 0.9999 0.9972 0.9996

Inject 7 0.9999 1.0000 0.9999 0.9997 0.9996

Parameter DIBP DBP BBP DEHP DNIP

Inject 1 0.9927 0.9899 0.9905 0.9897 0.9881 Inject 2 0.9893 0.9861 0.9856 0.9841 0.9816

Inject 3 0.9934 0.9895 0.9906 0.9891 0.9858

Inject 4 0.9876 0.9811 0.9843 0.9829 0.9818

Inject 5 0.9817 0.9772 0.9843 0.9818 0.9753

Inject 6 0.9777 0.9731 0.9746 0.9725 0.9697

Inject 7 0.9753 0.9691 0.9707 0.9690 0.9645

The Correlation of Standard

Concentration to A STD/A ISTD

The Correlation of StandardConcentration to A STD


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CONCLUSION

Based on the calculation, it can be concluded that the

performance of GC/MS Agilent 5975 Series is still ingood condition and the addition of internalstandards is important in phthalate analysis by the

method of GC / MS.


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SUGGESTION

The maintenance needs to be done regularly to

achieve the optimum conditions, such as cleaning theion source, checking the vacuum pressure, interface,and column.

Limit of Quantitation (LoQ) and Limit of Detection(LoD) of the instrument needs to be verified again sothat the reading process of the analyte is stable and

under control.


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THANK YOU

final slide industrial work practice presentation

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