for skin care professionalscosmeticclinicsheffield.co.uk/all-about-obagi.pdf · for skin care...

For skin care professionals

Only Obagi

• Young, healthy skin that is smooth, clear, wrinkle-free and firm renews itself every 5 to 6 weeks through a process called cellular turnover.

• During cellular turnover, the top layer of dead skin cells (stratum corneum) is constantly sloughing off and being replaced by new healthy cells.


Sun exposure, aging, stress, trauma, pollution, and hormonal changes damage skin cells.

• They actually change the way in which your skin cells function and slow the process of cellular turnover.

• Common signs of damaged skin cells are wrinkles, brown spots, freckles, age spots, and an uneven, rough texture.

• Changes in cellular structure also cause skin to become less firm and supple.

Only Obagi


• Only Obagi offers complete skin care systems designed for the purpose of delivering prescription ingredients skin on a cellular level.

• These ingredients correct the damage within skin and increase cellular turnover.

• Skin will go through an amazing Transformation on the outside which is the direct result of a deep cellular Transformation on the inside.

• That’s why you can depend on Obagi to give you skin that looks and acts younger and healthier.

Only Obagi


Facing the Facts: Your Outside Skin

The healthy epidermis • The skin you see in the mirror, the epidermis,

is your protection from the environment and toxins.

• The epidermis is actually very thin, only 3 to 4

sheets of paper thick. • Cells called keratinocytes make up to 90% of

the epidermis. • During cellular turnover, keratinocytes

migrate from the bottom layer of the epidermis to the top.

• Melanocytes protect the body from UV

radiation. • Melanocytes are found in the bottom layer of

the epidermis where they attach to keratinocytes and migrate upwards with them.

stratum corneum

migrating K cells

Healthy epidermis

M cells


• In young, healthy skin, keratinocytes and melanocytes work together to produce skin cells that are well organized and uniform in size, shape, pigmentation, and structure.

Skin in need of repair

• Repeated exposure to radiation from sunlight, along with environmental toxins, cause cells to function improperly.

• Abnormal keratinocytes are produced, causing the structure of the epidermis to become disorganized.

• Melanocytes become overactive, which leads to brown spots, age spots, and freckling.

• Cellular turnover slows down, causing a thick buildup of dead skin cells on the skin’s surface (stratum corneum). This gives your skin an uneven texture and makes fine lines and wrinkles more noticeable.

Facing the Facts: Your Outside Skin

Unhealthy epidermis

Healthy epidermis


The Inside Story: Your Skin Within

The healthy dermis

• The dermis is up to 10 times thicker than the

epidermis.

• If you think of the healthy epidermis as a smooth,

fresh top sheet, the healthy dermis is the firm mattress that it supports.

• The dermis provides collagen and elastin which

give the skin suppleness, firmness, and elasticity.

• It also provides nutrients and moisture to the

epidermis.

Healthy dermis

healthy blood flow to epidermis

strong network of collagen and elastin fibers


Sagging, dull skin

• In the normal course of aging and during periods of stress, trauma, or hormonal changes, collagen and elastin production decreases.

• Collagen and elastin fibers become damaged.

• This damage weakens the tissue of the dermis turning it into a flat, worn-out mattress.

• The dermis can no longer support the epidermis.

• That smooth, fresh “sheet” on top becomes wrinkled.

• What you see is sagging skin that has lost its “snap back” quality and has fine lines and wrinkles.

• To demonstrate, ask the patient to lightly pinch the skin on the top of the hand to see how quickly the skin “snaps back.” When the dermis is compromised, less blood and fewer

nutrients flow to the epidermis, translating into dull, lifeless, sallow skin.

The Inside Story: Your Skin Within

Unhealthy dermis


The Obagi Nu-Derm System

• The Obagi Nu-Derm System is the leading, clinically tested, FDA-approved, prescription strength skin care system combining tretinoin and hydroquinone.

• Tretinoin is the most studied topical remedy for aging skin.1,2

• Hydroquinone evens skin tone and reduces hyperpigmentation.3

• Whereas most other products only work on the surface of the skin, products in the Obagi Nu-Derm System work together to ensure deep penetration of active ingredients.

References: 1. Kang S, Bergfeld W, Gottlieb AB, et al. Long-term efficacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: a two-year, randomized, placebo-controlled trial. Am J Clin Dermatol. 2005;6:245-253. 2. Kockaert M, Neumann M. Systemic and topical drugs for aging skin. J Drugs Dermatol. 2003;2:435-441.

3. Stratigos AJ, Katsambas AD. Optimal management of recalcitrant disorders of hyperpigmentation in dark-skinned patients. Am J Clin Dermatol. 2004;5:161-168. 4. Sigler ML, Stephens TJ, Herndon JH Jr. Clinical evaluation of a prescription skin therapy system designed to treat facial photodamage: efficacy and safety comparisons to 0.1% tretinoin regimen, 4% hydroquinone regimen, and over-the-counter (OTC) regimen [poster]. Presented at: 63rd Annual Meeting of the American Academy of Dermatology; February 18-22, 2005; New

Orleans, La. Study funded by Obagi Medical Products, Inc.

Prescription Strength Ingredients


• In a recent 24-week study with 301 patients, the Obagi Nu-Derm System was shown to be 2 times more effective than either tretinoin or hydroquinone alone.1

• In the same study, the Obagi Nu-Derm System was shown to be 5 to 10 times more effective than a leading combination of physician-recommended skin care products.1

The Obagi Nu-Derm System Prescription Strength Ingredients

1. Sigler ML, Stephens TJ, Herndon JH Jr. Clinical evaluation of a prescription skin therapy system designed to treat facial photodamage: efficacy and safety comparisons to 0.1% tretinoin regimen, 4% hydroquinone regimen, and over-the-counter (OTC) regimen [poster]. Presented at: 63rd Annual Meeting of the American Academy of Dermatology; February 18-22, 2005; New Orleans, La. Study funded by Obagi Medical Products, Inc.


Deep Penetration on a Cellular Level

Most other products only work here

How the Obagi Nu-Derm System Works

Increases cellular turnover1-11

Makes cells uniform and healthy for a smooth, even texture2,3,6,8,11,12

Reduces overactive melanocyte production to correct hyperpigmentation and distribute melanin evenly3,8,11-14

Increases collagen and elastin production for firmer, more supple skin1,3,9,11,15

Increases blood flow and nutrients to the epidermis giving skin a healthy glow3,6,7,12,16,17

References: 1. Buka R, Gordon M, Lebwohl M. How to use retinoids to prevent skin cancer and treat photoaging. Skin and Aging. June 1999;32-39. 2. Elias PM. Epidermal effects of retinoids: supramolecular observations and clinical implications. J Am Acad Dermatol. 1986;15:797-809. 3. Green LJ, McCormick A, Weinstein GD. Photoaging and the skin. The effects of tretinoin. Dermatol Clin. 1993;11:97-105. 4. Kang S, Duell EA, Fisher GJ, et al. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol. 1995;105:549-556. 5. Kligman LH, Duo CH, Kligman AM. Topical retinoic acid enhances the repair of ultraviolet damaged dermal connective tissue. Connect Tissue Res. 1984;12:139-150. 6. Kligman AM, Grove GL, Hirose R, Leyden JJ. Topical tretinoin for photoaged skin. J Am Acad Dermatol. 1986;15:836-859. 7. Kuenzli S, Saurat JH. Medical therapy: retinoids. In: Bolognia JL, Jorizzo J, Rapini RP, et al, eds. Dermatology. Vol 2. London: Elsevier Limited; 2003:1991-2006. 8. Lowe N. Understanding how topical retinoids work. Skin and Aging. Feb 1999;39-42. 9. Olsen EA, Katz HI, Levine N, et al. Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. J Am Acad Dermatol. 1997;37:217-226. 10. Physicians Prescribing Information—tretinoin, USP. 11. Zelickson AS, Mottaz JH, Weiss JS, Ellis CN, Voorhees J. Topical tretinoin in photoaging: an ultrastructural study. J Cutan Aging Cosmetic Dermatol. 1998;1:41-47. 12. Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees J. Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study. JAMA. 1988;259:527-532. 13. Physicians Prescribing Information—hydroquinone, USP. 14. Weinstein GD, Nigra TP, Pochi PE, et al. Topical tretinoin for treatment of photodamaged skin. A multicenter study. Arch Dermatol. 1991;127:659-665. 15. Griffiths C, Russman AN, Majmudar G, Singer RS, Hamilton TA, Voorhees J. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med. 1993;329:530-535. 16. Kligman LH. The ultraviolet-irradiated hairless mouse: a model for photoaging. J Am Acad Dermatol. 1989;21:623-631. 17. Kligman AM, Dogadkina D, Lavker RM. Effects of topical tretinoin on non-sun-exposed protected skin of the elderly. J Am Acad Dermatol. 1993;29:25-33.


The Obagi Nu-Derm System:

– Reduces wrinkles and brown spots

– Smoothes rough, uneven skin

– Increases collagen production

– Evens skin tone and reduces hyperpigmentation

* Results shown above were obtained from using the Obagi Nu-Derm System for 14 weeks. The standard corrective program lasts up to 18 weeks.

From the Inside Out

Before After


A True Cellular Transformation

• Look younger

• Have smaller pores

• Moderate to severe photodamage

• Hyperpigmentation

• Fine lines and wrinkles

• Laxity

• Acne

• Have smoother skin

• Reduce brown/sun spots

From the Inside Out – Patient Treatment Guide

The Obagi Nu-Derm System is for patients who want to

Patients appropriate for this system have

Patients must be committed to Transforming their skin and willing to undergo therapeutic effects.


Obagi Nu-Derm System for Pre and Post Procedure Conditioning

• Conditioning skin before and after an aesthetic procedure has been shown to improve overall results while improving tolerance1

• The Obagi Nu-Derm System uses proven ingredients to pre-condition skin for treatment or surgery

• Post-conditioning with the Obagi Nu-Derm System helps your skin heal quickly and reduces the likelihood of post-procedural reactions or complications, such as post-inflammatory hyperpigmentation, erythema (redness), acne and scarring2

Using the Obagi Nu-Derm System pre and post procedure can

help ensure a successful outcome for any of the following:

• Micro-Dermabrasion • Botox® and Fillers • Intense Pulsed Light

• Non-Ablative Laser • Chemical Peels • Ablative Laser

• Specialty Laser • Facial Surgical Procedures • Laser Hair Removal

References: 1. Lowe NJ, Lask G, Griffin ME. Laser skin resurfacing. Pre- and posttreatment guidelines. Dermatol Surg. 1995;21:1017-1019. 2. Obagi Z. Master the Art of Pre- & Post-procedure conditioning. Practical Dermatol. October 2004;47-51.


Obagi-C Rx Simple Care for Radiant Skin

• The Obagi-C RX System is the only prescription-strength skin care system with professional strength vitamin C.

• This simple, yet effective skin care system combines a patented formula of professional-strength vitamin C and 4% prescription-strength hydroquinone.

• The main benefits of vitamin C on the skin are antioxidant protection and direct stimulation of collagen synthesis.1

• Hydroquinone evens out skin tone and reduces hyperpigmentation.2

References: 1. Burke KE. Photodamage of the skin: protection and reversal with topical antioxidants. J Cosmetic

Dermatol. 2004;3:149-155. 2. Stratigos AJ, Katsambas AD. Optimal management of recalcitrant disorders of hyperpigmentation in dark-skinned patients. Am J Clin Dermatol. 2004;5:161-168.


C-Clarifying Serum (a combination of 4% hydroquinone and 10% vitamin C) provides 2 times better penetration than the leading competitor’s vitamin C serum.1

The Obagi-C Rx System

• Evens tone, resulting in more radiant skin

• Enhances collagen production for smoother skin

• Protects skin from free radicals, minimizing skin cell damage from the environment


References: 1. Data on file.

2 times better penetration


Before After

In just 12 weeks, patients can have:

• Radiant, brighter skin

• Fewer freckles and brown spots

• Younger looking skin

* Results shown above were obtained from using the Obagi-C Rx System for 3 weeks. The standard corrective program lasts up to 12 weeks. Photos courtesy of Dr. Corey S. Maas, California.



Simple Care for Radiant Skin

• Have bright, radiant skin

• Prevent future aging

• Early photodamage

• Mild hyperpigmentation

• Dull, lifeless skin

• Reduce freckles and brown spots

• Have a simple, effective skin care system

Patient Treatment Guide

The Obagi-C Rx System is for patients who want to

Patients appropriate for this system have

A simple skin care system for radiant skin


Obagi Professional-C Serum Superior Antioxidant Protection

• Obagi Professional-C Serum is a complete line of antioxidant therapy that can be used alone or with the Obagi Nu-Derm System

• Available in 4 concentrations:

– 20% for the highest concentration of L-ascorbic acid

– 15% for all skin types

– 10% for dry, sensitive, or reactive skin

– 5% protection for the sensitive eye area


• Exposure to sunlight, pollution, smoking, and other environmental assaults causes the production of free radicals, which can prematurely age skin.

• Obagi Professional-C Serum, a naturally occurring antioxidant, neutralizes free radicals to prevent skin cell damage and premature signs of aging.

• Vitamin C has been proven effective for preventing and treating sun-damaged skin by minimizing skin cell damage caused by the environment.1

• Vitamin C protects the skin from future sun damage.1

References: 1. Farris PK. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg. 2005;31:814-818.



• Vitamin C stimulates collagen production,1 so it helps your skin stay firm and supple.

• To prevent sun damage and to stimulate collagen and elastin production, Vitamin C must penetrate to the dermis.2

• Obagi Professional-C Serum provides up to 2 times better penetration than other professional vitamin C serums and stays stable longer.3

In addition, Obagi Professional-C Serum helps reduce inflammation and increase hydration.1


References: 1. Burke KE. Photodamage of the skin: protection and reversal with topical antioxidants. J Cosmetic Dermatol. 2004;3:149-155. 2. Fitzpatrick RE, Rostan EF. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatol Surg. 2002;28:231-236. 3. Data on file.

2 times better penetration

Taking Transformation to a whole new level


Obagi Blue Peel

• The Obagi Blue Peel is a fast way to dramatically improve the appearance and health of skin.

• It effectively removes layers of aged and damaged skin and replaces dead skin cells with healthier ones. This allows the skin’s own clarity and tightness to resurface.

• The Obagi Blue Peel allows the skin care professional to precisely control the peel in order to tailor the process to each patient’s specific needs.

The ultimate in healthier, younger-looking skin


• The Obagi Blue Peel is effective for all skin colors and thicknesses.

• The Obagi Blue Peel is effective for many conditions including:

- Laxity

- Wrinkles

- Brown spots/age spots

- Large pores

- Acne

• Obagi Blue Peel can also be used on the neck, chest, hands, arms, and even legs.

• Patients should use the Obagi Nu-Derm System for at least 6 to 12 weeks before having a Blue Peel, and then continue using the Nu-Derm System after the procedure to maintain the results achieved.

Obagi Blue Peel The ultimate in healthier, younger-looking skin


The ultimate in healthier, younger-looking skin

Before After

Obagi Nu-Derm System and Blue Peel*

* Results shown above were obtained from preconditioning skin with the Obagi Nu-Derm System for 20 weeks, followed by 1 medium depth Obagi Blue Peel and 7 months of

Obagi Nu-Derm maintenance. The Obagi Blue Peel is a unique procedure to precisely control the depth of Trichloroacetic (TCA) peels. Physicians must be properly trained in acid TCA usage and acquire skills of peel

management before performing any TCA peel including the Obagi Blue Peel. All procedures have a potential for a wide variety of complications, especially if they are performed improperly, if unsuitable patients are selected, and if patient management is below accepted standards. Procedures are performed at sole responsibility of physician. Obagi Medical

Products does not manufacture, sell, or provide TCA in the Obagi Blue Peel kit. TCA must be obtained from a dependable source.


Obagi Nu-Derm® System After 14 weeks


Obagi-C Rx System After 10 weeks


Obagi Nu-Derm® System and 2 Obagi Blue Peels

After 12 weeks


Obagi Nu-Derm® System and 1 Obagi Blue Peel

After 28 weeks

for skin care professionalscosmeticclinicsheffield.co.uk/all-about-obagi.pdf · for skin care...

Documents