folding - molecular biology
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New RNA Repair Technology and
Therapeutic Strategies for Controlling Gene
ExpressionAnny Carolina Sarria MenaMedicine Student, 3rd
semesterTeacher: Lina María Martinez
SánchezMolecular Biology
UPB - 2012
INTRODUCTION
The proper use of the tools offered by molecular biology would be of great benefit to modern medicine, as with so many technological advances, to the heart of mutations and would reduce the pathologies that they can be repaired.Interestingly travésde as identifyingRNA sequences and errors in the maturation of the same drugs can create and repair mechanisms such as RNA.
Scientists Create Novel RNA Repair Technology
Identification a compound that can help repair a specific type of defect in RNA, a type of genetic material.
Methods in the new study could accelerate the development of therapeutics to treat a variety of incurable diseases such as Huntington's disease, Spinocerebellar ataxia, and Kennedy disease.
Scientists Create Novel RNA Repair Technology
Describe a method to find compounds that target defective RNAs, specifically RNA that carries a structural motif known as an "expanded triplet repeat.
The triplet repeat, a series of three nucleotides repeated many more times than normal in the genetic code of affected individuals, has been associated with a variety of neurological and neuromuscular disorders.
It has been shown recently that both the protein and the RNA are toxic. The toxic RNA defect actually sucks up other proteins that play critical roles in RNA processing, and that is what contributes to these various diseases.
Also opens up new avenues for therapeutic development because we have clearly demonstrated that small molecules can reverse this type of defect.
Scientists Create Novel RNA Repair Technology
New RNA-Based Therapeutic Strategies
for Controlling Gene Expression Small RNA-based nucleic acid drugs represent a
promising new class of therapeutic agents for silencing abnormal or overactive disease-causing genes.
Short strands of nucleic acids, called small RNAs, can be used for targeted gene silencing, making them attractive drug candidates.
New RNA-Based Therapeutic Strategies
for Controlling Gene Expression
Researchers have discovered new
mechanisms by which RNA drugs can control gene activity. A comprehensive review article in Nucleic Acid Therapeutics, a peer-reviewed journal published by Mary Ann Liebert, Inc., details these advances.
New RNA-Based Therapeutic Strategies
for Controlling Gene Expression Review common features shared by RNAi
pathways for controlling gene expression and focus in detail on the potential for Argonaute-RNA complexes in gene regulation and other exciting new options for targeting emerging forms of non-coding RNAs and pre-mRNAs in the article "Argonaute and the Nuclear RNAs: New Pathways for RNA Mediated Control of Gene Expression."
Medical UtilityThe RNA may represent one of the great advances in medicine, if
used properly and that the viruses that plague humanity are
involved in transcription and maturation of the same.
And with the proper identification of the processing and
maturation of these viruses can find a solution by
using drugs that can attack in its genome.
Medical Utility
If accurately elucidate the general maturation
and processing of RNA from this may create drugs that can "manipulate" the RNA and fix all the
mutations that can occur.
Medical Utility
Through the years and with the expertise of researchers
have made significant progress in the field of medicine have been
established treatments and therapies, drugs and
instruments which act on the genome
and polymorphisms reduce all thanks to Molecular Biology.
BIBLIOGRAPHY• “Scientists Create Novel RNA Repair
Technology”, Science Daily Journal, internet edition, January 2012, http://www.sciencedaily.com/releases/2012/01/120117191544.htm
• “New RNA-Based Therapeutic Strategies for Controlling Gene Expression”, Science Daily Journal, internet edition, February 2012, http://www.sciencedaily.com/releases/2012/02/120202164825.htm