M a t r i x R I B ® F I X A T I O N S Y S T E M : E V I D E N C E S U M M A R Y

BENEFITS OF OPERATIVE FIXATION FOR SEVERE RIB FRACTURES

a prevalence of chronic pain of 22%6 and disability of 53%6RIB FRACTURES PATIENTS SHOW

The MatrixRIB® System has been evaluated in 52 PUBLISHED STUDIES involving 1,028 PATIENTS

M a t r i x R I B ® F I X A T I O N S Y S T E M | O P E R A T I V E T R E A T M E N T R E S U LT S

Operative fixation of flail chest injuries shows a significant reduction (p < 0.05) compared to nonoperative rib fixation7 in terms of

Very satisfied patients rating MatrixRIB® System as 9.2 out of 109

Significant reduction of ventilator days from 9 to 2.7 days from non-operated to operated patients8

Days on a Ventilator

Operated patient

Non-operated patient

Improvement of pulmonary function by regaining 84% Forced Vital Capacity (FVC) and 77% Forced Expiratory Volume (FEV1)3

of patients had NO PAIN at 16 months9

84%

5-13%

of patients would recommend the surgery to friends/family9

94%

FLAIL CHEST OCCURS IN

of patients with chest wall trauma1 10-20%

WITH A MORTALITY RATE OF2,3,4,5

MANAGEMENT OF SEVERE RIB FRACTURES

90%of employed patients returned to the same work at 8.5 weeks9

* Image courtesy of Mario G. Gasparri, MD at Medical College of Wisconsin, USA

Synthes USA, LLC1101 Synthes AvenueMonument, CO 80132

To order (USA): 800-523-0322To order (Canada): 844-243-4321

© DePuy Synthes 2019. All rights reserved. 119090-190722 DSUS

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1. LoCicero J, Mattox KL. Epidemiology of chest trauma. Surg Clin North Am. 1989;69(1):15-19.2. Simon B, Ebert J, Bokhari F, et al. Management of pulmonary contusion and flail chest: an Eastern Association for the Surgery of Trauma practice management guideline. J Trauma Acute Care Surg. 2012;73(5)(suppl 4):351S-361S.3. Bottlang M, Long WB, Phelan D, Fielder D, Madey SM. Surgical stabilization of flail chest injuries with MatrixRIB implants: a prospective observational study. Injury. 2013;44(2):232-238.4. Kasotakis G, Hasenboehler EA, Streib EW, et al. Operative fixation of rib fractures after blunt trauma: A practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2017;82(3):618-626.5. Dehghan N, de Mestral C, McKee MD, Schemitsch EH, Nathens A. Flail chest injuries: a review of outcomes and treatment practices from the National Trauma Data Bank. J Trauma Acute Care Surg. 2014;76(2):462-468.6. Gordy S, Fabricant L, Ham B, Mullins R, Mayberry J. The contribution of rib fractures to chronic pain and disability. Am J Surg. 2014;207(5):659-662; discussion 662-653.7. Swart E, Laratta J, Slobogean G, Mehta S. Operative treatment of rib fractures in flail chest injuries: a meta-analysis and cost-effectiveness analysis. J Orthop Trauma. 2017;31(2):64-70.8. Granhed HP, Pazooki D. A feasibility study of 60 consecutive patients operated for unstable thoracic cage. J Trauma Manag Outcomes. 2014;8(1):20.9. Majercik S, Cannon Q, Granger SR, VanBoerum DH, White TW. Long-term patient outcomes after surgical stabilization of rib fractures. Am J Surg. 2014;208(1):88-92.10. Michelitsch C, Acklin YP, Hassig G, Sommer C, Furrer M. Operative Stabilization of Chest Wall Trauma: Single-Center Report of Initial Management and Long-Term Outcome. World J Surg. 2018;42(12):3918-3926.11. Agency for Healthcare Research and Quality (AHRQ) Healthcare Cost and Utilization Project (HCUP). 2016 Costs for Flail Chest and Pneumonia. https://hcupnet.ahrq.gov/#setup. Accessed May 21, 2019.12. Zilberberg MD, Shorr AF. Prolonged acute mechanical ventilation and hospital bed utilization in 2020 in the United States: implications for budgets, plant and personnel planning. BMC Health Serv Res. 2008;25;8:242.13. Childers CP, Maggard-Gibbons M. Understanding costs of care in the operating room. JAMA Surg. 2018;153(4):e176233.

Please also refer to the eIFU or other labeling associated with the implant identified in this brochure for a full list of indications, contraindications, precautions and warnings.

$3.4M with use of MatrixRIB® System are estimated to be

Increased cost of surgery* is offset by decreased:

The total potential cost savings

for 100 patients with flail chest.3,7,10-13**

ECONOMIC IMPLICATIONS OF THE MatrixRIB® SYSTEM

Length of stay in both the ICU and non-ICU

Duration of mechanical ventilation

Cost due to pneumonia3,7,10-13

*OR and implant costs.**Values based on US costs from US Hospital Inpatient National Statistic.