fistula-in-ano: a probing of the treatment options john goligher colorectal unit david jayne...
TRANSCRIPT
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Fistula-in-ano: a probing of the treatment options
John Goligher Colorectal Unit
David JayneProfessor of Surgery
University of Leeds & Leeds Teaching Hospitals NHS Trust
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The Problem
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Aetiology
• Cryptoglandular
• Crohn’s disease
• Other– Malignant– Obstetric– Radiation
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Classification
45%30%
20%5%
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Goodsall’s Rule
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Treatment Aims
• Eradicate disease (if possible)
• Preservation of continence
• Benign condition• Quality of life
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Principles• Control sepsis– EUA– Laying open abscesses and secondary tracts– Adequate drainage – seton insertion
• Define anatomy– Openings and tracts
• Internal and External• Single –v- multiple• Extensions / Horseshoe
– Relation to sphincter complex• High –v- Low
• Exclude co-existent disease
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MRI for fistula-in-ano
HALLIGAN Radiology 2006Abscesses &Extensions
Contralateral disease Other pathology
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Surgical Options – Fistulotomy
• Fistula tract identified with probe
• Extent of external sphincter involvement assessed
• Tract and muscle divided• Secondary tracts laid open• +/- marsupialisation
wound
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Surgical Options – Cutting Seton
• Lay open external tract• Draining seton replaced with
cutting seton• 1/0 Prolene suture• Tied tight around sphincter
complex• Simultaneous slow cutting
and repair of sphincter• May require re-tightening
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Surgical Options – Fistulectomy
• Draining seton
• Core out tract
• Direct visualisation of secondary tracts
• Sphincter repair +/- advancement flap
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Advancement Flaps
Endorectal• Fistula tract probed• Flap raised– Mucosa + Int. Sphincter
• Internal opening excised/closed
• Flap advanced & sutured
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Advancement Flap
Anodermal• Fistula tract probed• Flap raised– Anodermal
• Flap advanced & sutures• External defect closed
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Fistula Plug
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Fistula Plug
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LIFT Procedure
Ligation of IntersphinctericFistula Tract• Transsphincteric fistula• Draining seton – 6 weeks
• Tract prepared with fistula brush– Debrides– De-epithelializes
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LIFT Procedure
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PROS CONSCutting Seton Simple
CheapRepeat EUARecurrence 0 – 8%Incontinence• minor 34 – 63%• major 2 – 26%
Fistulotomy SimpleCheap
Recurrence 2 – 9%Incontinence 50%
Advancement Flap Can be difficult?Preserves sphincter
Recurrence 25 – 50%Incontinence 30 – 35%
Fistula Plug SimplePreserves sphincter
Plug expensive ~£400Recurrence 20 – 85%Continence preserved
LIFT SimplePreserves sphincter
Recurrence 15 - 40%Continence preserved
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ACPGBI FIAT Trial
Fistula Plug Insertion
Surgeon’s Preference
EUA: transsphincteric fistula ≥ 1/3 of sphincter
complex Insertion of draining
seton
RANDOMISE
MRI fistulography
Advancement Flap
Cutting Seton Fistulotomy LIFT
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ACPGB&I FIATPrimary end-points• Faecal incontinence QoL• Generic QoL
Secondary end-points• Healing – 12 months• Complications• Faecal incontinence• Re-interventions• Health resource
utilisation• Cost effectiveness
Patient identificationEUA & draining seton
Eligibility & Consent
Randomisation1:1 plug –v- surgeon’s preference
6-week FU
6-monthFU
12-month FU+ MRI scan
Surgisis® fistula plugSurgeon’s preference
(fistulotomy, seton, advancement flap, LIFT)
MRI scan
Surgery(6-weeks post seton insertion)
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FIAT FACTSRecruitment: 76Target: 500Open centres: 36Recruiting centres: 21
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Join the FIAT Trial!
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Fistula-in-ano: a probing of the treatment options
John Goligher Colorectal Unit
David JayneProfessor of Surgery
University of Leeds & Leeds Teaching Hospitals NHS Trust