fully implantable transmitters. product range ecg, eeg, emg, sampled at 2khz. sna (sympathetic nerve...

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fully implantable transmitters

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Page 1: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

fully implantable transmitters

Page 2: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

product range

ecg, eeg, emg, sampled at 2kHz.

sna (sympathetic nerve activity) sampled at 8kHz

temperature

pressure (arterial or venous blood, bladder, pleural), sampled at 500Hz

Page 3: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

transmitter features (1/2)

fully implantable

covered with medical grade silicone

completely sealed, with no battery to be replaced

transmission up to 5m

large and small animal models available

Page 4: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

transmitter features (2/2)

designed to be reused in multiple animals

pressure leads are filled with gel that prevents blood from entering the catheter lumen

ecg cables are filled with a biocompatible silicone to avoid contamination

Page 5: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

6 types of transmitters

1 pressure1 pressure + 1 biopotential1 biopotential2 biopotential1 SNA + 1 pressure1 SNA + 1 biopotential

temperature is standard in all devices

transmitters can remotely be turned on and off

no need to enter the room and disturb the animals

transmitters

Page 6: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

implants are fitted with a rechargeable battery

recharging is performed through patented inductive energy transfer

measurement from the subject may continue while the implant is recharged

there are no costs or down times due battery replacements and refurbishments

chargers

Page 7: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

rat data a few hours after implantation(courtesy Sanofi Aventis, France)

blood pressure, ecg, temperature

Page 8: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

implants for large animalscan run up to 200 hours without recharging

using the remote on/off feature, allow recording of 10mn every hour for more than 6 weeks

long transmission range (5m)

high signal resolution

ability pair or group house animals

Page 9: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

one receiver can acquire up to 12 transmitters

open system with analog outputs, compatible with all data acquisition systems

receivers

Page 10: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

recharging causes an increase in tissue temperature

false: continuous temperature recordings remain stable whether charging is off or on

misconceptions about inductive energy transfer

Page 11: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

misconceptions about inductive energy transfer

repeated recharging has long term consequences

false: experiments of more than 130 days, performed to verify pressure sensor stability, concurrently verified stability of all other physiological parameters

recharging influences physiological parameters

false: recordings show that blood pressure, heart rate, ecg morphology, and eeg power spectrum remain stable independent of charging status

Page 12: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

sympathetic nerve activity (SNA) by telemetry

a challenging application

small signal amplitude (+/- 60µV)

high frequency

high sampling rate required

Page 13: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

sympathetic nerve activity (SNA) by telemetry

TR system provides

8kHz sampling rate

integrated output with: adjustable gain adjustable integrator time constant

audio output

Page 14: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

sympathetic nerve activity (SNA) by telemetry

electrodes and placement of electrodes

Page 15: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

sympathetic nerve activity (SNA) by telemetry

sample SNA recording

Page 16: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

feature comparisonTelemetry Research competitor

sampling frequency up to 8000 Hz <= 500Hz

pressure measurement

gel filled catheter yes yes

battery rechargeable return to factory

range of transmitter up to 5 m up to 1 m

group housing up to 12 1

software open platform specific software

Page 17: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

visit our websites for complete product descriptions, case studies, a knowledge base, & frequently asked questions:

www.emka.fr

website

Page 18: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial

contact us!

please contact us to see how we can help you meet your implantable telemetry research goals!

Page 19: Fully implantable transmitters. product range ecg, eeg, emg, sampled at 2kHz. sna (sympathetic nerve activity) sampled at 8kHz temperature pressure (arterial