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http://www.bioimagene.com

Enabling Digital PathologyEnabling Digital Pathology

September 2007September 2007

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About BioImagene

Mission To enable affordable digital pathology for every pathologist in every hospital and laboratory worldwide

Our BusinessTo provide total digital pathology solutions for clinicaldiagnostics and drug discovery, using innovations in technology and bio sciences

BioImagene’s digital pathology solutionFully integrated hardware and software systems to acquire, view, analyze, manage, archive and share tissue images in a pathology laboratory

CustomersLeading Reference Labs, Clinicians, Pharmaceutical companies

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BioImagene, Inc.

Founded in Jan 2003, HQ in Silicon Valley, software development and research center in Pune, India

Team of around 75 professionals globally

Acquired Scimagix Inc, leader in Image Management in Nov 2004

Acquired TissueInformatics Inc, leader in toxicological image analysis provider in June 2006.

1000+ users

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Research Diagnostics

Applications

3i Framework

Drug Development

Drug Development Discovery Discovery Diagnosis Diagnosis Prognosis Prognosis

Tissue Slides

Markers : H&E, IHC, ISH, & FISH…..

TissueMineTM PathiamTM

ImageManagement

Distributed ImageProcessing

ImageAnalysis

Regulatory Module – 21 CFR Part 11 Compliant

Image Reference Library

Tissue Types : Breast, Postrate, Liver, Colon…

Total Digital Pathology Solution Architecture

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Total Digital Pathology Solution

Tissue sample preparation

Reagents

Capture Manage Analyze Report/Share

Mine Interpret CollaborateDigitize

Services

Efficiency | Accuracy | Consistency | Low Cost | Enables Audits

Breast Panel Analysis

Prostate Panel Analysis

Colon Panel Analysis

IHC Membrane Quantification

IHC Cytoplasmic Quantification

IHC Nuclear Quantification

Pathiam™/TissueMine™

Digital Pathology Application

On board the iScan

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PATHIAM™ RUO

Image Analysis Breast Panel (included); FDA Cleared Her2 image analysis Prostate Panel (optional) Colon Panel (optional)

Image Management Report generation with user selected images Share images in real time online, chat function Search functionality for finding old images/cases Add annotations to images Record measurements 21CFR11 compliant Optional LIS/LIMS integration

Image Acquisition - iScan™ Resolution; 20X and 40X Automated 160 capacity slide loader (1x3 slide format) Eight (8) Sakura rack holders for 1x3 slide format Four (4) rack holders for 2x3 slide format 1D and 2D Barcode support Label image capture Small footprint (18” x 18” x 17”)

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TissueMine™

Image Analysis IHC nuclear quantification IHC cytoplasmic quantification IHC membrane quantification TMA gridding tool

Image Management Report generation with user selected images Share images in real time online, chat function Search functionality for finding old images/cases Add annotations to images Record measurements 21CFR11 compliant Optional LIS/LIMS integration

Image Acquisition - iScan™ Resolution; 20X and 40X Automated 160 capacity slide loader (1x3 slide format) Eight (8) Sakura rack holders for 1x3 slide format Four (4) rack holders for 2x3 slide format 1D and 2D Barcode support Label image capture Small footprint (18” x 18” x 17”)

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Investments

TissueMine™ Express ($99,000)

Image management Image analysis

Desktop ($49,000) Image management Image acquisition

Desktop ($99,000) Image management Image analysis Image acquisition

Pathiam™ RUO $0.99 per image created

$9.99 per image analyzed

Minimums Monthly rate Term