forensic toxicology - paul sabatier · pdf filedefinition • toxicology: science dealing...
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FORENSIC TOXICOLOGYFORENSIC TOXICOLOGY
LucieLucie Lxxx DCEM1Lxxx DCEM1
Toulouse Toulouse PurpanPurpan medical schoolmedical school
21/03/12 21/03/12 http://www.forensicmed.co.uk/science/toxicology/
OVERVIEWOVERVIEW
• Definitions
• Sources of poison
• Facts and Figures
• Samples of forensic interest
• Famous cases
DEFINITIONDEFINITION
• Toxicology: science dealing with properties, actions, toxicity, detection … of poisons
• Poison: any substance producing ill-health or death by its action
• Drug: any substance modifying physiological systems or pathological states
SOURCES OF POISONSOURCES OF POISON
• Domestic
• Agricultural and horticultural
• Industrial
• Commercial
• Drugs and medicines
• Food and drink
• Miscellaneoushttp://www.brindilles.fr/brindinfos/upload/vignettes/medium/28.jhttp://www.brindilles.fr/brindinfos/upload/vignettes/medium/28.jpgpg
DEATHS PER YEAR IN DEATHS PER YEAR IN FRANCEFRANCE
SAMPLES OF FORENSIC SAMPLES OF FORENSIC INTERESTINTEREST
•• BloodBlood
•• HairHair
•• UrineUrine
•• GastricGastric content and bilecontent and bile
•• LungLung
•• LiverLiver
•• VitreousVitreous humourhumour
BLOODBLOOD
•• Different anatomical Different anatomical sites of collectionsites of collection
•• Central site: Central site:
�� HeartHeart
•• Peripheral sites:Peripheral sites:
�� FemoralFemoral
�� IliacIliac
�� SubclavianSubclavian
Heart
Subclavian
Iliac
Femoral
www.utm.utoronto.ca/.../03_postmortem.ppt
HAIRHAIR
•• Stability of drug and poisonStability of drug and poison
•• Historical recordHistorical record
•• Racial variability?Racial variability?
GASTRIC CONTENT GASTRIC CONTENT
•• Not always oral Not always oral ingestioningestion
•• Not homogenous Not homogenous contentcontent
•• Undigested pills or Undigested pills or liquidsliquids
http://library.med.utah.edu/WebPath/GIHTML/GI162.html
SAMPLES OF FORENSIC SAMPLES OF FORENSIC INTERESTINTEREST
•• BloodBlood
•• HairHair
•• UrineUrine
•• GastricGastric content and bilecontent and bile
•• LungLung
•• LiverLiver
•• VitreousVitreous humourhumour
FAMOUS CASES (1)FAMOUS CASES (1)
•• Emile Zola: carbon Emile Zola: carbon monoxide poisoningmonoxide poisoning
http://fr.wikipedia.org/wiki/Fichier:ZOLA_1902B.jpghttp://fr.wikipedia.org/wiki/Fichier:ZOLA_1902B.jpg
•• Alexander Alexander LitvinenkoLitvinenko: : lethal dose of lethal dose of poloniumpolonium--210 210 (poisoning)(poisoning)
Http://en.wikipedia.org/wiki/File:AlexanderLitvinenkoHospital.jpg
FAMOUS CASES (2)FAMOUS CASES (2)
•• Michael Jackson: Michael Jackson: lethal dose of lethal dose of propofolpropofol
http://www.zoom-cinema.fr/news/2011/ http://www.lastfm.fr/music/Janis+Joplin/+images/83069
•• Janis Joplin: heroin Janis Joplin: heroin overdoseoverdose
TAKE HOME MESSAGETAKE HOME MESSAGE
•• POISON MAY BE EVERYWHERE, BE CAREFUL! POISON MAY BE EVERYWHERE, BE CAREFUL!
•• Lots of samples of forensic interestLots of samples of forensic interest
http://www.tgdaily.com/security-features/52895-wikileaks-threatens-poison-pill-if-site-shut-down
BIBLIOGRAPHYBIBLIOGRAPHY
•• http://www.forensichttp://www.forensic--medecine.info/medecine.info/
•• http://www.forensicmed.co.uk/pathology/http://www.forensicmed.co.uk/pathology/
•• http://www.forensicmed.co.uk/science/http://www.forensicmed.co.uk/science/
•• http://www.forensicindia.com/ugteaching/forensictoxicology.pdfhttp://www.forensicindia.com/ugteaching/forensictoxicology.pdf
•• http://www.forensicindia.com/autopsy.htmhttp://www.forensicindia.com/autopsy.htm
•• http://www.keewu.com/IMG/pdf/Medicolegale.pdf http://www.keewu.com/IMG/pdf/Medicolegale.pdf
•• http://wwwhttp://www--sante.ujfsante.ujf--grenoble.fr/SANTE/cms/sites/medatice/home/addictologie/docs/2011grenoble.fr/SANTE/cms/sites/medatice/home/addictologie/docs/201102150215112609/TD_Toxicologie_H.Eysseric.pdf112609/TD_Toxicologie_H.Eysseric.pdf
•• http://sfta.org/presentation/main/consensus/techniques/plvtsautohttp://sfta.org/presentation/main/consensus/techniques/plvtsautopsie.pdfpsie.pdf
•• http://www.medicalgeek.com/lecturehttp://www.medicalgeek.com/lecture--notes/21539notes/21539--forensicforensic--medicinemedicine--toxicologytoxicology--lastlast--momentmoment--revisions.htmlrevisions.html