first-class publications from verlag helvetica chimica actaalkaloids nature's curse or...

VERLAG HELVETICA CHIMICA ACTA

First-Class Publications from Verlag Helvetica Chimica Acta

Philip Kraft / Karl A. D. Swift

Perspectives in Flavor andFragrance Chemistry2005. 230 pages. Hardcover. ¤ 129.00/SFr 190.00/GBP 90.00/US$ 170.00. ISBN 3-906390-36-5

From the smell of a rich and sensual musky perfume tothe taste sensation imparted by the finest of wines, thesenses of smell and taste are fundamental to all of us.This book is a compilation of 18 of the 24 talks presentedat the 2004 RSC–SCI Flavors and Fragrances conferenceat the Manchester Conference Center. The meeting wasspaced over two and a half days and saw speakers anddelegates from all corners of the world exchanging ideasand information. The aim was to bring together scientistsfrom both industry and the academic world, who have acommon interest in flavors and fragrances. The subjectmatter was intentionally broad, including natural prod-ucts, fragrance chemistry, perfumery, and olfaction, aswell as foods and flavors. Chemistry was the central dis-cipline and served as the common strand for the meeting.

Manfred Hesse

AlkaloidsNature's Curse or Blessing?

2002. 414 pages with 185 figures, 110 in color. Hardcover.¤ 129.00/SFr 190.00/GBP 90.00/US$ 160.00. ISBN 3-906390-24-1

This is the first comprehensive reference work providinga concise overview of structure, properties, and historyof these unique and fascinating substances! The volumeis organized into three main sections:

Part 1 examines the chemically relevant aspects bymeans of carefully selected examples. After a structuralclassification, structure elucidation (including commonpitfalls) is discussed. Moreover, chiroptical propertiesand synthetic pathways are detailed.Part 2 is devoted to biological and biochemical aspects.It rationalizes chemotaxonomy and biogenesis by meansof examples (indole and 1-benzyl isoquinoline alkaloids)and presents details about the functionality of severalalkaloids produced by plants and animals. Part 3 finally describes the cultural and historical signi-ficance of the most important alkaloid sources. Excitinganecdotes and historical reports illuminate the use ofhemlock, ergot, opium, tobacco, coffee, and cinchona, toname only a few.The unique and comprehensive explanation of the mostimportant features of alkaloids makes this book a com-pendium valuable not only for experts but also for thelayman interested in pharmacy.

deutsche Ausgabe:

Manfred Hesse

AlkaloideFluch oder Segen der Natur?

2000. 432 Seiten mit 186 Abbildungen und 14 Tabellen. Gebunden.¤ 129.00/SFr 190.00/GBP 90.00/US$ 160.00. ISBN 3-906390-19-5

M. Volkan Kisakürek (Ed.)

HominatioAn International Tribute to Albert Eschenmoser

2001. 996 pages. Hardcover.¤ 139.00/SFr 205.00/GBP 100.00/US$ 174.00. ISBN 3-906390-27-6

Few individuals have so fundamentally influenced thescience of organic chemistry as Albert Eschenmoser. Inaddition to revealing the beautiful reaction pathwaysleading to compounds of great biochemical significance,Albert Eschenmoser has contributed innovativemethods of outstanding utility for organic synthesis. Over the years, a sizable fraction of Albert Eschenmo-ser's work has been published in Helvetica ChimicaActa, hence the Editor's decision to produce a specialissue of the journal on the occasion of Albert Eschenmo-ser's 75th birthday. The highly impressive set of 67 origi-nal research papers submitted in response to the Edi-tor's invitation were divided over the August and Sep-tember issues. The international reaction to this tributehas been so overwhelmingly enthusiastic that the twoissues have now been combined in this single volume.

M. Volkan Kisakürek / Edgar Heilbronner (Eds.)

Highlights of Chemistryas Mirrored in Helvetica Chimica Acta

1994. 992 pages with 996 figures. Hardcover.¤ 129.00/SFr 190.00/GBP 90.00/US$ 160.00. ISBN 3-527-29238-1

This book provides a comprehensive overview of morethan 75 years of Swiss chemical research. Leading aut-hors, among them L. M. Venanzi, H. Zollinger, E. Heil-bronner, and J. D. Dunitz, highlight outstanding piecesof research that have appeared in Helvetica ChimicaActa since its foundation in 1917.

Hans-Georg W. Leuenberger / Bertraud Nagel / Heinz Kölbl (Eds.)

A Multilingual Glossary ofBiotechnological TermsIUPAC Recommendations


This volume contains IUPAC-approved definitions ofover 230 terms most frequently used in the multidiscipli-nary field of biotechnology, together with their transla-tion into six further languages, namely French, German,Japanese, Portuguese, Russian, and Spanish. The termsare presented in dictionary format for easy look-up. Theaim is to facilitate communication between chemists,chemical engineers, biologists, and bioengineers, and torender biotechnology more accessible to the chemicalprofession. The scope of this work includes the fields ofmicrobiology, genetic engineering, biochemistry, molec-ular biology, biochemical engineering, bioprocessing,general concepts of biotechnology making this compila-tion and indispensable reference.

Organic Chemistry /Organische Chemie

Jack D. Dunitz

X-Ray Analysis and the Structureof Organic Molecules2nd edition

1995. 514 pages with 197 figures and 30 tables. Hardcover.¤ 65.00/SFr 96.00/GBP 45.00/US$ 81.00. ISBN 3-906390-14-4

This is the second corrected reprint of 'X-Ray Analysis',published in 1979, and consists of two parts. Part onedeals with crystal structure analysis, while the secondpart deals with molecular structure. All the informationis of considerable value, especially to those working in,or about to embark upon X-ray crystal structure analysis.

Beat Ernst / Christian Leumann (Eds.)

Modern Synthetic Methods 19951995. 464 pages with 200 figures, 49 in color. Hardcover.¤ 75.00/SFr 111.00/GBP 55.00/US$ 94.00. ISBN 3-906390-12-8

This collection of the six contributions at the 7th Interna-tional Seminar on Modern Synthetic Methods, writtenby leading experts in their fields, provides an overviewof the state of the art, trends, and new accomplishmentsin solvent effects on chemical transformations, in reac-tions on surfaces, in the synthesis of oligosaccharidesand nucleid acid analogues, and in antibody catalysis.An invaluable companion to both active research chem-ists and advanced students, fascinated by the world ofbiologically important compounds and by the creativity insynthetic techniques directed towards their preparation.

Gerhard Quinkert / Ernst Egert / Christian Griesinger

Aspects of Organic ChemistryStructure


This book focuses on molecular structure, especiallythat of nucleid acids and proteins. The author team ofinternationally recognized specialists presents a mod-

ern interdisciplinary concept between chemistry andbiology – an approach that proved to be useful in univer-sity education. A unique book, important for both lectur-ers and students.

Gerhard Quinkert / Ernst Egert / Christian Griesinger

Aspekte der Organischen ChemieStruktur

1995. 503 Seiten mit 262 Abbildungen und 79 Tabellen. Gebunden.¤ 89.00/SFr 131.00/GBP 65.00/US$ 148.00. ISBN 3-906390-11-X

In diesem Buch wird die chemische Struktur so vielseitigwie nie zuvor behandelt. Die Auswahl der detailliertbeschriebenen Moleküle und Übermoleküle entsprichtdem Anliegen der renommierten Autoren, Grenzüber-schreitungen zwischen Chemie und Biologie zur Selbst-verständlichkeit zu verhelfen.

Albert Gossauer

Struktur und Reaktivität derBiomoleküleEine Einführung in die Organische Chemie

2005. ca. 550 Seiten. Softcover.ca. ¤ 98.00/SFr 145.00. ISBN 3-906390-29-2Erscheinungstermin: ca. September 2005

Dieses Lehrbuch behandelt den für einen Grundkurs inorganischer Chemie an der Universität üblichen Stoff aufeine neue Weise und fördert so die Kommunikation zwi-schen Chemikern und Biologen. Darin werden anhandzahlreicher Beispiele die Struktur und Reaktivität organi-scher Moleküle sowie die Mechanismen einfacher Reak-tionen der organischen Chemie erläutert, die in biologi-schen Prozessen relevant sind. Damit im Zusammenhangstehende biologisch relevante Stoffe und enzymatischeReaktionen stellen dann den Bezug zur Biologie her.Zudem wird anhand von mehr als 100 Lebenswerkenberühmter Wissenschaftler die geschichtlichen Zusam-menhänge aufgezeichnet, die das 20. Jahrhundert alsdie Epoche der großen Errungenschaften in der moder-nen Chemie und Physik charakterisieren.

General Chemistry / Allgemeine Chemie / Sachbuch

Ahmed Zewail

Reise durch die Zeit – Weg zum Nobel-Preis2005. 321 Seiten. 150 Farbabbildungen. Gebunden.¤ 49.00/SFr 73.00/GBP 34.95/US$ 42.95. ISBN 3-906390-32-2Erscheinungstermin: ca. August 2005

Ahmed Zewail erzählt sein Leben und führt gleichzeitigdurch die extrem kurzlebige Welt der Moleküle. Voneiner ägyptischen Stadt im Nildelta und dem Hafen vonAlexandria bis zu den malerischen Landschaften Südka-liforniens führt der Weg. Fesselnd erzählt der Forschervon seinen Erlebnissen und seiner Arbeit bis zur Verlei-hung des Nobelpreises 1999; allgemein verständlicherklärt er die Beobachtung von Molekülen im Zeitmaß-stab von Femtosekunden.Aus seinem bisherigen Leben zieht der Autor Lehren, under denkt über den Einfluss des wissenschaftlichen Fort-schritts auf die Gesellschaft nach. Den Besitzlosen erteilter konkrete Ratschläge zum Handeln. Am Ende desBuches spricht er die Hoffnung aus, Ägypten möge sichauf die junge Generation – seinen größten Naturschatz –besinnen und Amerika möge neue Visionen der Innen-und Außenpolitik hervorbringen.Ein Buch für den allgemein interessierten und den natur-wissenschaftlich ambitionierten Leser.

Günther Ohloff

Düfte – Signale der Gefühlswelt2004. 321 Seiten mit 150 Farbabbildungen. Gebunden.¤ 98.00/SFr 145.00/GBP 70.00/US$ 140.00. ISBN 3-906390-30-6

Die Macht der Gerüche ergriff Dichter und Denker allerZeiten. Sie dienten besonders den französischen Schrift-

stellern des 19. Jahrhunderts als wesentliche Quelle derInspiration, lange bevor sich die Psychologie und Neuro-wissenschaften mit der seelischen Auswirkung derGerüche auseinandergesetzt hatten.Der prominente Duftstoffchemiker Günther Ohloff (Irdi-sche Düfte – Himmlische Lust, eine Kulturgeschichte derDuftstoffe) diskutiert, wofür Düfte verantwortlich sind,was sie mit uns machen. Er veranschaulicht außerdem,in welcher Beziehung Geruch, Erinnerung und Emotio-nen zueinander stehen.Auch die Forschung der Nobelpreisträger 2004 für Medi-zin, Linda Buck und Richard Axel, die für die Verdiensteum die Erklärung des Geruchssinns geehrt wurden, wirdin diesem Buch beschrieben.Ein Buch mit 150 Farbabbildungen für Parfumliebhaber,Literaten und solche, die mehr erfahren wollen über den«unbewußten» Sinn des Menschen.

IN PREPARATION:

Roman Kaiser

Meaningful Scents around the World2005. ca. 250 pages. Hardcover.ca. ¤ 98.00/SFr 145.00/GBP 70.00/US$ 85.50. ISBN 3-906390-37-3Due: November 2005

Günther Ohloff

Earthly Scents – Heavenly PleasuresA Cultural History of Scents

2006. ca. 300 pages. Hardcover.ca. ¤ 49.90/SFr 75.00/GBP 34.95/US$ 43.50. ISBN 3-906390-34-9Due: ca. January 2006

Gerhard Quinkert / M. Volkan Kisakürek (Eds.)

Essays in Contemporary ChemistryFrom Molecular Structure towards Biology

2001. 471 pages with 230 figures, 116 in color. Hardcover.¤ 149.00/SFr 220.00/GBP 105.00/US$ 185.00. ISBN 3-906390-28-4

In this volume, internationally renowned chemists re-count their roles in the progress of chemistry researchtowards the elucidation of biological processes. Begin-ning with a historical perspective on the development ofX-ray crystallography, the reader is regaled with first-hand accounts of research milestones, including• nuclear-magnetic-resonance techniques• electron-paramagnetic-resonance spectroscopic

techniques• the dynamics of ultra-fast reactions• the central problem of molecular oxygen activation

in biological processes

• chiral auxiliaries in organic synthesis • photochemistry in natural product synthesis• innovations in combinatorial synthesis approaches• molecular recognition • modulation of molecular functionThese are rounded off with a note on how the frontiersof medical ethics may be breached by molecular manip-ulations. The contributors, who number among the finest scien-tists in the world, including two Nobel Prize winners, arePeter B. Dervan, Jack D. Dunitz, Christian Griesinger,Jean-Marie Lehn, Thomas F. Prisner, Gerhard Quinkert,Peter G. Schultz, Helmut Schwarz, Dieter Seebach, andAhmed Zewail with a prologue by Albert Eschenmoser,for whom this collection was conceived.

Bernhard Lippert (Ed.)

CisplatinChemistry and Biochemistry of a Leading Anticancer Drug


What the reviews have to say:The discovery of Cisplatin has inspired many scientistsfrom diverse backgrounds and this is demonstratedthroughout the many excellent reviews. Bernhard Lip-pert is to be congratulated on producing a book consis-ting not only of numerous scientific articles of highquality describing current research, but also a book thatconveys the essence of scientific research. This book isrecommended to all those with an interest in platiniumchemistry, bioinorganic chemistry, biochemistry, and theclinical development of platinum anticancer drugs, andis a good illustration of their significance.

Platinum Metals Review

This book does not present a guide on ‘how to build thebest antiocancer drug ever’… In almost all otherrespects, however, it is an excellent investment and agreat pleasure to read. One needs to spend a very longtime in the library and copy a great number of originalpapers to get a similar outstandning overview of a topi-cal area of chemistry.

Angewandte Chemie International Edition

Hanns Fischer (Ed.)

Praktikum in Allgemeiner ChemieTeil 2: Organische und Physikalische Chemiezweite Auflage

1995. 250 Seiten mit 33 Abbildungen. Spiralbindung¤ 27.90/SFr 42.00/GBP 19.99/US$ 48.00. ISBN 3-906390-10-1

Edgar Heilbronner / Jack D. Dunitz

Reflections on SymmetryIn Chemistry... and Elsewhere


A fascinating book on a fascinating topic. This is a highlyreadable introduction to symmetry in art and science. Lucidly written and beautifully illustrated, this book pro-vides an eminently readable discussion of the omnipres-ent concept of symmetry, its application in all branchesof science, and its perception in nature, art and else-where.

Edgar Heilbronner / Foil A.Miller

A Philatelic Ramble through Chemistry2003. 278 pages with 1025 figures. Softcover.¤ 79.00/SFr 116.00/GBP 55.00/US$ 105.00. ISBN 3-906390-31-4


This is not a history of chemistry using stamps instead ofthe usual illustrations, but a collection of short essaysand comments on such chemistry as can be found onpostage stamps and other philatelic items. The choice oftopics is thus dictated by the philatelic material availa-ble, such that readers will find detailed comments onsuch lesser-known chemists as Wilhelm August Lampa-dius who has been honored with two stamps by the Ger-man Post Office, but hardly anything on such luminariesas Robert Bunsen, who have yet to be deemed worthy ofa commemorative issue.

Pharmaceutical and Medicinal Chemistry / Pharmazeutische und Medizinische Chemie

Heinrich Zollinger

FarbeEine multidisziplinäre Betrachtung

2005. ca. 300 Seiten, ca. 70 Abbildungen. Softcover.ca. ¤ 98.00/SFr 145.00/GBP 70.00/US$ 85.50. ISBN 3-906390-33-0Erscheinungstermin: ca. August 2005

Die Welt der Farben – wen zieht sie nicht an, wen faszi-niert oder verblüfft sie nicht? Zunächst natürlich Maler,aber auch Biologen und Mineralogen, die sich für dieFarbe der lebendigen und der anorganischen, der«toten» Welt interessieren, oder Neurowissenschaftler,Psychologen und Ophthalmologen, die sich mit dem Vor-gang der Farbempfindung und der Verarbeitung vonFarbstimuli im Auge und im Gehirn beschäftigen. Physi-ker und Chemiker widmen sich der Farblehre – sie unter-suchen, wie Farben entstehen.In allen Kulturkreisen der Welt kommt der Farbe durchihren Symbolcharakter zentrale Bedeutung zu. Die Spra-che kennt spezielle Begriffe, um Farben und Farbigkeitzu bezeichnen. Und so ließen sich weitere Beispiele fin-den, die den Einfluß der Farben auf unser täglichesLeben, unsere Kultur bezeugen...Nicht alle Aspekte des Phänomens «Farbe» sind durchdie «exakte» Wissenschaft erklärbar. Dieses faszinie-rende Buch widmet sich den vielfältigen Facetten desThemas in einer auch für interessierte Laien verständli-chen Weise.

Heinrich Zollinger

Color ChemistrySyntheses, Properties, and Applications of Organic Dyesand Pigments3rd edition


This new edition of the classical text has been thor-oughly updated and rewritten. Special attention is givento those topic areas that have undergone the mostresearch activity and industrial development since publi-cation of the second edition. An extensive new sectiondevoted to synthetic polyenes developed during the lastdecade that have shown promising electrooptical proper-ties has been added, while the chapter on aza[18]annule-nes has been expanded to include improved and sophisti-cated synthetic approaches to the phthalocyanines andporphyrins, as well as the application of these com-pounds in functional dyes and pigments. Research anddevelopment activities in the discovery of new dyes forcoloration is described in the sections on dispersed, reac-tive, and sulfur dyes, as well as in new chapters coveringcarbonyl and the diketopyrrolo-pyrrole (DPP) family ofpigments. In addition, it contains a first review of thelimited number of published investigations of blackcolorants. With its many changes and additions, thisthird edition is a significantly expanded successor to thehighly successful predecessor, and is destined to becomea classical reference work consulted by researchers inthis exciting and important subdiscipline of chemistry.

Heinrich Zollinger

ColorA Multidisciplinary Approach


Who is not attracted, fascinated or even amazed by theworld of colors? Painters of course, but also biologistsand mineralogists are interested in colors of the living

and the inorganic, 'dead', world. There are neuroscien-tists, psychologists and ophthalmologists, who study thesensation of color vision and the processing of colorstimuli in the eye and the brain. Physicists and chemistsinvestigate color science, i.e., the various causes ofcolor. Interior designers know how the colors of furnitureand textiles can influence our condition. In all cultures,colors play a central role due to their symbolic content.All languages have special terms to describe colors andcolorfulness. Visual artists play with colors to reflect theworld, perhaps to alienate it, and to give us an idea of theirpersonal point of view. Many other examples of the influ-ence of colors on our daily life, our culture could be found...This fascinating book, written in a style that is under-standable for interested lay readers, deals with all thevaried facets of this subject.

P. Heinrich Stahl / Camille G. Wermuth (Eds.)

Pharmaceutical SaltsProperties, Selection, and Use


About half of all drugs used in medicine are adminis-tered as salts, and the formation and the selection of asuitable salt for a drug candidate is an essential step inthe preclinical phase of drug development. In this first comprehensive resource to address the prep-aration, selection, and use of pharmaceutically activesalts, an international team of seventeen authors fromacademia and pharmaceutical industry present thenecessary theoretical foundations as well as a wealth ofdetailed practical experience in the choice of pharma-ceutically active salts.Altogether, the contributions reflect the multidisciplinarynature of the science involved in selection of suitable saltforms for new drug products. The editors have taken careto address every conceivable aspect of the preparation ofpharmaceutical salts. This book is destined to be anessential reference for students of medicinal and phar-maceutical chemistry, and an indispensable handbook forR&D chemists, analytical chemists, biologists, develop-ment pharmacists, regulatory and patent specialists, andmedicinal scientists engaged in preclinical developmentof drugs. A comprehensive up-to-date guide for all scien-tists involved in research and development of drugs and,in particular, of pharmaceutical dosage forms.

Color Chemistry / Farbstoffchemie

M. Volkan Kisakürek / Helmut Rosemeyer (Eds.)

Perspectives in Nucleoside andNucleic Acid Chemistry2000. 430 pages. Hardcover.¤ 139.00/SFr 205.00/GBP 100/US$ 174.00. ISBN 3-906390-21-7

Many of the most important recent advances in medici-nal chemistry have occured in this field with the develop-ment of novel nucleoside- and nucleotide-based antiviraland antitumor drugs. New synthesis strategies involvingnovel protecting groups have helped spur progress indrug-development and genome-sequencing research.This volume, comprised of contributions by internation-ally recognized experts, covers the latest developmentsin current nucleoside and nucleic acid research, including• combinatorial approaches• spectroscopy and structural studies• thermodynamic and computational investigations• stability assessments, and • medicinal applications.

Synthetic, physical, organic, bioorganic, and medicinalchemists working on all aspects of nucleoside andnucleic acid research will value this comprehensivestate-of-the-art overview.

Bernard Testa, Stefanie D. Krämer, Heidi Wunderli-Allensbach, Gerd Folkers (Eds.)

Pharmacokinetic Profiling in Drug ResearchBiological, Physicochemical, and Computational Strategies

2005. ca. 400 pages. Hardcover.ca. ¤ 159.00/SFr 235.00/GBP 115.00/US$ 195.00. ISBN 3-906390-35-7 / Due: December 2005

incl. CD-ROM

The profiling of ADME properties (absorption, distribu-tion, metabolism, and excretion) is the focus of this book.Many major advances have been made during the lastyears in biological, physicochemical, or computationalstrategies. International authorities and practicing ex-

perts from academia and industry offer state-of-the-artpresentations of concepts, methods, and technologiesnow in use or development in drug research.In addition to its 28 chapters, the book includes a CD-ROM containing the invited lectures, oral communica-tions, and posters (in full version) presented at the ThirdLogP Symposium, 'Physicochemical and Biological Profil-ing in Drug Research', held at the Federal Institute ofTechnology (ETH) of Zürich in March 2004.

Bernard Testa, Han van Waterbeemd, Gerd Folkers,Richard Guy (Eds.)

Pharmacokinetic Optimization in Drug ResearchBiological, Physicochemical, and Computational Strategies


incl. CD-ROM

The optimization of pharmacokinetic properties hasbecome the bottleneck and a major challenge in drugresearch. There was thus an urgent need for a bookcovering this field in an authoritative, comprehensive,factual, and conceptual manner. In addition to its 33 chapters, the book includes a CD-ROMcontaining the invited lectures, oral communications andposters (in full version) presented at the Second LogPSymposium, 'Lipophilicity in Drug Disposition – Practicaland Computational Approaches to Molecular PropertiesRelated to Drug Permeation, Disposition and Metab-olism', held at the University of Lausanne in March 2000.

Han van de Waterbeemd / Bernard Testa / Gerd Folkers (Eds.)

Computer-Assisted Lead Findingand OptimizationCurrent Tools for Medicinal Chemistry

1997. 566 pages with 232 figures, 51 in color, and 57 tables. Hardcover.¤ 139.00/SFr 205.00/GBP 100.00/US$ 174.00. ISBN 3-906390-16-0

An account of current strategies used in computer-assis-ted drug design. Important topics include progress inchemometrics, molecular modeling and three-dimension-al QSAR approaches. As is amply illustrated, importantprogress has been made in lead finding strategies,which is of great importance to the pharmaceuticalindustry.

Bernard Testa / Joachim M. Mayer

Hydrolysis in Drug and ProdrugMetabolismChemistry, Biochemistry, and Enzymology

2003. 780 pages. Hardcover.¤ 159.00/SFr 235.00/GBP 115.00/US$ 210.00. ISBN 3-906390-25-X

In this volume, Bernard Testa and Joachim M. Mayerdiscuss the molecular and biochemical aspects of meta-bolic reactions of hydrolysis and hydration. While anencyclopedic treatment is avoided, the topics coveredinclude • biochemical properties of the enzymes/isozymes• drug–enzyme interactions• the various chemical reactions catalyzed by enzymes• reaction mechanisms and catalytic cycles• regio- and stereoselectivities• structure–metabolism relationships• molecular aspects of toxification and detoxification,

as well as • enzyme inhibition.

The classification of materials is based mainly on thetypes of target groups and compounds being transfor-med, with carefully selected examples to illustrate thereactions under discussion. This approach has heuristicvalue since it allows readers to make educated guesseson the metabolism of other or novel drugs.

Helvetica Chimica Acta

Volume 88, 2005, 12 issuesISSN Print: 0018-019XISSN Online: 1522-2675

www.interscience.wiley.com/journal/hca

Helvetica Chimica Acta is dedicated to the dissemina-tion of knowledge in all areas of chemistry and to thetimely publication of original full-paper contributionsfrom all over the world. With emphasis on the multidis-ciplinary nature of the journal, progress in subdisci-plines is reported, including but not limited to:

• Organic Chemistry• Inorganic Chemistry• Physical Chemistry• Technical Chemistry• Analytical Chemistry

Readers profit from:

• refereed contributions by outstanding professionals• about 300 published papers per year• no restrictions on the length of papers submitted• no restrictions on the scope of the chemistry

presented• preliminary communications and selected

review papers• a society owned journal (Swiss Chemical Society)• a remarkable high impact factor• quick publication: on average within three months of

receipt

Special Issue in 2005:Special Issue in honor of the 85th Birthday of Prof. RolfHuisgen, an amazingly creative organic chemist whohas made landmark discoveries in many important theo-retical and synthetic areas, best known for his superbmechanistic studies of 1,3 dipolar cycloaddition reac-tions.

Chemistry & Biodiversity

Volume 2, 2005, 12 issuesISSN Print: 1612-1872ISSN Online: 1612-1880

www.interscience.wiley.com/journal/chembiodiv

The new journal Chemistry & Biodiversity serves as ahigh-quality forum covering all aspects of biologicallyrelevant field specific and interdisciplinary chemistryresearch in the form of:

• Full-length original papers• Short communications• Commentaries• Reviews

The journal covers all biologically relevant researchfields, aiming to elucidate the overlap between the chem-ical and biological sciences. Chemistry & Biodiversityaims to demonstrate how chemistry can contribute toour understanding of biodiversity with the ultimate goalto benefiting from and preserving nature.Our material world is made up of highly interconnectedand interacting molecules: Chemistry & Biodiversityreports research on the (bio)molecules and (bio)chemi-cal reactions of that world. Our journal rightfully carriesthe motto «Chemistry Probing Nature» and is of vitalinterest to all chemists and molecular scientists in thelife-sciences community.

EditorsM. Volkan KisakürekBernard Testa

Official journal of:Center for the Study of Biological Complexity(CSBC)Virginia Commonwealth University,USA

Both journals are available online through WileyInterScience at:

http://www.interscience.wiley.com

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Philip Kraft / Karl A. D. Swift (Eds.)Perspectives in Flavor and Fragrance Chemistry¤ 129.00/SFr 190.00/GBP 90.00/US$ 170.00 ISBN 3-906390-36-5

Manfred HesseAlkaloids¤ 129.00/SFr 190.00/GBP 90.00/US$ 160.00 ISBN 3-906390-24-1

Manfred HesseAlkaloide¤ 129.00/SFr 190.00/GBP 90.00/US$ 160.00 ISBN 3-906390-19-5

M. Volkan Kisakürek (Ed.)Hominatio¤ 139.00/SFr 205.00/GBP 100.00/US$ 174.00ISBN 3-906390-27-6

M. Volkan Kisakürek / Edgar Heilbronner (Eds.)Highlights of Chemistry¤ 129.00/SFr 190.00/GBP 90.00/US$ 160.00 ISBN 3-527-29238-1

Hans-Georg W. Leuenberger / Bertraud Nagel / Heinz Kölbl (Eds.)A Multilingual Glossary of BiotechnologicalTerms¤ 42.90/SFr 64.00/GBP 29,95/US$ 55.00 ISBN 3-906390-13-6

Jack D. DunitzX-Ray Analysis and the Structure of OrganicMolecules¤ 65.00/SFr 96.00/GBP 45.00/US$ 81.00 ISBN 3-906390-14-4

Beat Ernst / Christian Leumann (Eds.)Modern Synthetic Methods 1995¤ 75.00/SFr 111.00/GBP 55.00/US$ 94.00 ISBN 3-906390-12-8

Gerhard Quinkert / Ernst Egert / Christian GriesingerAspects of Organic Chemistry¤ 85.00/SFr 125.00/GBP 60.00/US$ 105.00ISBN 3-906390-15-2

Gerhard Quinkert / Ernst Egert / Christian GriesingerAspekte der Organischen Chemie¤ 89.00/SFr 131.00/GBP 65.00/US$ 148.00 ISBN 3-906390-11-X

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Ahmed ZewailReise durch die Zeit – Weg zum Nobel-Preisca. ¤ 49.00/SFr 73.00/GBP 34.95/US$ 42.95 ISBN 3-906390-32-2

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Roman KaiserMeaningful Scents around the Worldca. ¤ 98.00/SFr 145.00/GBP 70.00/US$ 85.50 ISBN 3-906390-37-3

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Gerhard Quinkert / M. Volkan Kisakürek (Eds.)Essays in Contemporary Chemistry¤ 149.00/SFr 220.00/GBP 105.00/US$ 185.00ISBN 3-906390-28-4

Bernhard Lippert (Ed.)Cisplatin¤ 169.00/SFr 250.00/GBP 120.00/US$ 210.00 ISBN 3-906390-20-9

Hanns Fischer (Ed.)Praktikum in Allgemeiner Chemie¤ 27.90/SFr 42.00/GBP 19.99/US$ 48.00ISBN 3-906390-10-1

Edgar Heilbronner / Jack D. DunitzReflections on Symmetry¤ 37.90/SFr 57.00/GBP 27.50/US$ 47.00ISBN 3-527-28488-5

Edgar Heilbronner / Foil A. MillerA Philatelic Ramble through ChemistrySoftcover ¤ 79.00/SFr 116.00/GBP 55.00/US$ 99.00 ISBN 3-906390-31-4Hardcover ¤ 139.00/SFr 205.00/GBP 100.00/US$ 174.00 ISBN 3-906390-17-9

Heinrich ZollingerFarbeca. ¤ 98.00/SFr 145.00/GBP 70.00/US$ 85.50 ISBN 3-906390-33-0

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Heinrich ZollingerColor¤ 119.00/SFr 176.00/GBP 85.00/US$ 149.00 ISBN 3-906390-18-7

P. Heinrich Stahl / Camille G. Wermuth (Eds.)Pharmaceutical Salts¤ 149.00/SFr 220.00/GBP 105.00/US$ 185.00 ISBN 3-906390-26-8

M. Volkan Kisakürek / Helmut Rosemeyer (Eds.)Perspectives in Nucleoside and Nucleic AcidChemistry¤ 139.00/SFr 205.00/GBP 100.00/US$ 174.00 ISBN 3-906390-21-7

Bernard Testa et al. (Eds.)Pharmacokinetic Profiling in Drug Researchca. ¤ 159.00/SFr 235.00/GBP 115.00/US$ 195.00ISBN 3-906390-35-7

Bernard Testa et al. (Eds.)Pharmacokinetic Optimization in DrugResearch¤ 169.00/SFr 250.00/GBP 120.00/US$ 220.00 ISBN 3-906390-22-5

Han van de Waterbeemd / Bernard Testa / Gerd Folkers (Eds.)Computer-Assisted Lead Finding and Optimization¤ 139.00/SFr 205.00/GBP 100.00/US$ 174.00 ISBN 3-906390-16-0

Bernard Testa / Joachim M. MayerHydrolysis in Drug and Prodrug Metabolism¤ 159.00/SFr 235.00/GBP 115.00/US$ 210.00 ISBN 3-906390-25-X

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