Human protein

atlas and artificial

proteinsMaria Cristina Benjumea Zuluaga

Third semester

Molecular biology

Folding

Folding

Introduction

Each protein has an unique

sequence of amino-acids

Technology allows to create new

proteins and to modify those ones

with mutations

There are methods to locate

proteins in the human tissues

Human 'Atlas' Reveals Where

Proteins Reside in the Body. January 22,

2015

Researchers created an

atlas where we can find

the location of human

proteins in different

tissues.

We have 20000 genes that

encode proteins.

Human 'Atlas' Reveals Where

Proteins Reside in the Body. January 22,

2015

Almorst half of the proteins

are in all the body They

participate in many

functions.

Proteins of brain, liver and

testicles are specific for that

tissues.

Human 'Atlas' Reveals Where

Proteins Reside in the Body. January 22,

2015

Drugs that target proteins (30% of

the total) are in all the organs.

That explains the side effects of

some drugs.

Human 'Atlas' Reveals Where

Proteins Reside in the Body. January 22,

2015

This human protein atlas is

available online:

http://www.proteinatlas.org/

Personal opinion

It is incredible for me to

see how technology can

advance in a short time.

We have 30000 types of

protein and now we can

know where is located

each of them. I think is

very important to know

why does the side effects

of a drug occur, because

with that scientists can

make more drugs with

higher specificty to the

proteins. That is also a

way to avoid other

diseases caused by

medicaments.

Artificial proteins could bring

the next biological revolution –

starting with MRI. February 13 2015

Biomimetics: it uses ideas from

nature to solve human problems.

Syntethic biology: to make artificial

things with biological functions.

The principal part of a protein is the

metal ion inside of its structures:

metalloproteins.

The rest of the protein gives stability

and the characteristics to the ion.

Artificial proteins could bring

the next biological revolution –

starting with MRI. February 13 2015

There is not always biological

activity of a synthetic protein

because proteins need special

conditions to be active and

they don’t tolerate big

changes in the enviroment.

Metalloproteins usually have

metals of the transition

metals.

The investigation group of

Anna Peacock designed

proteins with gadolinium (a

lanthanide).

Nowadays we don’t know the

biological function of

lanthanides.

Transition metals

Lanthanides

Artificial proteins could bring

the next biological revolution –

starting with MRI. February 13 2015

The Gadolinium is used for

magenit resonances (MRI). It

is in the sustance injected to

the patient to enhance

contrast.

Anna Peacock and her group

put de gadolinium in 3 short

α-hélices of synthetic protein

forming a coiled coil.

Artificial proteins could bring

the next biological revolution –

starting with MRI. February 13 2015

This new protein can increase the contrast of the MRI,

increasing the effience of the diagnosis.

Peacock said: “Nature can achieve so much with just a

few metals. If we can carefully design new metal

environments then perhaps we can achieve chemistry

that were never thought possible.”

Personal opinion

I think that technology can make amazing things. Each

day, there is a new thing that tries to improve our

quality life in all aspects. In this case, it was the turn of

the diagnosis methods.

The new protein searches to increase the efficiency of

the RMI. In a near future, synthetic proteins will be

easier to create, and we will be able to make very good

treatments for our patients, treatments that maybe

now don’t sound like something real.

Medical utility

The human protein atlas can

help scientists to increase the

specificity of some drugs, so

them will just act in the tissue

that needs it and we will avoid

secondary events.

Medical utility

The atlas will also help

doctors to make deep

studies and researches

about diseases where

proteins are not

functioning well, as in

cancer. By that way, we

can start to stop the

proliferation of malign

cells and delete cancer

of the population.

Medical utility

Synthetic proteins will replace or repare the wrong

proteins in the body that are causing some deseases.

This can increase the life expectancy of people.

Medical utility

As a doctors, we will have new tools to use in our daily

work life. Our patients will have a quickly recovery and

they will avoid new diseases caused by abnormal

proteins. This will help us to make more effective

treatments in a short time.

Bibliography

Artificial proteins could bring the next biological revolution – starting with MRI. The converation. February 13, 2015. [ Accesed on February 14th, 2015] . Available in : http://theconversation.com/artificial-proteins-could-bring-the-next-biological-revolution-starting-with-mri-37312

Artificial proteins could bring the next biological revolution – starting with MRI. The converation. February 13, 2015. [ Accesed on February 14th, 2015] . Available in : http://theconversation.com/artificial-proteins-could-bring-the-next-biological-revolution-starting-with-mri-37312