Animals are able to produce Butyric acid. Phytogenics are extracts from plants.Mother Nature obviously had a good reason for this.

THE NEW GENERATION ACIDIFIER IN BROILER DIETS

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T H E VA LU E O F O R G A N I C AC I D S I N B R O I L E R D I E T S

INTRODUCTION

Successful feed formulations must both promote the growth of the ani-mal and discourage the growth of pathogenic bacteria in the gastroin-testinal tract. Feeding for health as well as growth is certainly a major criterion in the design and formulation of poul-try feeds.Organic acids are used in feeds for their various beneficial effects in the gut: feed preservation to control mi-crobial growth, reduction of the feed buffer capacity, inhibition of patho-genic bacteria and improvement of nutrient digestibility. These effects will result in improved growth perfor-mance and improved profitability of poultry production.Due to their different chemical struc-tures, different acids have different properties. The response to diet acidi-fication may be affected by type of acid, inclusion level, diet composition

and dietary buffering capacity. The key basic principle on the mode of ac-tion of organic acids on bacteria is that non-dissociated (non-ionized) organic acids can penetrate the bacteria cell wall and disrupt the normal physiol-ogy of certain types of bacteria. We call these bacteria “pH sensitive” meaning that they cannot tolerate a wide inter-nal and external pH gradient. Among those bacteria we have E.Coli, Salmo-nella spp, C.perfringens. It has been well demonstrated that the state of organic acids (non-dissociated or dis-sociated) is extremely important to de-fine their capacity to inhibit the growth of bacteria. As a general rule, we need more than ten to twenty times the level of dissociated acids to reach the same inhibition of bacteria, compared to non-dissociated acids. Amongst the wide range of organic acids used in animal nutrition, butyric acid takes a unique position.

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THE NE W GENERATION ACIDIFIER IN BROILER DIE TS

Monobutyrin, the monoglyceride of butyric acid, is a polar molecule. Due to the fact that most pathogens (E-Coli, Salmonella, Clostridium Per-fringens and others) have a hydro-philic membrane, Monobutyrin can enter the pathogens and destroy the cell. Monoglycerides from organic acids are up to 30 times more effec-tive against bacteria then its original organic acid. Another advantage of monobutyrin is that it is soluble in

water, which makes it also active in the crop and the gizzard.Di- and tri-glycerides of butyric acid are non-polar, and have a negative influence on the palatability. They have no effect on bacteria in the crop and gizzard. Di- and tri- glycerides, contained byMonobutyrin, have the following specific and unique functions:

MONOBUTYRIN, A NEW MOLECULE 1) It fuels the gut mucosa cells by providing extra energy in the gutand consequently plays an important role in the proliferation and differentiation of the epithelial cells

2) IIt stimulates the developmentof a favourable intestinal flora (e.g. Lac-tobacilli)

3) It reduces the colonization andinvasiveness of Salmonella in the gut(caeca)

4) It reduces the risks for incidence such as Necrotic Enteritis (Clostridium perfringens) and Colibacillosis.

5) It enhances the barrier func-tion of the intestinal epithelium since butyrate up-regulates the expression of tight junction proteins (=’glue’ join-ing the epithelial cells together)

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Nutrition of coloncyte (butyrate)Energy salvage

Immunomodulation

Increase sodium absorption Increase mucosal blood flow

Regulate cell proliferationEffect on cell differentation

Decrease blood cholesterol(propionate)

Butyrate and other SCFAs

Fig. 1Flowchart summarizing the different mode of actions of butyrate in the gut

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Plant parts, plant extracts

and essential oils.

Plant parts and plant extracts, are the fundamentals for the phytogenic com-plex. Next to this, essential oils and herbs are included. The most active substances in the complex for poultry are: Foenicu-lum vulgarae. (Fennel), Melissa officinalis L. (Melissa balm), Men-tha arvensis L. (Peppermint), Pimpinella anisum L. (Anise), Quercus cortex (Oak), Syzygium aromaticum L. (Clove), Thymus vulgaris L. (Thyme)Plant parts and extracts contain a high number of active components like saponins and tannins. Saponins stimu-late the activities of all organs and im-prove the effectiveness of medication. The content of the different active substances is standardized to aim for constant quality while the quantities of the active components can differ in

the basic ingredients Tannin substances (e.g. oak bark) have an antibacterial effect and show positive effects against wet litter.Essential oils (e.g. peppermint oil) pro-duce a very characteristic smell and taste and disappears at room tempera-ture. The smell and taste influence the stomach and intestine, the ingredients stimulate the saliva production. Other ingredients of essential oils have an in-fluence on the gall bladder. In volatile form these essential oils ease their res-piration and have an antibacterial and mould inhibiting function.

In Holland a trial has been conducted over 6 rounds with 100.000 animals per cycle. In table 1 the results are presented.

Table 1

Based on research the most important effects are:• Improvement of taste (increase of feed intake)• Improvement of the enzyme secretion resulting in better weight gain and feed conversion.• Stabilisation of health status and stimulation of the immune system of the animals• Prevention of wet litter (due to products with tannins)

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MODE OF ACTION IN

Liver, Kidneys:optimised function for

detoxfication

Gall bladder:higher production of conjugated bile acids

Pancreas:higher enzyme secretion (e.g.

amylase, maltase, lipases)

Small intestine :optimisation of

nutrient absorption

Whole gut:stabilisation of

physiological micro flora

Proventriculus:higher production of HCI and pepsin

Fig. 2 Mode of action of phytogenics in poultry

Number broilers totalAnimals started per roundGrowing daysbody weight/animal [g]Daily gain [g]Mortality [%]Broilers/m2Feed intake/animal [g]FCR netto [kg/kg]FCR corrected 1500 g [kg/kg]EPEFManure [kg/animal]Medication costs/round [€]

average

593,60098,94344.22\24650.84.720.440511.8051.5072681.312246

average

588,61698,10343.2236754.85.321.041791.7651.4182941.261222

effect of complex

- 1.0+ 121+ 4.,0+ 0.6 + 128- 0.04--0.09+ 26 - 0.05- 1024

control + Phytogene complex

PHYTOGENIC COMPLEX, A NATURAL DIGESTIBILITY ENHANCER

The phytogenic complex is a mixture of fine grinded natural herbs enriched with extracts and essential oils. The phytogenic complex is defined as a flavour/aroma for animal feed and is approved in the EU and US. The phytogenic complex is developed to: • stimulate the feed intake• improve the digestion of nutrients• stimulate the production of animal own enzymes• increase the health status of the animals (reduction of mortality and morbidity)

THE NE W GENERATION ACIDIFIER IN BROILER DIE TS

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CONCLUSION

The combination of monobutyrin and the phytogenic complex has a great synergy. The effect of the phytogenic complex to enhance the body’s own enzyme production will improve the digestibility, the feed intake, the growth and reduce the feed conver-sion. By stimulating the immune sys-tem of the animal, the mortality and morbidity of the flock will go down. By killing the pathogenic bacteria in the crop and gizzard, they will not enter the intestine. When there will be an attack by pathogenic bacteria from the caeca to the distal part of the in-testine, the monobutyrin is still able to kill these bugs. These combinations will result in healthier animals with better technical and financial results of the broilers.

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THE NE W GENERATION ACIDIFIER IN BROILER DIE TS

FR A® BP BROILER B UT YRIC / P HY TOGENIC

DOSAGE:

POULTRY:- Feed 0.08%

the versatile acidifier

THE PRODUCT IS:

- GRAS (Generally Recommended As Safe)- non-corrosive- safe in transport- safe in handling- safe in processing

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